Is Tetrasodium Iminodisuccinate safe in cosmetics?
Tetrasodium Iminodisuccinate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Tetrasodium Iminodisuccinate
Also known as: Aspartic acid, N-(1,2-dicarboxyethyl)-, tetrasodium salt, Aspartic acid, N-(1,2-dicarboxyethyl)-, sodium salt (1:4), UNII-GYS41J2635
INCI: TETRASODIUM IMINODISUCCINATE
Tetrasodium Iminodisuccinate (CAS 144538-83-0) is a cosmetic cosmetic ingredient functioning as Chelating Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 144538-83-0 →
Auto-generated CPSR Part A draft with source citations
Function
Chelating Agent
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
tetrasodium;2-(1,2-dicarboxylatoethylamino)butanedioate
InChIKey
GYBINGQBXROMRS-UHFFFAOYSA-J
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR concluded safe (March 2023). EPA exempt from tolerance as inert ingredient.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrasodium Iminodisuccinate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Preservative
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Tetrasodium Iminodisuccinate.
Regulatory Flags
epa_safer_alternative
Known Synonyms
Aspartic acid, N-(1,2-dicarboxyethyl)-, tetrasodium salt
Aspartic acid, N-(1,2-dicarboxyethyl)-, sodium salt (1:4)
UNII-GYS41J2635
Chemical Function
Chelating agent
Regulatory Lists
SCIL (9/2019)
inert_ingredient; non_food_use; Pesticides
Cleaning products and household care; Europe
Cleaning products and household care; Europe
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Tetrasodium Iminodisuccinate allowed in the EU?
Tetrasodium Iminodisuccinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrasodium Iminodisuccinate do in cosmetics?
Tetrasodium Iminodisuccinate functions as: Chelating Agent. It is classified as a cosmetic ingredient in our database. CAS number: 144538-83-0.
Is Tetrasodium Iminodisuccinate used outside cosmetics?
Tetrasodium Iminodisuccinate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetrasodium Iminodisuccinate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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