Is Tonalide safe in cosmetics?
Tonalide has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Tonalide
INCI: ACETYL HEXAMETHYL TETRALIN
Tonalide (CAS 1506-02-1) is a cosmetic fragrance functioning as Fragrance fixative (polycyclic synthetic musk, warm musky woody scent). NOAEL 15 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.1% leave-on non-hydroalcoholic; 1.0% leave-on hydroalcoholic; 2.5% fine fragrance; 0.5% fragrance cream; 0.2% rinse-off. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1506-02-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance fixative (polycyclic synthetic musk, warm musky woody scent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(3,5,5,6,8,8-hexamethyl-6,7-dihydronaphthalen-2-yl)ethanone
InChIKey
DNRJTBAOUJJKDY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.1% leave-on non-hydroalcoholic; 1.0% leave-on hydroalcoholic; 2.5% fine fragrance; 0.5% fragrance cream; 0.2% rinse-off
US US Status
permitted
US Notes
EPA has established usage limits and environmental guidelines; subject to REACH scrutiny
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tonalide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tonalide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tonalide across SCCS product categories, with measured dermal absorption where available.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα, AR, PR
LOEC: 100 nM
EU status: allowed (IFRA limits)
agonist (ERα); antagonist (AR, PR)
Dose-Response Data Points
| Endpoint | Target | Value | Direction |
|---|---|---|---|
| Cell proliferation | ER | EC50/IC50: EC50 in uM range (low relative potency vs E2); LOEC: ~0.1 uM; NOEC: 0.01 uM mixed | agonist (significant, unlike HHCB) |
| PR-mediated transcriptional antagonism | PR | EC50/IC50: IC50 ~0.01-0.02 uM (20 nM); LOEC: 0.01 uM (10 nM); NOEC: 0.001 uM mixed | antagonist |
| Progesterone/cortisol synthesis; 3bHSD2 gene expression | steroidogenesis | EC50/IC50: Significant at >=10 uM; LOEC: 10 uM; NOEC: 1 uM mixed | inhibitor (downarrow progesterone, downarrow cortisol) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for Tonalide.
Regulatory Flags
polycyclic-musk
bioaccumulation
environmental-persistence
detected-in-breast-milk
detected-in-blood
reach-regulated
epa-regulated
clean-beauty-concern
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tonalide by CAS number or substance name.
Studies
1
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
15 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Fragrance
Regulatory Lists
Europe
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Tonalide allowed in the EU?
Tonalide EU regulatory status: restricted. Maximum allowed concentration: 0.1% leave-on non-hydroalcoholic; 1.0% leave-on hydroalcoholic; 2.5% fine fragrance; 0.5% fragrance cream; 0.2% rinse-off. This is based on EU Regulation 1223/2009 and its amendments.
What does Tonalide do in cosmetics?
Tonalide functions as: Fragrance fixative (polycyclic synthetic musk, warm musky woody scent). It is classified as a Fragrance in our database. CAS number: 1506-02-1.
What is the NOAEL for Tonalide?
The NOAEL (No Observed Adverse Effect Level) for Tonalide is =15 mg/kg bw/day based on a developmental study via oral route in Rabbit. Source: ToxValDB_ECHA_IUCLID.
Compliance Tools
Check Tonalide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ACETYL HEXAMETHYL TETRALIN
Moderate
Chemical family
Fragrance
Acetyl Hexamethyl Tetralin (AHTN)
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TRACHELOSPERMUM JASMINOIDES EXTRACT
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