NOAEL Studies
Cosmetic Ingredient
Triethanolamine NOAEL Studies
INCI: TRIETHANOLAMINE
CAS: 102-71-6
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 120 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 350 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 170 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1125 | mg/kg bw/day | mouse | oral | 10 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 5000 | mg/kg bw/day | mouse | oral | 574 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 2000 | IARC Monographs | {"additional_info":"volume_publication_year=2000","evaluation_year":2000,"source_table":"iarc_classifications","volume":"77"} |
INCHEM_WHO_kemi_kemi_ah2003_16 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_kemi_kemi_ah2003_16 | LOEL | =230 | mg/m3 | Rat | inhalation | 11-week | Inhalation toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=7f6cf9e718c95f42; raw_unit=mg/m3; context=In an 11-week inhalation study with rats, the LOEL (Lowest Observed Effect Level) for increased liver weight (hypertrophy) was 230 mg/m3 (the lowest exposure level) (14). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | LOEL | =230 | mg/m3 | Rat | inhalation | 11-week | Inhalation toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=7f6cf9e718c95f42; raw_unit=mg/m3; context=In an 11-week inhalation study with rats, the LOEL (Lowest Observed Effect Level) for increased liver weight (hypertrophy) was 230 mg/m3 (the lowest exposure level) (14). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | LOEL | =230 | mg/m3 | Rat | inhalation | 11-week | Inhalation toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=7f6cf9e718c95f42; raw_unit=mg/m3; context=In an 11-week inhalation study with rats, the LOEL (Lowest Observed Effect Level) for increased liver weight (hypertrophy) was 230 mg/m3 (the lowest exposure level) (14). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | LOEL | =230 | mg/m3 | Rat | inhalation | 11-week | Inhalation toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=7f6cf9e718c95f42; raw_unit=mg/m3; context=In an 11-week inhalation study with rats, the LOEL (Lowest Observed Effect Level) for increased liver weight (hypertrophy) was 230 mg/m3 (the lowest exposure level) (14). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =60 | mg/kg bw | Rat | - | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=da307854c69b6b38; raw_unit=mg/kg; context=In a 13-week study in which rats were given chlorobenzene orally, the LOEL for this effect was 125 mg/kg and the NOEL (No Observed Effect Level) was 60 mg/kg (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =125 | mg/kg bw/day | Mouse | oral | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=0f3f1c434a4dba84; raw_unit=mg/kg/day; context=In a 13-week study with mice (oral administration), the LOEL for dilation of renal tubules and interstitial nephritis (kidney inflammation) was 250 mg/kg/day and the NOEL 125 mg/kg/day (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw/day | Rat | - | 13 weeks | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=4b74ecf8e7b2748a; raw_unit=mg/kg/day; context=In the same study, bone marrow depression was seen in rats after 13 weeks of exposure to 500 mg/kg/day chlorobenzene (NOEL 250 mg/kg/day) (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw | Rat; Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=387a46345632d671; raw_unit=mg/kg; context=In a more recent study with oral exposures, the reported NOEL for similar effects is 250 mg/kg for rats and 125 mg/kg for mice (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =230 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=9b9cd4c95caeb015; raw_unit=mg/m3; context=NOEL 230 mg/m3). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =60 | mg/kg bw | Rat | - | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=da307854c69b6b38; raw_unit=mg/kg; context=In a 13-week study in which rats were given chlorobenzene orally, the LOEL for this effect was 125 mg/kg and the NOEL (No Observed Effect Level) was 60 mg/kg (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =125 | mg/kg bw/day | Mouse | oral | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=0f3f1c434a4dba84; raw_unit=mg/kg/day; context=In a 13-week study with mice (oral administration), the LOEL for dilation of renal tubules and interstitial nephritis (kidney inflammation) was 250 mg/kg/day and the NOEL 125 mg/kg/day (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw/day | Rat | - | 13 weeks | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=4b74ecf8e7b2748a; raw_unit=mg/kg/day; context=In the same study, bone marrow depression was seen in rats after 13 weeks of exposure to 500 mg/kg/day chlorobenzene (NOEL 250 mg/kg/day) (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw | Rat; Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=387a46345632d671; raw_unit=mg/kg; context=In a more recent study with oral exposures, the reported NOEL for similar effects is 250 mg/kg for rats and 125 mg/kg for mice (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =230 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=9b9cd4c95caeb015; raw_unit=mg/m3; context=NOEL 230 mg/m3). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =60 | mg/kg bw | Rat | - | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=da307854c69b6b38; raw_unit=mg/kg; context=In a 13-week study in which rats were given chlorobenzene orally, the LOEL for this effect was 125 mg/kg and the NOEL (No Observed Effect Level) was 60 mg/kg (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =125 | mg/kg bw/day | Mouse | oral | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=0f3f1c434a4dba84; raw_unit=mg/kg/day; context=In a 13-week study with mice (oral administration), the LOEL for dilation of renal tubules and interstitial nephritis (kidney inflammation) was 250 mg/kg/day and the NOEL 125 mg/kg/day (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw/day | Rat | - | 13 weeks | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=4b74ecf8e7b2748a; raw_unit=mg/kg/day; context=In the same study, bone marrow depression was seen in rats after 13 weeks of exposure to 500 mg/kg/day chlorobenzene (NOEL 250 mg/kg/day) (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw | Rat; Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=387a46345632d671; raw_unit=mg/kg; context=In a more recent study with oral exposures, the reported NOEL for similar effects is 250 mg/kg for rats and 125 mg/kg for mice (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =230 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=9b9cd4c95caeb015; raw_unit=mg/m3; context=NOEL 230 mg/m3). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =60 | mg/kg bw | Rat | - | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=da307854c69b6b38; raw_unit=mg/kg; context=In a 13-week study in which rats were given chlorobenzene orally, the LOEL for this effect was 125 mg/kg and the NOEL (No Observed Effect Level) was 60 mg/kg (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =125 | mg/kg bw/day | Mouse | oral | 13-week | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=0f3f1c434a4dba84; raw_unit=mg/kg/day; context=In a 13-week study with mice (oral administration), the LOEL for dilation of renal tubules and interstitial nephritis (kidney inflammation) was 250 mg/kg/day and the NOEL 125 mg/kg/day (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw/day | Rat | - | 13 weeks | Subchronic toxicity | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=4b74ecf8e7b2748a; raw_unit=mg/kg/day; context=In the same study, bone marrow depression was seen in rats after 13 weeks of exposure to 500 mg/kg/day chlorobenzene (NOEL 250 mg/kg/day) (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =250 | mg/kg bw | Rat; Mouse | oral | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=387a46345632d671; raw_unit=mg/kg; context=In a more recent study with oral exposures, the reported NOEL for similar effects is 250 mg/kg for rats and 125 mg/kg for mice (9). |
| INCHEM_WHO_kemi_kemi_ah2003_16 | NOEL | =230 | mg/m3 | - | - | - | Toxicology study | document_id=kemi_kemi_ah2003_16; title=Scientific Basis for Swedish Occupational Standards XXIV; path=mirror/documents/kemi/kemi/ah2003_16.pdf; row_hash=9b9cd4c95caeb015; raw_unit=mg/m3; context=NOEL 230 mg/m3). |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =5530 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | JRC AcutoxBase (undated); record_id=acute_oral_251; row=15397; data_type=In Vivo; mixture=Chemical; chemical_name=Triethanolamine; preferred_name=Triethanolamine; dtxsid=DTXSID9021392; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021392; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =8000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_252; row=15398; data_type=In Vivo; mixture=Chemical; chemical_name=Triethanolamine; preferred_name=Triethanolamine; dtxsid=DTXSID9021392; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9021392; source_file=acute_oral.xlsx |
NTP_ICE_cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=9962; Record_ID=cancer_958; Data_Type=WOE; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/95; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_cancer | POLY-3 lowest dose | 100 | mg/kg bw/day | Mouse | Dermal | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=9954; Record_ID=cancer_959; Data_Type=In Vivo; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=100; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dermal; Level_of_Evidence=Some evidence; Tissue=Liver; Lesion=Hepatocellular carcinoma or hepatocellular adenoma; Reference=TR-518; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr518/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_cancer | Top dose | 1000 | mg/kg | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=9951; Record_ID=cancer_956; Data_Type=In Vivo; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=1000; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1/N; Sex=Female; Route=Dermal; Reference=TR-518; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr518/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_cancer | Top dose | 2000 | mg/kg | Mouse | Dermal | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=9952; Record_ID=cancer_955; Data_Type=In Vivo; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=mg/kg; Species=Mouse; Strain=B6C3F1/N; Sex=Male; Route=Dermal; Reference=TR-518; URL=https://ntp.niehs.nih.gov/publications/reports/tr/500s/tr518/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_cancer | Top dose | 125 | mg/kg | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=9953; Record_ID=cancer_953; Data_Type=In Vivo; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=125; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Male; Route=Inhalation; Reference=TR-449; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr449/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_cancer | Top dose | 250 | mg/kg | Rat | Inhalation | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=9961; Record_ID=cancer_963; Data_Type=In Vivo; Formulation_Name=Triethanolamine; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=250; Response_Unit=mg/kg; Species=Rat; Strain=F344/N; Sex=Female; Route=Inhalation; Reference=TR-449; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr449/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15782; RecordID=ARPathway2016_427; DatasetName=ARPathway2016; DTXSID=DTXSID9021392; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
NTP_ICE_eye_irritation 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2762; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2762; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2762; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2762; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2757; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2757; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2757; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2757; Record_ID=eye_irritation_190; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Intensity | 0.17 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2761; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Intensity; Response=0.17; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Intensity | 0.17 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2761; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Intensity; Response=0.17; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Intensity | 0.17 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2761; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Intensity; Response=0.17; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Intensity | 0.17 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2761; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Intensity; Response=0.17; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2760; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2760; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2760; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Lag time | 0 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2760; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Lag time; Response=0; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Plateau level | 31 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2759; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Plateau level; Response=31; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Plateau level | 31 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2759; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Plateau level; Response=31; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Plateau level | 31 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2759; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Plateau level; Response=31; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_eye_irritation | Plateau level | 31 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=2759; Record_ID=eye_irritation_1250; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Vitrigel; Endpoint=Plateau level; Response=31; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
NTP_ICE_skin_irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | Breakthrough Time | 55.3 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5856; Record_ID=skin_irritation_invitro_194; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Corrositex; Endpoint=Breakthrough Time; Response=55.3; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_irritation | Breakthrough Time | 42.7 | min | - | Dermal | - | In Vitro; Corrositex | sheet=Data_invitro; excel_row=5858; Record_ID=skin_irritation_invitro_192; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Corrositex; Endpoint=Breakthrough Time; Response=42.7; Response_Unit=min; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_irritation | Positive reaction | 0 | % | Human | Dermal | - | In Vivo; Four-hour Human Patch Test | sheet=Data_invivo; excel_row=1852; Record_ID=skin_irritation_invivo_77; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=Four-hour Human Patch Test; Endpoint=Positive reaction; Response=0; Response_Unit=%; Species=Human; Reference=Basketter et al. 2004; 15291823; 10.1111/j.0105-1873.2004.00385.x; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_irritation | TER | 11.2 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5851; Record_ID=skin_irritation_invitro_2526; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=TER Corrosion; Endpoint=TER; Response=11.2; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_irritation | TER | 11.6 | kiloohms | - | Dermal | - | In Vitro; TER Corrosion | sheet=Data_invitro; excel_row=5857; Record_ID=skin_irritation_invitro_2527; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=TER Corrosion; Endpoint=TER; Response=11.6; Response_Unit=kiloohms; Reference=Botham et al. 1995; Not available; 10.1177/026119299502300207; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
NTP_ICE_skin_sensitization 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 1718.3 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2354; Record_ID=skin_sensitization_invitro_574; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=1718.3; Reported_Response_Unit=ug/mL; Response=1718.3; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 1936.4 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2355; Record_ID=skin_sensitization_invitro_574; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=1936.4; Reported_Response_Unit=ug/mL; Response=1936.4; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 189.48 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8687; Record_ID=skin_sensitization_invitro_2405; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=189.48; Reported_Response_Unit=ug/mL; Response=189.48; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | CV70 | >200 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8689; Record_ID=skin_sensitization_invitro_2405; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=U-SENS; Endpoint=CV70; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=200; Reported_Response_Unit=ug/mL; Response=200; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | CV75 | 4167 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2356; Record_ID=skin_sensitization_invitro_574; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=h-CLAT; Endpoint=CV75; Reported_Response=4167; Reported_Response_Unit=ug/mL; Response=4167; Response_Unit=ug/mL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4069; Record_ID=skin_sensitization_invitro_932; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
| NTP_ICE_skin_sensitization | Imax | 1.11 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=4074; Record_ID=skin_sensitization_invitro_932; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID9021392; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1100000000000001; Reported_Response_Unit=Unitless; Response=1.11; Response_Unit=Ratio; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9021392; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9021392 |
ToxRefDB_ToxRefDB_v3_pod.csv 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 13 week | SUB | study_id=6540; toxval_study_source_id=studyid6540_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-kidney-nephropathy|organ weight-kidney-relative to body weight|in life observation-body weight-body weight gain|pathology microscopic-skin-inflammation|pathology microscopic-kidney-mineralization|urinalysis-specific gravity/osmolality-specific gravity/osmolality|pathology gross-skin-irregular surface|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|clinical chemistry-albumin-albumin|clinical chemistry-urea nitrogen-urea nitrogen|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-body weight-body weight|hematology-neutrophils-neutrophils|pathology microscopic-pituitary gland-hypertrophy; dose_level=3; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =250 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 13 week | SUB | study_id=6541; toxval_study_source_id=studyid6541_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|pathology microscopic-skin-acanthosis|organ weight-spleen-absolute|organ weight-kidney-absolute|organ weight-liver-absolute|organ weight-spleen-relative to body weight|pathology microscopic-skin-inflammation|pathology gross-skin-irregular surface; dose_level=1; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =63 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 2 year | CHR | study_id=6542; toxval_study_source_id=studyid6542_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-inflammation|pathology microscopic-skin-acanthosis|pathology microscopic-skin-ulcer|pathology microscopic-skin-erosion|organ weight-kidney-relative to body weight|organ weight-kidney-absolute; dose_level=2; study_year=1999; study_citation=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =300 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 2 year | CHR | study_id=6543; toxval_study_source_id=studyid6543_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-eosinophilic focus|pathology microscopic-liver-adenoma|pathology gross-skin-irregular surface|pathology microscopic-liver-adenoma/carcinoma combined|pathology microscopic-skin-inflammation; dose_level=2; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =630 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 2 year | CHR | study_id=6543; toxval_study_source_id=studyid6543_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to body weight|organ weight-kidney-absolute|pathology microscopic-skin-atrophy|pathology microscopic-skin-acanthosis|pathology microscopic-liver-eosinophilic focus|pathology microscopic-skin-inflammation|pathology microscopic-liver-adenoma|in life observation-body weight-body weight|pathology gross-skin-irregular surface; dose_level=2; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =1000 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 13 week | SUB | study_id=6540; toxval_study_source_id=studyid6540_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-skin-inflammation|pathology microscopic-kidney-mineralization|pathology gross-skin-irregular surface|pathology microscopic-kidney-nephropathy; dose_level=4; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =4000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 13 week | SUB | study_id=6541; toxval_study_source_id=studyid6541_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-acanthosis|pathology microscopic-skin-inflammation; dose_level=5; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | >250 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 2 year | CHR | study_id=6542; toxval_study_source_id=studyid6542_Adult_F0_F_NA; dose_level=4; study_year=1999; study_citation=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =250 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 13 week | SUB | study_id=6540; toxval_study_source_id=studyid6540_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-kidney-nephropathy|pathology gross-skin-irregular surface|organ weight-kidney-relative to body weight|clinical chemistry-albumin-albumin|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|in life observation-body weight-body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-kidney-mineralization|urinalysis-specific gravity/osmolality-specific gravity/osmolality|hematology-neutrophils-neutrophils|pathology microscopic-pituitary gland-hypertrophy|pathology microscopic-skin-inflammation|clinical chemistry-urea nitrogen-urea nitrogen|in life observation-body weight-body weight gain|pathology microscopic-skin-acanthosis; dose_level=2; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 13 week | SUB | study_id=6540; toxval_study_source_id=studyid6540_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|hematology-leukocyte (wbc) count differential-leukocyte (wbc)|clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|urinalysis-protein-protein|pathology microscopic-pituitary gland-hypertrophy|hematology-neutrophils-neutrophils|hematology-eosinophils-eosinophils|pathology gross-skin-irregular surface|urinalysis-specific gravity/osmolality-specific gravity/osmolality|clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|pathology microscopic-skin-acanthosis|organ weight-kidney-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-skin-inflammation|in life observation-body weight-body weight; dose_level=1; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 13 week | SUB | study_id=6541; toxval_study_source_id=studyid6541_Adult_F0_F_systemic; toxval_effect_list=pathology gross-skin-irregular surface|organ weight-kidney-absolute|organ weight-kidney-relative to body weight|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|organ weight-spleen-absolute|pathology microscopic-skin-inflammation|pathology microscopic-skin-acanthosis|organ weight-spleen-relative to body weight|organ weight-liver-absolute; dose_level=0; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =32 | mg/kg bw/day | rat (fischer; Fischer 344) | dermal | 0 day to 2 year | CHR | study_id=6542; toxval_study_source_id=studyid6542_Adult_F0_F_systemic; toxval_effect_list=organ weight-kidney-absolute|pathology microscopic-skin-acanthosis|pathology microscopic-skin-ulcer|pathology microscopic-skin-erosion|pathology microscopic-skin-inflammation|organ weight-kidney-relative to body weight; dose_level=1; study_year=1999; study_citation=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =100 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 2 year | CHR | study_id=6543; toxval_study_source_id=studyid6543_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-eosinophilic focus|pathology gross-skin-irregular surface|pathology microscopic-liver-adenoma|pathology microscopic-liver-adenoma/carcinoma combined|pathology microscopic-skin-inflammation; dose_level=1; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 2 year | CHR | study_id=6543; toxval_study_source_id=studyid6543_Adult_F0_M_systemic; toxval_effect_list=pathology gross-skin-irregular surface|pathology microscopic-skin-inflammation|in life observation-body weight-body weight|organ weight-kidney-relative to body weight|organ weight-kidney-absolute|pathology microscopic-liver-adenoma|pathology microscopic-liver-eosinophilic focus|pathology microscopic-skin-acanthosis|pathology microscopic-skin-atrophy; dose_level=1; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =2000 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | dermal | 0 day to 13 week | SUB | study_id=6541; toxval_study_source_id=studyid6541_Adult_F0_F_systemic; toxval_effect_list=pathology gross-skin-irregular surface|organ weight-liver-absolute|organ weight-spleen-relative to body weight|pathology microscopic-skin-acanthosis|pathology microscopic-skin-inflammation|organ weight-spleen-absolute|clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|organ weight-kidney-relative to body weight|organ weight-kidney-absolute; dose_level=4; study_year=1999; study_citation=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); dsstox_substance_id=DTXSID9021392; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | >1150 | mg/kg bw/day | Rat | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1f8e4b0a7c65d230e9b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24152/7/9/3?documentUUID=67634b04-7449-41e1-97d2-4c86574de0e6; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821236_15821872:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_048a76ac7ff69861ea925b50a063fa5b |
| ToxValDB_ECHA_IUCLID | NOAEL | >1125 | mg/kg bw/day | Mouse | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac56e4b0a7c65d1bea1a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30056/7/9/3?documentUUID=be9191c8-d8c4-4d39-a894-38bef2f67c1d; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID:15821693:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4b007b99888e79d61bf82963dbd9722e |
| ToxValDB_ECHA_IUCLID | NOAEL | >1800 | mg/kg bw/day | Rat | dermal | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d206e4b0a7c65d2313d4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/30056/7/9/3?documentUUID=be9191c8-d8c4-4d39-a894-38bef2f67c1d; YEAR=2018; ORIGINAL_YEAR=2018; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821236_15821872:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f877801bc484686d252337765c49633a |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635365:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9e6ae941170c8402f5baf32cffb0f6d5 |
ToxValDB_TX_TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | NOAEL | =100 | mg/m3 | Rat | inhalation | short-term; 5 days | short-term | LONG_REF=Gamer, A.O., Rossbacher, R., Kaufmann, W. and van Ravenzwaay, B. 2008. The inhalation toxicity of di- and triethanolamine upon repeated exposure. Food and Chemical Toxicology. 46: 2173-2183; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5b1b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/dea-tea.pdf; YEAR=2018; ORIGINAL_YEAR=2018; TOXICOLOGICAL_EFFECT=Laryngeal inflammation and edema; STUDY_GROUP=TX TCEQ:15954704:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b64aa76ab551da58ae99976507965fc2 |
ToxValDB_ToxRefDB 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =500 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6540; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology gross-skin-irregular surface|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-kidney-mineralization|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: hematology-neutrophils-neutrophils|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: pathology microscopic-pituitary gland-hypertrophy|systemic: clinical chemistry-albumin-albumin; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15712225_15712226_15712227_15712228:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afb7ba4a8c9dfd55d88aaec9e90894a7 |
| ToxValDB_ToxRefDB | LEL | =250 | mg/kg bw/day | Mouse | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6541; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-relative to body weight|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: organ weight-spleen-absolute|systemic: organ weight-liver-absolute|systemic: organ weight-spleen-relative to body weight|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-skin-inflammation|systemic: organ weight-kidney-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712233_15712234_15712235:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fbd7ad1164bb047c297c9457a156d6a4 |
| ToxValDB_ToxRefDB | LEL | =63 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | LONG_REF=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-ulcer|systemic: pathology microscopic-skin-erosion|systemic: organ weight-kidney-absolute|systemic: organ weight-kidney-relative to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712239_15712240_15712241_15712242:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28ee6e4c8c0dda3026e5ffde4a96c36a |
| ToxValDB_ToxRefDB | LEL | =300 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6543; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-eosinophilic focus|systemic: pathology microscopic-liver-adenoma/carcinoma combined|systemic: pathology microscopic-liver-adenoma|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-skin-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15712247_15712248_15712249_15712250:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3470695bdfc9fc2a1315dcbaeab0e94c |
| ToxValDB_ToxRefDB | LEL | =630 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6543; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-liver-eosinophilic focus|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-atrophy|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-acanthosis|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-liver-adenoma; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712251_15712252_15712253_15712254:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c8a1eaa5c7453ab828eb2d19e93fa66 |
| ToxValDB_ToxRefDB | LOAEL | =1000 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6540; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-kidney-mineralization; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15712225_15712226_15712227_15712228:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d57556702fbaf96af6c975671f14c3e9 |
| ToxValDB_ToxRefDB | LOAEL | =4000 | mg/kg bw/day | Mouse | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6541; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-skin-inflammation; STUDY_GROUP=ToxRefDB_dup_-_15712233_15712234_15712235:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4cb44c406a24db1602a08a2f85fbb0e3 |
| ToxValDB_ToxRefDB | LOAEL | >250 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | LONG_REF=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; STUDY_GROUP=ToxRefDB_dup_-_15712239_15712240_15712241_15712242:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2da5fb4b9d80a08579155783b894af0f |
| ToxValDB_ToxRefDB | NEL | =250 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6540; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-kidney-mineralization|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality|systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-kidney-nephropathy|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-skin-irregular surface|systemic: clinical chemistry-albumin-albumin|systemic: pathology microscopic-skin-acanthosis|systemic: pathology microscopic-pituitary gland-hypertrophy|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15712225_15712226_15712227_15712228:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f821b26021523b4358749d83862523f |
| ToxValDB_ToxRefDB | NEL | =125 | mg/kg bw/day | Rat | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6540; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: organ weight-kidney-relative to body weight|systemic: hematology-leukocyte (wbc) count differential-leukocyte (wbc)|systemic: hematology-neutrophils-neutrophils|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-alanine aminotransferase (alt/sgpt)-alanine aminotransferase (alt/sgpt)|systemic: hematology-eosinophils-eosinophils|systemic: pathology microscopic-skin-inflammation|systemic: clinical chemistry-aspartate aminotransferase (ast/sgot)-aspartate aminotransferase (ast/sgot)|systemic: urinalysis-protein-protein|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-acanthosis|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-pituitary gland-hypertrophy|systemic: urinalysis-specific gravity/osmolality-specific gravity/osmolality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|organ weight|urinalysis; STUDY_GROUP=ToxRefDB_dup_-_15712229_15712230_15712231_15712232:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8b809b46927bce92191dcff893061b9c |
| ToxValDB_ToxRefDB | NEL | =32 | mg/kg bw/day | Rat | dermal | chronic; 2 years | chronic | LONG_REF=NTP. (1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Rat); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-erosion|systemic: pathology microscopic-skin-inflammation|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-skin-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712239_15712240_15712241_15712242:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ea2c4c79ba99349d1119f475fd507e3 |
| ToxValDB_ToxRefDB | NEL | =100 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6543; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-liver-eosinophilic focus|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-liver-adenoma|systemic: pathology microscopic-liver-adenoma/carcinoma combined; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ToxRefDB_dup_-_15712247_15712248_15712249_15712250:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed9021615aa1bc6518566f849b9dd770 |
| ToxValDB_ToxRefDB | NEL | =200 | mg/kg bw/day | Mouse | dermal | chronic; 2 years | chronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Chronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6543; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: organ weight-kidney-relative to body weight|systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-absolute|systemic: pathology gross-skin-irregular surface|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-liver-adenoma|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-eosinophilic focus|systemic: pathology microscopic-skin-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712251_15712252_15712253_15712254:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8e0aee9e9cac78336bbf84c5a72f982b |
| ToxValDB_ToxRefDB | NOAEL | =2000 | mg/kg bw/day | Mouse | dermal | subchronic; 13 weeks | subchronic | LONG_REF=(1999) TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES). NTP TR 449, NIH Publication No. 00-3365. (Subchronic Mouse); TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRIETHANOLAMINE (CAS NO. 102-71-6) IN F344/N RATS AND B6C3F1 MICE (DERMAL STUDIES); AUTHOR=NTP; EXTERNAL_SOURCE_ID=6541; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-absolute|systemic: organ weight-spleen-absolute|systemic: organ weight-spleen-relative to body weight|systemic: clinical chemistry-sorbitol dehydrogenase-sorbitol dehydrogenase|systemic: pathology microscopic-skin-acanthosis|systemic: organ weight-kidney-relative to body weight|systemic: pathology gross-skin-irregular surface|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-skin-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15712233_15712234_15712235:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f08f7dfd570f324f6cc94a129e68f6a5 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 9O3K93S3TK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H15NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9O3K93S3TK"} |
| openFDA substances | FDA UNII substance identifier | 9O3K93S3TK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H15NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9O3K93S3TK"} |
| openFDA substances | FDA UNII substance identifier | 9O3K93S3TK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H15NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9O3K93S3TK"} |
| openFDA substances | FDA UNII substance identifier | 9O3K93S3TK | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H15NO3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"9O3K93S3TK"} |