NOAEL Studies
Cosmetic Ingredient
TBHQ NOAEL Studies
CAS: 1948-33-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 14 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 125 | mg/kg bw/day | dog | oral | 819 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 600 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 277 | mg/kg bw/day | rat | oral | NA | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 326 | mg/kg bw/day | rat | oral | 20 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 224 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 600 | mg/kg bw/day | hamster | oral | 140 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2000 | mg/kg bw/day | rat | oral | NA | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 400 | mg/kg bw/day | rat | oral | 357 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 252 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 900 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1950 | mg/kg bw/day | mouse | oral | 91 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 700 | mg/kg bw/day | mouse | oral | 707 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 231 | mg/kg bw/day | rat | oral | 900 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx | NOAEL | =72 | mg/kg bw/day | Dog | oral: feed | 819 days | chronic/long term toxicity | EFSA AFC - 2004 - OutputID 311 - clinical chemistry - hemopoietic - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ) - doi:10.2903/j.efsa.2004.84 |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | <=0.7 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2004 - OutputID 311 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ) - doi:10.2903/j.efsa.2004.84 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | <=0.7 | mg/kg bw/day | Consumers | - | - | ADI | EFSA AFC - 2004 - OutputID 311 - Consumers - Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ) - doi:10.2903/j.efsa.2004.84 |
INCHEM_WHO_jecfa_jecmono_v040je02 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v040je02 | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | long-term | Health guidance value | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=6d5e1dc28061c26e; raw_unit=mg/kg bw; context=At the forty-fourth meeting, the previously-established temporary ADI of 0-0.2 mg/kg bw was extended pending results from ongoing long-term studies in rodents. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | ADI | range:0-0.70.7 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=55537e58c655318b; raw_unit=mg/kg bw; context=The Committee allocated an ADI of 0-0.7 mg/kg bw based on the NOEL of 70 mg/kg bw per day to which a 100-fold safety factor was applied. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | ADI | range:0-0.20.2 | mg/kg bw/day | - | - | long-term | Health guidance value | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=6d5e1dc28061c26e; raw_unit=mg/kg bw; context=At the forty-fourth meeting, the previously-established temporary ADI of 0-0.2 mg/kg bw was extended pending results from ongoing long-term studies in rodents. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | ADI | range:0-0.70.7 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=55537e58c655318b; raw_unit=mg/kg bw; context=The Committee allocated an ADI of 0-0.7 mg/kg bw based on the NOEL of 70 mg/kg bw per day to which a 100-fold safety factor was applied. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =1500 | mg/kg bw/day | Dog | oral | 117-week | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=c44c2d79c1dd6e15; raw_unit=mg/kg; context=This ADI was derived from a NOEL of 1500 mg/kg of feed (equivalent to 37.5 mg/kg bw per day) in a 117-week feeding study in dogs on the basis of haematological changes observed at the next highest dose level of 5000 mg/kg feed (Annex 1, reference 39). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =5000 | mg/kg bw/day | - | dermal | - | Dermal toxicity | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=32220276e34cfec5; raw_unit=mg/kg; context=The NOEL was 5000 mg/kg (equal to 870 mg/kg bw per day) based on decreased body weight gain and increased incidence of mucosal hyperplasia of the forestomach and inflammation of both the nose and skin at higher doses (NTP, 1995). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =50 | mg/kg bw/day | - | oral | long-term | Chronic toxicity | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=acf8903bf2ce4df6; raw_unit=mg/kg bw per day; context=The NOEL for the long-term toxicity of TBHQ was 1250 mg/kg diet (equal to 50 mg/kg bw per day) based on an increased incidence of cysts and suppurative inflammation in the kidneys of males and an increased incidence of chronic inflammation of the kidneys of females at higher doses (NTP, 1995). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =72 | mg/kg bw/day | Dog | oral | 112 weeks | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=af786adca6e22298; raw_unit=mg/kg bw per day; context=Under these study conditions, the NOEL for long-term toxicity in the dog was 1580 mg/kg diet (equal to 72 mg/kg bw per day) based on decreased haemoglobin and/or haematocrits at various time points throughout the study and decreased RBC counts at 112 weeks in high-dose dogs of both sexes. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =870 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=d66d0cb8b9cb1256; raw_unit=mg/kg bw per day; context=The NOEL for the study was 870 mg/kg bw per day. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =125 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=d57c9123544f9124; raw_unit=mg/kg bw per day; context=The effect on pup body weight was late-occurring in terms of the lactation period and the NOEL was 0.25% diet, equivalent to 125 mg/kg bw per day. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =70 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=f045c53c68c878ec; raw_unit=mg/kg bw per day; context=The Committee allocated an ADI of 0-0.7 mg/kg bw based on the NOEL of 70 mg/kg bw per day to which a 100-fold safety factor was applied. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =1500 | mg/kg bw/day | Dog | oral | 117-week | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=c44c2d79c1dd6e15; raw_unit=mg/kg; context=This ADI was derived from a NOEL of 1500 mg/kg of feed (equivalent to 37.5 mg/kg bw per day) in a 117-week feeding study in dogs on the basis of haematological changes observed at the next highest dose level of 5000 mg/kg feed (Annex 1, reference 39). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =5000 | mg/kg bw/day | - | dermal | - | Dermal toxicity | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=32220276e34cfec5; raw_unit=mg/kg; context=The NOEL was 5000 mg/kg (equal to 870 mg/kg bw per day) based on decreased body weight gain and increased incidence of mucosal hyperplasia of the forestomach and inflammation of both the nose and skin at higher doses (NTP, 1995). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =50 | mg/kg bw/day | - | oral | long-term | Chronic toxicity | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=acf8903bf2ce4df6; raw_unit=mg/kg bw per day; context=The NOEL for the long-term toxicity of TBHQ was 1250 mg/kg diet (equal to 50 mg/kg bw per day) based on an increased incidence of cysts and suppurative inflammation in the kidneys of males and an increased incidence of chronic inflammation of the kidneys of females at higher doses (NTP, 1995). |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =72 | mg/kg bw/day | Dog | oral | 112 weeks | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=af786adca6e22298; raw_unit=mg/kg bw per day; context=Under these study conditions, the NOEL for long-term toxicity in the dog was 1580 mg/kg diet (equal to 72 mg/kg bw per day) based on decreased haemoglobin and/or haematocrits at various time points throughout the study and decreased RBC counts at 112 weeks in high-dose dogs of both sexes. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =870 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=d66d0cb8b9cb1256; raw_unit=mg/kg bw per day; context=The NOEL for the study was 870 mg/kg bw per day. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =125 | mg/kg bw/day | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=d57c9123544f9124; raw_unit=mg/kg bw per day; context=The effect on pup body weight was late-occurring in terms of the lactation period and the NOEL was 0.25% diet, equivalent to 125 mg/kg bw per day. |
| INCHEM_WHO_jecfa_jecmono_v040je02 | NOEL | =70 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v040je02; title=898. Butylhydroquinone, tert- (TBHQ) (WHO Food Additives Series 40); path=mirror/documents/jecfa/jecmono/v040je02.htm; row_hash=f045c53c68c878ec; raw_unit=mg/kg bw per day; context=The Committee allocated an ADI of 0-0.7 mg/kg bw based on the NOEL of 70 mg/kg bw per day to which a 100-fold safety factor was applied. |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | Top dose | 0.5 | % | Mouse | Dosed feed | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=6337; Record_ID=cancer_431; Data_Type=In Vivo; Formulation_Name=t-Butylhydroquinone; Mixture=Chemical; DTXSID=DTXSID6020220; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=0.5; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed feed; Reference=TR-459; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr459/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
NTP_ICE_endocrine 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | AC50 | 29.2127984648094 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15234; RecordID=ARPathway2016_102; DatasetName=ARPathway2016; DTXSID=DTXSID6020220; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=29.2127984648094; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | AC50 | 48.2539301566622 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15240; RecordID=ERPathway2016_469; DatasetName=ERPathway2016; DTXSID=DTXSID6020220; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=48.2539301566622; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | ACC | 41.1169587807493 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15235; RecordID=ARPathway2016_102; DatasetName=ARPathway2016; DTXSID=DTXSID6020220; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=41.1169587807493; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | ACC | 53.1811754076137 | uM | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15241; RecordID=ERPathway2016_469; DatasetName=ERPathway2016; DTXSID=DTXSID6020220; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=53.1811754076137; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | Model Score | 0.0164 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15236; RecordID=ARPathway2016_102; DatasetName=ARPathway2016; DTXSID=DTXSID6020220; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.0164; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15237; RecordID=ARPathway2016_102; DatasetName=ARPathway2016; DTXSID=DTXSID6020220; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
| NTP_ICE_endocrine | Model Score | 0.00291 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=15242; RecordID=ERPathway2016_469; DatasetName=ERPathway2016; DTXSID=DTXSID6020220; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.00291; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020220; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID6020220 |
ToxRefDB_ToxRefDB_v3_pod.csv 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1000 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=offspring survival early-birth index-birth index; dose_level=4; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =200 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Adult Pregnancy_F1_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length|reproductive performance-estrous cycle-periodicity|offspring survival early-dead fetuses-dead fetuses; dose_level=1; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =400 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Adult Pregnancy_F1_M_reproductive; toxval_effect_list=offspring survival early-dead fetuses-dead fetuses; dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =750 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Juvenile_F1_F_developmental; toxval_effect_list=offspring survival late-[other]-[other]; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =800 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Juvenile_F1_M_developmental; toxval_effect_list=offspring survival late-[other]-[other]; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2200 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5699; toxval_study_source_id=studyid5699_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-skin-inflammation|hematology-neutrophils-neutrophils|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight gain|pathology microscopic-skin-hyperplasia|in life observation-body weight-body weight|pathology microscopic-nose-inflammation; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1950 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5699; toxval_study_source_id=studyid5699_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-skin-hyperplasia|pathology microscopic-nose-inflammation|in life observation-body weight-body weight gain|pathology microscopic-skin-inflammation|pathology microscopic-stomach-hyperplasia|hematology-neutrophils-neutrophils; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >240 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F0_F_NA; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =60 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F1_F_systemic; toxval_effect_list=in life observation-clinical signs-fur (altered appearance)|in life observation-body weight-body weight|pathology microscopic-spleen-hemosiderosis; dose_level=1; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =50 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F1_M_systemic; toxval_effect_list=in life observation-clinical signs-fur (altered appearance)|pathology microscopic-kidney-cyst|pathology microscopic-kidney-inflammation|pathology microscopic-spleen-hemosiderosis|in life observation-body weight-body weight|pathology microscopic-nose-hyperplasia; dose_level=1; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =700 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5704; toxval_study_source_id=studyid5704_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =600 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5704; toxval_study_source_id=studyid5704_Adult_F0_M_systemic; toxval_effect_list=hematology-reticulocyte-reticulocyte|in life observation-body weight-body weight; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =200 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F1_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =500 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=offspring survival early-birth index-birth index; dose_level=3; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5695; toxval_study_source_id=studyid5695_Adult Pregnancy_F1_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length|offspring survival early-dead fetuses-dead fetuses|reproductive performance-estrous cycle-periodicity; dose_level=0; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1100 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5699; toxval_study_source_id=studyid5699_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-nose-inflammation|in life observation-body weight-body weight|pathology microscopic-skin-hyperplasia|in life observation-body weight-body weight gain|pathology microscopic-stomach-hyperplasia|hematology-neutrophils-neutrophils|pathology microscopic-skin-inflammation; dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =880 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 13 week | SUB | study_id=5699; toxval_study_source_id=studyid5699_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-skin-hyperplasia|pathology microscopic-skin-inflammation|in life observation-body weight-body weight gain|pathology microscopic-nose-inflammation|pathology microscopic-stomach-hyperplasia|hematology-neutrophils-neutrophils; dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =300 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5704; toxval_study_source_id=studyid5704_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =120 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F1_F_systemic; toxval_effect_list=pathology microscopic-spleen-hemosiderosis|in life observation-body weight-body weight|in life observation-clinical signs-fur (altered appearance); dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =100 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 30 month | CHR | study_id=5700; toxval_study_source_id=studyid5700_Adult_F1_M_systemic; toxval_effect_list=pathology microscopic-nose-hyperplasia|pathology microscopic-kidney-cyst|in life observation-body weight-body weight|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-kidney-inflammation|pathology microscopic-spleen-hemosiderosis; dose_level=2; study_year=1997; study_citation=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; dsstox_substance_id=DTXSID6020220; admin_method=Feed; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =2 | % | Rat | oral | subchronic; 56 days | subchronic | LONG_REF=Toxicol. Appl. Pharmacol.99(1): 37-49 Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters 1989; TITLE=Changes in Urine Composition, Bladder Epithelial Morphology, and DNA Synthesis in Male F344 Rats in Response to Ingestion of Bladder Tumor Promoters; AUTHOR=Shibata,M.A., M. Yamada, H. Tanaka, M. Kagawa, and S. Fukushima; DOI=10.1016/0041-008x(89)90109-9; QUALITY=Control type: Multiple entries; EXTERNAL_SOURCE_ID=106692; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Genetics: DNA synthesis rate|Growth: Weight|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|other|urinalysis; STUDY_GROUP=ECOTOX:15601905:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=50af2c6dd752f9bcf8c16a45596688f4 |
ToxValDB_EFSA 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EFSA | NOAEL | =72 | mg/kg bw/day | Dog | oral | chronic; 117 weeks | chronic | LONG_REF=EFSA AFC (2004). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ). doi:10.2903/j.efsa.2004.84.; TITLE=Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a request from the Commission related to tertiary-Butylhydroquinone (TBHQ); AUTHOR=EFSA AFC; DOI=doi:10.2903/j.efsa.2004.84; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA_dup_-_15614209_15614210:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dfec24dbbf74dae8d359941e45c8b0c2 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =19.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630439:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8d2b863b38744ee07d8c933dc0e76d6e |
ToxValDB_HESS 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HESS | NOEL | =200 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df6e4b0a676289deacc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Clinical Observation: Hair discoloration|Blood Chemistry: Bile acid increase|Absolute Organ Weight: Lungs decrease|Relative Organ Weight: Right kidney increase, Liver increase, Lung decrease, Right testis increase|Histopathology: Spleen-Pigmentation; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|nonneoplastic histopathology|organ weight; STUDY_GROUP=HESS:15639026:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_130133e079905e9ebcbdf258fa4bc916 |
ToxValDB_ToxRefDB 20 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =1000 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-birth index-birth index; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709804_15709805_15709806_15709807:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5be1143c2c51ce01663b8f528d9817b1 |
| ToxValDB_ToxRefDB | LEL | =200 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-length|reproductive: offspring survival early-dead fetuses-dead fetuses|reproductive: reproductive performance-estrous cycle-periodicity; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB:15709808:F:F1adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b3c45e4a71561fdf1ddad3c9581e1585 |
| ToxValDB_ToxRefDB | LEL | =400 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-dead fetuses-dead fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709809_15709810:M:F1adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_49a83b973d778aed379cb1bed23cbffa |
| ToxValDB_ToxRefDB | LEL | =750 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-[other]-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15709817_15709818:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8130c1adb4ef71d12a2080cd1cd6df94 |
| ToxValDB_ToxRefDB | LEL | =800 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-[other]-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15709819_15709820:M:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c198de9116c0e1e4e3235ebc2fa7ec38 |
| ToxValDB_ToxRefDB | LEL | =2200 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5699; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight gain|systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-skin-hyperplasia|systemic: pathology microscopic-nose-inflammation|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709821_15709822_15709823_15709824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c8a79a48a065a1aeae1d2f16375f9338 |
| ToxValDB_ToxRefDB | LEL | =1950 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5699; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-skin-hyperplasia|systemic: pathology microscopic-nose-inflammation|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia|systemic: hematology-neutrophils-neutrophils; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709825_15709826_15709827_15709828:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_491ad27cce42374e85a87e6d4c6d333a |
| ToxValDB_ToxRefDB | LEL | >240 | mg/kg bw/day | Rat | oral | chronic; 30 months | chronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=ToxRefDB_dup_-_15709829_15709830_15709831_15709832:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_97a74edcc7c07c8bde505f993e663054 |
| ToxValDB_ToxRefDB | LEL | =60 | mg/kg bw/day | Rat | oral | chronic; 30 months | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-spleen-hemosiderosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709837_15709838_15709839:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ba9689a1a738d40e2fe56d785a6a0e96 |
| ToxValDB_ToxRefDB | LEL | =50 | mg/kg bw/day | Rat | oral | chronic; 30 months | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-kidney-cyst|systemic: pathology microscopic-nose-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-kidney-inflammation|systemic: pathology microscopic-spleen-hemosiderosis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709840_15709841_15709842:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_93e150218099cbef4990774239197563 |
| ToxValDB_ToxRefDB | LEL | =700 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5704; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709843_15709844_15709845_15709846:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c010c4d7ba34ab21401f247cd847f878 |
| ToxValDB_ToxRefDB | LEL | =600 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5704; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: hematology-reticulocyte-reticulocyte|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology; STUDY_GROUP=ToxRefDB_dup_-_15709847_15709848_15709849_15709850:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5712f447fefcccf1ad2f3b4b4bae24b2 |
| ToxValDB_ToxRefDB | LOAEL | =240 | mg/kg bw/day | Rat | oral | chronic; 30 months | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709837_15709838_15709839:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_83df6bcd3124853fcc469c086a83cf39 |
| ToxValDB_ToxRefDB | NEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-birth index-birth index; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709804_15709805_15709806_15709807:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0a30d648cedb602566ef8423d36ba4f5 |
| ToxValDB_ToxRefDB | NEL | =400 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5695; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=developmental: offspring survival late-[other]-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15709817_15709818:F:F1juvenile; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_21e4794217101e5da68f239020a8f5d4 |
| ToxValDB_ToxRefDB | NEL | =1100 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5699; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-nose-inflammation|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-skin-hyperplasia|systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-skin-inflammation|systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709821_15709822_15709823_15709824:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ce66d429d1fc0621e6039215b1944030 |
| ToxValDB_ToxRefDB | NEL | =880 | mg/kg bw/day | Mouse | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5699; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-skin-inflammation|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight gain|systemic: hematology-neutrophils-neutrophils|systemic: pathology microscopic-nose-inflammation|systemic: pathology microscopic-skin-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709825_15709826_15709827_15709828:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8996ad7836d9754c347ab505d4839abd |
| ToxValDB_ToxRefDB | NEL | =300 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5704; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15709843_15709844_15709845_15709846:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_41986a7b1bb18d0bcd15839dcc98d3b1 |
| ToxValDB_ToxRefDB | NOAEL | =120 | mg/kg bw/day | Rat | oral | chronic; 30 months | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hemosiderosis|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-fur (altered appearance); TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709837_15709838_15709839:F:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e21f894d10a68e3d3f2d1f376e9f4a7c |
| ToxValDB_ToxRefDB | NOAEL | =100 | mg/kg bw/day | Rat | oral | chronic; 30 months | reproduction developmental | LONG_REF=NTP_1997_Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; TITLE=Toxicology and Carcinogenesis Studies of t-Butylhydroquinone (CAS No. 1948-33-0) in F344/N Rats and B6C3F(1) Mice (Feed Studies)_Long-term_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5700; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-kidney-inflammation|systemic: pathology microscopic-spleen-hemosiderosis|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: pathology microscopic-kidney-cyst|systemic: pathology microscopic-nose-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709840_15709841_15709842:M:F1adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4de034e22dc19feb06e05f6e88518e57 |
ToxValDB_WHO_JECFA_ADI 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_ADI | ADI | <=0.7 | mg/kg | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650afb5ee4b0d99f5a87aca6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1900; YEAR=1997; ORIGINAL_YEAR=1997; STUDY_GROUP=WHO JECFA ADI:15715342:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_09b7e76a55f35c3ce99e0972fa981223 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | C12674942B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C12674942B"} |
| openFDA substances | FDA UNII substance identifier | C12674942B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C12674942B"} |
| openFDA substances | FDA UNII substance identifier | C12674942B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C12674942B"} |
| openFDA substances | FDA UNII substance identifier | C12674942B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H14O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"C12674942B"} |