NOAEL Studies Cosmetic Ingredient

Sodium Hypochlorite NOAEL Studies

INCI: SODIUM HYPOCHLORITE

CAS: 7681-52-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 130 mg/kg bw/day rat oral 728 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 200 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 250 mg/kg bw/day mouse oral 721 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 346 mg/kg bw/day guinea pig oral 35 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 393 mg/kg bw/day rat oral 42 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 5075 mg/kg bw/day rat oral 9 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_skin_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_irritation Breakthrough Time 240 min - Dermal - In Vitro; Corrositex sheet=Data_invitro; excel_row=5100; Record_ID=skin_irritation_invitro_113; Data_Type=In Vitro; Formulation_ID=MIX793; Formulation_Name=liquid bleach; Percent_Active_Ingredient=100; Mixture=Mixture; DTXSID=DTXSID8021276; Assay=Corrositex; Endpoint=Breakthrough Time; Response=240; Response_Unit=min; Reference=Gordon et al. 1994; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID8021276
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX NOEL =30 mM Rat oral chronic; 182 days chronic LONG_REF=J. Gastroenterol.32(4): 435-441 Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis 1997; TITLE=Enhancement by Monochloramine of the Development of Gastric Cancers in Rats: a Possible Mechanism of Helicobacter pylori-Associated Gastric Carcinogenesis; AUTHOR=Iishi,H., M. Tatsuta, M. Baba, T. Mikuni, R. Yamamoto, K. Iseki, H. Yano, H. Uehara, and A. Nakaizumi; DOI=10.1007/BF02934080; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=151911; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Cell changes|Growth: Weight|Injury: Tumor induction; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|cancer|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15595388:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e7ae424a67846104fe9074eec618930e
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL local =1.55 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL_dup_-_15634825_15634826:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_902425491c14725ac2f90e7e2b757418
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier DY38VHM5OD UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DY38VHM5OD"}
openFDA substances FDA UNII substance identifier DY38VHM5OD UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DY38VHM5OD"}
openFDA substances FDA UNII substance identifier DY38VHM5OD UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DY38VHM5OD"}
openFDA substances FDA UNII substance identifier DY38VHM5OD UNII - - - chemical {"approval_status":null,"molecular_formula":"ClO.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"DY38VHM5OD"}