Is Transglutaminase safe in cosmetics?
Transglutaminase has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Transglutaminase
INCI: TRANSGLUTAMINASE
Transglutaminase (CAS 300711-04-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning / Hair conditioning — catalyzes protein cross-linking. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 300711-04-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning / Hair conditioning — catalyzes protein cross-linking (glutamine–lysine isopeptide bonds)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS for food (21 CFR); permitted in cosmetics; no specific restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Transglutaminase.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair, collagen-crosslinking", "mechanism_of_action": "Enzymatic activity, targeted protein modification", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Yes", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_…
Expert Verdict
Expert safety assessment and concern-level summary for Transglutaminase.
Frequently Asked Questions
Is Transglutaminase allowed in the EU?
Transglutaminase EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Transglutaminase do in cosmetics?
Transglutaminase functions as: Skin conditioning / Hair conditioning — catalyzes protein cross-linking (glutamine–lysine isopeptide bonds). It is classified as a cosmetic ingredient in our database. CAS number: 300711-04-6.
Compliance Tools
Check Transglutaminase compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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