Is Stigmasterol safe in cosmetics?
Stigmasterol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Stigmasterol
Also known as: (24S)-24-Ethylcholesta-5,22-dien-3β-ol, Stigmasta-5,22-dien-3-ol, (3β,22E)-, (24S)-5,22-Stigmastadien-3β-ol, Δ5-Stigmasterol, Δ5,22-Stigmastadien-3β-ol (+11 more)
INCI: STIGMASTEROL
Stigmasterol (CAS 83-48-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning, emollient, barrier reinforcement. Reported NOAEL =2571 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 83-48-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, emollient, barrier reinforcement
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(3S,8S,9S,10R,13R,14S,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChIKey
HCXVJBMSMIARIN-PHZDYDNGSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no FDA restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Stigmasterol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Stigmasterol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =2571 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Expert Verdict
Expert safety assessment and concern-level summary for Stigmasterol.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Stigmasterol by CAS number or substance name.
Studies
1
Lowest NOAEL
2571 mg/kg bw/day
Highest NOAEL
2571 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
(24S)-24-Ethylcholesta-5,22-dien-3β-ol
Stigmasta-5,22-dien-3-ol, (3β,22E)-
(24S)-5,22-Stigmastadien-3β-ol
Δ5-Stigmasterol
Δ5,22-Stigmastadien-3β-ol
β-Stigmasterol
Stigmasterin
Stigmasta-5,22-dien-3β-ol
Stigmasta-5,22(E)-dien-3β-ol
NSC 8095
(24S)-Stigmast-5,22-dien-3β-ol
(3β,22E)-Stigmasta-5,22-dien-3-ol
24-Ethyl-5,22-cholestadien-3β-ol
24β-Ethyl-5,22-cholestadien-3β-ol
stigmasta-5,22-dien-3-β-ol
EC No.: 201-482-7
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
STIGMASTEROL
ChEMBL ID
CHEMBL400247
Frequently Asked Questions
Is Stigmasterol allowed in the EU?
Stigmasterol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Stigmasterol do in cosmetics?
Stigmasterol functions as: Skin conditioning, emollient, barrier reinforcement. It is classified as a cosmetic ingredient in our database. CAS number: 83-48-7.
What is the NOAEL for Stigmasterol?
The NOAEL (No Observed Adverse Effect Level) for Stigmasterol is =2571 mg/kg bw/day based on a chronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Stigmasterol used outside cosmetics?
Stigmasterol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Stigmasterol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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