NOAEL Studies
Cosmetic Ingredient
Tall Oil Hydroxyethyl Imidazoline NOAEL Studies
INCI: TALL OIL HYDROXYETHYL IMIDAZOLINE
CAS: 61791-39-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ToxRefDB_ToxRefDB_v3_pod.csv 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =15 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 15 GD | DEV | study_id=6427; toxval_study_source_id=studyid6427_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-salivation|in life observation-clinical signs-anogenital staining|in life observation-food consumption-food consumption|in life observation-clinical signs-respiration (rales)|in life observation-clinical signs-body surface staining|in life observation-body weight-body weight|in life observation-food consumption-food efficiency|in life observation-body weight-body weight gain|in life observation-clinical signs-labored respiration|in life observation-mortality-mortality; dose_level=1; study_year=1992; study_citation=Schroeder, R.E. (1992) A Teratogenicity study in rats with EHandS 592. Study number 90-3613. Unpublished.; dsstox_substance_id=DTXSID6028109; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | >100 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 15 GD | DEV | study_id=6427; toxval_study_source_id=studyid6427_Fetal_Fetal_MF_NA; dose_level=3; study_year=1992; study_citation=Schroeder, R.E. (1992) A Teratogenicity study in rats with EHandS 592. Study number 90-3613. Unpublished.; dsstox_substance_id=DTXSID6028109; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (sprague dawley; CD(SD)BR) | oral | 6 GD to 15 GD | DEV | study_id=6427; toxval_study_source_id=studyid6427_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-labored respiration|in life observation-body weight-body weight gain|in life observation-clinical signs-salivation|in life observation-food consumption-food efficiency|in life observation-clinical signs-anogenital staining|in life observation-clinical signs-body surface staining|in life observation-body weight-body weight|in life observation-mortality-mortality|in life observation-food consumption-food consumption|in life observation-clinical signs-respiration (rales); dose_level=0; study_year=1992; study_citation=Schroeder, R.E. (1992) A Teratogenicity study in rats with EHandS 592. Study number 90-3613. Unpublished.; dsstox_substance_id=DTXSID6028109; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =60 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be513; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/9/3?documentUUID=4d140fbb-ab02-42d0-a8a4-f2b1d728ebda; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15823460:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c3a0340cab29c6ddd2ffcbf30ad26634 |
| ToxValDB_ECHA_IUCLID | NOAEL | =15 | mg/kg bw/day | Rat | oral | - | reproduction developmental | GUIDELINE=EPA OPP 83-3 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be505; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/9/3?documentUUID=4d140fbb-ab02-42d0-a8a4-f2b1d728ebda; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15825404:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6e9be9ca0dada14ce814c8b8136cf30b |
| ToxValDB_ECHA_IUCLID | NOEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=EPA OPP 83-3 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be505; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/9/3?documentUUID=4d140fbb-ab02-42d0-a8a4-f2b1d728ebda; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID:15825379:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_180c4044087da1be82d7afc8d075edb9 |
| ToxValDB_ECHA_IUCLID | NOEL | =60 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c913e4b0a7c65d21b56d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5449/7/9/2?documentUUID=4d140fbb-ab02-42d0-a8a4-f2b1d728ebda; YEAR=2012; ORIGINAL_YEAR=2012; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855038_15861517:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0ecbb0aa6de01fce88b8a097214f53ea |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632769_15632770:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0248cd25d00335dda96208b75be74cc7 |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =0.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15632769_15632770:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ced6b7e416e21645ef7f8b19d904b608 |