NOAEL Studies Active Ingredient

Triethyl Citrate NOAEL Studies

INCI: TRIETHYL CITRATE

CAS: 77-93-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 4000 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 280 mg/kg bw/day cat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 284 mg/kg bw/day dog oral 180 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 226 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 14.6809 mg/L - Inhalation Duration=6 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=586; Record_ID=acute_inhalation_2811; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0040701; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=14.6809; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040701
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15814; RecordID=ARPathway2016_1567; DatasetName=ARPathway2016; DTXSID=DTXSID0040701; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040701
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10276; Record_ID=skin_sensitization_invivo_2262; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0040701; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040701
NTP_ICE_skin_sensitization Induction dose per skin area 13500 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10274; Record_ID=skin_sensitization_invivo_2262; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0040701; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=13500; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040701
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10280; Record_ID=skin_sensitization_invivo_2262; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=20.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID0040701; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1975: report to RIFM|Opdyke 1979; Not available; 10.1016/0015-6264(79)90330-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0040701
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =73.5 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635383:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_855947acf50ec7b5879968884488cbc7
ToxValDB_WHO_JECFA_ADI 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_WHO_JECFA_ADI ADI <=20 mg/kg Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afda1e4b0d99f5a87eba7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3197; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=WHO JECFA ADI:15715493:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f073c9cf285609cc65736a676e79c02
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8Z96QXD6UM UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Z96QXD6UM"}
openFDA substances FDA UNII substance identifier 8Z96QXD6UM UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Z96QXD6UM"}
openFDA substances FDA UNII substance identifier 8Z96QXD6UM UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Z96QXD6UM"}
openFDA substances FDA UNII substance identifier 8Z96QXD6UM UNII - - - chemical {"approval_status":null,"molecular_formula":"C12H20O7","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8Z96QXD6UM"}