NOAEL Studies Cosmetic Ingredient

Tetrapotassium Pyrophosphate NOAEL Studies

INCI: TETRAPOTASSIUM PYROPHOSPHATE

CAS: 7320-34-5

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 >1.1 mg/L - Inhalation Duration=4 hr In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=2138; Record_ID=acute_inhalation_2974; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID3036446; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=1.1; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14700/7/3/3/?documentUUID=0273955c-ff8d-480c-ba19-ff6b80c03223; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID3036446
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL >7940 mg/kg bw/day Rabbit dermal acute; 24 hours acute QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c6184be4b096bca8762a56; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14700/7/3/4?documentUUID=3ba27ad2-a42b-4fcf-b6b7-09d9eb918d6c; YEAR=1987; ORIGINAL_YEAR=1987; STUDY_GROUP=ECHA IUCLID:15792583:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ef48b2970f74b993d81c005cac48e43
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =17.63 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635190:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_757a8ebaa63d58949dc9798919a06c01
ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) NOAEL =145.7 mg/kg bw/day Human oral - epidemiologic LONG_REF=IOM 1997, Nordin 1988; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1899; TOXICOLOGICAL_EFFECT=increased ecf serum phosphorus; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=PPRTV (CPHEA):15654056:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ef89a2ad95835f08dd22e91125abef09
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =49 mg/kg bw/day Human oral - Toxicity Value LONG_REF=IOM 1997, Nordin 1988; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd9a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1899; TOXICOLOGICAL_EFFECT=increased ecf serum phosphorus; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653993_15653994:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1c094fff396b4f5dcacdd8a6d6be2c3b
ToxValDB_RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_PPRTV_15658238_15663701:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c315cc12a0d3cdef0ec61cbf9475480
ToxValDB_RSL RfD =4 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_PPRTV_15658238_15663701:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7c41c3f7c105b2a5e4eb753318278834
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier B9W4019H5G UNII - - - chemical {"approval_status":null,"molecular_formula":"4K.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9W4019H5G"}
openFDA substances FDA UNII substance identifier B9W4019H5G UNII - - - chemical {"approval_status":null,"molecular_formula":"4K.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9W4019H5G"}
openFDA substances FDA UNII substance identifier B9W4019H5G UNII - - - chemical {"approval_status":null,"molecular_formula":"4K.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9W4019H5G"}
openFDA substances FDA UNII substance identifier B9W4019H5G UNII - - - chemical {"approval_status":null,"molecular_formula":"4K.O7P2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"B9W4019H5G"}