NOAEL Studies Active Ingredient

Undecylenic Acid NOAEL Studies

INCI: UNDECYLENIC ACID

CAS: 112-38-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =2500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_1195; row=14268; data_type=In Vivo; mixture=Chemical; chemical_name=10-Undecenoic acid; preferred_name=10-Undecenoic acid; dtxsid=DTXSID8035001; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >2000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_1194; row=14269; data_type=In Vivo; mixture=Chemical; chemical_name=10-Undecenoic acid; preferred_name=10-Undecenoic acid; dtxsid=DTXSID8035001; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=898; RecordID=ARPathway2016_606; DatasetName=ARPathway2016; DTXSID=DTXSID8035001; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation 37 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation ET50 15.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5451; Record_ID=skin_irritation_invitro_1466; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=15.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 6.4 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5452; Record_ID=skin_irritation_invitro_1462; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=6.4; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 6.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5453; Record_ID=skin_irritation_invitro_1459; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=6.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 7.1 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5481; Record_ID=skin_irritation_invitro_1464; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=7.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 34.2 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5496; Record_ID=skin_irritation_invitro_1476; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=34.2; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 33.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5497; Record_ID=skin_irritation_invitro_1474; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=33.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 28.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5498; Record_ID=skin_irritation_invitro_1472; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=28.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 22.1 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5499; Record_ID=skin_irritation_invitro_1470; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=22.1; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation ET50 18.5 min - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5500; Record_ID=skin_irritation_invitro_1468; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=ET50; Response=18.5; Response_Unit=min; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Positive reaction 3.5 % Human Dermal - In Vivo; Four-hour Human Patch Test sheet=Data_invivo; excel_row=1743; Record_ID=skin_irritation_invivo_85; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=3.5; Response_Unit=%; Species=Human; Reference=Jirova et al. 2010; 20136894; 10.1111/j.1600-0536.2009.01640.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 33.2 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5441; Record_ID=skin_irritation_invitro_421; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=33.20; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 7 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5442; Record_ID=skin_irritation_invitro_423; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=7; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 8.3 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5443; Record_ID=skin_irritation_invitro_424; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.30; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 8.4 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5444; Record_ID=skin_irritation_invitro_426; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=8.4; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 10.2 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5445; Record_ID=skin_irritation_invitro_427; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.20; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 12.1 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5446; Record_ID=skin_irritation_invitro_429; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.1; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 12.5 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5447; Record_ID=skin_irritation_invitro_431; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.5; Response_Unit=%; Reference=Fentem et al. 2001; 11259870; 10.1016/s0887-2333(01)00002-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 5.3 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5448; Record_ID=skin_irritation_invitro_432; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=Viability; Response=5.3; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 5.6 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5449; Record_ID=skin_irritation_invitro_434; Data_Type=In Vitro; Formulation_Name=10-Undecanoic acid; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=Viability; Response=5.6; Response_Unit=%; Reference=Zuang et al. 2002; 11827575; 10.1177/026119290203000110; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 12.3 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5454; Record_ID=skin_irritation_invitro_468; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=Viability; Response=12.3; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 10 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5455; Record_ID=skin_irritation_invitro_467; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=Viability; Response=10; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 31.05 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5456; Record_ID=skin_irritation_invitro_466; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=31.05; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 10.42 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5457; Record_ID=skin_irritation_invitro_465; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=10.42; Response_Unit=%; Reference=Cotovio et al. 2005; 16185103; 10.1177/026119290503300403; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 17.5 % - Dermal - In Vitro; EpiDerm Irritation sheet=Data_invitro; excel_row=5506; Record_ID=skin_irritation_invitro_416; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiDerm Irritation; Endpoint=Viability; Response=17.5; Response_Unit=%; Reference=Kandarova et al. 2004; 15329774; Not available|Kandarova et al. 2005; 16185104; 10.1177/026119290503300408; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 12.6 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5507; Record_ID=skin_irritation_invitro_418; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=12.6; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability 23.8 % - Dermal - In Vitro; EpiSkin Irritation sheet=Data_invitro; excel_row=5508; Record_ID=skin_irritation_invitro_419; Data_Type=In Vitro; Formulation_Name=10-Undecenoic acid; Concentration=98.8; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Irritation; Endpoint=Viability; Response=23.8; Response_Unit=%; Reference=Portes et al. 2002; 12423661; 10.1016/s0887-2333(02)00090-5; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (18 hours) 13 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=5502; Record_ID=skin_irritation_invitro_187; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (18 hours); Response=13; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (240 minutes) 101.6 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5458; Record_ID=skin_irritation_invitro_1726; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=101.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (240 minutes) 102.3 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5459; Record_ID=skin_irritation_invitro_1724; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=102.3; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (240 minutes) 60 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5460; Record_ID=skin_irritation_invitro_1722; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (240 minutes); Response=60; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (3 minutes) 96.7 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5464; Record_ID=skin_irritation_invitro_1726; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=96.7; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (3 minutes) 114.6 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5465; Record_ID=skin_irritation_invitro_1724; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=114.6; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (3 minutes) 118.2 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5466; Record_ID=skin_irritation_invitro_1722; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (3 minutes); Response=118.2; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (42 hours) 2 % - Dermal - In Vitro; Vitrolife-Skin Irritation sheet=Data_invitro; excel_row=5504; Record_ID=skin_irritation_invitro_187; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Vitrolife-Skin Irritation; Endpoint=Viability (42 hours); Response=2; Response_Unit=%; Reference=Morikawa et al. 2008; Not available; 10.11232/AATEX.13.11; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (60 minutes) 93.8 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5461; Record_ID=skin_irritation_invitro_1726; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=93.8; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (60 minutes) 134 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5462; Record_ID=skin_irritation_invitro_1724; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=134; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_irritation Viability (60 minutes) 67.4 % - Dermal - In Vitro; EpiSkin Corrosion sheet=Data_invitro; excel_row=5463; Record_ID=skin_irritation_invitro_1722; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=EpiSkin Corrosion; Endpoint=Viability (60 minutes); Response=67.40; Response_Unit=%; Reference=Alepee et al. 2014; 24211528; 10.1016/j.tiv.2013.10.016; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization 14 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Depletion Cys 11.4 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1160; Record_ID=skin_sensitization_invitro_314; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=11.4; Reported_Response_Unit=%; Response=11.4; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Depletion Lys -0.1 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1158; Record_ID=skin_sensitization_invitro_314; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-0.1; Reported_Response_Unit=%; Response=-0.1; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Depletion Lys + Cys 5.75 % - Dermal - In Vitro; DPRA2015; DPRA sheet=Data_invitro; excel_row=1162; Record_ID=skin_sensitization_invitro_314; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=5.75; Reported_Response_Unit=%; Response=5.75; Response_Unit=%; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization EC1.5 57 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4791; Record_ID=skin_sensitization_invitro_1107; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=57; Reported_Response_Unit=uM; Response=57; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization EC1.5 <172.36 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=8070; Record_ID=skin_sensitization_invitro_1823; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=172.36; Reported_Response_Unit=uM; Response=172.36; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization EC3 25 % Mouse Dermal - In Vivo; Urbisch_SkinSensitization2020; LLNA sheet=Data_invivo; excel_row=12909; Record_ID=skin_sensitization_invivo_2842; Data_Type=In Vivo; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=LLNA; Endpoint=EC3; Response=25; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization EC3 19.4 % Mouse Dermal - In Vivo; LLNAdb2013; LLNA sheet=Data_invivo; excel_row=12984; Record_ID=skin_sensitization_invivo_2918; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=LLNA; Endpoint=EC3; Response=19.4; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=EFfCI personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization IC50 >2000 uM - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4793; Record_ID=skin_sensitization_invitro_1107; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=KeratinoSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization IC50 >428.88 uM - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7654; Record_ID=skin_sensitization_invitro_1823; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=LuSens; Endpoint=IC50; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=428.88; Reported_Response_Unit=uM; Response=428.88; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Imax 23.3 ratio - Dermal - In Vitro; KeratinoSens2015; KeratinoSens sheet=Data_invitro; excel_row=4795; Record_ID=skin_sensitization_invitro_1107; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=23.3; Reported_Response_Unit=Unitless; Response=23.3; Response_Unit=Ratio; Reference=Bauch et al. 2012; 22659254; 10.1016/j.yrtph.2012.05.013; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Imax 8.048 ratio - Dermal - In Vitro; Urbisch_SkinSensitization2020; LuSens sheet=Data_invitro; excel_row=7557; Record_ID=skin_sensitization_invitro_1823; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=LuSens; Endpoint=Imax; Reported_Response=8.048332788; Reported_Response_Unit=Unitless; Response=8.048; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3782; Record_ID=skin_sensitization_invivo_938; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80156-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Induction dose per skin area 2700 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3780; Record_ID=skin_sensitization_invivo_938; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=2700; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80156-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=3786; Record_ID=skin_sensitization_invivo_938; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=4.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID8035001; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1976: report to RIFM|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80156-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8035001
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =450 mg/kg bw/day Rat oral - developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d18ae4b0a7c65d22f137; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10078/7/9/3?documentUUID=4212da69-bd9b-478c-bc52-620027d427ec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID:15821274:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_13fc78cde6f0a4ba64e5aaeffcd36f4b
ToxValDB_ECHA_IUCLID NOAEL =150 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c892e4b0a7c65d2193f5; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10078/7/9/2?documentUUID=4212da69-bd9b-478c-bc52-620027d427ec; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855721_15856485:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5016e13b7622e6dc505c6c23baf50bc0
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =5.92 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635641:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab092596a41dc0f16ea59d91da8d8044
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier K3D86KJ24N UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K3D86KJ24N"}
openFDA substances FDA UNII substance identifier K3D86KJ24N UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K3D86KJ24N"}
openFDA substances FDA UNII substance identifier K3D86KJ24N UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K3D86KJ24N"}
openFDA substances FDA UNII substance identifier K3D86KJ24N UNII - - - chemical {"approval_status":null,"molecular_formula":"C11H20O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"K3D86KJ24N"}