NOAEL Studies
Cosmetic Ingredient
Trimethylhexanol NOAEL Studies
INCI: TRIMETHYLHEXANOL
CAS: 3452-97-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 144 | mg/kg bw/day | rat | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_5778; row=12088; data_type=In Vivo; mixture=Chemical; chemical_name=3,5,5-Trimethyl-1-hexanol; preferred_name=3,5,5-Trimethyl-1-hexanol; dtxsid=DTXSID7029661; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029661; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=2980; RecordID=ARPathway2016_1160; DatasetName=ARPathway2016; DTXSID=DTXSID7029661; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029661 |
NTP_ICE_skin_sensitization 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6915; Record_ID=skin_sensitization_invivo_1580; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7029661; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80067-8|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659634; 10.1016/j.fct.2010.05.026; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029661 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 5400 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6913; Record_ID=skin_sensitization_invivo_1580; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7029661; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80067-8|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659634; 10.1016/j.fct.2010.05.026; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029661 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=6919; Record_ID=skin_sensitization_invivo_1580; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7029661; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=RIFM 1977; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 2000; Not available; 10.1016/S0278-6915(00)80067-8|Belsito et al. 2010; 20659630; 10.1016/j.fct.2010.05.046|Belsito et al. 2010; 20141871; 10.1016/j.fct.2009.11.007|McGinty et al. 2010; 20659634; 10.1016/j.fct.2010.05.026; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7029661 |
ToxValDB_ECHA_IUCLID 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =60 | mg/kg bw/day | Rat | oral | subchronic; 46 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c7a55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5418/7/6/2?documentUUID=0040c0ad-484c-4158-a690-be4c1ec8e700; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837066_15837067:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_297cc2e103f4adc20c0a6932cac80ae9 |
| ToxValDB_ECHA_IUCLID | NOAEL | <1800 | mg/kg bw/day | Rabbit | dermal | subchronic; 50 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61ee5e4b096bca877b68c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5418/7/6/4?documentUUID=0040c0ad-484c-4158-a690-be4c1ec8e700; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15826663:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d7cf9ddd2dea46b299346ed410f564c |
| ToxValDB_ECHA_IUCLID | NOAEL | =12 | mg/kg bw/day | Rat | oral | subchronic; 46 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae1fe4b0a7c65d1c7a55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5418/7/6/2?documentUUID=0040c0ad-484c-4158-a690-be4c1ec8e700; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837066_15837067:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7a7915ceca9461b6ef88b4f224dbc020 |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b81a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5418/7/9/2?documentUUID=0040c0ad-484c-4158-a690-be4c1ec8e700; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15855754:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4baf3fe3bdd19fe9c224580d7cda5b62 |
| ToxValDB_ECHA_IUCLID | NOAEL | =60 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaaeee4b0a7c65d1b81a0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5418/7/9/2?documentUUID=0040c0ad-484c-4158-a690-be4c1ec8e700; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ECHA IUCLID:15856513:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aa04b562e605add3e6743af7fd22f2f9 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | O5KUD6I57K | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O5KUD6I57K"} |
| openFDA substances | FDA UNII substance identifier | O5KUD6I57K | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O5KUD6I57K"} |
| openFDA substances | FDA UNII substance identifier | O5KUD6I57K | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O5KUD6I57K"} |
| openFDA substances | FDA UNII substance identifier | O5KUD6I57K | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C9H20O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"O5KUD6I57K"} |