Is Sulindac safe in cosmetics?
Sulindac has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Sulindac
Also known as: 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-, BRN 2951842, EINECS 253-819-2, (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid, Sulindacum (+6 more)
INCI: SULINDAC
Sulindac (CAS 38194-50-2) is a cosmetic cosmetic ingredient functioning as Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 38194-50-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sulindac is classified GHS Danger (H301, H317, H319, H334, H360, H361, H373) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
InChIKey
MLKXDPUZXIRXEP-MFOYZWKCSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
FDA-approved as an oral NSAID drug; cosmetic topical use not specifically restricted but primarily a pharmaceutical ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sulindac.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Regulatory List Membership (1)
California Proposition 65 (OEHHA)
Expert Verdict
Expert safety assessment and concern-level summary for Sulindac.
Regulatory Flags
prop65
Known Synonyms
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
BRN 2951842
EINECS 253-819-2
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
Sulindacum
UNII-184SNS8VUH
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidenyl)indene-3-acetic acid
EINECS 256-402-3
(Z)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
Chemical Function
Antioxidant
Regulatory Lists
pharmaceutical
OEHHA Proposition 65 (3/2019)
Canada; pharmaceutical
Canada; pharmaceutical
OEHHA Proposition 65 (1/2023)
Canada; consumer_product; Substances in Products - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SULINDAC
ChEMBL ID
CHEMBL15770
Max Phase
4
Adverse Event Associations
170
Frequently Asked Questions
Is Sulindac allowed in the EU?
Sulindac EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sulindac do in cosmetics?
Sulindac functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 38194-50-2.
Is Sulindac used outside cosmetics?
Sulindac also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sulindac have different safety status in cosmetics vs industrial chemicals?
Sulindac is classified GHS Danger (H301, H317, H319, H334, H360, H361, H373) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Sulindac compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(SH-Pentapeptide-10 6-Aminocaprooyl SH-Pentapeptide-11) SP
Moderate
Similar safety
Skin/hair conditioning (peptide-based...
1,2,3,4,4a,5,6,7-Octahydro-2,5,5-Trimethyl-2-Naphthol
Moderate
Similar safety
Fragrance ingredient
Sabal Serrulatum Fruit Extract
Good
Browse nearby
Skin Conditioning, Anti-Hair-Loss, An...
Sabatia Angularis Extract
Moderate
Browse nearby
Skin conditioning
Saccharated Lime
Moderate
Browse nearby
Emulsion stabilizing
Is Sulindac in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Sulindac in your formulation.