Is Trihydroxychalcone safe in cosmetics?
Trihydroxychalcone has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Trihydroxychalcone
INCI: TRIHYDROXYCHALCONE
Trihydroxychalcone (CAS 961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone)) is a cosmetic cosmetic ingredient functioning as Skin conditioning, antioxidant (chalcone flavonoid, also known as. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone)
View industrial chemical safety profile →
Function
Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; naturally occurring in licorice root; no specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Trihydroxychalcone.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Trihydroxychalcone.
Frequently Asked Questions
Is Trihydroxychalcone allowed in the EU?
Trihydroxychalcone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Trihydroxychalcone do in cosmetics?
Trihydroxychalcone functions as: Skin conditioning, antioxidant (chalcone flavonoid, also known as isoliquiritigenin). It is classified as a cosmetic ingredient in our database. CAS number: 961-29-5 (isoliquiritigenin / 2',4,4'-trihydroxychalcone).
Compliance Tools
Check Trihydroxychalcone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
Deoxyguanosine
Good
Chemical family
Hair conditioning, skin conditioning
TRI (POLYGLYCERYL-3/LAURYL) HYDROGENATED TRILINOLEATE
Good
Browse nearby
Surfactant - Cleansing, Surfactant - ...
TRICHLOROMETHYL PHENYL CARBINYL ACETATE
Good
Browse nearby
Perfuming
Is Trihydroxychalcone in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Trihydroxychalcone in your formulation.