NOAEL Studies Cosmetic Ingredient

Sodium Hexametaphosphate NOAEL Studies

INCI: SODIUM HEXAMETAPHOSPHATE

CAS: 68915-31-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_PPRTV_(CPHEA) 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_PPRTV_(CPHEA) NOAEL =145.7 mg/kg bw/day Human oral - epidemiologic LONG_REF=IOM 1997, Nordin 1988; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd7c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1886; TOXICOLOGICAL_EFFECT=increased ecf serum phosphorus; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=PPRTV (CPHEA):15654053:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5d4f8e03f294ae3714c06aed4f33d2dc
ToxValDB_PPRTV_(CPHEA) RfD (provisional) =49 mg/kg bw/day Human oral - Toxicity Value LONG_REF=IOM 1997, Nordin 1988; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/640754fce4b08a6b3934bd7c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/pprtv/basic-information-about-provisional-peer-reviewed-toxicity-values-pprtvs; SUBSOURCE_URL=https://cfpub.epa.gov/ncea/pprtv/chemicalLanding.cfm?pprtv_sub_id=1886; TOXICOLOGICAL_EFFECT=increased ecf serum phosphorus; STUDY_GROUP=PPRTV (CPHEA)_dup_PPRTV Summary_15653987_15653988:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_137155d66596e86bf7d11ded4441ecc2
ToxValDB_RSL 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_RSL RfD =1 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_PPRTV_15658222_15663697:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cec7a20dfdf12043fcc408b94986f8b1
ToxValDB_RSL RfD =4 mg/kg bw/day Human oral - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL_dup_PPRTV_15658222_15663697:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5ede8d8135bafda74a504d34322f7b85
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier concept identifier - - - concept {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"concept","unii_code":null}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}
openFDA substances FDA UNII substance identifier P1BM4ZH95L UNII - - - polymer {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"polymer","unii_code":"P1BM4ZH95L"}