NOAEL Studies
Cosmetic Ingredient
TAED NOAEL Studies
CAS: 10543-57-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | >2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_495; row=9288; data_type=In Vivo; mixture=Chemical; chemical_name=Tetraacetylethylenediamine; preferred_name=Tetraacetylethylenediamine; dtxsid=DTXSID5040752; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =7940 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | OECD eChemPortal (undated); record_id=acute_oral_497; row=9289; data_type=In Vivo; mixture=Chemical; chemical_name=Tetraacetylethylenediamine; preferred_name=Tetraacetylethylenediamine; dtxsid=DTXSID5040752; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752; source_file=acute_oral.xlsx |
NTP_ICE_dart 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_dart | LOEL | 200 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=89366; Record_ID=dart_33935; Data_Type=In Vivo; DTXSID=DTXSID5040752; Assay=DART, In life observation; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0043094;CUI;Weight Gain; Reference=ToxRefDB v2 , ID = 4309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752 |
| NTP_ICE_dart | LOEL | 200 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=89367; Record_ID=dart_33936; Data_Type=In Vivo; DTXSID=DTXSID5040752; Assay=DART, In life observation; Endpoint=LOEL; Response=200; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 4309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752 |
| NTP_ICE_dart | LOEL | 1000 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=89368; Record_ID=dart_33943; Data_Type=In Vivo; DTXSID=DTXSID5040752; Assay=DART, In life observation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0005910;CUI;Body Weight|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0751992;CUI;Fetal Weight; Reference=ToxRefDB v2 , ID = 4309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752 |
| NTP_ICE_dart | LOEL | 1000 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=89369; Record_ID=dart_33944; Data_Type=In Vivo; DTXSID=DTXSID5040752; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=1000; Response_Unit=mg/kg/day; Species=Rat; Strain=CD(SD)BR; Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0205394;CUI;Other; Reference=ToxRefDB v2 , ID = 4309; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5040752 |
ToxRefDB_ToxRefDB_v3_pod.csv 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =500 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 day to 90 day | SUB | study_id=4307; toxval_study_source_id=studyid4307_Adult_F0_F_systemic; toxval_effect_list=organ weight-liver-relative to brain weight|in life observation-body weight-body weight|organ weight-liver-absolute|in life observation-body weight-body weight gain|pathology microscopic-liver-cytomegaly|organ weight-liver-relative to body weight|clinical chemistry-protein-protein|clinical chemistry-globulins-globulins; dose_level=2; study_year=2000; study_citation=Wolfe, G and S Borst. 2000. 90-day oral toxicity study of tetraacetylethylenediamine (TAED) in Sprague-Dawley rats. TherImmune Research Corporation (Gaithersburg, MD). TherImmune Study no. 1151-102, Oct 19, 2000. MRID 45299703.; dsstox_substance_id=DTXSID5040752; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2000 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | dermal | 0 day to 90 day | SUB | study_id=4308; toxval_study_source_id=studyid4308_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hypertrophy; dose_level=3; study_year=2000; study_citation=Wolfe, G and A Okoth. 2000. 90-day dermal toxicity study of tetraacetylethylenediamine (TAED) in Sprague Dawley Rats. TherImmune Research Corporation (Gaithersburg, MD). Study no. 1152-103, Oct 20, 2000. MRID 45274305.; dsstox_substance_id=DTXSID5040752; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =25 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 day to 90 day | SUB | study_id=4307; toxval_study_source_id=studyid4307_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-cytomegaly|clinical chemistry-globulins-globulins|organ weight-liver-relative to body weight|organ weight-liver-relative to brain weight|in life observation-body weight-body weight gain|organ weight-liver-absolute|clinical chemistry-protein-protein|in life observation-body weight-body weight; dose_level=1; study_year=2000; study_citation=Wolfe, G and S Borst. 2000. 90-day oral toxicity study of tetraacetylethylenediamine (TAED) in Sprague-Dawley rats. TherImmune Research Corporation (Gaithersburg, MD). TherImmune Study no. 1151-102, Oct 19, 2000. MRID 45299703.; dsstox_substance_id=DTXSID5040752; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | oral | 0 day to 90 day | SUB | study_id=4307; toxval_study_source_id=studyid4307_Adult_F0_M_systemic; toxval_effect_list=organ weight-liver-absolute|organ weight-liver-relative to brain weight|pathology gross-liver-enlarged|clinical chemistry-protein-protein|organ weight-liver-relative to body weight|in life observation-food consumption-food consumption|pathology microscopic-liver-cytomegaly|clinical chemistry-albumin-albumin|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-testes-degeneration; dose_level=0; study_year=2000; study_citation=Wolfe, G and S Borst. 2000. 90-day oral toxicity study of tetraacetylethylenediamine (TAED) in Sprague-Dawley rats. TherImmune Research Corporation (Gaithersburg, MD). TherImmune Study no. 1151-102, Oct 19, 2000. MRID 45299703.; dsstox_substance_id=DTXSID5040752; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =200 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley) | dermal | 0 day to 90 day | SUB | study_id=4308; toxval_study_source_id=studyid4308_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hypertrophy; dose_level=2; study_year=2000; study_citation=Wolfe, G and A Okoth. 2000. 90-day dermal toxicity study of tetraacetylethylenediamine (TAED) in Sprague Dawley Rats. TherImmune Research Corporation (Gaithersburg, MD). Study no. 1152-103, Oct 20, 2000. MRID 45274305.; dsstox_substance_id=DTXSID5040752; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOEL | =2000 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dcfb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/4?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826872_15826873:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b02e01c3de2a96d702d05c4b0e450655 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=283 | mg/m3 | Rat | inhalation | short-term; 23 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/3?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15827985:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_776cf2b865d2f73ba8c76d8d883f8433 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=99.7 | mg/m3 | Rat | inhalation | subchronic; 13 weeks | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/3?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15829511:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fae5273eb6a52f7fc34427d6cc27ec3e |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabace4b0a7c65d1bb3cb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/9/3?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15823943:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8d5ee3a4a89ba971327c09c0e37346f |
| ToxValDB_ECHA_IUCLID | NOAEL | =200 | mg/kg bw/day | Rat | oral | short-term; 28 days | short-term | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a35; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/2?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID:15850291:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_55c7219367a31b0d0722e3eec38880c3 |
| ToxValDB_ECHA_IUCLID | NOAEL | =90 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca01e4b0a7c65d21fbb9; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/2?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843026_15843027_15850294:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_049bc53fb1d9765c0480a7add47bcbe9 |
| ToxValDB_ECHA_IUCLID | NOEL | =200 | mg/kg bw/day | Rat | dermal | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61f82e4b096bca877dcfb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/4?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826872_15826873:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_827e44de5af0d6ab3e3779e7524104c0 |
| ToxValDB_ECHA_IUCLID | NOEL | >=25 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eacc0e4b0a7c65d1c0a37; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14315/7/6/2?documentUUID=aa294b83-e09b-4ab2-8da6-93ad764a7cd8; YEAR=1982; ORIGINAL_YEAR=1982; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843026_15843027_15850294:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6c92624eb68418e40d5f1efc789222be |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =6.4 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631867:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_301afad3b2776a0a4df03d08fa6a7dbb |
ToxValDB_ToxRefDB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =500 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Wolfe, G & S Borst. 2000. 90-day oral toxicity study of tetraacetylethylenediamine (TAED) in Sprague-Dawley rats. TherImmune Research Corporation (Gaithersburg, MD). TherImmune Study no. 1151-102, Oct 19, 2000. MRID 45299703.; TITLE=90-day oral toxicity study of tetraacetylethylenediamine (TAED) in Sprague-Dawley rats; AUTHOR=Wolfe, G & S Borst; EXTERNAL_SOURCE_ID=4307; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=systemic: organ weight-liver-relative to brain weight|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-liver-cytomegaly|systemic: organ weight-liver-absolute|systemic: in life observation-body weight-body weight gain|systemic: organ weight-liver-relative to body weight|systemic: clinical chemistry-protein-protein|systemic: clinical chemistry-globulins-globulins; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15707293_15707294_15707295_15707296:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e4cc89d4a4e394552cc22a35a9351f5f |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | P411ED0N2B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16N2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P411ED0N2B"} |
| openFDA substances | FDA UNII substance identifier | P411ED0N2B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16N2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P411ED0N2B"} |
| openFDA substances | FDA UNII substance identifier | P411ED0N2B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16N2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P411ED0N2B"} |
| openFDA substances | FDA UNII substance identifier | P411ED0N2B | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C10H16N2O4","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"P411ED0N2B"} |