Is Tocotrienols safe in cosmetics?
Tocotrienols has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Antioxidant
Tocotrienols
Also known as: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-, 2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, 3,4-Dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-2H-1-benzopyran-6-ol, 6-Chromanol, 2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, UNII-0867I0N41V
INCI: TOCOTRIENOLS
Tocotrienols (CAS 6829-55-6) is a cosmetic antioxidant functioning as Antioxidant; lipid-soluble free radical scavenger (HAT mechanism);. EU Regulation 1223/2009 status: permitted, max 0.05–1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 6829-55-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant; lipid-soluble free radical scavenger (HAT mechanism); skin-conditioning agent; anti-aging active
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-methyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
InChIKey
GJJVAFUKOBZPCB-ZGRPYONQSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.05–1%
US US Status
permitted
US Notes
CIR Expert Panel has assessed tocopherol and mixed tocopherol fractions (including tocotrienol-containing natural extracts) as safe in cosmetics. No standalone CIR formal assessment for isolated tocotrienols. FDA-GRAS for food use as part of mixed tocopherol fractions (palm oil, annatto-derived). No concentration limits imposed.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tocotrienols.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
7 property records from structured ingredient metadata.
acne
{"cas_number": "6829-55-6", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "2", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-wrinkle", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journa…
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "1", "skin_type_suitability": "all,combination,normal,mature", "acne_safe": "yes", "source": "Vitamin E form"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Vitamin E family; safe", "source": "dermatology literature"}
sensory
{"silky": "oily", "smooth, glides easily": "smooth, powerful antioxidant", "dry-touch, non-greasy": "protected, soft", "instant": "moderate", "low": "medium", "w/o": "w/o", "very-high": "high", "no": "no", "yes": "no", "light-diffusing": "luminous", "1.40": "1.50", "transparent": "transparent", "colorless": "amber", "excellent": "good", "light": "medium", "synthetic": "botanical"}
solubility_hlb
{"water_soluble": "no", "oil_soluble": "yes", "soluble_in": "oils, ethanol", "insoluble_in": "water, glycerin, propylene glycol", "log_p": "11.2", "appearance": "amber viscous liquid", "source": "ExcelVite"}
supply_chain
{"primary_producing_countries": "Malaysia, USA, Japan", "secondary_producing_countries": "Singapore, Germany, France", "raw_material_origin": "plant", "agricultural_crop_or_wild_harvested": "palm_rice_extraction", "cultivation_climate_required": "palm_rice_oil", "harvest_season": "continuous", "annual_global_production_tonnes": "420", "market_share_top_producer_pct": "72", "supply_chain_length": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
UV stabilizer
Expert Verdict
Expert safety assessment and concern-level summary for Tocotrienols.
Regulatory Flags
antioxidant
lipophilic
hat-mechanism
vitamin-e-family
emerging-evidence
superior-per-molecule
palm-oil-source
annatto-source
anti-aging
photoprotective
encapsulation-recommended
Known Synonyms
2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-
2H-1-Benzopyran-6-ol, 3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-
3,4-Dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-2H-1-benzopyran-6-ol
6-Chromanol, 2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-
UNII-0867I0N41V
Chemical Function
UV stabilizer
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TOCOTRIENOL
ChEMBL ID
CHEMBL120643
Max Phase
3
Frequently Asked Questions
Is Tocotrienols allowed in the EU?
Tocotrienols EU regulatory status: permitted. Maximum allowed concentration: 0.05–1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Tocotrienols do in cosmetics?
Tocotrienols functions as: Antioxidant; lipid-soluble free radical scavenger (HAT mechanism); skin-conditioning agent; anti-aging active. It is classified as a Antioxidant in our database. CAS number: 6829-55-6.
Is Tocotrienols used outside cosmetics?
Tocotrienols also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tocotrienols compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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