Is Sodium Hyaluronate Crosspolymer safe in cosmetics?
Sodium Hyaluronate Crosspolymer has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Sodium Hyaluronate Crosspolymer
INCI: SODIUM HYALURONATE CROSSPOLYMER
Sodium Hyaluronate Crosspolymer (CAS 1186211-02-8) is a cosmetic humectant functioning as Humectant, skin-conditioning, film-forming, thickener. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 1186211-02-8 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin-conditioning, film-forming, thickener
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel: safe as used in cosmetics (reaffirmed March 2023). Self-crosslinked cosmetic grade — no FDA PMA required (distinct from BDDE-crosslinked dermal fillers which are Class III medical devices).
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Hyaluronate Crosspolymer.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Sodium Hyaluronate Crosspolymer, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
Variable Da
Log P
-10.5
Systemic Absorption
no
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Source: J Cosmet Dermatol 2019
Additional Ingredient Properties
8 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_acne": "No restriction", …
anti_aging
{"anti_aging_claim": "hydration-plumping, firming", "mechanism_of_action": "Humectant, water binding, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "10-18", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JD…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,combination,normal,acne-prone", "acne_safe": "yes", "source": "High MW HA"}
dermal_absorption
{"molecular_weight_da": "Variable", "log_p_value": "-10.5", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "no", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "no", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "minimal", "source": "J…
humectant
{"cas_number": "variable", "ingredient_class": "humectant/glycosaminoglycan", "molecular_weight_Da": "variable", "chemical_type": "polysaccharide", "water_binding_mechanism": "hydrogen_bonding/hygroscopic/film_forming", "water_holding_capacity_g_per_g": "10.0-20.0", "hygroscopicity_at_50_RH": "excellent", "hygroscopicity_at_80_RH": "excellent", "NMF_component": "no", "NMF_percentage_natural": "0",…
skin_suitability
{"oily_skin": "recommended", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "recommended", "normal_skin": "recommended", "acne_prone": "recommended", "rosacea": "recommended", "eczema": "recommended", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "hydrating", "skin_benefit_secondary": "long-la…
synergy
{"inci_name_2": "Hyaluronic Acid (Low MW)", "synergy_type": "moisturizing-synergy", "synergy_description": "Stable cross-linked HA with penetrating HA for sustained hydration", "combined_benefit": "Long-lasting surface moisture + deep hydration, improved texture", "efficacy_multiplier": "2.1x", "mechanism_of_action": "Crosspolymer resists degradation providing lasting surface effect; low MW penetr…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Hyaluronate Crosspolymer.
Frequently Asked Questions
Is Sodium Hyaluronate Crosspolymer allowed in the EU?
Sodium Hyaluronate Crosspolymer EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Hyaluronate Crosspolymer do in cosmetics?
Sodium Hyaluronate Crosspolymer functions as: Humectant, skin-conditioning, film-forming, thickener. It is classified as a Humectant in our database. CAS number: 1186211-02-8.
Compliance Tools
Check Sodium Hyaluronate Crosspolymer compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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