NOAEL Studies Cosmetic Ingredient

Theobromine NOAEL Studies

INCI: THEOBROMINE

CAS: 83-67-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 17 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB LOAEL 41 mg/kg bw/day rabbit oral 6-29 Gestation day Developmental PAFA; FOOD CHEM TOXICOL 24:363-374
COSMOS_DB LOAEL 125 mg/kg bw/day rabbit oral 6-29 Gestation day Developmental PAFA; FOOD CHEM TOXICOL 24:363-374
COSMOS_DB NOAEL 21 mg/kg bw/day rabbit oral 24 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 53 mg/kg bw/day rat oral 14 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 75 mg/kg bw/day rabbit oral 24 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 88.2 mg/kg bw/day rabbit oral 120 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 110 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 144 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 199 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day rat oral 448 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 300 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 375 mg/kg bw/day mouse oral NA Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 500 mg/kg bw/day rat oral 8 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 501 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 518 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 600 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 638 mg/kg bw/day syrian hamster oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip 21 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL <=349 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=true; upper_value=349; entry_uuid=6043dd88-35ab-43d7-9998-b070cafd0e88
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 144 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=92507cd4-6c4f-4dd8-8c63-cd0615926889
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 110 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=c0ba3a73-ac6f-4d63-a013-4e0355fe02f0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 200 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=3ff046df-f39d-4595-8cdb-8c692cd8e945
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 531 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=1d4716ee-1205-4365-b39c-46d4cfe9d88f_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=1d4716ee-1205-4365-b39c-46d4cfe9d88f/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1984; basis=body weight and weight gain; key_result=true; entry_uuid=ba84a17d-cd2b-4859-bcf6-1e62ff81a26f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL <=349 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=true; upper_value=349; entry_uuid=6043dd88-35ab-43d7-9998-b070cafd0e88
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 144 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=92507cd4-6c4f-4dd8-8c63-cd0615926889
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 110 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=c0ba3a73-ac6f-4d63-a013-4e0355fe02f0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 200 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=3ff046df-f39d-4595-8cdb-8c692cd8e945
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 531 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=1d4716ee-1205-4365-b39c-46d4cfe9d88f_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=1d4716ee-1205-4365-b39c-46d4cfe9d88f/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1984; basis=body weight and weight gain; key_result=true; entry_uuid=ba84a17d-cd2b-4859-bcf6-1e62ff81a26f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL <=349 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=true; upper_value=349; entry_uuid=6043dd88-35ab-43d7-9998-b070cafd0e88
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 144 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=92507cd4-6c4f-4dd8-8c63-cd0615926889
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 110 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=c0ba3a73-ac6f-4d63-a013-4e0355fe02f0
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 200 mg/kg bw/day rat oral: feed - short-term repeated dose toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=0b3b3def-abd8-45dd-b0b4-9fb1bd1ec035/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-12-04; basis=body weight and weight gain; key_result=false; entry_uuid=3ff046df-f39d-4595-8cdb-8c692cd8e945
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip LOAEL 531 mg/kg bw/day rat oral: feed - sub-chronic toxicity: oral dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=1d4716ee-1205-4365-b39c-46d4cfe9d88f_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=1d4716ee-1205-4365-b39c-46d4cfe9d88f/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1984; basis=body weight and weight gain; key_result=true; entry_uuid=ba84a17d-cd2b-4859-bcf6-1e62ff81a26f
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=126 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=reproductive function (sperm measures); key_result=true; upper_value=126; entry_uuid=e7882d9e-7810-4e12-bb72-8d60932ba0ab
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=630 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=organ weights and organ / body weight ratios; key_result=true; upper_value=630; entry_uuid=2774a962-f725-468e-a45e-a43d7190a300
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=126 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=reproductive function (sperm measures); key_result=true; upper_value=126; entry_uuid=e7882d9e-7810-4e12-bb72-8d60932ba0ab
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=630 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=organ weights and organ / body weight ratios; key_result=true; upper_value=630; entry_uuid=2774a962-f725-468e-a45e-a43d7190a300
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=126 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=reproductive function (sperm measures); key_result=true; upper_value=126; entry_uuid=e7882d9e-7810-4e12-bb72-8d60932ba0ab
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip NOAEL <=630 mg/kg bw/day mouse oral: feed - two-generation reproductive toxicity dossier=69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6z; document=b6745af3-ee34-4cff-8828-6ae2f1309def_69c0902c-d3b1-4789-8b5f-96e47b5d6851.i6d; document_key=b6745af3-ee34-4cff-8828-6ae2f1309def/69c0902c-d3b1-4789-8b5f-96e47b5d6851; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1997; basis=organ weights and organ / body weight ratios; key_result=true; upper_value=630; entry_uuid=2774a962-f725-468e-a45e-a43d7190a300
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =21 mg/kg bw/day Rabbit - - reproduction toxicity EFSA CONTAM - 2008 - OutputID 104 - development - teratogenic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =7 mg/kg bw/day Pig oral: feed - subchronic EFSA CONTAM - 2008 - OutputID 104 - growth - systemic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL ca.35 mg/kg bw/day Sheep oral: feed 90 days subchronic EFSA CONTAM - 2008 - OutputID 104 - food consumption - systemic - Theobromine as undesirable substances in animal feed - doi:10.2903/j.efsa.2008.725
IARC Monographs 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
IARC Monographs IARC carcinogenicity classification 3 IARC group - - 1990 IARC Monographs {"additional_info":"volume_publication_year=1991","evaluation_year":1990,"source_table":"iarc_classifications","volume":"51"}
NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =950 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10770; row=15669; data_type=In Vivo; mixture=Chemical; chemical_name=Theobromine; preferred_name=Theobromine; dtxsid=DTXSID9026132; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026132; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 =1265 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10771; row=15670; data_type=In Vivo; mixture=Chemical; chemical_name=Theobromine; preferred_name=Theobromine; dtxsid=DTXSID9026132; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9026132; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 396 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=3668; Record_ID=adme_parameters_1092; Data_Type=Measured; DTXSID=DTXSID9026132; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=396.0; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132
NTP_ICE_adme_parameters Fu 0.955 fraction Human - - Measured; httk, Human Plasma Fraction Unbound sheet=Data; excel_row=3667; Record_ID=adme_parameters_1092; Data_Type=Measured; DTXSID=DTXSID9026132; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.955; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132
NTP_ICE_cancer 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_cancer IARC group 3 unitless - - - WOE; IARC Carcinogenicity sheet=Data; excel_row=10245; Record_ID=cancer_4428; Data_Type=WOE; Formulation_Name=Theobromine; Mixture=Chemical; DTXSID=DTXSID9026132; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/69; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=15384; RecordID=ARPathway2016_1633; DatasetName=ARPathway2016; DTXSID=DTXSID9026132; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9026132; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9026132
ToxValDB_ECHA_IUCLID 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =200 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830503_15849922:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3927235c30aa1b9783e9ae2ef2ed77bd
ToxValDB_ECHA_IUCLID LOAEL <=349 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|histopathology: non-neoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15849921:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_986688f236ec3400e2722820296f53c0
ToxValDB_ECHA_IUCLID LOAEL =144 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830503_15849922:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d7b24b82d1e164d0eed0d02b62a6d373
ToxValDB_ECHA_IUCLID LOAEL =110 mg/kg bw/day Rat oral short-term; 28 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc82e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/6/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=body weight and weight gain|food consumption and compound intake|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight; STUDY_GROUP=ECHA IUCLID:15849923:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_caeda062f0f9386c7df37110e3df9eec
ToxValDB_ECHA_IUCLID NOAEL <630 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba303; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/9/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856389_15863138:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d60811524469c95bcd3ac92def96f207
ToxValDB_ECHA_IUCLID NOAEL <=126 mg/kg bw/day Mouse oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba303; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17899/7/9/2?documentUUID=69c0902c-d3b1-4789-8b5f-96e47b5d6851; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=P0: reproductive function (sperm measures)|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856389_15863138:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4aa81b198c4c9804ce6f79e5c33882a0
ToxValDB_EFSA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =21 mg/kg bw/day Rabbit oral - developmental LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=development; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=EFSA:15613919:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e34e72b39e215a69014c108a178ca188
ToxValDB_EFSA NOAEL ~35 mg/kg bw/day Sheep oral subchronic; 3 months subchronic LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=EFSA:15613921:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0c41244ac9b592b6970c3200fc2b1140
ToxValDB_EFSA NOAEL =7 mg/kg bw/day Pig oral - subchronic LONG_REF=EFSA CONTAM (2008). Theobromine as undesirable substances in animal feed. doi:10.2903/j.efsa.2008.725.; TITLE=Theobromine as undesirable substances in animal feed; AUTHOR=EFSA CONTAM; DOI=doi:10.2903/j.efsa.2008.725; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=growth; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15613922:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c4797cc4a943dbf57ec91391210fcbdd
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier OBD445WZ5P UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OBD445WZ5P"}
openFDA substances FDA UNII substance identifier OBD445WZ5P UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OBD445WZ5P"}
openFDA substances FDA UNII substance identifier OBD445WZ5P UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OBD445WZ5P"}
openFDA substances FDA UNII substance identifier OBD445WZ5P UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H8N4O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OBD445WZ5P"}