NOAEL Studies UV Filter / Sunscreen

Uvasorb HEB (Diethylhexyl Butamido Triazone) NOAEL Studies

INCI: DIETHYLHEXYL BUTAMIDO TRIAZONE

CAS: 154702-15-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_3031; row=8106; data_type=In Vivo; mixture=Chemical; chemical_name=Iscotrizinol; preferred_name=Iscotrizinol; dtxsid=DTXSID40870027; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID40870027; source_file=acute_oral.xlsx
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =500 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaa7e4b0a7c65d1b6dd9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3505/7/9/2?documentUUID=1192f0cb-a0c5-4b43-a8b2-fd7572b41423; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855158_15855522_15856032_15856328:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7496d40ab890ef601d108d39c64bb2f
ToxValDB_ECHA_IUCLID NOAEL =831 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4ab3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3505/7/6/2?documentUUID=1192f0cb-a0c5-4b43-a8b2-fd7572b41423; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight and weight gain|ophthalmological examination|urinalysis|water consumption and compound intake|clinical biochemistry|clinical signs|food consumption and compound intake|food efficiency|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|other|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831518_15837606:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a123da553d7f680e7bfc1d6d090618ec
ToxValDB_ECHA_IUCLID NOAEL =963 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead8ae4b0a7c65d1c4ab3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3505/7/6/2?documentUUID=1192f0cb-a0c5-4b43-a8b2-fd7572b41423; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=body weight and weight gain|ophthalmological examination|urinalysis|water consumption and compound intake|clinical biochemistry|clinical signs|food consumption and compound intake|food efficiency|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|other|urinalysis; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15831519_15837607:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_243e7f98ccff05dd0ff44335e21a7e98
ToxValDB_ECHA_IUCLID NOAEL >=1000 mg/kg bw/day Rat dermal short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e6be4b096bca8779a2d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/3505/7/6/4?documentUUID=fc81b084-d747-45b2-bf9f-64b6cce9328c; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15826506:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d114cd7799245d9deab2e14acd4e7702
ToxValDB_GESTIS_DNEL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =7.347 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630193_15630194_15630195:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a3381fce52ffd6a003ec383fca689a9c
ToxValDB_GESTIS_DNEL DNEL systemic =10.858 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15630193_15630194_15630195:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a141ae7dddc756a9449919262637297
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2UTZ0QC864 UNII - - - chemical {"approval_status":null,"molecular_formula":"C44H59N7O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2UTZ0QC864"}
openFDA substances FDA UNII substance identifier 2UTZ0QC864 UNII - - - chemical {"approval_status":null,"molecular_formula":"C44H59N7O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2UTZ0QC864"}
openFDA substances FDA UNII substance identifier 2UTZ0QC864 UNII - - - chemical {"approval_status":null,"molecular_formula":"C44H59N7O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2UTZ0QC864"}
openFDA substances FDA UNII substance identifier 2UTZ0QC864 UNII - - - chemical {"approval_status":null,"molecular_formula":"C44H59N7O5","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2UTZ0QC864"}