INCI: TETRAHYDROPYRANYLOXY PHENOL
Tetrahydropyranyloxy Phenol (Deoxyarbutin) (CAS 53936-56-4) is a cosmetic cosmetic ingredient functioning as Skin lightening / Bleaching agent (tyrosinase inhibitor). Reported NOAEL =0.0218 mg/kg bw/day in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 53936-56-4 →
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydropyranyloxy Phenol (Deoxyarbutin).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Tetrahydropyranyloxy Phenol (Deoxyarbutin). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.0218 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =0.77 mg/kg | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =15 mg/kg/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| UK | banned | - | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 82.04% | - | - | SCCS/1554/15 |
Expert safety assessment and concern-level summary for Tetrahydropyranyloxy Phenol (Deoxyarbutin).
Public NOAEL study rows linked to Tetrahydropyranyloxy Phenol (Deoxyarbutin) by CAS number or substance name.
Units vary across source rows: mg/kg bw/day, mg/kg, mg/kg/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 82.04% | SCCS opinion extraction | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) functions as: Skin lightening / Bleaching agent (tyrosinase inhibitor). It is classified as a cosmetic ingredient in our database. CAS number: 53936-56-4.
The NOAEL (No Observed Adverse Effect Level) for Tetrahydropyranyloxy Phenol (Deoxyarbutin) is =0.0218 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Tetrahydropyranyloxy Phenol (Deoxyarbutin) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Check Tetrahydropyranyloxy Phenol (Deoxyarbutin) compliance across multiple jurisdictions:
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Tetrahydropyranyloxy Phenol (Deoxyarbutin) in your formulation.