Is Sodium Hyaluronate safe in cosmetics?
Sodium Hyaluronate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Sodium Hyaluronate
Also known as: Hyaluronic acid, sodium salt, Chlamyhyaluronic acid sodium salt, Healon (polysaccharide), Ostenil, Hyalurone sodium (+9 more)
INCI: SODIUM HYALURONATE
Sodium Hyaluronate (CAS 9067-32-7) is a cosmetic humectant functioning as Humectant, skin-conditioning, film-forming, viscosity modifier. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 9067-32-7 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, skin-conditioning, film-forming, viscosity modifier
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel: safe as used in cosmetics (2009, reaffirmed March 2023). Most used HA form — 4713 formulations per FDA 2023 data.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Hyaluronate.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Sodium Hyaluronate, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
surface/stratum corneum
Molecular Weight
50000-200000 Da
Log P
-9.0
Systemic Absorption
no
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Source: SCCS/1512/13
EPA ToxValDB — Toxicity Values
3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2400 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >1000 mg/kg | Rabbit | oral | - | ChemIDplus |
| LD50 | >800 mg/kg | Rat | oral | - | ChemIDplus |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.01–0.5 | 2 | CIR/VCRP |
| Serum | 0.1–1 | 2 | CIR/VCRP |
| Eye Cream | 0.1–0.5 | 1 | CIR/VCRP |
| Body Lotion | 0.05–0.3 | 1 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "9067-32-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction…
baby_pediatric
{"cas_number": "9067-32-7", "ingredient_class": "moisturizer_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Humectant, biocompatible, safe, hydrating", "transepidermal_absorption_risk_pediatric": "very_low", "dose_per_kg_body_weight_concern": "Surface hydration", "skin_surface…
biopolymer
{"cas_number": "9067-32-7", "polymer_class": "hyaluronic_acid", "botanical_source": "Microbial fermentation/rooster comb", "molecular_weight_range_kDa": "10-3000", "monosaccharide_composition": "glucuronic acid/N-acetylglucosamine", "degree_of_branching": "linear", "charge_type": "anionic", "viscosity_1pct_solution_mPas": "varies_by_MW", "pseudoplastic_behavior": "strong", "thixotropy": "yes", "yi…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,dry,sensitive,combination,normal,acne-prone,mature,rosacea", "acne_safe": "yes", "source": "Hyaluronic acid salt"}
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "0.5", "typical_concentration_pct": "0.3", "product_type": "Sheet Mask", "function_at_concentration": "Intense hydration", "source": "Supplier TDS"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "90", "estimated_cost_per_kg_usd_high": "150", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "China", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Hyaluronic Acid…
dermal_absorption
{"molecular_weight_da": "50000-200000", "log_p_value": "-9.0", "skin_penetration_level": "surface", "penetration_depth": "surface/stratum corneum", "absorption_pct": "0.5-2", "systemic_absorption": "no", "penetration_enhancer": "no", "occlusion_effect": "yes", "vehicle_dependent": "no", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.2-1", "safety_margin_factor": "minimal",…
hair_care
{"hair_function": "moisturizing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "moisture", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "ker…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Regulatory List Membership (1)
EU Restricted for Children (Cosmetics)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Hyaluronate.
Regulatory Flags
eu_children_restricted
Known Synonyms
Hyaluronic acid, sodium salt
Chlamyhyaluronic acid sodium salt
Healon (polysaccharide)
Ostenil
Hyalurone sodium
Hyaluronic acid sodium
Supartz
Khionat
Hyladerm Khionat
UNII-YSE9PPT4TH
EUFLEXXA injection
EUFLEXXA
Sodium hyaluronate HMW
Hyalovet
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
children; Europe; Personal care
children; Europe; Personal care - general moisturizing - hand/body lotion
supplements
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
122
Frequently Asked Questions
Is Sodium Hyaluronate allowed in the EU?
Sodium Hyaluronate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Hyaluronate do in cosmetics?
Sodium Hyaluronate functions as: Humectant, skin-conditioning, film-forming, viscosity modifier. It is classified as a Humectant in our database. CAS number: 9067-32-7.
Is Sodium Hyaluronate used outside cosmetics?
Sodium Hyaluronate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Hyaluronate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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SODIUM (ASTROCARYUM VULGARE/EUTERPE OLERACEAE/PALM) FRUIT/(ASTROCARYUM VULGARE/PALM) KERNEL/(ASTROCARYUM MURUMURU/BABASSU/BERTHOLLETIA EXCELSA/CARAPA GUIANENSIS/COCOA/FEVILLEA TRILOBATA/PASSIFLORA EDULIS/THEOBROMA GRANDIFLORUM) SEEDATE
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