Is Tangeritin safe in cosmetics?
Tangeritin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Tangeritin
Also known as: 5-18-05-00491, 4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(p-methoxyphenyl)-, BRN 0351695, EINECS 207-570-1, 2-(4-Methoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one (+7 more)
INCI: TANGERITIN
Tangeritin (CAS 481-53-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning (polymethoxylated flavone from citrus peels). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 481-53-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tangeritin is classified GHS Danger (H300) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, skin conditioning (polymethoxylated flavone from citrus peels)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one
InChIKey
ULSUXBXHSYSGDT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically regulated; permitted under general cosmetic provisions. Classified as research chemical by some suppliers
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tangeritin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tangeritin.
Known Synonyms
5-18-05-00491
4H-1-Benzopyran-4-one, 5,6,7,8-tetramethoxy-2-(p-methoxyphenyl)-
BRN 0351695
EINECS 207-570-1
2-(4-Methoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one
NSC 53909
Pentamethoxyflavone
4',5,6,7,8-Pentamethoxyflavone
Ponkanetin
UNII-I4TLA1DLX6
5,6,7,8,4'-Pentamethoxyflavone
5,6,7,8-tetramethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Chemical Function
Antioxidant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TANGERETIN
ChEMBL ID
CHEMBL73930
Frequently Asked Questions
Is Tangeritin allowed in the EU?
Tangeritin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tangeritin do in cosmetics?
Tangeritin functions as: Antioxidant, skin conditioning (polymethoxylated flavone from citrus peels). It is classified as a cosmetic ingredient in our database. CAS number: 481-53-8.
Is Tangeritin used outside cosmetics?
Tangeritin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tangeritin have different safety status in cosmetics vs industrial chemicals?
Tangeritin is classified GHS Danger (H300) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tangeritin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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TARAXACUM OFFICINALE ROOT
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Not Reported
TARAXACUM OFFICINALE ROOT EXTRACT
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Skin Conditioning
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