NOAEL Studies
Cosmetic Ingredient
Thiram NOAEL Studies
INCI: THIRAM (TETRAMETHYLTHIURAM DISULFIDE) — NO COSMETIC INCI ASSIGNMENT
CAS: 137-26-8
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 36 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1000 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=body weight and weight gain; key_result=true; entry_uuid=ae19c21b-3d44-452d-8c3a-ef06d8070e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=fetal/pup body weight changes; key_result=true; entry_uuid=30b8e14a-ffe2-462f-b1a8-b0d3b9abf9c8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: acute oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=0b9d24b8-0126-459d-89f7-eee317e75c76_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=0b9d24b8-0126-459d-89f7-eee317e75c76/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1993-07-26; basis=other:; key_result=false; entry_uuid=1fd88ec5-3799-40da-87c0-22ed1046bd4b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=3550e3a2-60e4-496f-9dd2-ae0a394500dd_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=3550e3a2-60e4-496f-9dd2-ae0a394500dd/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-11-27; basis=body weight and weight gain; key_result=false; entry_uuid=f1df5349-dd7d-456a-93ae-bbc762caf009 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=body weight and weight gain; key_result=true; entry_uuid=c7853f29-7237-43ae-b4b1-12fd28e11c02 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1000 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=body weight and weight gain; key_result=true; entry_uuid=ae19c21b-3d44-452d-8c3a-ef06d8070e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=fetal/pup body weight changes; key_result=true; entry_uuid=30b8e14a-ffe2-462f-b1a8-b0d3b9abf9c8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: acute oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=0b9d24b8-0126-459d-89f7-eee317e75c76_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=0b9d24b8-0126-459d-89f7-eee317e75c76/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1993-07-26; basis=other:; key_result=false; entry_uuid=1fd88ec5-3799-40da-87c0-22ed1046bd4b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=3550e3a2-60e4-496f-9dd2-ae0a394500dd_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=3550e3a2-60e4-496f-9dd2-ae0a394500dd/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-11-27; basis=body weight and weight gain; key_result=false; entry_uuid=f1df5349-dd7d-456a-93ae-bbc762caf009 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=body weight and weight gain; key_result=true; entry_uuid=c7853f29-7237-43ae-b4b1-12fd28e11c02 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 1000 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=body weight and weight gain; key_result=true; entry_uuid=ae19c21b-3d44-452d-8c3a-ef06d8070e24 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 15 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=fetal/pup body weight changes; key_result=true; entry_uuid=30b8e14a-ffe2-462f-b1a8-b0d3b9abf9c8 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 150 | mg/kg bw/day | rat | oral: gavage | - | neurotoxicity: acute oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=0b9d24b8-0126-459d-89f7-eee317e75c76_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=0b9d24b8-0126-459d-89f7-eee317e75c76/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=Neurotoxicity; literature=Name=Unnamed; ReferenceYear=1993; ReportDate=1993-07-26; basis=other:; key_result=false; entry_uuid=1fd88ec5-3799-40da-87c0-22ed1046bd4b |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 20 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=3550e3a2-60e4-496f-9dd2-ae0a394500dd_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=3550e3a2-60e4-496f-9dd2-ae0a394500dd/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1986; ReportDate=1986-11-27; basis=body weight and weight gain; key_result=false; entry_uuid=f1df5349-dd7d-456a-93ae-bbc762caf009 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | LOAEL | 300 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=body weight and weight gain; key_result=true; entry_uuid=c7853f29-7237-43ae-b4b1-12fd28e11c02 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; entry_uuid=fa48b909-f577-42e9-bdb1-ec61768f007e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=100 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; upper_value=100; entry_uuid=31828de1-b0ca-44be-b918-c3b5b62ce4a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=10 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=749e69a4-2227-466a-8167-1fd6cf293cb2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=993cdc3d-78f6-47a7-96b1-0306745a2d50 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 2.5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=9ceb7105-1ce3-4ddd-bb9d-d800552184bc_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=9ceb7105-1ce3-4ddd-bb9d-d800552184bc/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-03-15; basis=other:; key_result=true; entry_uuid=0d755818-564f-4f44-88f4-08655e5d1798 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=7.5 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=body weight and weight gain; key_result=true; upper_value=7.5; entry_uuid=dbbc9da9-dc73-4c95-ad6e-b67f797e4fe2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=other:; key_result=false; entry_uuid=ce3db584-176f-428c-8445-9d0cc3605978 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; entry_uuid=fa48b909-f577-42e9-bdb1-ec61768f007e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=100 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; upper_value=100; entry_uuid=31828de1-b0ca-44be-b918-c3b5b62ce4a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=10 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=749e69a4-2227-466a-8167-1fd6cf293cb2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=993cdc3d-78f6-47a7-96b1-0306745a2d50 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 2.5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=9ceb7105-1ce3-4ddd-bb9d-d800552184bc_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=9ceb7105-1ce3-4ddd-bb9d-d800552184bc/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-03-15; basis=other:; key_result=true; entry_uuid=0d755818-564f-4f44-88f4-08655e5d1798 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=7.5 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=body weight and weight gain; key_result=true; upper_value=7.5; entry_uuid=dbbc9da9-dc73-4c95-ad6e-b67f797e4fe2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=other:; key_result=false; entry_uuid=ce3db584-176f-428c-8445-9d0cc3605978 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 300 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; entry_uuid=fa48b909-f577-42e9-bdb1-ec61768f007e |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=100 | mg/kg bw/day | rabbit | - | - | short-term repeated dose toxicity: dermal | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=02e0c25b-686e-4b72-85ea-6b330c61cfe1_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=02e0c25b-686e-4b72-85ea-6b330c61cfe1/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityDermal; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-11-12; basis=other:; key_result=true; upper_value=100; entry_uuid=31828de1-b0ca-44be-b918-c3b5b62ce4a3 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | >=10 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=749e69a4-2227-466a-8167-1fd6cf293cb2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=d4236cd5-b438-4af6-a776-9a9bf95a562d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=d4236cd5-b438-4af6-a776-9a9bf95a562d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1992; ReportDate=1992-02-18; basis=other:; key_result=true; entry_uuid=993cdc3d-78f6-47a7-96b1-0306745a2d50 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 2.5 | mg/kg bw/day | rabbit | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=9ceb7105-1ce3-4ddd-bb9d-d800552184bc_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=9ceb7105-1ce3-4ddd-bb9d-d800552184bc/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-03-15; basis=other:; key_result=true; entry_uuid=0d755818-564f-4f44-88f4-08655e5d1798 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | <=7.5 | mg/kg bw/day | rat | oral: gavage | - | developmental toxicity | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=83357a3a-e769-4c75-9f6b-910beffc2e5d_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=83357a3a-e769-4c75-9f6b-910beffc2e5d/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1988; ReportDate=1988-01-28; basis=body weight and weight gain; key_result=true; upper_value=7.5; entry_uuid=dbbc9da9-dc73-4c95-ad6e-b67f797e4fe2 |
| ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip | NOAEL | 1000 | mg/kg bw/day | rat | oral: gavage | - | short-term repeated dose toxicity: oral | dossier=502ddbbe-8660-42be-8155-be5a2f6657e5.i6z; document=72ea5e5e-e767-46bf-98aa-4b855be624fb_502ddbbe-8660-42be-8155-be5a2f6657e5.i6d; document_key=72ea5e5e-e767-46bf-98aa-4b855be624fb/502ddbbe-8660-42be-8155-be5a2f6657e5; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=2015; ReportDate=2015-04-01; basis=other:; key_result=false; entry_uuid=ce3db584-176f-428c-8445-9d0cc3605978 |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1.6 | mg/kg bw/day | Rat | - | - | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =0.84 | mg/kg bw/day | Dog | - | 365 days | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - haematology - hepatotoxicity - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =1.5 | mg/kg bw/day | Rat | - | 730 days | chronic/long term toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | <7.5 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =3 | mg/kg bw/day | Rat | - | - | reproduction toxicity | EFSA - 2017 - OutputID 3606 - body weight - systemic - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =2 | mg/kg bw/day | Dog | - | 90 days | subchronic | EFSA - 2017 - OutputID 3606 - haematology - hepatotoxicity - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.01 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =0.01 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ARfD | =0.025 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ARfD | =0.025 | mg/kg bw/day | Consumers | - | - | ARfD | EFSA - 2017 - OutputID 3606 - Consumers - Peer review of the pesticide risk assessment of the active substance thiram - doi:10.2903/j.efsa.2017.4700 |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOEL | =5 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=840487bde155d1b7; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOEL : 5 mg/kg-day; system=Nervous; basis=Neurotoxicity; point_of_departure=NOEL : 5 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID5021332; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0267_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.005 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=f665b7bdf24592c5; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=5e-3; system=Nervous; basis=Neurotoxicity; point_of_departure=NOEL : 5 mg/kg-day; composite_uf=1000; confidence=Low; dtxsid=DTXSID5021332; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0267_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | {"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"Sup 7, 53"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | {"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"Sup 7, 53"} |
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1990 | IARC Monographs | {"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"Sup 7, 53"} |
INCHEM_WHO_jmpr_jmpmono_v065pr41 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jmpr_jmpmono_v065pr41 | ADI | range:0-0.0250.025 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jmpr_jmpmono_v065pr41; title=041. Thiram (FAO Meeting Report PL/1965/10/1); path=mirror/documents/jmpr/jmpmono/v065pr41.htm; row_hash=a626e3fa292ff37b; raw_unit=mg/kg; context=An effect was found in the chick at 6.8 mg/kg body-weight.) Estimate of acceptable daily intake for man 0-0.025 mg/kg body-weight. |
NTP_ICE_acute_dermal 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1283; Record_ID=acute_dermal_234; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_dermal | EPA classification | 4 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1287; Record_ID=acute_dermal_436; Data_Type=In Vivo; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=4.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1284; Record_ID=acute_dermal_148; Data_Type=In Vivo; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_dermal | LD50 | >5000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1281; Record_ID=acute_dermal_148; Data_Type=In Vivo; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=5000; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1282; Record_ID=acute_dermal_234; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_acute_inhalation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | EPA Classification | 3 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2814; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | GHS Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2804; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | GHS Classification | 5 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2808; Record_ID=acute_inhalation_343; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=5; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | 4.42 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2802; Record_ID=acute_inhalation_1665; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=4.42; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | >5.13 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2803; Record_ID=acute_inhalation_343; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.13; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | 0.5 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2805; Record_ID=acute_inhalation_1185; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.5; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | >2.54 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2806; Record_ID=acute_inhalation_400; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX494; Formulation_Name=Tital FL; Percent_Active_Ingredient=9.49; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=2.54; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | 1.4 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2810; Record_ID=acute_inhalation_160; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.4; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_acute_inhalation | LC50 | 2.06 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=2811; Record_ID=acute_inhalation_90; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX144; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2.06; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_acute_oral 15 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12601; row=8587; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12960; row=8591; data_type=In Vivo; mixture=Mixture; formulation_id=MIX430; formulation_name=Sativa IMX Max; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=10.78; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8596; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | EPA classification | =4 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13028; row=8601; data_type=In Vivo; mixture=Mixture; formulation_id=MIX494; formulation_name=Tital FL; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=9.49; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8604; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13030; row=8605; data_type=In Vivo; mixture=Mixture; formulation_id=MIX494; formulation_name=Tital FL; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=9.49; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Male/Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12601; row=8606; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12960; row=8609; data_type=In Vivo; mixture=Mixture; formulation_id=MIX430; formulation_name=Sativa IMX Max; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=10.78; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =3129 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12960; row=8585; data_type=In Vivo; mixture=Mixture; formulation_id=MIX430; formulation_name=Sativa IMX Max; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=10.78; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12457; row=8586; data_type=In Vivo; mixture=Mixture; formulation_id=MIX144; formulation_name=DeerPro Winter Animal Repellant; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=25.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Male) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12605; row=8590; data_type=In Vivo; mixture=Mixture; formulation_id=MIX227; formulation_name=Foundation Lite; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=6.8; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >5000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13029; row=8593; data_type=In Vivo; mixture=Mixture; formulation_id=MIX494; formulation_name=Tital FL; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; percent_active_ingredient=9.49; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =560 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_2410; row=8597; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >1800 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2412; row=8598; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <2700 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_2414; row=8599; data_type=In Vivo; mixture=Chemical; chemical_name=Thiram; preferred_name=Bis(dimethylaminothiocarbonyl) disulfide; dtxsid=DTXSID5021332; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021332; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 816 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1969; Record_ID=adme_parameters_1093; Data_Type=Measured; DTXSID=DTXSID5021332; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=816.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_adme_parameters | Fu | 3.86e-8 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1968; Record_ID=adme_parameters_1093; Data_Type=Measured; DTXSID=DTXSID5021332; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=3.86e-08; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=5698; Record_ID=cancer_6778; Data_Type=WOE; Formulation_Name=Thiram; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/71; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_dart 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78621; Record_ID=dart_17126; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78622; Record_ID=dart_17127; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78623; Record_ID=dart_17188; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0205204;CUI;Scab; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78624; Record_ID=dart_17189; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0151907;CUI;Discoloration of skin; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 15 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=78625; Record_ID=dart_17207; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1282719;CUI;Incomplete ossification; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 15 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=78626; Record_ID=dart_17208; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=15; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C1806781;CUI;Short|UMLS;C1883702;CUI;Supernumerary; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_dart | LOEL | 7.5 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=78627; Record_ID=dart_17128; Data_Type=In Vivo; DTXSID=DTXSID5021332; Assay=DART, In life observation; Endpoint=LOEL; Response=7.5; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0002170;CUI;Alopecia; Reference=ToxRefDB v2 , ID = 3546; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_endocrine 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 25.92490805 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5628; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=25.92490805; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | AC50 | 15.8495315173844 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5634; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=15.8495315173844; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | ACC | 1.69650633256529 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5629; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=1.69650633256529; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | ACC | 13.9488404367794 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5635; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=13.9488404367794; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | Model Score | 0.0731 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=5630; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0731; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5631; RecordID=ARPathway2016_70; DatasetName=ARPathway2016; DTXSID=DTXSID5021332; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_endocrine | Model Score | 0.00506 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=5636; RecordID=ERPathway2016_442; DatasetName=ERPathway2016; DTXSID=DTXSID5021332; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00506; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_eye_irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | EPA Classification | 4 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1490; Record_ID=eye_irritation_481; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID303; Formulation_Name=DeerPro Winter Animal Repellant; Percent_Active_Ingredient=25.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=1493; Record_ID=eye_irritation_626; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID475; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_skin_irritation 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1011; Record_ID=skin_irritation_invivo_1316; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reported_Strain=New Zealand white; Strain=New Zealand White; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1013; Record_ID=skin_irritation_invivo_435; Data_Type=In Vivo; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1014; Record_ID=skin_irritation_invivo_690; Data_Type=In Vivo; Formulation_ID=MIX227; Formulation_Name=Foundation Lite; Percent_Active_Ingredient=6.8; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
NTP_ICE_skin_sensitization 123 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD54, EC200 | 2.7 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2174; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.7; Reported_Response_Unit=ug/mL; Response=2.7; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 2.46 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3313; Record_ID=skin_sensitization_invitro_769; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=2.46; Reported_Response_Unit=ug/mL; Response=2.46; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2011; 21767275; 10.1111/j.1600-0536.2011.01952.x|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada personal communication (undated)|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 3.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3324; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=3.9; Reported_Response_Unit=ug/mL; Response=3.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 5.2 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3334; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=5.2; Reported_Response_Unit=ug/mL; Response=5.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 0.1 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3344; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=0.1; Reported_Response_Unit=ug/mL; Response=0.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD54, EC200 | 3 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3354; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD54, EC200; Reported_Response=3; Reported_Response_Unit=ug/mL; Response=3; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 9.11 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2176; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=9.11; Reported_Response_Unit=ug/mL; Response=9.11; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 8.1 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3326; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=8.1; Reported_Response_Unit=ug/mL; Response=8.1; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 14.6 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3335; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=14.6; Reported_Response_Unit=ug/mL; Response=14.6; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | <8.9 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3346; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=8.9; Reported_Response_Unit=ug/mL; Response=8.9; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 3.8 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3355; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CD86, EC150; Reported_Response=3.8; Reported_Response_Unit=ug/mL; Response=3.8; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | 0.06 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8245; Record_ID=skin_sensitization_invitro_2268; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CD86, EC150; Reported_Response=0.249543543; Reported_Response_Unit=uM; Conversion_Factor_Value=240.42; Conversion_Factor_Source=EPA Dashboard; Converted_Response=0.06; Converted_Response_Unit=ug/mL; Response=0.06; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CD86, EC150 | <0.1 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8480; Record_ID=skin_sensitization_invitro_2336; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.1; Reported_Response_Unit=ug/mL; Response=0.1; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV70 | 3.06 | ug/mL | - | Dermal | - | In Vitro; CE_USENSE2018; U-SENS | sheet=Data_invitro; excel_row=8481; Record_ID=skin_sensitization_invitro_2336; Data_Type=In Vitro; Internal_Data_Source=CE_USENSE2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=U-SENS; Endpoint=CV70; Reported_Response=3.06; Reported_Response_Unit=ug/mL; Response=3.06; Response_Unit=ug/mL; Reference=Piroird et al. 2015; 25820135; 10.1016/j.tiv.2015.03.009; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV75 | 10 | ug/mL | - | Dermal | - | In Vitro; CE_hCLAT2018; h-CLAT | sheet=Data_invitro; excel_row=2178; Record_ID=skin_sensitization_invitro_537; Data_Type=In Vitro; Internal_Data_Source=CE_hCLAT2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=10; Reported_Response_Unit=ug/mL; Response=10; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV75 | 8.2 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3328; Record_ID=skin_sensitization_invitro_771; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=8.1999999999999904; Reported_Response_Unit=ug/mL; Response=8.2; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV75 | 14.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3337; Record_ID=skin_sensitization_invitro_773; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=14.7; Reported_Response_Unit=ug/mL; Response=14.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV75 | 26.7 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3345; Record_ID=skin_sensitization_invitro_775; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=26.7; Reported_Response_Unit=ug/mL; Response=26.7; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | CV75 | 11.5 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3356; Record_ID=skin_sensitization_invitro_777; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=h-CLAT; Endpoint=CV75; Reported_Response=11.5; Reported_Response_Unit=ug/mL; Response=11.5; Response_Unit=ug/mL; Reference=Sakaguchi et al. 2010; 20510347; 10.1016/j.tiv.2010.05.012|h-CLAT RingTrial EC values for NICEATM (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 5.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4895; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=5.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 1.5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4908; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=1.5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 7.8125 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4923; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=7.8125; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 6.875 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4937; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=6.875; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 31.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4940; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=31.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 28.75 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4954; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, 5% incidence of positive responses; Response=28.75; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 5 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4893; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=5; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 1.667 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4904; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=1.667; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 6.25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4920; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=6.25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 25 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4936; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Concentration, one positive response; Response=25; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Cys | 99.5 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1164; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=99.5; Reported_Response_Unit=%; Response=99.5; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Cys | 100 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1174; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=100; Reported_Response_Unit=%; Response=100; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Lys | 6.9 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1163; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=6.9; Reported_Response_Unit=%; Response=6.9; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Lys | 1.6 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1172; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=1.6; Reported_Response_Unit=%; Response=1.6; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 53.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1168; Record_ID=skin_sensitization_invitro_315; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=53.2; Reported_Response_Unit=%; Response=53.2; Response_Unit=%; Reference=Jaworska 2011; 23670904; 10.1002/jat.2869|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 51 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1176; Record_ID=skin_sensitization_invitro_317; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=51; Reported_Response_Unit=%; Response=51; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 0.827 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5030; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.82699999999999996; Reported_Response_Unit=uM; Response=0.827; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 0.89 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5031; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.89; Reported_Response_Unit=uM; Response=0.89; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 0.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5032; Record_ID=skin_sensitization_invitro_1165; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.9; Reported_Response_Unit=uM; Response=0.9; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | <0.97 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5033; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.97; Reported_Response_Unit=uM; Response=0.97; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | <0.98 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5036; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=0.98; Reported_Response_Unit=uM; Response=0.98; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 1.6 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5043; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.6; Reported_Response_Unit=uM; Response=1.6; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 1.9 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5044; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=1.9; Reported_Response_Unit=uM; Response=1.9; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 2.33 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5045; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=2.33; Reported_Response_Unit=uM; Response=2.33; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 3.11 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5046; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.11; Reported_Response_Unit=uM; Response=3.11; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 3.32 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5047; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=3.32; Reported_Response_Unit=uM; Response=3.32; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 4.1 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5049; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.0999999999999996; Reported_Response_Unit=uM; Response=4.1; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 4.39 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5050; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=4.3899999999999997; Reported_Response_Unit=uM; Response=4.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 5.12 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5052; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=5.12; Reported_Response_Unit=uM; Response=5.12; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 9.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5054; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=9.8000000000000007; Reported_Response_Unit=uM; Response=9.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | 0.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5117; Record_ID=skin_sensitization_invitro_1187; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC1.5; Reported_Response=0.8; Reported_Response_Unit=uM; Response=0.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC1.5 | <20.82 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7598; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=EC1.5; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=20.82; Reported_Response_Unit=uM; Response=20.82; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC3 | 10.676 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5056; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=EC3; Reported_Response=10.676; Reported_Response_Unit=uM; Response=10.676; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC3 | 5.2 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=12905; Record_ID=skin_sensitization_invivo_2840; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=EC3; Response=5.2; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=Gerberick et al. 2005; 16536334; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | EC3 | 0.13 | % | Mouse | Dermal | - | In Vivo; LLNAdb2013; LLNA | sheet=Data_invivo; excel_row=12908; Record_ID=skin_sensitization_invivo_2841; Data_Type=In Vivo; Internal_Data_Source=LLNAdb2013; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=EC3; Response=0.13; Response_Unit=%; Species=Mouse; Route=Dermal; Reference=De Jong et al. 2002; 12062936; 10.1016/s0300-483x(02)00131-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13884; Record_ID=skin_sensitization_invivo_3949; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13884; Record_ID=skin_sensitization_invivo_3949; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13884; Record_ID=skin_sensitization_invivo_3949; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | GHS Classification | 1 | unitless | Mouse | Dermal | - | In Vivo; SkinSensitization6pack; LLNA | sheet=Data_invivo; excel_row=13884; Record_ID=skin_sensitization_invivo_3949; Data_Type=In Vivo; Internal_Data_Source=SkinSensitization6pack; Formulation_ID=MIX430; Formulation_Name=Sativa IMX Max; Percent_Active_Ingredient=10.78; Mixture=Mixture; DTXSID=DTXSID5021332; Assay=LLNA; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Mouse; Route=Dermal; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 11.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5058; Record_ID=skin_sensitization_invitro_1171; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=11.8; Reported_Response_Unit=uM; Response=11.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 12.35 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5060; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=12.35; Reported_Response_Unit=uM; Response=12.35; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 13.74 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5062; Record_ID=skin_sensitization_invitro_1175; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=13.74; Reported_Response_Unit=uM; Response=13.74; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 17.39 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5064; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=17.39; Reported_Response_Unit=uM; Response=17.39; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 22.94 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5066; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=22.94; Reported_Response_Unit=uM; Response=22.94; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 22.98 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5068; Record_ID=skin_sensitization_invitro_1167; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=22.98; Reported_Response_Unit=uM; Response=22.98; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 23.59 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5070; Record_ID=skin_sensitization_invitro_1173; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=23.59; Reported_Response_Unit=uM; Response=23.59; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 23.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5072; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=23.8; Reported_Response_Unit=uM; Response=23.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 25.68 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5076; Record_ID=skin_sensitization_invitro_1168; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=25.68; Reported_Response_Unit=uM; Response=25.68; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 26.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5078; Record_ID=skin_sensitization_invitro_1170; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=26.8; Reported_Response_Unit=uM; Response=26.8; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 27.03 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5080; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=27.03; Reported_Response_Unit=uM; Response=27.03; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 36.6 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5082; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=36.6; Reported_Response_Unit=uM; Response=36.6; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 38.65 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5084; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=38.65; Reported_Response_Unit=uM; Response=38.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 39.1 | uM | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5086; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=39.1; Reported_Response_Unit=uM; Response=39.1; Response_Unit=uM; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 46.8 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5088; Record_ID=skin_sensitization_invitro_1172; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=46.8; Reported_Response_Unit=uM; Response=46.8; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 47.01 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5090; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=47.01; Reported_Response_Unit=uM; Response=47.01; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 52.85 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5092; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=52.85; Reported_Response_Unit=uM; Response=52.85; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 53.65 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5094; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=53.65; Reported_Response_Unit=uM; Response=53.65; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 53.7 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5096; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=53.7; Reported_Response_Unit=uM; Response=53.7; Response_Unit=uM; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 54.57 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5098; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=54.57; Reported_Response_Unit=uM; Response=54.57; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 9.78 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5100; Record_ID=skin_sensitization_invitro_1174; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=IC50; Reported_Response=9.7799999999999994; Reported_Response_Unit=uM; Response=9.78; Response_Unit=uM; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | IC50 | 49.5 | uM | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7668; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=IC50; Reported_Response=49.49606853; Reported_Response_Unit=uM; Response=49.5; Response_Unit=uM; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 1.978 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5102; Record_ID=skin_sensitization_invitro_1184; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.978; Reported_Response_Unit=Unitless; Response=1.978; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 13.119 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5104; Record_ID=skin_sensitization_invitro_1167; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.119; Reported_Response_Unit=Unitless; Response=13.119; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 13.24 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5106; Record_ID=skin_sensitization_invitro_1172; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=13.244999999999999; Reported_Response_Unit=Unitless; Response=13.24; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 15.413 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5108; Record_ID=skin_sensitization_invitro_1179; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=15.413; Reported_Response_Unit=Unitless; Response=15.413; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 16.36 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5110; Record_ID=skin_sensitization_invitro_1168; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=16.364000000000001; Reported_Response_Unit=Unitless; Response=16.36; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 17.7 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5111; Record_ID=skin_sensitization_invitro_1181; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=17.7; Reported_Response_Unit=Unitless; Response=17.7; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 18.52 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5114; Record_ID=skin_sensitization_invitro_1182; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=18.515999999999998; Reported_Response_Unit=Unitless; Response=18.52; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 19.16 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5116; Record_ID=skin_sensitization_invitro_1183; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=19.155999999999999; Reported_Response_Unit=Unitless; Response=19.16; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 22.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5118; Record_ID=skin_sensitization_invitro_1169; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=22.3; Reported_Response_Unit=Unitless; Response=22.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 3.021 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5119; Record_ID=skin_sensitization_invitro_1173; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=3.0209999999999999; Reported_Response_Unit=Unitless; Response=3.021; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 37.32 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5120; Record_ID=skin_sensitization_invitro_1166; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=37.316000000000003; Reported_Response_Unit=Unitless; Response=37.32; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 48.11 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5121; Record_ID=skin_sensitization_invitro_1164; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=48.110999999999997; Reported_Response_Unit=Unitless; Response=48.11; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 58.427 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5122; Record_ID=skin_sensitization_invitro_1178; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=58.427; Reported_Response_Unit=Unitless; Response=58.427; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 6.18 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5124; Record_ID=skin_sensitization_invitro_1187; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.18; Reported_Response_Unit=Unitless; Response=6.18; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 6.75 | ratio | - | Dermal | - | In Vitro; CE_KeratinoSense2018; KeratinoSens | sheet=Data_invitro; excel_row=5126; Record_ID=skin_sensitization_invitro_1163; Data_Type=In Vitro; Internal_Data_Source=CE_KeratinoSense2018; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=6.75; Reported_Response_Unit=Unitless; Response=6.75; Response_Unit=Ratio; Reference=Emter et al. 2010; 20307559; 10.1016/j.taap.2010.03.009|Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 67.9 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5128; Record_ID=skin_sensitization_invitro_1177; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=67.900000000000006; Reported_Response_Unit=Unitless; Response=67.9; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 7.321 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5130; Record_ID=skin_sensitization_invitro_1165; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=7.3209999999999997; Reported_Response_Unit=Unitless; Response=7.321; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 8.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5132; Record_ID=skin_sensitization_invitro_1170; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.1; Reported_Response_Unit=Unitless; Response=8.1; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 8.739 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5134; Record_ID=skin_sensitization_invitro_1176; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=8.7390000000000008; Reported_Response_Unit=Unitless; Response=8.739; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 9.3 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5135; Record_ID=skin_sensitization_invitro_1171; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.3000000000000007; Reported_Response_Unit=Unitless; Response=9.3; Response_Unit=Ratio; Reference=Natsch et al. 2011; 22023385; 10.1021/tx2003678; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 9.513 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5137; Record_ID=skin_sensitization_invitro_1175; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.5129999999999999; Reported_Response_Unit=Unitless; Response=9.513; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 9.6 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5139; Record_ID=skin_sensitization_invitro_1174; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=9.6; Reported_Response_Unit=Unitless; Response=9.6; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 97.17 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=5141; Record_ID=skin_sensitization_invitro_1180; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=97.17; Reported_Response_Unit=Unitless; Response=97.17; Response_Unit=Ratio; Reference=Joint Research Centre of the European Union 2014; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Imax | 5.287 | ratio | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; LuSens | sheet=Data_invitro; excel_row=7571; Record_ID=skin_sensitization_invitro_1837; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=LuSens; Endpoint=Imax; Reported_Response=5.287027612; Reported_Response_Unit=Unitless; Response=5.287; Response_Unit=Ratio; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 33.33 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4900; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=33.33; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4905; Record_ID=skin_sensitization_invivo_1173; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 16 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4916; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=16; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 9.091 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4921; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=9.091; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 18.18 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4929; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=18.18; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 4 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4932; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 4.348 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4946; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=4.348; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 6207 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4898; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=6207; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 15520 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4913; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=15520; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 3414 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4896; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=3414; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 931 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4910; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=931; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 4849 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4924; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4849; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 17840 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4925; Record_ID=skin_sensitization_invivo_1176; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=17840; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 4267 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4939; Record_ID=skin_sensitization_invivo_1177; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=4267; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 19400 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4942; Record_ID=skin_sensitization_invivo_1178; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=19400; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 3103 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4894; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=3103; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 1034 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4906; Record_ID=skin_sensitization_invivo_1172; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=1034; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 3879 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4922; Record_ID=skin_sensitization_invivo_1175; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=25.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Induction dose per skin area, one positive response; Response=3879; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924294; 10.1038/jid.1966.160|Marzulli and Maibach 1976; 801606; 10.1111/j.1600-0536.1976.tb02972.x|Basketter et al. 1996; 9012774; 10.1016/s0278-6915(96)00059-2|Gerberick et al. 2000; 10684384; 10.1053/ajcd.2000.0003|Akkan et al. 2003; Not available; Not available|Griem et al. 2003; 14623479; 10.1016/j.yrtph.2003.07.001|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
| NTP_ICE_skin_sensitization | Relative reliability score | 1 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=4897; Record_ID=skin_sensitization_invivo_1171; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=10.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5021332; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=1; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1966; 5924293; 10.1038/jid.1966.159|Akkan et al. 2003; Not available; Not available|Schneider and Akkan 2004; 15135206; 10.1016/j.yrtph.2004.02.002; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021332; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021332 |
ToxRefDB_ToxRefDB_v3_pod.csv 32 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2.35 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-cholesterol-cholesterol|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-albumin-albumin|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein|in life observation-clinical signs-emesis|clinical chemistry-calcium-calcium|in life observation-food consumption-food consumption|in life observation-body weight-body weight|hematology-platelet-platelet|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=1; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2.26 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_M_systemic; toxval_effect_list=hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-cholesterol-cholesterol|in life observation-body weight-body weight|clinical chemistry-calcium-calcium|hematology-platelet-platelet|in life observation-clinical signs-emesis|in life observation-food consumption-food consumption|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein|clinical chemistry-albumin-albumin|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); dose_level=1; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =7.5 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3546; toxval_study_source_id=studyid3546_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-skin discoloration|in life observation-clinical signs-scabbing|in life observation-clinical signs-alopecia|in life observation-body weight-body weight gain|in life observation-clinical signs-[other]|in life observation-clinical signs-salivation|organ weight-placenta-nos; dose_level=1; study_year=1988; study_citation=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; dsstox_substance_id=DTXSID5021332; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =4.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain|in life observation-food consumption-food consumption|in life observation-body weight-body weight|pathology microscopic-pituitary gland-angiectasis; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =12.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-prostate-inflammation|in life observation-food consumption-food consumption; dose_level=3; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =5.4 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =4.9 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Juvenile_F1_M_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight gain|in life observation-body weight-offspring (pup) weight; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =0.9 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_F_systemic; toxval_effect_list=hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-cholesterol-cholesterol|clinical chemistry-albumin-albumin|organ weight-liver-relative to body weight|clinical chemistry-protein-protein; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =0.84 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-cholesterol-cholesterol|clinical chemistry-protein-protein|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|organ weight-liver-relative to body weight|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-albumin-albumin|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =57 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-pigmentation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-urinary bladder-[other]|in life observation-body weight-body weight gain|hematology-platelet-platelet|pathology microscopic-eye-atrophy|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-skin-inflammation|in life observation-body weight-body weight|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|pathology microscopic-skin-necrosis; dose_level=2; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =24 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-skin-necrosis|in life observation-body weight-body weight|pathology microscopic-eye-atrophy|in life observation-body weight-body weight gain|pathology microscopic-skin-inflammation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-urinary bladder-[other]|pathology microscopic-stomach-hyperkeratosis; dose_level=2; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1.8 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-hematocrit (hct)-hematocrit (hct)|pathology gross-adrenal gland-cyst|pathology microscopic-liver-hyperplasia|pathology microscopic-pancreas-steatosis|pathology microscopic-thyroid gland-hyperplasia|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|pathology microscopic-pancreas-infiltration cellular|clinical chemistry-glucose-glucose|pathology microscopic-liver-hematopoietic cell proliferation|organ weight-ovary-relative to brain weight|organ weight-ovary-absolute; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =7.3 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-pancreas-infiltration cellular|pathology microscopic-pancreas-steatosis|in life observation-body weight-body weight gain|pathology microscopic-pancreas-atrophy|pathology gross-kidney-discolored|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|clinical chemistry-glucose-glucose|organ weight-kidney-absolute|pathology gross-lymph node-discolored|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology gross-liver-foci|organ weight-kidney-relative to brain weight; dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=1; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-body weight-body weight|in life observation-body weight-body weight gain; dose_level=1; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =7.34 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-cholesterol-cholesterol|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-protein-protein|clinical chemistry-calcium-calcium|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch); dose_level=2; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =7.01 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_M_systemic; toxval_effect_list=in life observation-food consumption-food consumption|hematology-platelet-platelet|clinical chemistry-cholesterol-cholesterol|in life observation-body weight-body weight|clinical chemistry-calcium-calcium|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|clinical chemistry-albumin-albumin|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-protein-protein; dose_level=2; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =15 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=3546; toxval_study_source_id=studyid3546_Fetal_Fetal_MF_developmental; toxval_effect_list=developmental malformation-bone-short supernumerary|developmental malformation-bone-incomplete ossification; dose_level=2; study_year=1988; study_citation=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; dsstox_substance_id=DTXSID5021332; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =2.54 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 week to 52 week | CHR | study_id=3550; toxval_study_source_id=studyid3550_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-cholesterol-cholesterol|clinical chemistry-albumin-albumin|organ weight-liver-relative to body weight|clinical chemistry-protein-protein; dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =8.9 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_F_systemic; toxval_effect_list=hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|pathology microscopic-liver-hyperplasia|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|in life observation-body weight-body weight gain|clinical chemistry-urea nitrogen-urea nitrogen|hematology-hematocrit (hct)-hematocrit (hct); dose_level=2; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =6.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=3; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =6.6 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=3; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | dog (beagle; beagle) | oral | 0 day to 90 day | SUB | study_id=3542; toxval_study_source_id=studyid3542_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-emesis|clinical chemistry-calcium-calcium|clinical chemistry-protein-protein|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|clinical chemistry-cholesterol-cholesterol|hematology-hemoglobin (hgb)-hemoglobin (hgb)|in life observation-food consumption-food consumption|clinical chemistry-albumin-albumin|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-platelet-platelet|in life observation-body weight-body weight; dose_level=0; study_year=1990; study_citation=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1.6 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-pituitary gland-angiectasis|in life observation-body weight-body weight|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =4.2 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-prostate-inflammation|in life observation-food consumption-food consumption; dose_level=2; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1.8 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Adult_F1_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1.7 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 90 days (premating) to 2 generation | MGR | study_id=3549; toxval_study_source_id=studyid3549_Juvenile_F1_M_systemic; toxval_effect_list=in life observation-body weight-offspring (pup) weight|in life observation-body weight-offspring (pup) weight gain; dose_level=1; study_year=1997; study_citation=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =3.1 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-inflammation|in life observation-body weight-body weight|pathology microscopic-stomach-hyperkeratosis|hematology-hematocrit (hct)-hematocrit (hct)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-spleen-pigmentation|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|pathology microscopic-urinary bladder-[other]|in life observation-body weight-body weight gain|hematology-platelet-platelet|pathology microscopic-skin-necrosis|pathology microscopic-eye-atrophy; dose_level=1; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =2.5 | mg/kg bw/day | mouse (cd1; Crl:CD-1(ICR)BR) | oral | 0 day to 97 week | CHR | study_id=3551; toxval_study_source_id=studyid3551_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-urinary bladder-[other]|pathology microscopic-skin-inflammation|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|in life observation-body weight-body weight gain|pathology microscopic-eye-atrophy|pathology microscopic-stomach-hyperkeratosis|pathology microscopic-skin-necrosis|in life observation-body weight-body weight; dose_level=1; study_year=1992; study_citation=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1.5 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 0 day to 104 week | CHR | study_id=3552; toxval_study_source_id=studyid3552_Adult_F0_M_systemic; toxval_effect_list=organ weight-kidney-relative to brain weight|pathology gross-liver-foci|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|clinical chemistry-glucose-glucose|organ weight-kidney-absolute|pathology gross-lymph node-discolored|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|pathology gross-kidney-discolored|pathology microscopic-pancreas-atrophy|in life observation-body weight-body weight gain|pathology microscopic-pancreas-steatosis|pathology microscopic-pancreas-infiltration cellular; dose_level=1; study_year=1991; study_citation=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; dsstox_substance_id=DTXSID5021332; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =3.8 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=2; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =3.8 | mg/kg bw/day | rat (Sprague Dawley (SD) rat; Crl: CD(SD)IGS BR) | oral | 3 GD (gestation day) to 1 Generation | DNT | study_id=776296; toxval_study_source_id=studyid776296_Adult_F0_F_neurological; toxval_effect_list=detailed clin obs: dam lactation #2-autonomic function-palpebral closure (ptosis)|detailed clin obs: dam lactation #2-convulsive behavior-tremors|detailed clin obs: dam lactation #2-unusual behavior or appearance-rearing activity|detailed clin obs: dam lactation #2-unusual behavior or appearance-activity; dose_level=2; study_year=2005; study_citation=Fulcher, S.M. (2005) Thiram: developmental neurotoxicity study in the CD rat by dietary administration. Huntingdon Life Sciences, Ltd., Wooley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Laboratory study no. PFX/004; January 18, 2005. MRID 46455201. Piccirillo, V. (2008) Response to Data Evaluation Record for Developmental Neurotoxicity Study in Rats With Thiram (MRID 46455201). Huntingdon Life Sciences, Ltd., Wo'oley Road, Alconbury, Huntingdon, Cambridgeshire, PE28 4HS, England. Project Number: 2008/1, PFX/004, PFX004/042634; January 1, 2008. MRID 47429501. Stannard, D. (2010) Thiram: Morphometric Examination of Brains Derived from a Developmental Neurotoxicity Study in the CD Rat. Huntingdon Life Sciences, Eye Research Center, Eye, Suffolk, IP23 7PX, UK. Project Number: SMJ000l, PFX/004/042634. MRID 48291001.; dsstox_substance_id=DTXSID5021332; admin_method=Diet; vehicle=diet; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_AU_DWG 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_AU_DWG | NOEL | =0.4 | mg/kg bw/day | Dog | oral | chronic; 2 years | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c82db5e4b02565fc7d237c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nhmrc.gov.au; SUBSOURCE_URL=https://www.nhmrc.gov.au/sites/default/files/documents/attachments/publications/Australian_Drinking_Water_Guidelines_ADWG_V3-8_Sep2022.pdf; TOXICOLOGICAL_EFFECT=neurological disturbances, anaemia and changes in the liver; STUDY_GROUP=AU DWG:15951776:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3418a97c60dd5a7e534fc96f6523b768 |
ToxValDB_ECHA_IUCLID 34 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOAEL | =11.7 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver: body weight and weight gain|food consumption and compound intake|gross pathology|haematology|histopathology: non-neoplastic|liver: histopathology: neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|food and/or water consumption|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817560_15817561:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_62c17fe71608959eddc92ed98dad4abb |
| ToxValDB_ECHA_IUCLID | LOAEL | =27.75 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817939_15817942:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fb812a7a377a9544e238f592f9a269b8 |
| ToxValDB_ECHA_IUCLID | LOAEL | =88.65 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e7e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=hepatobiliary: spleen: immunology; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825513_15825514:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2fd8ea3a51ac07daeaf9ca5a3128ca28 |
| ToxValDB_ECHA_IUCLID | LOAEL | =150 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 418 (Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218169; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825580_15825581:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71506f0b6d992279f283dfe7e4840716 |
| ToxValDB_ECHA_IUCLID | LOAEL | =90 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical signs|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825586_15825587:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c2e6aee59ec40f534a00e14c565cf1cd |
| ToxValDB_ECHA_IUCLID | LOAEL | =125 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3cdb2af307e8a89287f4ddb47260273e |
| ToxValDB_ECHA_IUCLID | LOAEL | =500 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=behavior: functional findings; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99144b3df616a6c10f6df6edb26d9643 |
| ToxValDB_ECHA_IUCLID | LOAEL | =60 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825800_15825801:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5c98116772e335e72435b5b44a870f0e |
| ToxValDB_ECHA_IUCLID | LOAEL | =1000 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_65b8c9c571b5b8af8e2efefa13bfa934 |
| ToxValDB_ECHA_IUCLID | LOAEL | =48 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222053; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|gross pathology|haematology|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833271_15833272_15836628_15836629:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_71820374655bcfefffbe15e76eefa9a1 |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | mg/kg bw/day | Rat | oral | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222074; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837261_15837262:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3ae84defe7c6bc6697c36519a3d66540 |
| ToxValDB_ECHA_IUCLID | LOAEL | =9.25 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|food consumption and compound intake|haematology; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837590_15837591_15840866_15840867:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_855b7bae3079447eaae58885373e3495 |
| ToxValDB_ECHA_IUCLID | LOAEL | =300 | ppm | Mouse | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838325_15838327_15839196:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0cb7211e2c4b0e9b180010c612947276 |
| ToxValDB_ECHA_IUCLID | LOAEL | =600 | ppm | Mouse | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838325_15838327_15839196:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c05d35a88ab9d3a9b4d77fc448a37735 |
| ToxValDB_ECHA_IUCLID | LOAEL | =5 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver: clinical biochemistry|haematology|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841286_15841288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f078eff30aed043b4024b90ee13bc34 |
| ToxValDB_ECHA_IUCLID | LOAEL | =60 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bde4b0a7c65d219fbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/9/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855336_15856171_15856717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a150a952b16e525e9ba3b5ce36b0ac55 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2.34 | mg/kg bw/day | Rat | oral | - | chronic | GUIDELINE=OECD Guideline 453 (Combined Chronic Toxicity / Carcinogenicity Studies); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817560_15817561:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7426a733f94e671aa9196191282587f4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =55.5 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817939_15817942:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ce959a42caa75611a7d0e0387b960d1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =111 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817940_15817943:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f705b0fb57d0ca1c745029e66c4e2848 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2.775 | mg/kg bw/day | Mouse | oral | - | chronic | GUIDELINE=OECD Guideline 451 (Carcinogenicity Studies); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c80fe4b0a7c65d2166c8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/8?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID:15817941:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_791ecdb9f2c3342c33a9b053b36a09e8 |
| ToxValDB_ECHA_IUCLID | NOAEL | >5 | mg/kg bw/day | Rabbit | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac93e4b0a7c65d1bfdf4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11549/7/9/3?documentUUID=bffc9e90-e74d-4644-9f2b-e987470690fd; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820672_15821426:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5b5d3065cc32ca5fa0e4b693fd14189c |
| ToxValDB_ECHA_IUCLID | NOAEL | =29.55 | mg/kg bw/day | Mouse | oral | - | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c851e4b0a7c65d217e7e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=hepatobiliary: spleen; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Immunotoxicity_15825513_15825514:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_116c9323993ab82e309bc7c385a9e3e8 |
| ToxValDB_ECHA_IUCLID | NOAEL | =45 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825586_15825587:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6b01a256d02f7c6847f267cf34606955 |
| ToxValDB_ECHA_IUCLID | NOAEL | =20 | ppm | Rat | oral | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64cd00f94483e75b4f464f68c44d0827 |
| ToxValDB_ECHA_IUCLID | NOAEL | =30 | ppm | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21816f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825588_15825589_15825590_15825763_15825764_15825765_15825766:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e5b1961a511623b564ffcdd97302df16 |
| ToxValDB_ECHA_IUCLID | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | repeat dose other | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218171; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/10/1?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825800_15825801:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_01c17850d2d8ce1533d2175de6d9251d |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d88efcd686eaf467f2137440d12cd9e |
| ToxValDB_ECHA_IUCLID | NOAEL | <100 | mg/kg bw/day | Rabbit | dermal | short-term; 21 days | short-term | GUIDELINE=OECD Guideline 410 (Repeated Dose Dermal Toxicity: 21/28-Day Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61d3ae4b096bca8774fa1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/4?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826099_15826100_15826101:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4885b3ba2167b8208c4b52fb9d02629e |
| ToxValDB_ECHA_IUCLID | NOAEL | =4.8 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222053; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833271_15833272_15836628_15836629:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a7cc4d0aba969ea2fb9939248a4154ff |
| ToxValDB_ECHA_IUCLID | NOAEL | =125 | ppm | Dog | oral | short-term; 4 weeks | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222060; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15834088_15834089_15836232_15836233:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2c4885936a628f20dfdcf0b9bd534f13 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca77e4b0a7c65d222074; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837261_15837262:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9efa4253c6fd1508336a2d82c2e4819b |
| ToxValDB_ECHA_IUCLID | NOAEL | =0.6 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841285_15841287:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b9e35fc3510947ee0217551f9f299fe5 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1.8 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca78e4b0a7c65d2220d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/6/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=liver; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841286_15841288:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_77cb92ccb35364e4e94345fc0b12d9ae |
| ToxValDB_ECHA_IUCLID | NOAEL | =180 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c8bde4b0a7c65d219fbc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11311/7/9/2?documentUUID=502ddbbe-8660-42be-8155-be5a2f6657e5; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855336_15856171_15856717:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7f23de17ff1dcb95bfe35f0fad8a5580 |
ToxValDB_ECOTOX 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =50 | ul/org | Mouse | dermal | short-term; 18 days | short-term | LONG_REF=Toxicology176(1-2): 123-134 De Jong,W.H., M. Tentij, S.W. Spiekstra, R.J. Vandebriel, and H. Van Loveren Determination of the Sensitising Activity of the Rubber Contact Sensitisers TMTD, ZDMC, MBT and DEA in a Modified Local Lymph Node Assay and the Effect of Sodium Dodecyl Sulfate Pretreatment on Local Lymph Node Response 2002; TITLE=Determination of the Sensitising Activity of the Rubber Contact Sensitisers TMTD, ZDMC, MBT and DEA in a Modified Local Lymph Node Assay and the Effect of Sodium Dodecyl Sulfate Pretreatment on Local Lymph Node Response; AUTHOR=De Jong,W.H., M. Tentij, S.W. Spiekstra, R.J. Vandebriel, and H. Van Loveren; DOI=10.1016/s0300-483x(02)00131-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99302; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Histology: Proliferation|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15594832:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4e4c92acdbe6b0dd46089db4031e8f9e |
| ToxValDB_ECOTOX | LOEL | =25 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fb34e74e94c486d49fb7f1bf6e4ecf54 |
| ToxValDB_ECOTOX | LOEL | =76 | mL/454 g diet | Mouse | oral | short-term; 4 days | short-term | LONG_REF=Int. Biodeterior. Biodegrad.45:169-174 Nolte,D.L., and J.P. Barnett A Repellent to Reduce Mouse Damage to Longleaf Pine Seed 2000; TITLE=A Repellent to Reduce Mouse Damage to Longleaf Pine Seed; AUTHOR=Nolte,D.L., and J.P. Barnett; DOI=10.1016/S0964-8305(00)00060-3; QUALITY=Control type: Baseline control |::| Control type: Concurrent control; EXTERNAL_SOURCE_ID=74471; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Avoidance: Food avoidance; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15605086:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2eb5f8208a8bca04f0e00551af4ad9c8 |
| ToxValDB_ECOTOX | LOEL | =1 | mmol/kg | Mouse | oral | acute; 1 days | acute | LONG_REF=Toxicol. Lett.42(1): 87-98 Borg,K., and H. Tjalve Effect of Thiram and Dithiocarbamate Pesticides on the Gastrointestinal Absorption and Distribution of Nickel in Mice 1988; TITLE=Effect of Thiram and Dithiocarbamate Pesticides on the Gastrointestinal Absorption and Distribution of Nickel in Mice; AUTHOR=Borg,K., and H. Tjalve; DOI=10.1016/0378-4274(88)90106-3; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=90179; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Biochemistry: Nickel content; STUDY_GROUP=ECOTOX:15605694:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ccaef8edfd8ec15b83da2e2c8768c857 |
| ToxValDB_ECOTOX | NOEL | =12.5 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f24b2917b921e7f5b8bfbd9ff52aaed1 |
| ToxValDB_ECOTOX | NOEL | =37.5 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells|Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594976_15594977_15596212_15607992:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3a9c98231fec70f81126969008162427 |
| ToxValDB_ECOTOX | NOEL | =50 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596604_15599023_15609795_15609796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4874ab26437ec2a74945282c3aaa7197 |
| ToxValDB_ECOTOX | NOEL | =80 | mg/kg bw/day | Rat | injection | short-term; 5 days | short-term | LONG_REF=Arch. Toxicol.8:77-79 Komulainen,H., and K. Savolainen Effect of Dithiocarbamate Fungicides and Thiurams on 3H-Haloperidol Binding in Rat Brain 1985; TITLE=Effect of Dithiocarbamate Fungicides and Thiurams on 3H-Haloperidol Binding in Rat Brain; AUTHOR=Komulainen,H., and K. Savolainen; DOI=10.1007/978-3-642-69928-3_8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=90501; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Protein binding; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15599546:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a76d61c06246f5004256399de43d537b |
| ToxValDB_ECOTOX | NOEL | =366.7 | mg/kg bw/day | Mouse | injection | short-term; 2 days | short-term | LONG_REF=Mutat. Res.518(2): 145-150 Grisolia,C.K. A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides 2002; TITLE=A Comparison Between Mouse and Fish Micronucleus Test Using Cyclophosphamide, Mitomycin C and Various Pesticides; AUTHOR=Grisolia,C.K.; DOI=10.1016/s1383-5718(02)00086-4; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=74478; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX:15606416:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8344a78ba71d20d4dcaa6f19b2ca3a72 |
| ToxValDB_ECOTOX | NOEL | =250 | mg/kg bw/day | Mouse | oral | short-term; 1.25 days | short-term | LONG_REF=Mutat. Res.48(2): 225-236 Seiler,J.P. Nitrosation In Vitro and In Vivo by Sodium Nitrite, and Mutagenicity of Nitrogenous Pesticides 1977; TITLE=Nitrosation In Vitro and In Vivo by Sodium Nitrite, and Mutagenicity of Nitrogenous Pesticides; AUTHOR=Seiler,J.P.; DOI=10.1016/0027-5107(77)90164-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=88676; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15609136:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=03144c9447194fdcee7e5302dfd13404 |
| ToxValDB_ECOTOX | NOEL | =25 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Teratog. Carcinog. Mutagen.12(3): 97-112 Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test 1992; TITLE=Further In Vitro and In Vivo Mutagenicity Assays with Thiram and Ziram Fungicides: Bacterial Reversion Assays and Mouse Micronucleus Test; AUTHOR=Crebelli,R., A. Zijno, L. Conti, B. Crochi, P. Leopardi, F. Marcon, L. Renzi, and A. Carere; DOI=10.1002/tcm.1770120302; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=99049; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596604_15599023_15609795_15609796:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0de1ccecb035bdda920efdf305bb566e |
| ToxValDB_ECOTOX | NOEL | =10 | mg/kg bw/day | Mouse | oral | chronic; 547.92 days | chronic | LONG_REF=J. Natl. Cancer Inst.42:1101-1114 Innes,J.R.M., B.M. Ulland, M.G. Valerio, L. Petrucelli, L. Fishbein, E.R. Hart, A.J. Pallotta, R.R. Bates, H.L. Falk, J Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note 1969; TITLE=Bioassay of Pesticides and Industrial Chemicals for Tumorigenicity in Mice: A Preliminary Note; AUTHOR=Innes,J.R.M., B.M. Ulland, M.G. Valerio, L. Petrucelli, L. Fishbein, E.R. Hart, A.J. Pallotta, R.R. Bates, H.L. Falk, J; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=71346; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1969; ORIGINAL_YEAR=1969; TOXICOLOGICAL_EFFECT=Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=cancer; STUDY_GROUP=ECOTOX:15611931:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=9bc8d73f3fcbc419ee2ee58aa7d545c0 |
ToxValDB_EFSA 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =1.5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15623339:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf3c3dfee4c734740417e9fa939557f9 |
| ToxValDB_EFSA | NOAEL | =0.84 | mg/kg bw/day | Dog | oral | chronic; 1 years | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15623340:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f32149ef25c5b2291cebd1b92accbf77 |
| ToxValDB_EFSA | NOAEL | <7.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA_dup_-_15623341_15623344:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_be3468867fe35cb65c7b0402ca8ddbd4 |
| ToxValDB_EFSA | NOAEL | =2 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=hematological; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=EFSA:15623343:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1351304bc95f0785803e296ecc5df7e5 |
| ToxValDB_EFSA | NOAEL | =3 | mg/kg bw/day | Rat | oral | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA_dup_-_15623341_15623344:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_64d314bfe070c03d4252a652a2742be7 |
| ToxValDB_EFSA | NOAEL | =1.6 | mg/kg bw/day | Rat | oral | - | chronic | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=EFSA:15623345:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4948426c199a3861759771567c38a30 |
| ToxValDB_EFSA | NOEC | =37.5 | mg/kg bw/day | Northern Bobwhite Quail | inhalation | - | reproduction developmental | LONG_REF=EFSA (2017). Peer review of the pesticide risk assessment of the active substance thiram. doi:10.2903/j.efsa.2017.4700.; TITLE=Peer review of the pesticide risk assessment of the active substance thiram; AUTHOR=EFSA; DOI=doi:10.2903/j.efsa.2017.4700; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=EFSA:15623350:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f3a2acd27e59c676c74e3777facd629 |
ToxValDB_EPA_OPP 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_OPP | PAD (RfD) | =0.014 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15790228_15790230:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_693e7e84b82389d2671019141b726f52 |
| ToxValDB_EPA_OPP | PAD (RfD) | =0.015 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63d99625e4b02a0c3a37c5d8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/sdwa/2021-human-health-benchmarks-pesticides; YEAR=2021; ORIGINAL_YEAR=2021; STUDY_GROUP=EPA OPP_dup_HHBP_15790228_15790230:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b997a0afacd7db6a1e70308df4ffe0af |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.118 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635243:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb8f47db92215504b43a784a65c4819d |
ToxValDB_HPVIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HPVIS | NOAEL | ~2.5 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=HLA 6111-110 (1988)Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=1; EXTERNAL_SOURCE_ID=61975; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=HPVIS:15639828:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e29623f43b7ca213d3e0bcc90f1dc6bf |
| ToxValDB_HPVIS | NOAEL | =7.5 | mg/kg bw/day | Rat | oral | short-term; 10 days | developmental | LONG_REF=Thiram Task Force, 1987Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=2; EXTERNAL_SOURCE_ID=58346; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=HPVIS:15642417:F:F1offspring; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_dcf77757deefbf1b0e82e28df33347cd |
| ToxValDB_HPVIS | NOAEL | =5 | mg/kg bw/day | Rabbit | oral | short-term; 14 days | reproduction developmental | LONG_REF=LSR 87/TRK 004/541 (1988)Posting date of document from which data were extracted for entry into HPVIS: July 25, 2003.; QUALITY=1; EXTERNAL_SOURCE_ID=59944; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1988; ORIGINAL_YEAR=1988; STUDY_GROUP=HPVIS:15642914:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7c8655204d490c478c27cc38b37fdb9e |
ToxValDB_IRIS 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LEL | =15 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644769_15644771:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f70f1eb808c5d7349799b1f207cb879d |
| ToxValDB_IRIS | NOEL | =5 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=neurotoxicity; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=IRIS_dup_IRIS Summary_15644769_15644771:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aa6138f13f03ff074b2dfe3675d3ddc3 |
| ToxValDB_IRIS | RfD | =0.005 | mg/kg bw/day | Human | oral | - | Toxicity Value | LONG_REF=E.I. duPont de Nemours & Co., Inc. 1954. MRID. No. 0045162. HED Doc. No. 004550. Available from EPA. Write to FOI, EPA, Washington, DC 20460.; AUTHOR=E.I. duPont de Nemours & Co., Inc; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a35e4b045b9ff7a542d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=267; TOXICOLOGICAL_EFFECT=Neurotoxicity in male/female rats; STUDY_GROUP=IRIS:15645482:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6a36ced23cca8bf6a386b20a402f136d |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfD | =0.006 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663807:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3911e6e1405e290bea642788b8b361a4 |
ToxValDB_ToxRefDB 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =2.35 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-protein-protein|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-clinical signs-emesis|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-albumin-albumin|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-food consumption-food consumption|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: in life observation-body weight-body weight|systemic: hematology-platelet-platelet; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702529_15702530_15702531:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e02033e71d6f8f0437d234d22def0f5f |
| ToxValDB_ToxRefDB | LEL | =2.26 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-albumin-albumin|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-platelet-platelet|systemic: in life observation-clinical signs-emesis|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-food consumption-food consumption|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702532_15702533_15702534:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_172a81f62317fefa461707d1c80f2441 |
| ToxValDB_ToxRefDB | LEL | =4.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-pituitary gland-angiectasis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702540_15702541_15702542_15702543:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4d5db3998579058abb9cb7dbae00b316 |
| ToxValDB_ToxRefDB | LEL | =12.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-prostate-inflammation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702544_15702545:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5f03fdfa6b0ee108faec68acd41e9d64 |
| ToxValDB_ToxRefDB | LEL | =5.4 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15702546_15702547_15702548_15702549:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f25cad235c439e7b0410ff4b162a591 |
| ToxValDB_ToxRefDB | LEL | =4.9 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight|systemic: in life observation-body weight-offspring (pup) weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702554_15702555_15702556_15702557:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1f0b98231c4a5977b48fe4757c3ac834 |
| ToxValDB_ToxRefDB | LEL | =0.9 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; TITLE=52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3550; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-cholesterol-cholesterol|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-protein-protein; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702566_15702567_15702568:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1fda1665314c8292ade9e771bed0c31a |
| ToxValDB_ToxRefDB | LEL | =57 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: hematology-platelet-platelet|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-eye-atrophy|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-spleen-pigmentation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-urinary bladder-[other]|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-necrosis|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-hematocrit (hct)-hematocrit (hct); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702571_15702572_15702573_15702574:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0d04a8f6fdcad36c2255d0028b4d1b06 |
| ToxValDB_ToxRefDB | LEL | =24 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-eye-atrophy|systemic: in life observation-body weight-body weight gain|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-urinary bladder-[other]|systemic: pathology microscopic-stomach-hyperkeratosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702575_15702576_15702577_15702578:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a907fed8a11788c2b0319a2ab12b0f40 |
| ToxValDB_ToxRefDB | LEL | =1.8 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-liver-hyperplasia|systemic: pathology microscopic-thyroid gland-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-adrenal gland-cyst|systemic: pathology microscopic-pancreas-steatosis|systemic: pathology microscopic-pancreas-infiltration cellular|systemic: organ weight-ovary-relative to brain weight|systemic: organ weight-ovary-absolute|systemic: clinical chemistry-glucose-glucose|systemic: pathology microscopic-liver-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702579_15702580_15702581:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e4c31addd126e86131a0866394ae65a |
| ToxValDB_ToxRefDB | LEL | =7.3 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-pancreas-infiltration cellular|systemic: pathology microscopic-pancreas-steatosis|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-pancreas-atrophy|systemic: clinical chemistry-glucose-glucose|systemic: organ weight-kidney-absolute|systemic: pathology gross-lymph node-discolored|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology gross-liver-foci|systemic: pathology gross-kidney-discolored|systemic: organ weight-kidney-relative to brain weight|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|gross pathology|hematology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702582_15702583_15702584_15702585:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fcce5407c1b1177b71a93e26596414ec |
| ToxValDB_ToxRefDB | LOAEL | =7.34 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-cholesterol-cholesterol|systemic: clinical chemistry-protein-protein|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: clinical chemistry-calcium-calcium|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: in life observation-food consumption-food consumption|systemic: clinical chemistry-albumin-albumin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702529_15702530_15702531:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09900eb5c06dea2ea9faceb8b1d75ff7 |
| ToxValDB_ToxRefDB | LOAEL | =7.01 | mg/kg bw/day | Dog | oral | subchronic; 90 days | subchronic | LONG_REF=Kehoe, D. (1990) 13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017. Unpublished study prepar- ed Hazleton Laboratories America, Inc. 237 p.; TITLE=13-Week Toxicity Study with Thiram in Dogs: Lab Project Number: HLA 6111-121: 90-017; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3542; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: in life observation-food consumption-food consumption|systemic: hematology-platelet-platelet|systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: clinical chemistry-cholesterol-cholesterol|systemic: hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|systemic: in life observation-body weight-body weight|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: clinical chemistry-calcium-calcium|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-albumin-albumin; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|hematology; STUDY_GROUP=ToxRefDB_dup_-_15702532_15702533_15702534:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ee7305999a0e4a0032c921e443e5409e |
| ToxValDB_ToxRefDB | LOAEL | =15 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Tesh, J.; McAnulty, P.; Willoughby, C.; et al. (1988) Thiram: Teratology Study in the Rat: 87/TRK002/179. Unpublished study prepared by Life Science Research. 91 p.; TITLE=Thiram: Teratology Study in the Rat: 87/TRK002/179; AUTHOR=Tesh, J.; McAnulty, P.; Willoughby, C.; et al; EXTERNAL_SOURCE_ID=3546; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-bone-incomplete ossification|developmental: developmental malformation-bone-short supernumerary; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702537_15702538_15702539:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7dd1cd690f6a00e50612fff600e17ce7 |
| ToxValDB_ToxRefDB | LOAEL | =2.54 | mg/kg bw/day | Dog | oral | chronic; 52 weeks | chronic | LONG_REF=Kehoe, D. (1991) 52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112. Unpublished study prepared by Hazleton Laboratories America, Inc. 545 p.; TITLE=52-Week Dietary Chronic Toxicity Study with Thiram in Dogs: Final Report: Lab Project Number: HLA 6111-112; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3550; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-albumin-albumin|systemic: clinical chemistry-cholesterol-cholesterol|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-protein-protein; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15702566_15702567_15702568:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f954c0714817e7ad873592a768d99377 |
| ToxValDB_ToxRefDB | LOAEL | =8.9 | mg/kg bw/day | Rat | oral | chronic; 104 weeks | chronic | LONG_REF=Kehoe, D. (1991) 104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113. Unpublished study prepared by Hazleton Labs America, Inc. 2513 p.; TITLE=104-Week Combined Chronic Toxicity and Carcino- genicity Study with Thiram in Rats: Lab Project Number: HLA 6111 113; AUTHOR=Kehoe, D; EXTERNAL_SOURCE_ID=3552; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=systemic: hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|systemic: clinical chemistry-urea nitrogen-urea nitrogen|systemic: pathology microscopic-liver-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702579_15702580_15702581:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c045a6e894047ac14ec87a19cb4f4cf5 |
| ToxValDB_ToxRefDB | NEL | =1.6 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-pituitary gland-angiectasis|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702540_15702541_15702542_15702543:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_10f960d3ad1de1ab80d433995d8f7d98 |
| ToxValDB_ToxRefDB | NEL | =4.2 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-prostate-inflammation|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702544_15702545:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7d9d4691033ef70efa4d9bcee90d3ea5 |
| ToxValDB_ToxRefDB | NEL | =1.8 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15702546_15702547_15702548_15702549:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6f61234b6276c54cf698eed574b82a2 |
| ToxValDB_ToxRefDB | NEL | =1.7 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=Turck, P. (1997) Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180. Unpublished study prepared by MPI Research. 1579 p.; TITLE=Two Generation Reproduction/Fertility Study in Rats with Thiram: Lab Project Number: 399-180; AUTHOR=Turck, P; EXTERNAL_SOURCE_ID=3549; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-offspring (pup) weight gain|systemic: in life observation-body weight-offspring (pup) weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15702554_15702555_15702556_15702557:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2613d6d33b35aff5fda3f1063cd37680 |
| ToxValDB_ToxRefDB | NEL | =3.1 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-spleen-pigmentation|systemic: hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|systemic: pathology microscopic-urinary bladder-[other]|systemic: hematology-hematocrit (hct)-hematocrit (hct)|systemic: in life observation-body weight-body weight|systemic: hematology-hemoglobin (hgb)-hemoglobin (hgb)|systemic: in life observation-body weight-body weight gain|systemic: hematology-platelet-platelet|systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-eye-atrophy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702571_15702572_15702573_15702574:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8ab16dfc92fec546d0ceff7a2595f11 |
| ToxValDB_ToxRefDB | NEL | =2.5 | mg/kg bw/day | Mouse | oral | chronic; 97 weeks | chronic | LONG_REF=Trutter, J. (1992) Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223. Unpublished study prepared by Hazleton Washington, Inc. 2965 p.; TITLE=Oncogenicity Study in Mice with Thiram: Lab Project Number: 798-223; AUTHOR=Trutter, J; EXTERNAL_SOURCE_ID=3551; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-eye-atrophy|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-skin-necrosis|systemic: pathology microscopic-stomach-hyperkeratosis|systemic: pathology microscopic-urinary bladder-[other]|systemic: in life observation-body weight-body weight|systemic: hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15702575_15702576_15702577_15702578:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a4a71fbd810c3f6bfa895cc778feff4c |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 0D771IS0FH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12N2S4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0D771IS0FH"} |
| openFDA substances | FDA UNII substance identifier | 0D771IS0FH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12N2S4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0D771IS0FH"} |
| openFDA substances | FDA UNII substance identifier | 0D771IS0FH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12N2S4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0D771IS0FH"} |
| openFDA substances | FDA UNII substance identifier | 0D771IS0FH | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C6H12N2S4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0D771IS0FH"} |