Is Trimethylolpropane Triacrylate safe in cosmetics?
Trimethylolpropane Triacrylate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Trimethylolpropane Triacrylate
Also known as: 2-Propenoic acid, 2-ethyl-2-[[(1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester, Acrylic acid, 1,1,1-(trihydroxymethyl)propane triester, EINECS 239-701-3, NK Ester A TMPT, 1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, triacrylate (+3 more)
INCI: TRIMETHYLOLPROPANE TRIACRYLATE
Trimethylolpropane Triacrylate (CAS 15625-89-5) is a cosmetic cosmetic ingredient functioning as Film forming, hair conditioning, hair fixative. Reported NOAEL =240 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 15625-89-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Trimethylolpropane Triacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H336, H351, H360, H400, H410).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film forming, hair conditioning, hair fixative
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,2-bis(prop-2-enoyloxymethyl)butyl prop-2-enoate
InChIKey
DAKWPKUUDNSNPN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
CIR reviewed — considered safe in the present practices of use and concentration; not prohibited by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trimethylolpropane Triacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Trimethylolpropane Triacrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =240 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Sensitization Profile
Contact sensitization data for Trimethylolpropane Triacrylate based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.3%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis
Source: IVDK; ESSCA
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
122
Evaluation Year
2018
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Health HazardHarmful / IrritantEnvironmental Hazard
Hazard Class and Category
Carc. 2; Skin Irrit. 2; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H351 Suspected of causing cancer
- H315 Causes skin irritation
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 1; M = 1
Inserted via ATP: ATP18
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1718
(EU) 2023/1490
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1721
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "other", "cross_reactivity_group": "acrylate-group", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
Trimethylolpropane triacrylate, technical grade | Group 2B: Possibly carcinogenic to humans | Volume 122: (2019) Isobutyl Nitrite, β-Picoline, and Some Acrylates
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Trimethylolpropane Triacrylate | TR-576: Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats (Topical Application Studies) (2012 ) | 02/08/12 | Equivocal Evidence | No Evidence | No Evidence | Some Evidence | Under the conditions of these 2-year dermal studies, there was equivocal evidence of carcinogenic activity of
Source: NTP Technical Reports
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Hair fixative
Softener and conditioner
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Trimethylolpropane Triacrylate.
Regulatory Flags
potential-allergen
prop65
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Trimethylolpropane Triacrylate by CAS number or substance name.
Studies
2
Lowest NOAEL
240 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenoic acid, 2-ethyl-2-[[(1-oxo-2-propenyl)oxy]methyl]-1,3-propanediyl ester
Acrylic acid, 1,1,1-(trihydroxymethyl)propane triester
EINECS 239-701-3
NK Ester A TMPT
1,3-Propanediol, 2-ethyl-2-(hydroxymethyl)-, triacrylate
UNII-4B67KGL96S
TMPTA
Ethyl-2-(Hydroxymethyl)-1,3-Propanediol Triacrylate
Chemical Function
Film former
Softener and conditioner
Hair fixative
Regulatory Lists
OEHHA Proposition 65 (1/2023)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1886556
Frequently Asked Questions
Is Trimethylolpropane Triacrylate allowed in the EU?
Trimethylolpropane Triacrylate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Trimethylolpropane Triacrylate do in cosmetics?
Trimethylolpropane Triacrylate functions as: Film forming, hair conditioning, hair fixative. It is classified as a cosmetic ingredient in our database. CAS number: 15625-89-5.
What is the NOAEL for Trimethylolpropane Triacrylate?
The NOAEL (No Observed Adverse Effect Level) for Trimethylolpropane Triacrylate is =240 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Trimethylolpropane Triacrylate used outside cosmetics?
Trimethylolpropane Triacrylate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Trimethylolpropane Triacrylate have different safety status in cosmetics vs industrial chemicals?
Trimethylolpropane Triacrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H336, H351, H360, H400, H410).
Compliance Tools
Check Trimethylolpropane Triacrylate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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