NOAEL Studies
Cosmetic Ingredient
Sodium Nitrite NOAEL Studies
INCI: SODIUM NITRITE
CAS: 7632-00-0
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 45 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | NOAEL | 5 | mg/kg bw/day | mouse | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 10 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 13 | mg/kg bw/day | rat | oral | 882 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 14 | mg/kg bw/day | rat | oral | 60 day | Neurotoxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 20 | mg/kg bw/day | rat | oral | 90 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 23 | mg/kg bw/day | hamster | oral | 5 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 25 | mg/kg bw/day | mouse | oral | 21 day | Immunotoxicology | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 30.5 | mg/kg bw/day | hamster | oral | 770 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 40 | mg/kg bw/day | mouse | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 46 | mg/kg bw/day | mouse | oral | 870 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 50 | mg/kg bw/day | rat | oral | NA | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 51 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 70 | mg/kg bw/day | mouse | oral | 70 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 80 | mg/kg bw/day | rat | oral | 480 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 100 | mg/kg bw/day | rat | oral | NA | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 103 | mg/kg bw/day | rat | oral | 43 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 120 | mg/kg bw/day | rat | oral | 10 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 130 | mg/kg bw/day | rat | oral | 735 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 150 | mg/kg bw/day | rat | oral | 300 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 160 | mg/kg bw/day | rat | oral | 3 day | Special Toxicology Study | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 164 | mg/kg bw/day | rat | oral | 37 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 169 | mg/kg bw/day | mouse | oral | 12 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 176 | mg/kg bw/day | rat | oral | 37 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 188 | mg/kg bw/day | rat | oral | 658 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 195 | mg/kg bw/day | rat | oral | 43 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 200 | mg/kg bw/day | rat | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 206 | mg/kg bw/day | rat | oral | 37 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 220 | mg/kg bw/day | mouse | oral | 728 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 240 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 250 | mg/kg bw/day | mouse | oral | 196 day | Chronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 254 | mg/kg bw/day | rat | oral | 875 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 300 | mg/kg bw/day | rat | oral | 658 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 321 | mg/kg bw/day | rat | oral | 43 day | Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 412 | mg/kg bw/day | mouse | oral | NA | Multigeneration Reproductive | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 440 | mg/kg bw/day | mouse | oral | 25 day | Developmental | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 445 | mg/kg bw/day | mouse | oral | 98 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 500 | mg/kg bw/day | mouse | oral | 140 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 510 | mg/kg bw/day | mouse | oral | 14 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 562 | mg/kg bw/day | rat | oral | 646 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 565 | mg/kg bw/day | guinea pig | oral | 53 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1000 | mg/kg bw/day | rat | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 1450 | mg/kg bw/day | mouse | oral | 763 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 2000 | mg/kg bw/day | syrian hamster | oral | 700 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 3000 | mg/kg bw/day | rat | oral | 840 day | Carcinogenicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
| COSMOS DB | NOAEL | 5000 | mg/kg bw/day | mouse | oral | 42 day | Short Term Toxicity | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
EFSA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA | ADI | =0.1 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2017 - OutputID 2956 - Consumers - Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives - doi:10.2903/j.efsa.2017.4786 |
| EFSA | ADI | =0.1 | mg/kg bw/day | Consumers | - | - | ADI | EFSA ANS - 2017 - OutputID 2956 - Consumers - Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives - doi:10.2903/j.efsa.2017.4786 |
| EFSA | BMDL | =9.63 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | LONG_REF=EFSA ANS (2017). Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives. doi:10.2903/j.efsa.2017.4786.; TITLE=Re-evaluation of potassium nitrite (E 249) and sodium nitrite (E 250) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2017.4786; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2017; ORIGINAL_YEAR=2017; TOXICOLOGICAL_EFFECT=clinical chemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=EFSA:15625113:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_acaf8b8c6617a52a7a5fdeed1bbb4ffe |
WHO/JECFA 28 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| WHO/JECFA | ADI | =0.06 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=4c3fc8bab342f420; raw_unit=mg/kg bw; context=On this basis, the Committee allocated an ADI of 00.06 mg/kg bw, expressed as nitrite ion, by applying a safety factor of 100. |
| WHO/JECFA | ADI | =0.06 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=4c3fc8bab342f420; raw_unit=mg/kg bw; context=On this basis, the Committee allocated an ADI of 00.06 mg/kg bw, expressed as nitrite ion, by applying a safety factor of 100. |
| WHO/JECFA | ADI | =0.07 | mg/kg bw/day | Rat | - | 2-year | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=d337fe404ba9ac2c; raw_unit=mg/kg bw; context=The Committee established an ADI of 00.07 mg/kg bw, expressed as nitrite ion, on the basis of the NOEL of 6.7 mg/kg bw per day for effects on the heart and lung in the 2-year study in rats and a safety factor of 100. |
| WHO/JECFA | ADI | =0.07 | mg/kg bw/day | Rat | - | 2-year | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=d337fe404ba9ac2c; raw_unit=mg/kg bw; context=The Committee established an ADI of 00.07 mg/kg bw, expressed as nitrite ion, on the basis of the NOEL of 6.7 mg/kg bw per day for effects on the heart and lung in the 2-year study in rats and a safety factor of 100. |
| WHO/JECFA | ADI | =0.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=2ee8241c4c19e7f3; raw_unit=mg/kg bw; context=At its seventeenth meeting, the Committee lowered the ADI for sodium nitrite to 00.2 mg/kg bw and made it temporary At that time, the Committee used a safety factor higher than normal (500) because the ADI was based on a marginal effect and there is a possibility of the endogenous formation of N- nitroso compounds from nitrite and N- nitrosatable comp |
| WHO/JECFA | ADI | =0.2 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=2ee8241c4c19e7f3; raw_unit=mg/kg bw; context=At its seventeenth meeting, the Committee lowered the ADI for sodium nitrite to 00.2 mg/kg bw and made it temporary At that time, the Committee used a safety factor higher than normal (500) because the ADI was based on a marginal effect and there is a possibility of the endogenous formation of N- nitroso compounds from nitrite and N- nitrosatable comp |
| WHO/JECFA | ADI | =0.4 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=90370cc43439e17e; raw_unit=mg/kg bw; context=At its sixth meeting, the Committee allocated an ADI of 00.4 mg/kg bw to this substance, expressed as sodium nitrite. |
| WHO/JECFA | ADI | =0.4 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=90370cc43439e17e; raw_unit=mg/kg bw; context=At its sixth meeting, the Committee allocated an ADI of 00.4 mg/kg bw to this substance, expressed as sodium nitrite. |
| WHO/JECFA | ADI | =100 | mg/kg bw/day | Rat | - | long-term | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=9a55204990924d07; raw_unit=mg/kg bw per day; context=This ADI was based on a marginal reduction in body-weight gain at a dose of 100 mg/kg bw per day in a long-term study in rats. |
| WHO/JECFA | ADI | =100 | mg/kg bw/day | Rat | - | long-term | Health guidance value | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=9a55204990924d07; raw_unit=mg/kg bw per day; context=This ADI was based on a marginal reduction in body-weight gain at a dose of 100 mg/kg bw per day in a long-term study in rats. |
| WHO/JECFA | NOEL | =5.4 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=397cc3dbda5eb016; raw_unit=mg/kg bw per day; context=The NOEL of 5.4 mg/kg bw per day (expressed as nitrite ion) was therefore considered to be no longer relevant, as it was based on the indirect effect on the adrenals described above. |
| WHO/JECFA | NOEL | =5.4 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=397cc3dbda5eb016; raw_unit=mg/kg bw per day; context=The NOEL of 5.4 mg/kg bw per day (expressed as nitrite ion) was therefore considered to be no longer relevant, as it was based on the indirect effect on the adrenals described above. |
| WHO/JECFA | NOEL | =6.7 | mg/kg bw/day | Rat | - | 2-year | Chronic toxicity | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=1570945b4339616f; raw_unit=mg/kg bw per day; context=A NOEL of 6.7 mg/kg bw per day was identified in a 2-year study in rats, in which effects on the heart and lungs were observed at the next higher dose . |
| WHO/JECFA | NOEL | =6.7 | mg/kg bw/day | Rat | - | 2-year | Chronic toxicity | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=1570945b4339616f; raw_unit=mg/kg bw per day; context=A NOEL of 6.7 mg/kg bw per day was identified in a 2-year study in rats, in which effects on the heart and lungs were observed at the next higher dose . |
| WHO/JECFA | NOEL | =50 | mg/L | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=fb3a7fe9e9b97de6; raw_unit=mg/l; context=The NOEL for potassium nitrite was 50mg/l in drinking-water, equivalent to 5 mg/kg bw per day (Til et al., 1997). |
| WHO/JECFA | NOEL | =50 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=f8370a70a19118eb; raw_unit=mg/kg bw per day; context=The NOEL in this strain of Wistar rats was 50 mg/kg bw per day, which is considerable higher than the NOEL in the strain used by Til et al. (1997), even though both NOELs were for hypertrophy of the renal zona glomerulosa. |
| WHO/JECFA | NOEL | =50 | mg/L | - | oral | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=fb3a7fe9e9b97de6; raw_unit=mg/l; context=The NOEL for potassium nitrite was 50mg/l in drinking-water, equivalent to 5 mg/kg bw per day (Til et al., 1997). |
| WHO/JECFA | NOEL | =50 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=f8370a70a19118eb; raw_unit=mg/kg bw per day; context=The NOEL in this strain of Wistar rats was 50 mg/kg bw per day, which is considerable higher than the NOEL in the strain used by Til et al. (1997), even though both NOELs were for hypertrophy of the renal zona glomerulosa. |
| WHO/JECFA | NOEL | =55 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=05b0df282a5f5624; raw_unit=mg/kg bw per day; context=As methaemoglobin formation of less than 3% is considered not to be adverse, the NOEL was 55 mg/kg bw per day on the basis of reduced sperm motility in rats at 120 mg/kg bw per day (National Toxicology Program, 2001). |
| WHO/JECFA | NOEL | =55 | mg/kg bw/day | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=05b0df282a5f5624; raw_unit=mg/kg bw per day; context=As methaemoglobin formation of less than 3% is considered not to be adverse, the NOEL was 55 mg/kg bw per day on the basis of reduced sperm motility in rats at 120 mg/kg bw per day (National Toxicology Program, 2001). |
| WHO/JECFA | NOEL | =84 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=21e29b3639d35c8c; raw_unit=mg/kg bw per day; context=Hypertrophy of the zona glomerulosa was seen at the two higher doses, the NOEL thus being 6 mmol/l (equivalent to 84 mg/kg bw per day). |
| WHO/JECFA | NOEL | =84 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=21e29b3639d35c8c; raw_unit=mg/kg bw per day; context=Hypertrophy of the zona glomerulosa was seen at the two higher doses, the NOEL thus being 6 mmol/l (equivalent to 84 mg/kg bw per day). |
| WHO/JECFA | NOEL | =100 | mg/L | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=5c619a0d62cf86da; raw_unit=mg/l; context=Rats As hypertrophy of the adrenal zona glomerulosa was observed at all concentrations of potassium nitrite tested, including the lowest (100 mg/l), a study was performed to establish a NOEL for nitrite. |
| WHO/JECFA | NOEL | =100 | mg/L | Rat | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=5c619a0d62cf86da; raw_unit=mg/l; context=Rats As hypertrophy of the adrenal zona glomerulosa was observed at all concentrations of potassium nitrite tested, including the lowest (100 mg/l), a study was performed to establish a NOEL for nitrite. |
| WHO/JECFA | NOEL | =190 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=8514d690540cdf8e; raw_unit=mg/kg bw per day; context=The NOEL was 190 mg/kg bw per day (National Toxicology Program, 2001). |
| WHO/JECFA | NOEL | =190 | mg/kg bw/day | - | - | - | Toxicology study | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=8514d690540cdf8e; raw_unit=mg/kg bw per day; context=The NOEL was 190 mg/kg bw per day (National Toxicology Program, 2001). |
| WHO/JECFA | NOEL | <=420 | mg/kg bw | Mouse | - | - | Reproductive toxicity | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=c75d7c345f07b4ed; raw_unit=mg/kg bw; context=Thus, sodium nitrite had no adverse effect on reproduction or reproductive performance at necropsy in mice treated at doses up to 420 mg/kg bw, which was the NOEL for reproductive toxicity (Chapin et al., 1997). |
| WHO/JECFA | NOEL | <=420 | mg/kg bw | Mouse | - | - | Reproductive toxicity | document_id=jecfa_jecmono_v50je05; title=Nitrite (JECFA Food Additives Series 50); path=mirror/documents/jecfa/jecmono/v50je05.htm; row_hash=c75d7c345f07b4ed; raw_unit=mg/kg bw; context=Thus, sodium nitrite had no adverse effect on reproduction or reproductive performance at necropsy in mice treated at doses up to 420 mg/kg bw, which was the NOEL for reproductive toxicity (Chapin et al., 1997). |
NTP ICE acute inhalation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | LC50 | 0.0055 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=122; Record_ID=acute_inhalation_3275; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID0020941; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.0055; Response_Unit=mg/L; Reference=ChemIDplus; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020941 |
NTP ICE cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE cancer | Top dose | 0.3 | % | Mouse | Dosed drinking water | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=293; Record_ID=cancer_3859; Data_Type=In Vivo; Formulation_Name=Sodium Nitrite; Mixture=Chemical; DTXSID=DTXSID0020941; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=0.3; Response_Unit=%; Species=Mouse; Strain=B6C3F1; Sex=Male; Route=Dosed drinking water; Reference=TR-495; URL=https://ntp.niehs.nih.gov/publications/reports/tr/400s/tr495/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020941 |
NTP ICE endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14630; RecordID=ARPathway2016_1538; DatasetName=ARPathway2016; DTXSID=DTXSID0020941; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID0020941; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID0020941 |
EPA ToxRefDB v3 22 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =30 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5652; toxval_study_source_id=studyid5652_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-urea nitrogen-urea nitrogen|hematology-methemoglobin-methemoglobin|pathology gross-sperm measure-sperm motility|pathology microscopic-bone marrow-hematopoietic cell proliferation|organ weight-spleen-relative to body weight|hematology-reticulocyte-reticulocyte|in life observation-clinical signs-ocular discharge|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|in life observation-clinical signs-body surface staining|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-body weight-body weight gain|organ weight-kidney-relative to body weight|in life observation-body weight-body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-stomach-hyperplasia|hematology-hematocrit (hct)-hematocrit (hct)|hematology-platelet-platelet|in life observation-water consumption-water consumption|in life observation-clinical signs-reduced activity; dose_level=1; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =35 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5656; toxval_study_source_id=studyid5656_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia; dose_level=1; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =40 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5652; toxval_study_source_id=studyid5652_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-alopecia|hematology-methemoglobin-methemoglobin|clinical chemistry-urea nitrogen-urea nitrogen|in life observation-clinical signs-body surface staining|in life observation-clinical signs-ocular discharge|clinical chemistry-creatinine-creatinine|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|pathology microscopic-bone marrow-hematopoietic cell proliferation|hematology-platelet-platelet|hematology-reticulocyte-reticulocyte|organ weight-kidney-relative to body weight|hematology-hematocrit (hct)-hematocrit (hct)|in life observation-water consumption-water consumption|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|organ weight-spleen-relative to body weight|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-stomach-hyperplasia; dose_level=1; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =45 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-[other]|in life observation-body weight-body weight; dose_level=1; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =60 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia; dose_level=1; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =345 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-testes-degeneration|in life observation-body weight-body weight gain|organ weight-spleen-relative to body weight|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia|pathology gross-sperm measure-sperm motility; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =445 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =130 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5656; toxval_study_source_id=studyid5656_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =150 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5656; toxval_study_source_id=studyid5656_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|pathology microscopic-stomach-hyperplasia; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =165 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =220 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia; dose_level=3; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =990 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-stomach-hyperplasia; dose_level=5; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LOAEL | =1230 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia; dose_level=5; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | >0 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 14 week | SUB | study_id=5652; toxval_study_source_id=studyid5652_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-urea nitrogen-urea nitrogen|hematology-hematocrit (hct)-hematocrit (hct)|hematology-mean corpuscular (cell) volume (mcv)-mean corpuscular (cell) volume (mcv)|in life observation-water consumption-water consumption|hematology-mean corpuscular hemoglobin concentration (mchc)-mean corpuscular hemoglobin concentration (mchc)|hematology-hemoglobin (hgb)-hemoglobin (hgb)|pathology microscopic-stomach-hyperplasia|in life observation-clinical signs-body surface staining|organ weight-spleen-relative to body weight|hematology-erythrocyte (rbc) count differential-erythrocyte (rbc)|hematology-mean corpuscular hemoglobin (mch)-mean corpuscular hemoglobin (mch)|in life observation-clinical signs-ocular discharge|pathology microscopic-bone marrow-hematopoietic cell proliferation|hematology-methemoglobin-methemoglobin|in life observation-body weight-body weight gain|hematology-reticulocyte-reticulocyte|in life observation-body weight-body weight|in life observation-clinical signs-alopecia|hematology-nucleated red blood cell (nrbc)-nucleated red blood cell (nrbc)|hematology-platelet-platelet|clinical chemistry-creatinine-creatinine|organ weight-kidney-relative to body weight; dose_level=0; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =190 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight gain|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight|pathology microscopic-testes-degeneration|pathology gross-sperm measure-sperm motility|in life observation-water consumption-water consumption|pathology microscopic-spleen-hematopoietic cell proliferation|organ weight-spleen-relative to body weight; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =240 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-estrous cycle-length; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =70 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5656; toxval_study_source_id=studyid5656_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =80 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 105 week | CHR | study_id=5656; toxval_study_source_id=studyid5656_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =90 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia|pathology microscopic-stomach-[other]; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =120 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 105 week | CHR | study_id=5659; toxval_study_source_id=studyid5659_Adult_F0_M_systemic; toxval_effect_list=in life observation-water consumption-water consumption|pathology microscopic-stomach-hyperplasia; dose_level=2; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =750 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_M_systemic; toxval_effect_list=pathology microscopic-testes-degeneration|in life observation-body weight-body weight|in life observation-body weight-body weight gain|pathology microscopic-stomach-hyperplasia|organ weight-spleen-relative to body weight|pathology microscopic-spleen-hematopoietic cell proliferation|in life observation-water consumption-water consumption|pathology gross-sperm measure-sperm motility; dose_level=4; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NOAEL | =840 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 14 week | SUB | study_id=5653; toxval_study_source_id=studyid5653_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-spleen-hematopoietic cell proliferation|organ weight-spleen-absolute|organ weight-liver-absolute|organ weight-kidney-relative to body weight|organ weight-liver-relative to body weight|pathology microscopic-stomach-hyperplasia|organ weight-spleen-relative to body weight|organ weight-heart-absolute|organ weight-kidney-absolute|organ weight-heart-relative to body weight; dose_level=4; study_year=2001; study_citation=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; dsstox_substance_id=DTXSID0020941; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | NOAEL | =260 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9df1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6784/7/9/2?documentUUID=ef81939d-43b4-47df-adea-254574df704a; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856177_15857665_15861983:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e44d58c421111998f32817284c478dec |
| ECHA | NOAEL | >=370 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c94fe4b0a7c65d21c512; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6784/7/9/2?documentUUID=ef81939d-43b4-47df-adea-254574df704a; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856177_15857665_15861983:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_34d06befd5f7c49474762a68fbc79b1e |
| ECHA | NOAEL | =425 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab5ae4b0a7c65d1b9df1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/6784/7/9/2?documentUUID=ef81939d-43b4-47df-adea-254574df704a; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856177_15857665_15861983:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c414e2a09587eded0499852eecb9383a |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =100 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15606565:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=75ad6e6da7b6a44cef5b22178206fb32 |
ToxValDB GESTIS DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB GESTIS DNEL | DNEL systemic | =2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634853:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9f929fde1d0f12489c38b61723ad2cdb |
ToxValDB HESS 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB HESS | NOEL | <30 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df5e4b0a676289dea54; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Hematology: Met-Hgb increase|Blood Chemistry: BUN increase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|hematology; STUDY_GROUP=HESS:15638692:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3955f5a2fb034dba97ffc9a8c132e28c |
| ToxValDB HESS | NOEL | <40 | mg/kg bw/day | Rat | oral | chronic; 14 weeks | chronic | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/60da0df5e4b0a676289dea54; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.nite.go.jp/en/chem/qsar/hess_update-e.html; TOXICOLOGICAL_EFFECT=Hematology: Met-Hgb increase; TOXICOLOGICAL_EFFECT_CATEGORY=hematology; STUDY_GROUP=HESS:15639022:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b15b4a1a83cfdaac20f2ccd62b1c31e4 |
ToxValDB ToxRefDB 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =35 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5656; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709761_15709762_15709763:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_dc906f24e242bfd5c062eb22e083d086 |
| ToxValDB ToxRefDB | LEL | =45 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709764_15709765_15709766:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ad5fff5c9dd97e85c5aaf2be47acde3 |
| ToxValDB ToxRefDB | LEL | =60 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709767_15709768_15709769:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05d358a20730f0313c1acdda392a2404 |
| ToxValDB ToxRefDB | LEL | =345 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: organ weight-spleen-relative to body weight|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-testes-degeneration|systemic: pathology gross-sperm measure-sperm motility|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709754_15709755_15709756_15709757:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_edd817aed2b2929379fa77fad8168dd3 |
| ToxValDB ToxRefDB | LEL | =445 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709748_15709749:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_45f2d2fd577afee177c841d6091cd916 |
| ToxValDB ToxRefDB | LOAEL | =130 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5656; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709761_15709762_15709763:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b4384d7119f57ff1d4baccd25a95fdf0 |
| ToxValDB ToxRefDB | LOAEL | =150 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5656; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709758_15709759_15709760:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f6c52e388ecd75d4879c11ac1d718c01 |
| ToxValDB ToxRefDB | LOAEL | =165 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709764_15709765_15709766:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b11a024ea2f82234fa8d91bd8c4eab07 |
| ToxValDB ToxRefDB | LOAEL | =220 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709767_15709768_15709769:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7e3c45f50a03893ab767ee2a0f37344d |
| ToxValDB ToxRefDB | LOAEL | =990 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709754_15709755_15709756_15709757:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_228637e9333bad2510708a358995b92f |
| ToxValDB ToxRefDB | LOAEL | =1230 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709750_15709751_15709752_15709753:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_589e8e3ecd6a66317cf99663a51da3b0 |
| ToxValDB ToxRefDB | NEL | =190 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology gross-sperm measure-sperm motility|systemic: in life observation-body weight-body weight gain|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-hyperplasia|systemic: pathology microscopic-testes-degeneration|systemic: organ weight-spleen-relative to body weight|systemic: pathology microscopic-spleen-hematopoietic cell proliferation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709754_15709755_15709756_15709757:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b690ce7d0ee737a48e71f03882e1ef70 |
| ToxValDB ToxRefDB | NEL | =240 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-estrous cycle-length; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15709748_15709749:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_05d475a3364db0916ea625535d6b9157 |
| ToxValDB ToxRefDB | NOAEL | =70 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5656; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709761_15709762_15709763:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4bd55a1ccb6c6518ceba206a5b251664 |
| ToxValDB ToxRefDB | NOAEL | =80 | mg/kg bw/day | Rat | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5656; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709758_15709759_15709760:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3976d1578fd0c048e21e1136aec08bea |
| ToxValDB ToxRefDB | NOAEL | =90 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight|systemic: pathology microscopic-stomach-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709764_15709765_15709766:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_daff60b7b56a60bb676133b81dd4f0b3 |
| ToxValDB ToxRefDB | NOAEL | =120 | mg/kg bw/day | Mouse | oral | chronic; 105 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Chronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5659; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15709767_15709768_15709769:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed57d64a6ce638a8fbc98223a395aeb6 |
| ToxValDB ToxRefDB | NOAEL | =750 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: organ weight-spleen-relative to body weight|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight gain|systemic: pathology gross-sperm measure-sperm motility|systemic: pathology microscopic-testes-degeneration|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|gross pathology|nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709754_15709755_15709756_15709757:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_aba0a7c4314f11efd98fcfbd118c51fd |
| ToxValDB ToxRefDB | NOAEL | =840 | mg/kg bw/day | Mouse | oral | chronic; 14 weeks | chronic | LONG_REF=NTP_2001_Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; TITLE=Toxicology and carcinogenesis studies of sodium nitrite (CAS NO. 7632-00-0) in F344/N rats and B6C3F1 mice (drinking water studies)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5653; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=systemic: organ weight-heart-absolute|systemic: organ weight-kidney-absolute|systemic: pathology microscopic-spleen-hematopoietic cell proliferation|systemic: organ weight-kidney-relative to body weight|systemic: organ weight-spleen-absolute|systemic: pathology microscopic-stomach-hyperplasia|systemic: organ weight-heart-relative to body weight|systemic: organ weight-spleen-relative to body weight|systemic: organ weight-liver-relative to body weight|systemic: organ weight-liver-absolute; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ToxRefDB_dup_-_15709750_15709751_15709752_15709753:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4e02c5f91ec280b0156fd7f7d7f8d857 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | M0KG633D4F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M0KG633D4F"} |
| openFDA substances | FDA UNII substance identifier | M0KG633D4F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M0KG633D4F"} |
| openFDA substances | FDA UNII substance identifier | M0KG633D4F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M0KG633D4F"} |
| openFDA substances | FDA UNII substance identifier | M0KG633D4F | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"NO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"M0KG633D4F"} |