Is Tyramine HCl safe in cosmetics?
Tyramine HCl has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Moderate
Cosmetic Ingredient
Tyramine HCl
Also known as: Phenol, 4-(2-aminoethyl)-, hydrochloride (1:1), 4-Hydroxyphenethylamine hydrochloride, Phenol, p-(2-aminoethyl)-, monohydrochloride, Phenol, 4-(2-aminoethyl)-, hydrochloride, Phenol, p-(2-aminoethyl)-, hydrochloride (8CI) (+9 more)
INCI: TYRAMINE HCL
Tyramine HCl (CAS 60-19-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 60-19-5 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-(2-aminoethyl)phenol;hydrochloride
InChIKey
RNISDHSYKZAWOK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not specifically listed; permissible under general cosmetic ingredient provisions (no monograph)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tyramine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expert Verdict
Expert safety assessment and concern-level summary for Tyramine HCl.
Known Synonyms
Phenol, 4-(2-aminoethyl)-, hydrochloride (1:1)
4-Hydroxyphenethylamine hydrochloride
Phenol, p-(2-aminoethyl)-, monohydrochloride
Phenol, 4-(2-aminoethyl)-, hydrochloride
Phenol, p-(2-aminoethyl)-, hydrochloride (8CI)
4-(2-Aminoethyl)phenol hydrochloride
EINECS 200-462-5
NSC 27430
Phenol, p-(2-aminoethyl)-, monochloride
p-Tryamine hydrochloride
p-Tyramine hydrochloride
Tyramine monochloride
Tyrosamine hydrochloride
UNII-Z5KDH3H147
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TYRAMINE HYDROCHLORIDE
ChEMBL ID
CHEMBL1255790
Frequently Asked Questions
Is Tyramine HCl allowed in the EU?
Tyramine HCl EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tyramine HCl do in cosmetics?
Tyramine HCl functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 60-19-5.
Is Tyramine HCl used outside cosmetics?
Tyramine HCl also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tyramine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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