NOAEL Studies Cosmetic Ingredient

Sodium Toluenesulfonate NOAEL Studies

INCI: SODIUM TOLUENESULFONATE

CAS: 657-84-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >7000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9040; row=16249; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium 4-methylbenzenesulfonate; preferred_name=Sodium 4-methylbenzenesulfonate; dtxsid=DTXSID9042415; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9042415; source_file=acute_oral.xlsx
NTP_ICE_acute_oral LD50 >3000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_9039; row=16250; data_type=In Vivo; mixture=Chemical; chemical_name=Sodium 4-methylbenzenesulfonate; preferred_name=Sodium 4-methylbenzenesulfonate; dtxsid=DTXSID9042415; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9042415; source_file=acute_oral.xlsx
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14420; RecordID=ARPathway2016_1452; DatasetName=ARPathway2016; DTXSID=DTXSID9042415; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID9042415
ToxValDB_ECHA_IUCLID 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral - short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caaae4b0a7c65d222e15; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/16108/7/6/2?documentUUID=adf6d422-182b-4e93-92db-c87c55916c77; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=body weight and weight gain|clinical biochemistry|clinical signs|gross pathology|haematology|histopathology: neoplastic|histopathology: non-neoplastic|mortality|organ weights and organ / body weight ratios|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|clinical chemistry|clinical signs|gross pathology|hematology|mortality/survival|nonneoplastic histopathology|organ weight|urinalysis; STUDY_GROUP=ECHA IUCLID:15838640:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a61786617074039c473cb4854d66c8b1
ToxValDB_ECHA_IUCLID NOAEL =300 mg/kg bw/day Rat oral - reproduction developmental QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab28e4b0a7c65d1b91d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15793/7/9/2?documentUUID=20a630b7-f7c8-4565-9a4e-152392960409; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: gross pathology; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|gross pathology; STUDY_GROUP=ECHA IUCLID:15857738:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1e4a6fca45e9068172f849947f31da81
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =37.4 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635287:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c773f0b116dfe01c81deeb42cabb51a1
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 2V179P6Q43 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H7O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V179P6Q43"}
openFDA substances FDA UNII substance identifier 2V179P6Q43 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H7O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V179P6Q43"}
openFDA substances FDA UNII substance identifier 2V179P6Q43 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H7O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V179P6Q43"}
openFDA substances FDA UNII substance identifier 2V179P6Q43 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H7O3S.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"2V179P6Q43"}