Is Solvent Yellow 33 safe in cosmetics?
Solvent Yellow 33 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted.
Moderate
Cosmetic Ingredient
Solvent Yellow 33
Also known as: C.I. Solvent Yellow 33, Yellow 11, D.C. Yellow Dye No. 11, Chinoline Yellow D sol. in spirits, EINECS 232-318-2 (+3 more)
INCI: CI 47000 (SOLVENT YELLOW 33)
Solvent Yellow 33 (CAS 8003-22-3) is a cosmetic cosmetic ingredient functioning as Colorant — quinoline-derived dye. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 8003-22-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Solvent Yellow 33 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H351).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Colorant — quinoline-derived dye
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-quinolin-2-ylindene-1,3-dione
InChIKey
IZMJMCDDWKSTTK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Listed as D\&C Yellow No. 11 — permitted for externally applied drugs and cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Solvent Yellow 33.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1358
(EC) 2013/344
Annex IV — Permitted Colorants
Product type: Yellow
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
India: Permitted Colorant
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
D & C Yellow No. 11 | TR-463: Toxicology and Carcinogenesis Studies of D&C Yellow No. 11 (CASRN 8003-22-3) in F344 Rats (Feed Studies) (1997 ) | 12/05/95 | Some Evidence | Some Evidence | Chemical Not Tested in Species/Sex | Chemical Not Tested in Species/Sex | Under the conditions of this perinatal exposure followed by a 2-year dosed feed study, there was some evidence of carcinogenic ac
Source: NTP Technical Reports
Regulatory (1)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Fragrance
Regulatory List Membership (4)
EU Banned in Cosmetics
IFRA Fragrance Transparency List
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Solvent Yellow 33.
Regulatory Flags
potential-allergen
colorant
eu_banned_cosmetics
ifra_fragrance
eu_cosing_listed
Known Synonyms
C.I. Solvent Yellow 33
Yellow 11
D.C. Yellow Dye No. 11
Chinoline Yellow D sol. in spirits
EINECS 232-318-2
2-(2-Quinolinyl)-1H-indene-1,3(2H)-dione
Solvant Yellow 33
UNII-44F3HYL954
Chemical Function
Dye
Fragrance
Regulatory Lists
banned; Europe; Personal care
IFRA Transparency
consumer_product
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Personal care
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1486465
Frequently Asked Questions
Is Solvent Yellow 33 allowed in the EU?
Solvent Yellow 33 EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Solvent Yellow 33 do in cosmetics?
Solvent Yellow 33 functions as: Colorant — quinoline-derived dye. It is classified as a cosmetic ingredient in our database. CAS number: 8003-22-3.
Is Solvent Yellow 33 used outside cosmetics?
Solvent Yellow 33 also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Solvent Yellow 33 have different safety status in cosmetics vs industrial chemicals?
Solvent Yellow 33 is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H317, H319, H335, H351).
Compliance Tools
Check Solvent Yellow 33 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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