NOAEL Studies
Cosmetic Ingredient
t-Butyl Benzoyl Peroxide NOAEL Studies
INCI: T-BUTYL BENZOYL PEROXIDE
CAS: 614-45-9
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
NTP_ICE_acute_inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | >0.26 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=5091; Record_ID=acute_inhalation_3049; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID9024699; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=0.26; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/3/3/?documentUUID=13b2d8a7-8052-4d27-bc68-6cf459e41589; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9024699; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9024699 |
NTP_ICE_acute_oral 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =1012 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_8377; row=15631; data_type=In Vivo; mixture=Chemical; chemical_name=tert-Butyl perbenzoate; preferred_name=tert-Butyl perbenzoate; dtxsid=DTXSID9024699; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9024699; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9024699; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_8379; row=15630; data_type=In Vivo; mixture=Chemical; chemical_name=tert-Butyl perbenzoate; preferred_name=tert-Butyl perbenzoate; dtxsid=DTXSID9024699; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9024699; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID9024699; source_file=acute_oral.xlsx |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=15202; RecordID=ARPathway2016_1398; DatasetName=ARPathway2016; DTXSID=DTXSID9024699; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9024699; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID9024699 |
ToxRefDB_ToxRefDB_v3_pod.csv 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =60 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5693; toxval_study_source_id=studyid5693_Adult_F0_F_systemic; toxval_effect_list=organ weight-stomach-nos|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight gain|in life observation-food consumption-food consumption; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =278 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5690; toxval_study_source_id=studyid5690_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|organ weight-stomach-nos|pathology microscopic-stomach-pigmentation|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-ulcer; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =250 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5693; toxval_study_source_id=studyid5693_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-inflammation|pathology microscopic-stomach-hyperplasia; dose_level=4; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5693; toxval_study_source_id=studyid5693_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-stomach-inflammation|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight gain|organ weight-stomach-nos; dose_level=0; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5693; toxval_study_source_id=studyid5693_Adult_F0_F_systemic; toxval_effect_list=organ weight-stomach-nos|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption|pathology microscopic-stomach-inflammation|in life observation-body weight-body weight gain; dose_level=1; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =140 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5690; toxval_study_source_id=studyid5690_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-pigmentation|pathology microscopic-stomach-hyperplasia|organ weight-stomach-nos|pathology microscopic-stomach-inflammation|pathology microscopic-stomach-ulcer; dose_level=2; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =125 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 13 week | SUB | study_id=5693; toxval_study_source_id=studyid5693_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-inflammation|in life observation-body weight-body weight gain|organ weight-stomach-nos|pathology microscopic-stomach-hyperplasia|in life observation-food consumption-food consumption; dose_level=3; study_year=1992; study_citation=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; dsstox_substance_id=DTXSID9024699; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ECHA_IUCLID 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEC | =3177.6 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c913e4b0a7c65d21b4fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855581_15856375:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7196df4e25655a0d99e437f22292cd81 |
| ToxValDB_ECHA_IUCLID | NOAEC | =63552.1 | mg/m3 | Rat | inhalation | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c913e4b0a7c65d21b4fe; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855581_15856375:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_44968a7e3e5cea11276d2d876e48a983 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~30 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae7ee4b0a7c65d1c992f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/6/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15847668:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_429628ed14550d15ac2be6d9019311f1 |
| ToxValDB_ECHA_IUCLID | NOAEL | =160 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8ddb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855565_15856510_15856808:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b03cd731b4e7e7dadfea5c7e9fff3dd0 |
| ToxValDB_ECHA_IUCLID | NOAEL | >200 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be29b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/3?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823190_15823449:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a0782085f983a0031da621b8a18edeb |
| ToxValDB_ECHA_IUCLID | NOAEL | =250 | mg/kg bw/day | Rabbit | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be295; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/3?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations|fetus: skeletal malformations|fetus: visceral malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15823502:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9f9e3c386a1c3664bddd7c4f42d5003d |
| ToxValDB_ECHA_IUCLID | NOAEL | <=300 | mg/kg bw/day | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be29b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/3?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in sex ratio|fetus: fetal/pup body weight changes|fetus: changes in litter size and weights|fetus: changes in postnatal survival|fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823190_15823449:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_772801939ba239ed2eb533730775346c |
| ToxValDB_ECHA_IUCLID | NOAEL | =400 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8ddb; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15855565_15856510_15856808:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_389f848ad740bffc196888f93d97c631 |
| ToxValDB_ECHA_IUCLID | NOEL | =100 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac3ee4b0a7c65d1be2a1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/3?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15825006:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0b620cb0a252a127627ae3eb4ebd9c5d |
| ToxValDB_ECHA_IUCLID | NOEL | =300 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8dd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; STUDY_GROUP=ECHA IUCLID:15861997:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_eac9de0d1e4fef295dda2570dd71eeb2 |
| ToxValDB_ECHA_IUCLID | NOEL | =750 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8dd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15861819:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2a89f6488cc1fea279322cc29dbe1076 |
| ToxValDB_ECHA_IUCLID | NOEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab1ae4b0a7c65d1b8dd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14209/7/9/2?documentUUID=899f765d-d624-4a71-8461-7a1a2bc48bf0; YEAR=1971; ORIGINAL_YEAR=1971; TOXICOLOGICAL_EFFECT=P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECHA IUCLID:15861119:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3f7e67c659f7770b6ac67941fd18f0c2 |
ToxValDB_EPA_TSCA_8e 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =300 | mg/kg bw/day | Rabbit | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21556_380387.pdf; TOXICOLOGICAL_EFFECT=body weight loss, decreased food consumption, reduced fecal production; STUDY_GROUP=EPA TSCA 8e_dup_-_15957639_15957640:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_cbbeda1b1a1617f6bface7c3dcf726de |
| ToxValDB_EPA_TSCA_8e | LEL | =400 | mg/kg bw/day | Rabbit | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-18-21556_380387.pdf; TOXICOLOGICAL_EFFECT=reduced fecal and urine output, small fecal pellets; STUDY_GROUP=EPA TSCA 8e_dup_-_15957639_15957640:F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9dd3894274ac7887aa1b6f806b4401c4 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =24.7 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630453:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d880b0f82e0ca331e622bfea2625c19a |
ToxValDB_ToxRefDB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =60 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; TITLE=Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5693; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-stomach-nos|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709789_15709790_15709791_15709792:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_73928e68de545e098e446320754303c8 |
| ToxValDB_ToxRefDB | LEL | =278 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; TITLE=Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5690; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: organ weight-stomach-nos|systemic: pathology microscopic-stomach-ulcer|systemic: pathology microscopic-stomach-pigmentation|systemic: pathology microscopic-stomach-inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709785_15709786:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f80ba3555c5748948587ed9dcec062d5 |
| ToxValDB_ToxRefDB | LOAEL | =250 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; TITLE=Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5693; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709789_15709790_15709791_15709792:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ef8e34a8b47520ba8893f7edbba298d |
| ToxValDB_ToxRefDB | NEL | =140 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; TITLE=Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_t-BP_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5690; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: organ weight-stomach-nos|systemic: pathology microscopic-stomach-inflammation|systemic: pathology microscopic-stomach-pigmentation|systemic: pathology microscopic-stomach-ulcer; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709785_15709786:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_60369e98077d4af2e46f782dca18026f |
| ToxValDB_ToxRefDB | NOAEL | =125 | mg/kg bw/day | Rat | oral | subchronic; 13 weeks | subchronic | LONG_REF=NTP_1992_Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; TITLE=Technical report on the toxicity studies of t-Butyl Perbenzoate (CAS No. 614-45-9) Administered By Gavage To F344/N Rats And B6C3F1 Mice_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5693; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=systemic: organ weight-stomach-nos|systemic: pathology microscopic-stomach-inflammation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-food consumption-food consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709789_15709790_15709791_15709792:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8705a623c99a2c6017380ac36e5b1470 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 54E39145KT | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"54E39145KT"} |
| openFDA substances | FDA UNII substance identifier | 54E39145KT | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"54E39145KT"} |
| openFDA substances | FDA UNII substance identifier | 54E39145KT | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"54E39145KT"} |
| openFDA substances | FDA UNII substance identifier | 54E39145KT | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C11H14O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"54E39145KT"} |