Is Thymol Trimethoxycinnamate safe in cosmetics?
Thymol Trimethoxycinnamate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Thymol Trimethoxycinnamate
Also known as: UNII-D8643OL0EL, 2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, 5-methyl-2-(1-methylethyl)phenyl ester, (2E)-, Thymyl 3,4,5-trimethoxycinnamate, Melasolv
INCI: THYMOL TRIMETHOXYCINNAMATE
Thymol Trimethoxycinnamate (CAS 504394-57-4) is a cosmetic cosmetic ingredient functioning as Skin Conditioning; Anti-melanogenic / Skin Brightening (marketed as "Melasolv"). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 504394-57-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning; Anti-melanogenic / Skin Brightening (marketed as "Melasolv")
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(5-methyl-2-propan-2-ylphenyl) (E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate
InChIKey
GTPUEIXKLQUDEJ-CSKARUKUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated; permitted under general cosmetic provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thymol Trimethoxycinnamate.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Humectant
Expert Verdict
Expert safety assessment and concern-level summary for Thymol Trimethoxycinnamate.
Known Synonyms
UNII-D8643OL0EL
2-Propenoic acid, 3-(3,4,5-trimethoxyphenyl)-, 5-methyl-2-(1-methylethyl)phenyl ester, (2E)-
Thymyl 3,4,5-trimethoxycinnamate
Melasolv
Chemical Function
Antioxidant
Humectant
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL460386
Frequently Asked Questions
Is Thymol Trimethoxycinnamate allowed in the EU?
Thymol Trimethoxycinnamate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thymol Trimethoxycinnamate do in cosmetics?
Thymol Trimethoxycinnamate functions as: Skin Conditioning; Anti-melanogenic / Skin Brightening (marketed as "Melasolv"). It is classified as a cosmetic ingredient in our database. CAS number: 504394-57-4.
Is Thymol Trimethoxycinnamate used outside cosmetics?
Thymol Trimethoxycinnamate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Thymol Trimethoxycinnamate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Same category
Skin conditioning (skin brightening/l...
4-Amino-3-Hydroxybutyric Acid
Excellent
Same category
Skin Conditioning
Acetyl Glycyl Beta-Alanine
Excellent
Same category
Skin conditioning agent with melanin ...
Acetyl Tripeptide-1
Excellent
Same category
Skin Conditioning
Acetylneuraminic Acid
Excellent
Same category
Skin Conditioning, Skin Protecting
Acetylphytosphingosine
Excellent
Same category
Skin Conditioning, Hair Conditioning;...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
THYMUS LINEARIS LEAF/(ANGELICA GLAUCA/BERGENIA CILIATA) ROOT/PRINSEPIA UTILIS SEED EXTRACT
Good
Browse nearby
Skin Conditioning
THYMUS SERPYLLUM EXTRACT
Good
Browse nearby
Skin Conditioning
THYMUS VULGARIS LEAF/STEM POWDER
Good
Browse nearby
Skin Conditioning
Is Thymol Trimethoxycinnamate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Thymol Trimethoxycinnamate in your formulation.