Is Strontium Chloride Hexahydrate safe in cosmetics?
Strontium Chloride Hexahydrate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Strontium Chloride Hexahydrate
Also known as: Strontium dichloride hexahydrate, UNII-O09USB7Z44, SrCl2.6H2O
INCI: STRONTIUM CHLORIDE HEXAHYDRATE
Strontium Chloride Hexahydrate (CAS 10025-70-4) is a cosmetic cosmetic ingredient functioning as Oral care, skin conditioning. NOAEL 9.9 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 3.5%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10025-70-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Strontium Chloride Hexahydrate is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics at max 3.5%.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Oral care, skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
strontium;dichloride;hexahydrate
InChIKey
AMGRXJSJSONEEG-UHFFFAOYSA-L
Regulatory Status
EU EU Status
restricted
EU Max Conc.
3.5%
US US Status
permitted
US Notes
Previously an FDA-approved OTC active for tooth desensitizing (10%); FDA removed this active in 2014 monograph update; still permitted as cosmetic ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Strontium Chloride Hexahydrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Strontium Chloride Hexahydrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =9.9 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =30 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Strontium Chloride Hexahydrate across SCCS product categories, with measured dermal absorption where available.
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Korea (Restricted): max 3.5%
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| GCC | restricted | 3.7 | Toothpaste products |
| BR | restricted | 3.5 (as Sr in dent.) / 2.1 (as Sr in shampoo) | a) Dentifrices: 3.5% as Sr; b) Shampoos & facial products: 2.1% as Sr; total Sr including other permitted Sr compounds must not exceed limits |
| ASEAN | restricted | 3.5% as SrCO₃ equiv (toothpaste); 2.1% as SrCO₃ (shampoo, face) | Toothpaste; shampoo; face cream |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Strontium Chloride Hexahydrate.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Strontium Chloride Hexahydrate by CAS number or substance name.
Studies
2
Lowest NOAEL
9.9 mg/kg bw/day
Highest NOAEL
30 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Strontium dichloride hexahydrate
UNII-O09USB7Z44
SrCl2.6H2O
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
STRONTIUM CHLORIDE HEXAHYDRATE
ChEMBL ID
CHEMBL1909080
Frequently Asked Questions
Is Strontium Chloride Hexahydrate allowed in the EU?
Strontium Chloride Hexahydrate EU regulatory status: restricted. Maximum allowed concentration: 3.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Strontium Chloride Hexahydrate do in cosmetics?
Strontium Chloride Hexahydrate functions as: Oral care, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 10025-70-4.
What is the NOAEL for Strontium Chloride Hexahydrate?
The NOAEL (No Observed Adverse Effect Level) for Strontium Chloride Hexahydrate is =9.9 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Strontium Chloride Hexahydrate used outside cosmetics?
Strontium Chloride Hexahydrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Strontium Chloride Hexahydrate have different safety status in cosmetics vs industrial chemicals?
Strontium Chloride Hexahydrate is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics at max 3.5%.
Compliance Tools
Check Strontium Chloride Hexahydrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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