NOAEL Studies Cosmetic Ingredient

Valeric Acid NOAEL Studies

INCI: VALERIC ACID (N-PENTANOIC ACID)

CAS: 109-52-4

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 50 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 75 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 750 mg/kg bw/day rat oral 10 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =1055 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_852; row=11697; data_type=In Vivo; mixture=Chemical; chemical_name=Pentanoic acid; preferred_name=Pentanoic acid; dtxsid=DTXSID7021655; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021655; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1720 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_853; row=11698; data_type=In Vivo; mixture=Chemical; chemical_name=Pentanoic acid; preferred_name=Pentanoic acid; dtxsid=DTXSID7021655; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021655; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =1844 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_854; row=11699; data_type=In Vivo; mixture=Chemical; chemical_name=Pentanoic acid; preferred_name=Pentanoic acid; dtxsid=DTXSID7021655; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021655; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =4600 mg/kg bw Rat oral acute Rat Acute Oral Toxicity ECHA ChemProp (undated); record_id=acute_oral_855; row=11696; data_type=In Vivo; mixture=Chemical; chemical_name=Pentanoic acid; preferred_name=Pentanoic acid; dtxsid=DTXSID7021655; url=https://echa.europa.eu/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021655; source_file=acute_oral.xlsx
NTP ICE endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=12982; RecordID=ARPathway2016_529; DatasetName=ARPathway2016; DTXSID=DTXSID7021655; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021655
ToxValDB DOE Protective Action Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB DOE Protective Action Criteria LEL =66835.8 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15521003:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ee9620b3ae8e9204258144e5b903847
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL =750 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb732; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14438/7/9/3?documentUUID=6d4466a5-ad34-4fb9-bfae-7f9a736500e1; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822976_15823005:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2b2d333eda7def3fdf093f2348e46850
ECHA NOAEL =50 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb729; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14438/7/9/3?documentUUID=6d4466a5-ad34-4fb9-bfae-7f9a736500e1; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID:15821420:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_248e5d969b6f0a575a81ce6f4181a7b6
ECHA NOEL =50 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabb9e4b0a7c65d1bb72d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14438/7/9/3?documentUUID=6d4466a5-ad34-4fb9-bfae-7f9a736500e1; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822976_15823005:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8c9e513ecb391f75cb6bf2042c781f0c
ToxValDB ECOTOX 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB ECOTOX LOEL =0.1 mM European Rabbit environmental short-term; 2 days developmental LONG_REF=Biol. Reprod.20(2): 323-332 Kane,M.T. Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae 1979; TITLE=Fatty Acids as Energy Sources for Culture of One-Cell Rabbit Ova to Viable Morulae; AUTHOR=Kane,M.T.; DOI=10.1095/biolreprod20.2.323; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=101665; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Development: Morula stage; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15598358:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8e3a053a88fd86ce33b29d87d74a7681
ToxValDB ECOTOX LOEL =25 mg Mouse dermal chronic; 560 days chronic LONG_REF=EPA/OTS Doc #88-8400625:102 p. Celanese Corp. Summary of Results for a Chronic Dermal Application Study of N-Pentanoic Acid, Heptanoic Acid and Nonanoic Acid in C3H/HeJ Mice with Cover Letter 043084 1984; TITLE=Summary of Results for a Chronic Dermal Application Study of N-Pentanoic Acid, Heptanoic Acid and Nonanoic Acid in C3H/HeJ Mice with Cover Letter 043084; AUTHOR=Celanese Corp.; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=119048; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15610806:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9f4377affc5b861cc2d0fd9bf278bc1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier GZK92PJM7B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GZK92PJM7B"}
openFDA substances FDA UNII substance identifier GZK92PJM7B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GZK92PJM7B"}
openFDA substances FDA UNII substance identifier GZK92PJM7B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GZK92PJM7B"}
openFDA substances FDA UNII substance identifier GZK92PJM7B UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"GZK92PJM7B"}