NOAEL Studies
Cosmetic Ingredient
Styrene (Monomer) NOAEL Studies
INCI: STYRENE
CAS: 100-42-5
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =85.1963 | mg/m3 | Human (M) | inhalation | chronic; 1 years | epidemiologic | ATSDR MRLs; row_hash=810e8118a4545375; source_hash=ToxValhc_6f843c859d11e81836b803691bee84ea; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=20; raw_unit=ppm; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Benignus VA, Geller AM, Boyes WK, et al. 2005. Human neurobehavioral effects of long\u0002term exposure to styrene: a meta-analysis. Environ Health Perspect 113:532-538.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805 |
| ATSDR_toxval_ATSDR_MRLs.xlsx | LOAEL | =100 | mg/kg/day | Rat (Wistar; M) | oral | short-term; 14 days | short-term | ATSDR MRLs; row_hash=3a3781f6ca890ea2; source_hash=ToxValhc_0e4652e6699103a1be328fa0445cb714; raw_endpoint_type=LOAEL; raw_endpoint_subtype=; raw_value=100; raw_unit=mg/kg/day; method=gavage; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Husain R, Srivastava SP, Seth PK. 1985. Some behavioral effects of early styrene intoxication in experimental animals. Arch Toxicol 57:53-55.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805 |
| ATSDR_toxval_ATSDR_MRLs.xlsx | NOAEL | =208.731 | mg/m3 | Human (M) | inhalation | acute; 6 hours | clinical | ATSDR MRLs; row_hash=400396fd6edd6349; source_hash=ToxValhc_6993b984cfd97375ad53afec1cb9ea89; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=49; raw_unit=ppm; effect=neurological; effect_category=clinical signs; file=toxval_ATSDR_MRLs.xlsx; long_ref=Ska B, Vyskocil A, Tardif R, et al. 2003. Effects of peak concentrations on the neurotoxicity of styrene in volunteers. Hum Exper Toxicol 22:407-415.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805 |
COSMOS_DB 21 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 400 | mg/kg bw/day | dog | oral | 560 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 300 | mg/kg bw/day | mouse | oral | 546 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 500 | mg/kg bw/day | rat | oral | 28 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 34.6 | mg/kg bw/day | rat | oral | 49 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 2150 | mg/kg bw/day | rat | oral | 49 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 464 | mg/kg bw/day | mouse | oral | 49 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 100 | mg/kg bw/day | rat | oral | 14 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 25 | mg/kg bw/day | rat | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 100 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1350 | mg/kg bw/day | mouse | oral | 840 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 250 | mg/kg bw/day | rat | oral | 364 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 21 | mg/kg bw/day | rat | oral | 710 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 20 | mg/kg bw/day | mouse | oral | 5 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1147 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 357 | mg/kg bw/day | rat | oral | 56 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 36 | mg/kg bw/day | mouse | oral | 28 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 229 | mg/kg bw/day | rat | oral | 28 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 114 | mg/kg bw/day | guinea pig | oral | 28 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 1250 | mg/kg bw/day | rat | oral | 1 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS_DB | NOAEL | 800 | mg/kg bw/day | rat | oral | 21 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
California Proposition 65 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 NSRL | AB27 | ug/day | - | - | 2016-04-22 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | AB27 | ug/day | - | - | 2016-04-22 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | AB27 | ug/day | - | - | 2016-04-22 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 NSRL | AB27 | ug/day | - | - | 2016-04-22 | No significant risk level | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","row_type":"nsrl","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2016-04-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2016-04-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2016-04-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | ABcancer | listing type | - | - | 2016-04-22 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"2016-04-22","listing_mechanism":"AB","madl":null,"nsrl":"27","source_table":"prop65_listings"} |
EPA_IRIS_iris_rfc_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfc_systems.csv | NOAEL (HEC) | =34 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system PoD | row_hash=e2773b960f6f86b3; file=iris_rfc_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL (HEC): 3.4e1 mg/m^3; system=Nervous; basis=CNS effects; point_of_departure=NOAEL (HEC): 3.4e1 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID2021284; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; rfc_last_updated=11/01/1992; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0104_summary.pdf |
| EPA_IRIS_iris_rfc_systems.csv | RfC | =1 | mg/m^3 | - | inhalation | chronic | IRIS chronic inhalation RfC system | row_hash=a3024086d8b507d6; file=iris_rfc_systems.csv; kind=reference_value; raw_column=rfc_mg_per_m3; raw_value=1; system=Nervous; basis=CNS effects; point_of_departure=NOAEL (HEC): 3.4e1 mg/m^3; composite_uf=30; confidence=Medium; dtxsid=DTXSID2021284; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; rfc_last_updated=11/01/1992; rfc_pdf_url=https://iris.epa.gov/static/pdfs/0104_summary.pdf |
EPA_IRIS_iris_rfd_systems.csv 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA_IRIS_iris_rfd_systems.csv | NOAEL | =200 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system PoD | row_hash=b53aef08071a1692; file=iris_rfd_systems.csv; kind=point_of_departure; raw_column=point_of_departure; raw_value=NOAEL : 2.00e2 mg/kg-day; system=Hepatic, Hematologic; basis=Red blood cell and liver effects; point_of_departure=NOAEL : 2.00e2 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID2021284; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0104_summary.pdf |
| EPA_IRIS_iris_rfd_systems.csv | RfD | =0.2 | mg/kg/day | - | oral | chronic | IRIS chronic oral RfD system | row_hash=fbe640bc99e68736; file=iris_rfd_systems.csv; kind=reference_value; raw_column=rfd_mg_per_kg_day; raw_value=2e-1; system=Hepatic, Hematologic; basis=Red blood cell and liver effects; point_of_departure=NOAEL : 2.00e2 mg/kg-day; composite_uf=1000; confidence=Medium; dtxsid=DTXSID2021284; detail_url=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; rfd_last_updated=01/31/1987; rfd_pdf_url=https://iris.epa.gov/static/pdfs/0104_summary.pdf |
IARC Monographs 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 2018 | IARC Monographs | {"additional_info":"volume_publication_year=2019","evaluation_year":2018,"source_table":"iarc_classifications","volume":"60, 82, 121"} |
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 2018 | IARC Monographs | {"additional_info":"volume_publication_year=2019","evaluation_year":2018,"source_table":"iarc_classifications","volume":"60, 82, 121"} |
| IARC Monographs | IARC carcinogenicity classification | 2A | IARC group | - | - | 2018 | IARC Monographs | {"additional_info":"volume_publication_year=2019","evaluation_year":2018,"source_table":"iarc_classifications","volume":"60, 82, 121"} |
INCHEM_WHO_iarc_iarcmono_v121iarc 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_iarc_iarcmono_v121iarc | TDI | =0.0077 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=iarc_iarcmono_v121iarc; title=STYRENE, STYRENE-7,8-OXIDE, AND QUINOLINE VOLUME 121 IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS This publication represents the views and; path=mirror/documents/iarc/iarcmono/v121iarc.pdf; row_hash=8bcfe9be6ea358d1; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=A tolerable daily intake of 7.7 ug/kg bw for styrene has been established by the World Health Organization, with a guideline value of 20 ug/L in drinking-water (WHO, 2004). |
| INCHEM_WHO_iarc_iarcmono_v121iarc | TDI | =0.0077 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=iarc_iarcmono_v121iarc; title=STYRENE, STYRENE-7,8-OXIDE, AND QUINOLINE VOLUME 121 IARC MONOGRAPHS ON THE EVALUATION OF CARCINOGENIC RISKS TO HUMANS This publication represents the views and; path=mirror/documents/iarc/iarcmono/v121iarc.pdf; row_hash=8bcfe9be6ea358d1; raw_unit=ug/kg bw; unit_normalization=converted from micrograms; context=A tolerable daily intake of 7.7 ug/kg bw for styrene has been established by the World Health Organization, with a guideline value of 20 ug/L in drinking-water (WHO, 2004). |
NTP_ICE_acute_inhalation 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_inhalation | LC50 | 11.754 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1370; Record_ID=acute_inhalation_2284; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.754; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 12 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1371; Record_ID=acute_inhalation_1063; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=12; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 11.7923 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1372; Record_ID=acute_inhalation_1574; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.7923; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 19.6595 | mg/L | - | Inhalation | Duration=6 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1373; Record_ID=acute_inhalation_2282; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=19.6595; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 27.5863 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1374; Record_ID=acute_inhalation_2280; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=27.5863; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 27.2883 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1375; Record_ID=acute_inhalation_2276; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=27.2883; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 26.8626 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1376; Record_ID=acute_inhalation_2278; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=26.8626; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 11.4943 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1377; Record_ID=acute_inhalation_2286; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.4943; Response_Unit=mg/L; Reference=AEGL; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_acute_inhalation | LC50 | 11.8 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=1378; Record_ID=acute_inhalation_2873; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=11.8; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =5000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_42; row=3918; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene; preferred_name=Styrene; dtxsid=DTXSID2021284; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021284; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =2650 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_40; row=3919; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene; preferred_name=Styrene; dtxsid=DTXSID2021284; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021284; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | =1000 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_38; row=3920; data_type=In Vivo; mixture=Chemical; chemical_name=Styrene; preferred_name=Styrene; dtxsid=DTXSID2021284; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID2021284; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 233.1 | uL/min/10^6 cells | Rat | - | - | Measured; httk, Rat Hepatic Intrinsic Clearance | sheet=Data; excel_row=823; Record_ID=adme_parameters_1110; Data_Type=Measured; DTXSID=DTXSID2021284; Assay=httk, Rat Hepatic Intrinsic Clearance; Endpoint=Clint; Response=233.1; Response_Unit=ul/min/10^6 cells; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_adme_parameters | Clint | 42.99 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=824; Record_ID=adme_parameters_1110; Data_Type=Measured; DTXSID=DTXSID2021284; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=42.99; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_adme_parameters | Fu | 0.1801 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=825; Record_ID=adme_parameters_1110; Data_Type=Measured; DTXSID=DTXSID2021284; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.1801; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_adme_parameters | Fu | 0.2071 | fraction | Rat | - | - | Measured; httk, Rat Plasma Fraction Unbound | sheet=Data; excel_row=826; Record_ID=adme_parameters_1110; Data_Type=Measured; DTXSID=DTXSID2021284; Assay=httk, Rat Plasma Fraction Unbound; Endpoint=Fu; Response=0.2071; Response_Unit=Unitless Fraction; Species=Rat; Reference=httk2.3.1, Linakis 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
NTP_ICE_cancer 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 2 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=2648; Record_ID=cancer_168; Data_Type=WOE; Formulation_Name=Styrene; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=2A; Response_Unit=Unitless; URL=http://publications.iarc.fr/78; http://publications.iarc.fr/100; http://publications.iarc.fr/582; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_cancer | Top dose | 700 | mg/kg bw/day | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2634; Record_ID=cancer_5549; Data_Type=In Vivo; Formulation_ID=Cancer_PID_141; Formulation_Name=Beta-nitrostyrene; Styrene; Percent_Active_Ingredient=70.0; Mixture=Mixture; DTXSID=DTXSID2021284; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=700; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-170; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr170/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_cancer | Top dose | 350 | mg/kg bw/day | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2636; Record_ID=cancer_5550; Data_Type=In Vivo; Formulation_ID=Cancer_PID_141; Formulation_Name=Beta-nitrostyrene; Styrene; Percent_Active_Ingredient=70.0; Mixture=Mixture; DTXSID=DTXSID2021284; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=350; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Female; Reference=TR-170; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr170/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_cancer | Top dose | 408 | mg/kg bw/day | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2638; Record_ID=cancer_5551; Data_Type=In Vivo; Formulation_ID=Cancer_PID_141; Formulation_Name=Beta-nitrostyrene; Styrene; Percent_Active_Ingredient=70.0; Mixture=Mixture; DTXSID=DTXSID2021284; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=408; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-170; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr170/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_cancer | Top dose | 2000 | mg/kg bw/day | Rat | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2643; Record_ID=cancer_163; Data_Type=In Vivo; Formulation_Name=Styrene; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=2000; Response_Unit=mg/kg/day; Species=Rat; Strain=F344/N; Sex=Male; Reference=TR-185; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr185/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_cancer | Top dose | 300 | mg/kg bw/day | Mouse | - | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2645; Record_ID=cancer_165; Data_Type=In Vivo; Formulation_Name=Styrene; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=300; Response_Unit=mg/kg/day; Species=Mouse; Strain=B6C3F1; Sex=Male; Reference=TR-185; URL=https://ntp.niehs.nih.gov/publications/reports/tr/100s/tr185/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
NTP_ICE_eye_irritation 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_eye_irritation | Draize rabbit irritation score | 6.8 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=752; Record_ID=eye_irritation_186; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=Draize rabbit irritation score; Response=6.8; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_eye_irritation | EPA Classification | 3 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=749; Record_ID=eye_irritation_186; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=3; Response_Unit=Unitless; Species=Rabbit; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_eye_irritation | Intensity | 0.01 | %/sec | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=751; Record_ID=eye_irritation_1247; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Vitrigel; Endpoint=Intensity; Response=0.01; Response_Unit=%/sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_eye_irritation | Lag time | >180 | s | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=755; Record_ID=eye_irritation_1247; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Vitrigel; Endpoint=Lag time; Response_Modifier=>; Response=180; Response_Unit=sec; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
| NTP_ICE_eye_irritation | Plateau level | 0 | % | - | Ocular | - | In Vitro; Vitrigel | sheet=Data; excel_row=754; Record_ID=eye_irritation_1247; Data_Type=In Vitro; Mixture=Chemical; DTXSID=DTXSID2021284; Assay=Vitrigel; Endpoint=Plateau level; Response=0; Response_Unit=%; PMID=26472347.0; Reference=Yamaguchi et al. 2016; URL=10.1002/jat.3254; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2021284; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2021284 |
ToxValDB_ATSDR_MRLs 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | LOAEL | =85.1963 | mg/m3 | Human | inhalation | chronic; 1 years | epidemiologic | LONG_REF=Benignus VA, Geller AM, Boyes WK, et al. 2005. Human neurobehavioral effects of long\u0002term exposure to styrene: a meta-analysis. Environ Health Perspect 113:532-538.; TITLE=Human neurobehavioral effects of long\u0002term exposure to styrene: a meta-analysis; AUTHOR=Benignus VA; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp53.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447796:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6f843c859d11e81836b803691bee84ea |
| ToxValDB_ATSDR_MRLs | LOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=Husain R, Srivastava SP, Seth PK. 1985. Some behavioral effects of early styrene intoxication in experimental animals. Arch Toxicol 57:53-55.; TITLE=Some behavioral effects of early styrene intoxication in experimental animals; AUTHOR=Husain R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp53.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447797:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0e4652e6699103a1be328fa0445cb714 |
| ToxValDB_ATSDR_MRLs | MRL | =21.2991 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447227_15447228:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cb72bcaa7b0121439a8970c641850b95 |
| ToxValDB_ATSDR_MRLs | MRL | =0.851963 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=neurological; STUDY_GROUP=ATSDR MRLs_dup_-_15447227_15447228:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_df90a3663007787f3679ea4a306d7c55 |
| ToxValDB_ATSDR_MRLs | MRL | =0.1 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=neurological in male rats; STUDY_GROUP=ATSDR MRLs:15447229:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cba42df543394d6f88882340216f4fe5 |
| ToxValDB_ATSDR_MRLs | NOAEL | =208.731 | mg/m3 | Human | inhalation | acute; 6 hours | clinical | LONG_REF=Ska B, Vyskocil A, Tardif R, et al. 2003. Effects of peak concentrations on the neurotoxicity of styrene in volunteers. Hum Exper Toxicol 22:407-415.; TITLE=Effects of peak concentrations on the neurotoxicity of styrene in volunteers; AUTHOR=Ska B; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f4e4b063812d585805; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp53.pdf; TOXICOLOGICAL_EFFECT=neurological; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ATSDR MRLs:15447795:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6993b984cfd97375ad53afec1cb9ea89 |
ToxValDB_Alaska_DEC 8 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Alaska_DEC | RfC | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445721:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=6cda7ab761532dbe64c9c3e04bd5423f |
| ToxValDB_Alaska_DEC | RfC | =1 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445721:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=6cda7ab761532dbe64c9c3e04bd5423f |
| ToxValDB_Alaska_DEC | RfD | =0.16 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445718:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=de6afc3b9f7213ad9d9f54611a771c40 |
| ToxValDB_Alaska_DEC | RfD | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445719:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=aa7c6469da28ec2cf632c63b2e1c5b6c |
| ToxValDB_Alaska_DEC | RfD | =0.286 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445720:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7c7f174cbf491fe94a2df20ae3fcd97f |
| ToxValDB_Alaska_DEC | RfD | =0.16 | mg/kg bw/day | Human | dermal | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445718:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=de6afc3b9f7213ad9d9f54611a771c40 |
| ToxValDB_Alaska_DEC | RfD | =0.2 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445719:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=aa7c6469da28ec2cf632c63b2e1c5b6c |
| ToxValDB_Alaska_DEC | RfD | =0.286 | mg/kg bw/day | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/610038e1e4b01a90a3f9ae63; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://dec.alaska.gov/spar/csp/; STUDY_GROUP=Alaska DEC:15445720:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=7c7f174cbf491fe94a2df20ae3fcd97f |
ToxValDB_Cal_OEHHA_REL_derivations 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Cal_OEHHA_REL_derivations | BMC (05) | =7.24169 | mg/m3 | Human | inhalation | chronic; 8.6 years | occupational | LONG_REF=Mutti A, Mazzucchi A, Rustichelli P, Frigeri G, Arfini G, and Franchini I. 1984b. Exposureeffect and exposure-response relationships between occupational exposure to styrene and neurophychological functions. Am. J. Ind. Med. 5:275-286.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32ce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd3final.pdf; YEAR=2000; ORIGINAL_YEAR=2000; TOXICOLOGICAL_EFFECT=Central nervous system; STUDY_GROUP=Cal OEHHA REL derivations:15952143:-:-styreneexposed workers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b5e8c7113b8fb25943922b5268f2b57f |
| ToxValDB_Cal_OEHHA_REL_derivations | NOAEL | =217.251 | mg/m3 | Human | inhalation | acute; 1 hours | clinical | LONG_REF=Stewart RD, Dodd HC, Baretta ED, Schaffer AW. Human exposure to styrene vapor. Arch Environ Health 1968;16:656-662.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c97043e4b02565fc7d32b8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://oehha.ca.gov/; SUBSOURCE_URL=https://oehha.ca.gov/sites/default/files/media/downloads/crnr/appendixd2final.pdf; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=eye and throat irritation; STUDY_GROUP=Cal OEHHA REL derivations:15951973:-:-volunteers; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b80a31ef22a99f7f401f6a7e935c51f0 |
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Protective_Action_Criteria | LEL | =38338.4 | mg/m3 | Human | inhalation | - | acute | LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2007; ORIGINAL_YEAR=2007; STUDY_GROUP=DOE Protective Action Criteria:15519848:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3dd90f5b1e379074eff63804be5e81fe |
ToxValDB_ECHA_IUCLID 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | ~800 | mg/kg bw/day | Rat | oral | - | acute | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/23027/7/3/2?documentUUID=0ac53c98-f974-4a29-8786-e78344080da4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID:15804401:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e5ac66d77a01b74ead94e64171404a1 |
ToxValDB_ECOTOX 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =1000 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601391_15608072:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=87184f7e94410b9bcf18baa99d7568a9 |
| ToxValDB_ECOTOX | LOEL | =300 | mg/kg bw/day | Rat | oral | acute; 0.75 days | reproduction developmental | LONG_REF=Reprod. Toxicol.8(1): 25-40 Taubeneck,M.W., G.P. Daston, J.M. Rogers, and C.L. Keen Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants 1994; TITLE=Altered Maternal Zinc Metabolism Following Exposure to Diverse Developmental Toxicants; AUTHOR=Taubeneck,M.W., G.P. Daston, J.M. Rogers, and C.L. Keen; DOI=10.1016/0890-6238(94)90064-7; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=78721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Biochemistry: Zinc content|Feeding behavior: Food consumption|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|other; STUDY_GROUP=ECOTOX:15611690:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=6b0a5776065931b704f4267de60734dd |
| ToxValDB_ECOTOX | LOEL | =1147 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=Teratology42(6): 651-658 Chernoff,N., R.W. Setzer, D.B. Miller, M.B. Rosen, and J.M. Rogers Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat 1990; TITLE=Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat; AUTHOR=Chernoff,N., R.W. Setzer, D.B. Miller, M.B. Rosen, and J.M. Rogers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=80558; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX:15612816:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8063a5d01c0d58d7fa9f7651f9c37f05 |
| ToxValDB_ECOTOX | NOEL | =500 | mg/kg bw/day | Rat | injection | short-term; 14 days | short-term | LONG_REF=Toxicol. Lett.45(2/3): 271-280 Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat 1989; TITLE=Evaluation of the Subacute Nephrotoxicity of Cyclohexane and Other Industrial Solvents in the Female Sprague-Dawley Rat; AUTHOR=Bernard,A.M., R. De Russis, J.C. Normand, and R.R. Lauwerys; DOI=10.1016/0378-4274(89)90018-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=113042; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Biochemistry: beta2-Microglobulin|Enzyme(s): beta-N-Acetylhexosaminidase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601391_15608072:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=12f60928ccdad232e89ae644600ad5b9 |
| ToxValDB_ECOTOX | NOEL | =1147 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Teratology42(6): 651-658 Chernoff,N., R.W. Setzer, D.B. Miller, M.B. Rosen, and J.M. Rogers Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat 1990; TITLE=Effects of Chemically Induced Maternal Toxicity on Prenatal Development in the Rat; AUTHOR=Chernoff,N., R.W. Setzer, D.B. Miller, M.B. Rosen, and J.M. Rogers; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=80558; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Fetus: Growth: Weight|Fetus: Morphology: Supernumerary full rib|Fetus: Mortality: Mortality; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX:15612815:F:-fetus; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=cec55699b76c8d71572cb4a16b791f6c |
ToxValDB_EPA_TSCA_8e 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_EPA_TSCA_8e | LEL | =42.5982 | mg/m3 | Mouse | inhalation | acute; 6 hours | acute | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20874_374108.pdf; TOXICOLOGICAL_EFFECT=partial closure of the eyes, clear discharge from the left eye, white material around the eyes, body weight loss; STUDY_GROUP=EPA TSCA 8e:15957615:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_88ca8f0e2906776a07dd16ddb712a806 |
| ToxValDB_EPA_TSCA_8e | LEL | =511.178 | mg/m3 | Mouse | inhalation | chronic; 10 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c96d15e4b02565fc7d3269; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://chemview.epa.gov; SUBSOURCE_URL=https://chemview.epa.gov/chemview/proxy?filename=8EHQ-17-20884_374230.pdf; TOXICOLOGICAL_EFFECT=bronchioalveolar adenomas and carcinomas, slight degeneration of epithelial cells lining terminal bronchioles and hyperplasia in the terminal bronchioles.; STUDY_GROUP=EPA TSCA 8e:15957616:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_df4e7360ba075864810e1b2909fcb88d |
ToxValDB_GESTIS_DNEL 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =100 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634969_15634970_15634971:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_179d672068af4798a7d5fc76f4e67fee |
| ToxValDB_GESTIS_DNEL | DNEL systemic | =85 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634969_15634970_15634971:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1eee5ff54f2fc28f5ba991db49296c92 |
ToxValDB_Health_Canada 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_Health_Canada | LOAEL | =260 | mg/m3 | Rat | inhalation | chronic (developmental) | developmental | LONG_REF=PSL: HC/EC, 1993g (based on Kishi et al., 1992); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reduced pup body weight, reduced neuroamines, neurological/behavioral changes; STUDY_GROUP=Health Canada:15637569:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ab1af374979f633a18c13a8dc1aa1760 |
| ToxValDB_Health_Canada | NOAEL | =12 | mg/kg bw/day | Rat | oral | chronic (developmental) | reproduction developmental | LONG_REF=PSL: HC 1996a; HC/EC 1993g (based on Beliles et al., 1985); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=reproductive effects: reduced gestational survival, pup survival, pup body weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=Health Canada:15637568:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1a49825dc323c294654ca445720f11a5 |
| ToxValDB_Health_Canada | TDI | =0.12 | mg/kg bw/day | Human | oral | chronic (developmental) | Toxicity Value | LONG_REF=PSL: HC 1996a; HC/EC 1993g (based on Beliles et al., 1985); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/61003a57e4b01a90a3f9c305; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://publications.gc.ca/site/eng/9.694269/publication.html; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=reproductive effects: reduced gestational survival, pup survival, pup body weight; STUDY_GROUP=Health Canada:15637476:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a18124825425763dd11f6678bfc6ce61 |
ToxValDB_IRIS 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_IRIS | LOAEL | =400 | mg/kg bw/day | Dog | oral | chronic; 19 months | chronic | LONG_REF=Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al. 1979. Results of a toxicity study of monomeric styrene administered to beagle dogs by oral intubation for 19 months. Toxicology Research Laboratory, Health and Environmental Sciences, DOW Chemical Co., Midland, MI. Final Report.; TITLE=Results of a toxicity study of monomeric styrene administered to beagle dogs by oral intubation for 19 months; AUTHOR=Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5014; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; TOXICOLOGICAL_EFFECT=red blood cell and liver effects; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645130_15645137:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_e8447a7713833436eb644c6d7643d8de |
| ToxValDB_IRIS | NOAEL | =200 | mg/kg bw/day | Dog | oral | chronic; 19 months | chronic | LONG_REF=Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al. 1979. Results of a toxicity study of monomeric styrene administered to beagle dogs by oral intubation for 19 months. Toxicology Research Laboratory, Health and Environmental Sciences, DOW Chemical Co., Midland, MI. Final Report.; TITLE=Results of a toxicity study of monomeric styrene administered to beagle dogs by oral intubation for 19 months; AUTHOR=Quast, J.F., C.G. Humiston, R.Y. Kalnins, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5014; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; TOXICOLOGICAL_EFFECT=red blood cell and liver effects; TOXICOLOGICAL_EFFECT_CATEGORY=multiple; STUDY_GROUP=IRIS_dup_IRIS Summary_15645130_15645137:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9dba29db033543dd7d8139c7d64c52a6 |
| ToxValDB_IRIS | NOAEL | =94 | mg/m3 | Human | inhalation | chronic; 8.6 years | occupational | LONG_REF=Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini. 1984. Exposure?effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am. J. Ind. Med. 5: 275-286.; TITLE=Exposure?effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions; AUTHOR=Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5014; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; TOXICOLOGICAL_EFFECT=central nervous system effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15645428_15645429_15645430:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b37093a2d522f8efc53da1d2d39da77f |
| ToxValDB_IRIS | NOAEL (HEC) | =34 | mg/m3 | Human | inhalation | chronic; 8.6 years | occupational | LONG_REF=Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini. 1984. Exposure?effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am. J. Ind. Med. 5: 275-286.; TITLE=Exposure?effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions; AUTHOR=Mutti, A., A. Mazzucchi, P. Rusticelli, G. Frigeri, G. Arfini, and I. Franchini; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652e8a31e4b045b9ff7a5014; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/iris; SUBSOURCE_URL=https://iris.epa.gov/ChemicalLanding/&substance_nmbr=104; TOXICOLOGICAL_EFFECT=central nervous system effects; STUDY_GROUP=IRIS_dup_IRIS Summary_15645428_15645429_15645430:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_18b53b39a9b4ff7ed117f11f1e2ea74b |
ToxValDB_NIOSH_IDLH 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_NIOSH_IDLH | LEL | =851.963 | mg/m3 | Human | inhalation | acute | occupational | LONG_REF=AIHA [1959]. Styrene monomer. In: Hygienic guide series. Akron, OH: American Industrial Hygiene Association.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b38ce4b02565fc7d7571; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/100425.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Drowsiness, nausea, headache, fatigue, and dizziness; STUDY_GROUP=NIOSH IDLH:15953706:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_333d5c6b8dd9c7c01ae1bdc6d99dc3c6 |
| ToxValDB_NIOSH_IDLH | LEL | =1601.69 | mg/m3 | Human | inhalation | acute; 7 hours | occupational | LONG_REF=Stewart RD, Dodd HC, Baretta ED, Schaffer AW [1968]. Human exposure to styrene vapor. Arch Environ Health 16:656-662.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b38ce4b02565fc7d7571; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/100425.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=unpleasant subjective symptoms and objective signs of neurologic impairment; STUDY_GROUP=NIOSH IDLH:15953707:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_92da88e22e644f8da4546fb63a63cfe5 |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfC | =3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15663775:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c3ed4a645a4b30f75b9fa3c1aad14c85 |
ToxValDB_TX_TCEQ 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_TX_TCEQ | BMCL (05) | =1.27795 | mg/m3 | Human | inhalation | chronic; 8.6 years | occupational | LONG_REF=Rabovsky, J, J Fowles, DH Martin, and DC Lewis. 2001. A health risk benchmark for the neurologic effects of styrene: Comparison with NOAEL/LOAEL approach. Risk Anyalysis 21(1): 117-126; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c993f9e4b02565fc7d5ac8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.tceq.texas.gov; SUBSOURCE_URL=https://www.tceq.texas.gov/downloads/toxicology/dsd/final/styrene.pdf; YEAR=2008 Accessible 2013; ORIGINAL_YEAR=2008 Accessible 2013; TOXICOLOGICAL_EFFECT=Memory and sensory/motor function; abnormal responses to neuropsychological tests; STUDY_GROUP=TX TCEQ:15954655:M:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_780b1239c1dea3a9db0c94d0c34e6c61 |
ToxValDB_WHO_JECFA_Tox_Studies 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_WHO_JECFA_Tox_Studies | NOEL | =7.7 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Chemical Manufacturers Association (1980). Toxicological study on styrene incorporated in drinking water of rats for two years in conjunction with a three-generation reproduction study. Litton Bionetics.; TITLE=Toxicological study on styrene incorporated in drinking water of rats for two years in conjunction with a three-generation reproduction study; AUTHOR=Chemical Manufacturers Association; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0435e4b0d99f5a889618; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1944; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Decreased bodyweight, females; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15716193_15716194:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_01e00e58e9131bc254951c678f78b3f1 |
| ToxValDB_WHO_JECFA_Tox_Studies | NOEL | =14 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | LONG_REF=Chemical Manufacturers Association (1980). Toxicological study on styrene incorporated in drinking water of rats for two years in conjunction with a three-generation reproduction study. Litton Bionetics.; TITLE=Toxicological study on styrene incorporated in drinking water of rats for two years in conjunction with a three-generation reproduction study; AUTHOR=Chemical Manufacturers Association; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/650b0435e4b0d99f5a889618; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/; SUBSOURCE_URL=https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/1944; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Decreased bodyweight, females; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=WHO JECFA Tox Studies_dup_-_15716193_15716194:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8dfd1f626d2b97646e49f3ac47c003ed |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 44LJ2U959V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"44LJ2U959V"} |
| openFDA substances | FDA UNII substance identifier | 44LJ2U959V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"44LJ2U959V"} |
| openFDA substances | FDA UNII substance identifier | 44LJ2U959V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"44LJ2U959V"} |
| openFDA substances | FDA UNII substance identifier | 44LJ2U959V | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C8H8","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"44LJ2U959V"} |