NOAEL Studies
Cosmetic Ingredient
Sodium Formate NOAEL Studies
INCI: SODIUM FORMATE
CAS: 141-53-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ToxValDB_ECHA_IUCLID 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =945 | mg/kg bw/day | Rat | oral | - | developmental | GUIDELINE=OECD Guideline 414 (Prenatal Developmental Toxicity Study); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabe9e4b0a7c65d1bc640; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14849/7/9/3?documentUUID=1ffbe38c-034e-4f47-b150-93b75a2c6989; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15820929:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_40c06772799ad67a740e0527b4a46ef0 |
| ToxValDB_ECHA_IUCLID | NOAEL | =750 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d1cfe4b0a7c65d2302cc; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/en/registration-dossier/-/registered-dossier/14285?documentUUID=61f7aee5-57e9-47bb-84b8-5dc8cd600c5d; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15822643:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_984b6ecbb3b382c35603a34f10f3a968 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa99e4b0a7c65d1b6a55; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14849/7/9/2?documentUUID=1ffbe38c-034e-4f47-b150-93b75a2c6989; YEAR=2002; ORIGINAL_YEAR=2002; STUDY_GROUP=ECHA IUCLID:15857586:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e6efaf0e5d31b3b39977dfad3e2720a0 |
ToxValDB_ECOTOX 11 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =4 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601392_15601393_15601394_15601395:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1cd53735f7d1dfdca7e53f7cef7e2128 |
| ToxValDB_ECOTOX | LOEL | =0.5 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601392_15601393_15601394_15601395:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=23d2756e9b6b20d08f2a4639460f847c |
| ToxValDB_ECOTOX | LOEL | =2 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606676_15606677:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ebcca7eaddae35a782801690149f040d |
| ToxValDB_ECOTOX | LOEL | =0.00101 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610911_15610912_15610913_15610915:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e3dd4133219c081c8fa4a5fefcb0ec84 |
| ToxValDB_ECOTOX | LOEL | =0.00151 | mg | Rat | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610914_15610916:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=22eaf75c6d37c3096aff57346f41ab72 |
| ToxValDB_ECOTOX | LOEL | =0.00003 | mg | Mouse | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Development: Normal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611110_15611111_15611112:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dbe9026b30a8e1605047be051ab95936 |
| ToxValDB_ECOTOX | NOEL | =2 | mg/mL | Mouse | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601392_15601393_15601394_15601395:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f607ecafc3e65a252c3eab254caa95dd |
| ToxValDB_ECOTOX | NOEL | =1 | mg/mL | Rat | environmental | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606676_15606677:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4c9dfc7a7d863641cf2f1a99e7a9a09e |
| ToxValDB_ECOTOX | NOEL | =0.00003 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Normal|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610911_15610912_15610913_15610915:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bda2e76adf072eb3c260e90880f5e37a |
| ToxValDB_ECOTOX | NOEL | =0.00051 | mg | Rat | injection | acute; 1 days | developmental | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Protein, total|Development: Organ/tissue formation; TOXICOLOGICAL_EFFECT_CATEGORY=development|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610911_15610912_15610913_15610915:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6982a0479eaaf10a436eaf1dbea6d8d6 |
| ToxValDB_ECOTOX | NOEL | =0.00101 | mg | Rat | injection | acute; 1 days | acute | LONG_REF=Birth Defects Res. A Clin. Mol. Teratol.73(2): 72-82 Hansen,J.M., K.M. Contreras, and C. Harris Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity 2005; TITLE=Methanol, Formaldehyde, and Sodium Formate Exposure in Rat and Mouse Conceptuses: A Potential Role of the Visceral Yolk Sac in Embryotoxicity; AUTHOR=Hansen,J.M., K.M. Contreras, and C. Harris; DOI=10.1002/bdra.20094; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=113153; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15610914_15610916:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6bbf4ecfaa29f6bcb9420576d536ac35 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =35.26 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634806:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a0384491d58e72d415ad9cd4f3511e85 |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 387AD98770 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CHO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387AD98770"} |
| openFDA substances | FDA UNII substance identifier | 387AD98770 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CHO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387AD98770"} |
| openFDA substances | FDA UNII substance identifier | 387AD98770 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CHO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387AD98770"} |
| openFDA substances | FDA UNII substance identifier | 387AD98770 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"CHO2.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"387AD98770"} |