Is Sodium Fluorosilicate safe in cosmetics?
Sodium Fluorosilicate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Sodium Fluorosilicate
Also known as: Caswell No. 771, Destruxol applex, Disodium hexafluorosilicate (2-), Disodium silicofluoride, EINECS 240-934-8 (+13 more)
INCI: SODIUM FLUOROSILICATE
Sodium Fluorosilicate (CAS 16893-85-9) is a cosmetic cosmetic ingredient functioning as Antiplaque agent, oral care. EU Regulation 1223/2009 status: restricted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 16893-85-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium Fluorosilicate is classified GHS Danger (H301, H311, H331, H402, H412) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antiplaque agent, oral care
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
disodium;hexafluorosilicon(2-)
InChIKey
TWGUZEUZLCYTCG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted in OTC oral care products under fluoride monograph; regulated as an active ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Fluorosilicate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
SkullToxicCancerHealth haz
Hazard Statements
Toxic if swallowed May cause damage to blood and cardiovascular system Causes damage to the bones and the teeth through prolonged or repeated exposure
Short-term Exposure Effects
The substance may cause effects on the blood and calcium metabolism. This may result in cardiac disorders. Medical observation is indicated. See Notes.
Long-term Exposure Effects
The substance may have effects on the bones and teeth. This may result in fluorosis.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Oral products. Max: 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 %.
BRIN Brazil/India Cosmetics
India: Restricted · max 0,15 % calculated as F. When mixed with other fluorine compounds permitted under this Annex, total F concentration must not exceed 0,15 %
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Evidence for Carcinogenicity
A4; Not classifiable as a human carcinogen. /Fluorides, as F/
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
1243
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Abrasive
Anti-scaling agent
Degradant/impurity
Pharmaceutical
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Fluorosilicate.
Regulatory Flags
eu_cosing_listed
Known Synonyms
Caswell No. 771
Destruxol applex
Disodium hexafluorosilicate (2-)
Disodium silicofluoride
EINECS 240-934-8
Ens-zem weevil bait
EPA Pesticide Chemical Code 075306
Fluosilicate de sodium
Ortho earwig bait
Ortho weevil bait
PSC Co-Op weevil bait
Salufer
Sodium hexafluosilicate
Super prodan
Natriumhexafluorosilicat
Fluorosilicate de sodium
Natriumsilicofluorid
UNII-806AV2E065
Chemical Function
Abrasive
Anti-scaling agent
Pharmaceutical
Degradant/impurity
Regulatory Lists
active_ingredient; Europe; Pesticides
Europe; Personal care; restricted
active_ingredient; Europe; Pesticides
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Sodium Fluorosilicate allowed in the EU?
Sodium Fluorosilicate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Fluorosilicate do in cosmetics?
Sodium Fluorosilicate functions as: Antiplaque agent, oral care. It is classified as a cosmetic ingredient in our database. CAS number: 16893-85-9.
Is Sodium Fluorosilicate classified as hazardous under GHS?
Sodium Fluorosilicate carries a GHS signal word of "DANGER". Hazard statements: Toxic if swallowed May cause damage to blood and cardiovascular system Causes damage to the bones and the teeth through prolonged or repeated exposure. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Sodium Fluorosilicate used outside cosmetics?
Sodium Fluorosilicate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium Fluorosilicate have different safety status in cosmetics vs industrial chemicals?
Sodium Fluorosilicate is classified GHS Danger (H301, H311, H331, H402, H412) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Sodium Fluorosilicate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acrylates/Vinyl Neodecanoate Crosspolymer
Excellent
Same category
Emulsion stabilising, film forming
Adipic Acid
Excellent
Same category
Buffering
Aluminum Magnesium Oxide
Excellent
Same category
Absorbent, bulking agent, opacifying ...
Ammonium VA/Acrylates Copolymer
Excellent
Same category
Antistatic, binding, film forming, ha...
Ammonium VA/Crotonic Acid Copolymer
Excellent
Same category
Antistatic, film forming, hair fixing...
Aphanothece Sacrum Polysaccharide
Excellent
Same category
Absorbent, emulsion stabilising, film...
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
SODIUM (ASTROCARYUM VULGARE/EUTERPE OLERACEAE/PALM) FRUIT/(ASTROCARYUM VULGARE/PALM) KERNEL/(ASTROCARYUM MURUMURU/BABASSU/BERTHOLLETIA EXCELSA/CARAPA GUIANENSIS/COCOA/FEVILLEA TRILOBATA/PASSIFLORA EDULIS/THEOBROMA GRANDIFLORUM) SEEDATE
Good
Browse nearby
Cleansing, Surfactant - Cleansing
SODIUM BEHENOYL/COCOYL (ALANINE/ARGININE/ASPARAGINE/ASPARTIC ACID/GLUTAMIC ACID/GLYCINE/ISOLEUCINE/LEUCINE/LYSINE/METHIONINE/PHENYLALANINE/PROLINE/SERINE/THREONINE/TRYPTOPHAN/TYROSINE/VALINE)
Good
Browse nearby
Cleansing, Emulsion Stabilising, Surf...
SODIUM BEHENOYL/COCOYL (ARGININE/GLUTAMIC ACID/ISOLEUCINE/LEUCINE/LYSINE/PHENYLALANINE/PROLINE/THREONINE/VALINE)
Good
Browse nearby
Cleansing, Surfactant - Cleansing, Su...
Is Sodium Fluorosilicate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Sodium Fluorosilicate in your formulation.