NOAEL Studies
Cosmetic Ingredient
Sodium Fluoride NOAEL Studies
INCI: SODIUM FLUORIDE
CAS: 7681-49-4
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
ATSDR_toxval_ATSDR_MRLs.xlsx 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ATSDR_toxval_ATSDR_MRLs.xlsx | NOAEL | =0.15 | mg/kg/day | Human (M/F) | oral | chronic; 1 years | epidemiologic | ATSDR MRLs; row_hash=1a5f33885cf92529; source_hash=ToxValhc_c4f47d572bf6382ac2e8127ef66edf26; raw_endpoint_type=NOAEL; raw_endpoint_subtype=; raw_value=0.15; raw_unit=mg/kg/day; method=drinking water; effect=musculoskeletal; effect_category=other; file=toxval_ATSDR_MRLs.xlsx; long_ref=Li Y, Liang C, Slemenda CW, et al. 2001. Effect of long-term exposure to fluoride in drinking water on risks of bone fractures. J Bone Miner Res 16:932-939.; stored_source_record=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585791 |
NTP_ICE_cancer 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | POLY-3 lowest dose | 175 | mg/L | Rat | Dosed drinking water | - | In Vivo; Two year cancer bioassay | sheet=Data; excel_row=2388; Record_ID=cancer_3896; Data_Type=In Vivo; Formulation_Name=Sodium fluoride; Mixture=Chemical; DTXSID=DTXSID2020630; Assay=Two year cancer bioassay; Endpoint=POLY-3 lowest dose; Response=175; Response_Unit=mg/L; Species=Rat; Strain=F344/N; Sex=Male; Route=Dosed drinking water; Level_of_Evidence=Equivocal evidence; Tissue=Bone; Lesion=Osteosarcoma; Reference=TR-393; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr393/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020630; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020630 |
| NTP_ICE_cancer | Top dose | 175 | ppm | Mouse | Dosed drinking water | - | In Vivo; NTP Carcinogenicity | sheet=Data; excel_row=2386; Record_ID=cancer_3895; Data_Type=In Vivo; Formulation_Name=Sodium Fluoride; Mixture=Chemical; DTXSID=DTXSID2020630; Assay=NTP Carcinogenicity; Endpoint=Top dose; Response=175; Response_Unit=ppm; Species=Mouse; Strain=B6C3F1; Sex=Female; Route=Dosed drinking water; Reference=TR-393; URL=https://ntp.niehs.nih.gov/publications/reports/tr/300s/tr393/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2020630; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID2020630 |
ToxRefDB_ToxRefDB_v3_pod.csv 18 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2.8 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=1937; toxval_study_source_id=studyid1937_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hepatoblastoma|clinical chemistry-flouride-fluoride|in life observation-clinical signs-tooth-discolored|in life observation-clinical signs-tooth-mottling|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-clinical signs-tooth-attrition|pathology gross-full gross necropsy-histiocytic sarcoma|pathology gross-full gross necropsy-lymphoma malignant; dose_level=1; study_year=1990; study_citation=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice. NTP TR 393. US Dept. of Health and Human Services, NIH.; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =2.4 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=1937; toxval_study_source_id=studyid1937_Adult_F0_M_systemic; toxval_effect_list=clinical chemistry-flouride-fluoride|in life observation-clinical signs-tooth-discolored|in life observation-clinical signs-tooth-mottling|pathology microscopic-liver-hepatoblastoma|in life observation-clinical signs-tooth-attrition|in life observation-clinical signs-tooth-dysplasia; dose_level=1; study_year=1990; study_citation=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice. NTP TR 393. US Dept. of Health and Human Services, NIH.; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =1.3 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 week to 103 week | CHR | study_id=1938; toxval_study_source_id=studyid1938_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-tooth-mottling|in life observation-clinical signs-tooth-dysplasia|clinical chemistry-flouride-fluoride|in life observation-clinical signs-tooth-degeneration|pathology microscopic-bone-osteosclerosis|in life observation-clinical signs-tooth-discolored|in life observation-clinical signs-tooth-deformity; dose_level=1; study_year=1990; study_citation=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Rats. NTP TR 393.; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =20 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5972; toxval_study_source_id=studyid5972_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-mortality-mortality|in life observation-clinical signs-hunched posture|in life observation-clinical signs-lethargy|in life observation-body weight-body weight|in life observation-clinical signs-dehydration; dose_level=4; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =120 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5975; toxval_study_source_id=studyid5975_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-water consumption-water consumption; dose_level=5; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 6 month | SUB | study_id=5976; toxval_study_source_id=studyid5976_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|in life observation-clinical signs-[other]|pathology gross-stomach-hemorrhage|clinical chemistry-flouride-fluoride|pathology microscopic-stomach-mitotic alteration|pathology microscopic-stomach-apoptosis|pathology microscopic-stomach-nuclear alteration|in life observation-body weight-body weight gain|in life observation-clinical signs-dental fluorosis|pathology gross-stomach-ulcer|in life observation-water consumption-water consumption|in life observation-clinical signs-fur (altered appearance)|pathology microscopic-stomach-depletion cellular|in life observation-food consumption-food consumption; dose_level=3; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LEL | =15 | mg/kg bw/day | mouse (B6C3F1; B6C3F1) | oral | 0 month to 6 month | SUB | study_id=5977; toxval_study_source_id=studyid5977_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-bone-proliferation|in life observation-clinical signs-dental fluorosis|in life observation-body weight-body weight gain|in life observation-clinical signs-[other]|in life observation-mortality-mortality|pathology microscopic-kidney-nephropathy|pathology microscopic-heart-mineralization|pathology microscopic-liver-syncytial alteration|pathology microscopic-heart-degeneration|pathology microscopic-liver-[other]|in life observation-clinical signs-tooth-degeneration; dose_level=3; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5972; toxval_study_source_id=studyid5972_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=2; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =7.5 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5975; toxval_study_source_id=studyid5975_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight; dose_level=1; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =15 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 6 month | SUB | study_id=5976; toxval_study_source_id=studyid5976_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-stomach-hyperplasia|pathology gross-stomach-hemorrhage|pathology microscopic-stomach-mitotic alteration|pathology microscopic-stomach-apoptosis|pathology microscopic-stomach-nuclear alteration|pathology gross-stomach-ulcer|pathology microscopic-stomach-depletion cellular; dose_level=4; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | LOAEL | =30 | mg/kg bw/day | mouse (B6C3F1; B6C3F1) | oral | 0 month to 6 month | SUB | study_id=5977; toxval_study_source_id=studyid5977_Adult_F0_F_systemic; toxval_effect_list=in life observation-body weight-body weight gain; dose_level=4; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 week to 103 week | CHR | study_id=1937; toxval_study_source_id=studyid1937_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-hepatoblastoma|clinical chemistry-flouride-fluoride|clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|in life observation-clinical signs-tooth-attrition|pathology gross-full gross necropsy-histiocytic sarcoma|pathology gross-full gross necropsy-lymphoma malignant|in life observation-clinical signs-tooth-mottling|in life observation-clinical signs-tooth-discolored; dose_level=0; study_year=1990; study_citation=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice. NTP TR 393. US Dept. of Health and Human Services, NIH.; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =10 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5972; toxval_study_source_id=studyid5972_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-lethargy|in life observation-clinical signs-hunched posture|in life observation-mortality-mortality|in life observation-water consumption-water consumption|in life observation-clinical signs-dehydration|in life observation-body weight-body weight; dose_level=3; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =60 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5975; toxval_study_source_id=studyid5975_Adult_F0_F_systemic; toxval_effect_list=in life observation-water consumption-water consumption|in life observation-body weight-body weight; dose_level=4; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =1.5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 month to 6 month | SUB | study_id=5976; toxval_study_source_id=studyid5976_Adult_F0_F_systemic; toxval_effect_list=clinical chemistry-flouride-fluoride|pathology gross-stomach-hemorrhage|in life observation-body weight-body weight gain|pathology microscopic-stomach-nuclear alteration|pathology microscopic-stomach-apoptosis|pathology microscopic-stomach-mitotic alteration|in life observation-clinical signs-[other]|pathology microscopic-stomach-hyperplasia|in life observation-body weight-body weight|in life observation-food consumption-food consumption|pathology microscopic-stomach-depletion cellular|in life observation-clinical signs-fur (altered appearance)|pathology gross-stomach-ulcer|in life observation-clinical signs-dental fluorosis|in life observation-water consumption-water consumption; dose_level=2; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NEL | =7.5 | mg/kg bw/day | mouse (B6C3F1; B6C3F1) | oral | 0 month to 6 month | SUB | study_id=5977; toxval_study_source_id=studyid5977_Adult_F0_F_systemic; toxval_effect_list=pathology microscopic-liver-[other]|in life observation-clinical signs-tooth-degeneration|pathology microscopic-liver-syncytial alteration|in life observation-clinical signs-dental fluorosis|in life observation-body weight-body weight gain|pathology microscopic-heart-degeneration|pathology microscopic-kidney-nephropathy|pathology microscopic-heart-mineralization|in life observation-body weight-body weight|in life observation-clinical signs-[other]|in life observation-mortality-mortality|pathology microscopic-bone-proliferation; dose_level=2; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | =2.5 | mg/kg bw/day | rat (fischer; Fischer 344) | oral | 0 day to 14 day | SAC | study_id=5972; toxval_study_source_id=studyid5972_Adult_F0_M_systemic; toxval_effect_list=in life observation-clinical signs-hunched posture|in life observation-water consumption-water consumption|in life observation-clinical signs-lethargy|in life observation-clinical signs-dehydration|in life observation-mortality-mortality|in life observation-body weight-body weight; dose_level=1; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| ToxRefDB_ToxRefDB_v3_pod.csv | NOAEL | >0 | mg/kg bw/day | mouse (b6c3f1; B6C3F1) | oral | 0 day to 14 day | SAC | study_id=5975; toxval_study_source_id=studyid5975_Adult_F0_M_systemic; toxval_effect_list=in life observation-body weight-body weight|in life observation-clinical signs-abnormal gait|in life observation-clinical signs-hunched posture|in life observation-mortality-mortality|in life observation-clinical signs-emaciation|in life observation-water consumption-water consumption; dose_level=0; study_year=1990; study_citation=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; dsstox_substance_id=DTXSID2020630; admin_method=Water; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ToxValDB_ATSDR_MRLs 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ATSDR_MRLs | MRL | =0.05 | mg/kg bw/day | Human | oral | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/674e166be4b0a7c65d36ea5d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://wwwn.cdc.gov/TSP/MRLS/mrlsListing.aspx; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=musculoskeletal; STUDY_GROUP=ATSDR MRLs:15447080:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_99a9c733ea9167189d57d019e4651945 |
| ToxValDB_ATSDR_MRLs | NOAEL | =0.15 | mg/kg bw/day | Human | oral | chronic; 1 years | epidemiologic | LONG_REF=Li Y, Liang C, Slemenda CW, et al. 2001. Effect of long-term exposure to fluoride in drinking water on risks of bone fractures. J Bone Miner Res 16:932-939.; TITLE=Effect of long-term exposure to fluoride in drinking water on risks of bone fractures; AUTHOR=Li Y; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6568f4f3e4b063812d585791; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.atsdr.cdc.gov/ToxProfiles/tp11.pdf; TOXICOLOGICAL_EFFECT=musculoskeletal; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ATSDR MRLs:15447612:M/F:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c4f47d572bf6382ac2e8127ef66edf26 |
ToxValDB_DOE_Wildlife_Benchmarks 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_DOE_Wildlife_Benchmarks | LOAEL | =52.75 | mg/kg bw/day | Mink | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511630_15511631:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e19a3f91b1a901d9c8b6c45699a844a8 |
| ToxValDB_DOE_Wildlife_Benchmarks | NOAEL | =31.37 | mg/kg bw/day | Mink | oral | - | repeat dose other | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65bd1d53e4b063812d68c240; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://rais.ornl.gov/documents/tm86r3.pdf; STUDY_GROUP=DOE Wildlife Benchmarks_dup_-_15511630_15511631:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_75ce037e29eb660b2c36740fcacf86bd |
ToxValDB_ECHA_IUCLID 19 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LEL | ~22.3 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3825; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13757/7/8?documentUUID=bd201942-e9ab-4653-9c02-841517ff66be; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816681_15817291_15817346_15818931_15820311_15820312_15820313_15820314:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_349a303dccf5314c4eb3489969cd7d4a |
| ToxValDB_ECHA_IUCLID | LOAEC | >=6.3 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3823; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14922/7/8?documentUUID=40e2f9a3-b07b-4ee9-b018-4d4d5267a7e4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817461_15818386_15818901_15819910_15820319_15820320_15820321_15820322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_0e3e65b6116847a0f90c0ef686c4596e |
| ToxValDB_ECHA_IUCLID | LOAEL | ~4 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3827; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13757/7/8?documentUUID=bd201942-e9ab-4653-9c02-841517ff66be; YEAR=2001; ORIGINAL_YEAR=2001; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816065_15818015_15818258_15819920_15820307_15820308_15820309_15820310:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2fa7bd1ba47967815797dff22b965504 |
| ToxValDB_ECHA_IUCLID | LOAEL | ~12.6 | mg/kg bw/day | Mouse | oral | chronic; 26 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead05e4b0a7c65d1c2107; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/5820/7/6/2?documentUUID=f4d2c3cf-f0a2-4b7d-945c-774dfeeab35f; YEAR=1991; ORIGINAL_YEAR=1991; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15830442_15833808_15834445_15845302_15850514_15850515_15850516_15850517:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fa075c3b02499a3dff578bb47c23aafe |
| ToxValDB_ECHA_IUCLID | LOEC | ~250 | ppm | Rat | oral | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231c8b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24788/7/9/3?documentUUID=f1416c13-6383-40dd-8e02-5f81b2043b58; YEAR=1959; ORIGINAL_YEAR=1959; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820764_15821812:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5505184274f33bbb5132f564f1e5ec0d |
| ToxValDB_ECHA_IUCLID | NOAEC | >300 | ppm | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231c2e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24194/7/9/3?documentUUID=6e1350b5-6d86-4d09-9ad0-6f1827cfb68b; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15820684_15820987_15821783_15821879:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6bfd0f1e903c8a69ee7e9186ffc78796 |
| ToxValDB_ECHA_IUCLID | NOAEC | >=400 | ppm | Rabbit | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231c9e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24788/7/9/3?documentUUID=f1416c13-6383-40dd-8e02-5f81b2043b58; YEAR=1959; ORIGINAL_YEAR=1959; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15821037_15821892_15821915:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f9b158a96995578db370089928e658e0 |
| ToxValDB_ECHA_IUCLID | NOAEC | ~25 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac6ee4b0a7c65d1bf142; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21956/7/9/3?documentUUID=786037b2-0f95-4150-81da-a521868057f4; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15823482_15823548:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6d40c60e421090e8d2784d4ab8675b21 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~25 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b381f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14922/7/8?documentUUID=40e2f9a3-b07b-4ee9-b018-4d4d5267a7e4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816065_15818015_15818258_15819920_15820307_15820308_15820309_15820310:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ff32ff0840a35a529bf423d096a11ac0 |
| ToxValDB_ECHA_IUCLID | NOAEL | >=44.1 | mg/kg bw/day | Mouse | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3823; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14922/7/8?documentUUID=40e2f9a3-b07b-4ee9-b018-4d4d5267a7e4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15817461_15818386_15818901_15819910_15820319_15820320_15820321_15820322:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_973a542a2147fd440726455dc1cc0a9b |
| ToxValDB_ECHA_IUCLID | NOAEL | ~5.575 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa25e4b0a7c65d1b479c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25032/7/8?documentUUID=39e6f8ac-9f1a-4354-a7e5-8675f357361b; YEAR=1985; ORIGINAL_YEAR=1985; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816681_15817291_15817346_15818931_15820311_15820312_15820313_15820314:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6b764bc739bfa1df141dfce83a4c0e67 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~39.025 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9f0e4b0a7c65d1b3821; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14922/7/8?documentUUID=40e2f9a3-b07b-4ee9-b018-4d4d5267a7e4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15820315_15820316_15820317_15820318:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_926366cf8af39187c5402badaf08251b |
| ToxValDB_ECHA_IUCLID | NOAEL | =150 | ppm | Rat | oral | - | reproduction developmental | GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231ca6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24359/7/9/3?documentUUID=12c81ac2-f87c-4fca-90e3-d92fed26853e; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15822318:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_668b2cb1402765961a5b42f6c776527c |
| ToxValDB_ECHA_IUCLID | NOAEL | =200 | ppm | Rabbit | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231cc1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24359/7/9/3?documentUUID=12c81ac2-f87c-4fca-90e3-d92fed26853e; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15823182:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7ed548387550a737ea0ee4a3c1c5b4c5 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~25 | ppm | Rat | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7caace4b0a7c65d2230b0; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14922/7/6/2?documentUUID=40e2f9a3-b07b-4ee9-b018-4d4d5267a7e4; YEAR=1989; ORIGINAL_YEAR=1989; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833248_15835817_15838158_15838168:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3daed813f9037c33062a2d6c13b98b05 |
| ToxValDB_ECHA_IUCLID | NOAEL | ~5.3 | mg/kg bw/day | Rat | oral | chronic; 2 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefce4b0a7c65d1cc039; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/21956/7/6/2?documentUUID=786037b2-0f95-4150-81da-a521868057f4; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=histopathology: nonneoplastic; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID:15848129:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_46f37ae9a4efd7a905c749d8b9cd84df |
| ToxValDB_ECHA_IUCLID | NOAEL | =2.52 | mg/kg bw/day | Mouse | oral | chronic; 26 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefce4b0a7c65d1cc02c; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24359/7/6/2?documentUUID=12c81ac2-f87c-4fca-90e3-d92fed26853e; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID:15849887:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d9b240fe40d900087cd544f68ec88830 |
| ToxValDB_ECHA_IUCLID | NOEC | ~175 | ppm | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d225e4b0a7c65d231c8b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24788/7/9/3?documentUUID=f1416c13-6383-40dd-8e02-5f81b2043b58; YEAR=1959; ORIGINAL_YEAR=1959; STUDY_GROUP=ECHA IUCLID_dup_Developmental Toxicity Teratogenicity_15822101_15823094:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b7bc15d80d7cef9972bff5a76f1623e1 |
| ToxValDB_ECHA_IUCLID | NOEL | =6.69 | mg/kg bw/day | Rat | oral | chronic; 26 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaefce4b0a7c65d1cc024; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24359/7/6/2?documentUUID=12c81ac2-f87c-4fca-90e3-d92fed26853e; YEAR=2017; ORIGINAL_YEAR=2017; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15833390_15849884:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c62c1b6956b6922a87bfa4e4017ca70 |
ToxValDB_ECOTOX 85 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =0.072 | mg/mL | Rat | dermal | acute; 0.125 days | acute | LONG_REF=Gen. Comp. Endocrinol.2(5): 473-479 Talmage,R.V., and S.B. Doty The Effect of Sodium Fluoride on Parathyroid Function in the Rat as Studied by Peritoneal Lavage 1962; TITLE=The Effect of Sodium Fluoride on Parathyroid Function in the Rat as Studied by Peritoneal Lavage; AUTHOR=Talmage,R.V., and S.B. Doty; DOI=10.1016/0016-6480(62)90045-x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98957; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1962; ORIGINAL_YEAR=1962; TOXICOLOGICAL_EFFECT=Physiology: Calcium excretion; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX:15594087:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=15b68183756c503c772a22826e00255e |
| ToxValDB_ECOTOX | LOEL | =100 | mg/L | Rat | oral | subchronic; 90 days | subchronic | LONG_REF=Bone (New York)16(1): 163-169 Sogaard,C.H., L. Mosekilde, W. Schwartz, G. Leidig, H.W. Minne, and R. Ziegler Effects of Fluoride on Rat Vertebral Body Biomechanical Competence and Bone Mass 1995; TITLE=Effects of Fluoride on Rat Vertebral Body Biomechanical Competence and Bone Mass; AUTHOR=Sogaard,C.H., L. Mosekilde, W. Schwartz, G. Leidig, H.W. Minne, and R. Ziegler; DOI=10.1016/s8756-3282(94)00025-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98753; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Ash content|Physiology: Compression strength; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594450_15606576:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2d8843456bf449df796aa80b02dce162 |
| ToxValDB_ECOTOX | LOEL | =100 | mg/kg bw/day | Rat | oral | acute; 0.125 days | acute | LONG_REF=Arch. Toxicol.59(4): 285-289 Hohenegger,M., I. Huber, H. Echsel, R. Skolek-Winnisch, and M. Vermes Metabolism of Free Fatty Acids (FA) and Triacylglycerol (TG) in Acute and Subacute Fluoride Intoxication of the Rat 1986; TITLE=Metabolism of Free Fatty Acids (FA) and Triacylglycerol (TG) in Acute and Subacute Fluoride Intoxication of the Rat; AUTHOR=Hohenegger,M., I. Huber, H. Echsel, R. Skolek-Winnisch, and M. Vermes; DOI=10.1007/BF00290552; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98009; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Accumulation: Accumulation, general|Biochemistry: Glucose|Physiology: Oxygen consumption; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|other; STUDY_GROUP=ECOTOX:15594616:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ab02bb2376ddd9ff640663647c15c5f2 |
| ToxValDB_ECOTOX | LOEL | =226 | mg/L | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=Fluoride36(3): 189-197 Ekambaram,P., and V. Paul Effect of Vitamin D on Chronic Behavioral and Dental Toxicities of Sodium Fluoride in Rats 2003; TITLE=Effect of Vitamin D on Chronic Behavioral and Dental Toxicities of Sodium Fluoride in Rats; AUTHOR=Ekambaram,P., and V. Paul; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98382; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Behavior: Motility|Biochemistry: Calcium content|Enzyme(s): Acetylcholinesterase|Feeding behavior: Food consumption|Growth: Weight|Histology: Lesions; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|neurobehavior|neurotransmitter|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15594981:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1357ad63eff6472b5ce60c38038f1da7 |
| ToxValDB_ECOTOX | LOEL | =20 | mg/L | Rat | oral | short-term; 28 days | short-term | LONG_REF=Fluoride45(3): 242-246 Dubey,N., R. Raina, and A.M. Khan Toxic Effects of Deltamethrin and Fluoride on Antioxidant Parameters in Rats 2012; TITLE=Toxic Effects of Deltamethrin and Fluoride on Antioxidant Parameters in Rats; AUTHOR=Dubey,N., R. Raina, and A.M. Khan; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=168348; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=Biochemistry: Malondialdehyde|Enzyme(s): Catalase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione S-transferase|Enzyme(s): Superoxide dismutase (SOD) enzyme activity; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595005_15595006:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f4c7d878fcaf904199e9fabff1c8b1ea |
| ToxValDB_ECOTOX | LOEL | =5 | mg/kg bw/day | European Rabbit | injection | chronic; 100 days | chronic | LONG_REF=Fluoride27(3): 155-159 Shashi,A., J.P. Singh, and S.P. Thapar Effect of Long-Term Administration of Fluoride on Levels of Protein, Free Amino Acids and RNA in Rabbit Brain 1994; TITLE=Effect of Long-Term Administration of Fluoride on Levels of Protein, Free Amino Acids and RNA in Rabbit Brain; AUTHOR=Shashi,A., J.P. Singh, and S.P. Thapar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98959; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Soluble proteins|Genetics: RNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595057:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7e09e379ac998a8304da2a7bc8af410b |
| ToxValDB_ECOTOX | LOEL | =300 | mg/L | Rat | oral | chronic; 182 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595117_15595118_15603722:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ad7086b35132cc2bbd551b255011ff1a |
| ToxValDB_ECOTOX | LOEL | =9 | mg/L | Rat | oral | subchronic; 75 days | subchronic | LONG_REF=BioMetals18(3): 207-212 Pushpalatha,T., M. Srinivas, and P. Sreenivasula Reddy Exposure to High Fluoride Concentration in Drinking Water Will Affect Spermatogenesis and Steroidogenesis in Male Albino Rats 2005; TITLE=Exposure to High Fluoride Concentration in Drinking Water Will Affect Spermatogenesis and Steroidogenesis in Male Albino Rats; AUTHOR=Pushpalatha,T., M. Srinivas, and P. Sreenivasula Reddy; DOI=10.1007/s10534-005-0336-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98573; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595131_15595132_15595133:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9016df9c139121d452f5ff3968875d5e |
| ToxValDB_ECOTOX | LOEL | =99.98 | mg/L | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=Anat. Rec.237(2): 243-258 Smith,C.E., A. Nanci, and P.K. Denbesten Effects of Chronic Fluoride Exposure on Morphometric Parameters Defining the Stages of Amelogenesis and Ameloblast Modulation in Rat Incisors 1993; TITLE=Effects of Chronic Fluoride Exposure on Morphometric Parameters Defining the Stages of Amelogenesis and Ameloblast Modulation in Rat Incisors; AUTHOR=Smith,C.E., A. Nanci, and P.K. Denbesten; DOI=10.1002/ar.1092370212; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98111; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Histology: Histological changes, general|Morphology: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595192_15596778:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f8234154d41e68e9e654d5372b5bfd2c |
| ToxValDB_ECOTOX | LOEL | =35 | mg/kg bw/day | Rat | injection | acute; 0.125 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.80(2): 199-205 Suketa,Y., Y. Asao, Y. Kanamoto, T. Sakashita, and S. Okada Changes in Adrenal Function as a Possible Mechanism for Elevation of Serum Glucose by a Single Large Dose of Fluoride 1985; TITLE=Changes in Adrenal Function as a Possible Mechanism for Elevation of Serum Glucose by a Single Large Dose of Fluoride; AUTHOR=Suketa,Y., Y. Asao, Y. Kanamoto, T. Sakashita, and S. Okada; DOI=10.1016/0041-008x(85)90076-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98005; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Enzyme(s): Glucose-6-phosphatase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15595761:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3a79131ae12f9114e94582da6e3dedb1 |
| ToxValDB_ECOTOX | LOEL | =1 | mg/kg bw/day | Rat | injection | short-term; 15 days | short-term | LONG_REF=Reprod. Toxicol.5(6): 505-512 Chinoy,N.J., M.V. Rao, M.V. Narayana, and E. Neelakanta Microdose Vasal Injection of Sodium Fluoride in the Rat 1991; TITLE=Microdose Vasal Injection of Sodium Fluoride in the Rat; AUTHOR=Chinoy,N.J., M.V. Rao, M.V. Narayana, and E. Neelakanta; DOI=10.1016/0890-6238(91)90022-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98178; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Sialic acid|Cell(s): Height|Enzyme(s): Succinate dehydrogenase|Morphology: Weight|Reproduction: Motility; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other|reproduction; STUDY_GROUP=ECOTOX:15595888:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f48f2b0cf3b206195a14cfd683460586 |
| ToxValDB_ECOTOX | LOEL | =20 | mg/kg bw/day | Rat | injection | acute; 0.0035 days | acute | LONG_REF=J. Dent. Res.64(11): 1281-1285 Monsour,P.A., B.J. Kruger, and J.R. Smid Effects of a Single Intravenous Dose of Sodium Fluoride on Plasma Electrolytes and Metabolites in Rats, Rabbits, and Cockerels 1985; TITLE=Effects of a Single Intravenous Dose of Sodium Fluoride on Plasma Electrolytes and Metabolites in Rats, Rabbits, and Cockerels; AUTHOR=Monsour,P.A., B.J. Kruger, and J.R. Smid; DOI=10.1177/00220345850640110501; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98956; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595910_15609837:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=799efb2c6ed16203f8436d763d94d400 |
| ToxValDB_ECOTOX | LOEL | =9.4 | mg/kg bw/day | Rat | injection | acute; 1 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.37(3): 445-453 Conine,D.L., G.K. Stookey, and R.B. Forney Toxicity of Sodium Pentafluorostannite, a new Anticariogenic Agent. II. Contribution of Tin to the Acute Toxicity of Sodium Pentafluorostannite in the Rat 1976; TITLE=Toxicity of Sodium Pentafluorostannite, a new Anticariogenic Agent. II. Contribution of Tin to the Acute Toxicity of Sodium Pentafluorostannite in the Rat; AUTHOR=Conine,D.L., G.K. Stookey, and R.B. Forney; DOI=10.1016/0041-008x(76)90206-4; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98338; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Physiology: Excretion rate; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595935:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=000617737bc0f93796e38f92a5e79ba5 |
| ToxValDB_ECOTOX | LOEL | =175 | mg/L | Rat | oral | short-term; 10 days | short-term | LONG_REF=Neurotoxicol. Teratol.17(2): 169-177 Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan Neurotoxicity of Sodium Fluoride in Rats 1995; TITLE=Neurotoxicity of Sodium Fluoride in Rats; AUTHOR=Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan; DOI=10.1016/0892-0362(94)00070-t; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97989; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15596201:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=05bc48248c935bdc142ba93537c5202b |
| ToxValDB_ECOTOX | LOEL | =50 | mg/L | Rat | oral | chronic; 180 days | reproduction developmental | LONG_REF=J. Appl. Toxicol.23(6): 437-446 Aydin,G., E. Cicek, M. Akdogan, and O. Gokalp Histopathological and Biochemical Changes in Lung Tissues of Rats Following Administration of Fluoride Over Several Generations 2003; TITLE=Histopathological and Biochemical Changes in Lung Tissues of Rats Following Administration of Fluoride Over Several Generations; AUTHOR=Aydin,G., E. Cicek, M. Akdogan, and O. Gokalp; DOI=10.1002/jat.935; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98404; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Growth: Weight|Injury: Inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596936_15596937_15600410_15600694:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e4c43c019800d37c597d3647c243a6cc |
| ToxValDB_ECOTOX | LOEL | =20 | mM | Mouse | oral | acute; 0.0556 days | acute | LONG_REF=Exp. Toxicol. Pathol.57(1): 59-64 Amira,S., S. Soufane, and K. Gharzouli Effect of Sodium Fluoride on Gastric Emptying and Intestinal Transit in Mice 2005; TITLE=Effect of Sodium Fluoride on Gastric Emptying and Intestinal Transit in Mice; AUTHOR=Amira,S., S. Soufane, and K. Gharzouli; DOI=10.1016/j.etp.2005.04.002; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98750; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Physiology: Physiology, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596951_15596952:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e527cd9e7dbbf7696d323a0ac8887870 |
| ToxValDB_ECOTOX | LOEL | =5000 | mg/kg bw/day | Mouse | injection | acute; 0.0003 days | acute | LONG_REF=Biochem. Pharmacol.21(1): 115-117 Leonard,B.E. Effect of Phentolamine on the Increase in Brain Glycolysis Following the Intraventricular Administration of Dibutyryl-3,5-Cyclic Adenosine Monophosphate and Sodium Fluoride to Mice 1972; TITLE=Effect of Phentolamine on the Increase in Brain Glycolysis Following the Intraventricular Administration of Dibutyryl-3,5-Cyclic Adenosine Monophosphate and Sodium Fluoride to Mice; AUTHOR=Leonard,B.E.; DOI=10.1016/0006-2952(72)90257-2; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=99010; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1972; ORIGINAL_YEAR=1972; TOXICOLOGICAL_EFFECT=Biochemistry: Glucose; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15597179:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=78f6399af263777c58de3da4fed55e7c |
| ToxValDB_ECOTOX | LOEL | =5 | mg/L | Rat | oral | short-term; 14 days | short-term | LONG_REF=Fluoride36(4): 263-266 Inkielewicz,I., and J. Krechniak Fluoride Content in Soft Tissues and Urine of Rats Exposed to Sodium Fluoride in Drinking Water 2003; TITLE=Fluoride Content in Soft Tissues and Urine of Rats Exposed to Sodium Fluoride in Drinking Water; AUTHOR=Inkielewicz,I., and J. Krechniak; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98391; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15597226:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a6b6f6eb680f5f6591992a548b9725bf |
| ToxValDB_ECOTOX | LOEL | =5 | mM | Rat | oral | chronic; 100 days | chronic | LONG_REF=Bone Miner.16(2): 101-108 Rigalli,A., J.C. Ballina, and R.C. Puche Bone Mass Increase and Glucose Tolerance in Rats Chronically Treated with Sodium Fluoride 1992; TITLE=Bone Mass Increase and Glucose Tolerance in Rats Chronically Treated with Sodium Fluoride; AUTHOR=Rigalli,A., J.C. Ballina, and R.C. Puche; DOI=10.1016/0169-6009(92)90880-m; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98862; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597239_15599529:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b6e9a4b5928d817ce3d08d16ec4e491e |
| ToxValDB_ECOTOX | LOEL | =30 | mg/kg bw/day | Mouse | injection | acute; 1 days | reproduction developmental | LONG_REF=Environ. Res.37(2): 461-474 Daston,G.P., B.F. Rehnberg, B. Carver, and R.J. Kavlock Toxicity of Sodium Fluoride to the Postnatally Developing Rat Kidney 1985; TITLE=Toxicity of Sodium Fluoride to the Postnatally Developing Rat Kidney; AUTHOR=Daston,G.P., B.F. Rehnberg, B. Carver, and R.J. Kavlock; DOI=10.1016/0013-9351(85)90128-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98336; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Growth: Weight|Morphology: Weight|Physiology: Osmolality; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597304_15603143_15603144:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3cc4ba12ed023e8cbeaf2679be93640a |
| ToxValDB_ECOTOX | LOEL | =125 | mg/L | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=Neurotoxicol. Teratol.17(2): 169-177 Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan Neurotoxicity of Sodium Fluoride in Rats 1995; TITLE=Neurotoxicity of Sodium Fluoride in Rats; AUTHOR=Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan; DOI=10.1016/0892-0362(94)00070-t; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97989; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597323_15597324_15598688_15599594:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9b57f229c85c7e882668732a212984c |
| ToxValDB_ECOTOX | LOEL | =100 | ppm | Mouse | oral | short-term; 7 days | short-term | LONG_REF=Geobios22(1): 18-21 Sondhi,H., M.L. Gupta, and G.L. Gupta Effects of Sodium Fluoride on Swiss Albino Mice 1995; TITLE=Effects of Sodium Fluoride on Swiss Albino Mice; AUTHOR=Sondhi,H., M.L. Gupta, and G.L. Gupta; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98182; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Glycogen|Enzyme(s): Acid phosphatase|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|organ weight|other; STUDY_GROUP=ECOTOX:15597468:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5a527802ae829a53faa021486a2ea120 |
| ToxValDB_ECOTOX | LOEL | =400 | mg/L | Rat | oral | short-term; 14 days | short-term | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599110_15599111:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0fda50e361ad32ee6f79a61916927264 |
| ToxValDB_ECOTOX | LOEL | =94.3 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Arch. Toxicol.73(6): 346-351 Usuda,K., K. Kono, T. Dote, H. Nishiura, and T. Tagawa Usefulness of the Assessment of Urinary Enzyme Leakage in Monitoring Acute Fluoride Nephrotoxicity 1999; TITLE=Usefulness of the Assessment of Urinary Enzyme Leakage in Monitoring Acute Fluoride Nephrotoxicity; AUTHOR=Usuda,K., K. Kono, T. Dote, H. Nishiura, and T. Tagawa; DOI=10.1007/s002040050628; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98249; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutathione S-transferase|Physiology: Volume; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599124_15599125_15605993:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=11b58ce8bdd89ecc28e22c0bdda7072c |
| ToxValDB_ECOTOX | LOEL | =24 | mM | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Food Chem. Toxicol.24(1): 33-36 Shayiq,R.M., H. Raza, and A.M. Kidwai Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ 1986; TITLE=Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ; AUTHOR=Shayiq,R.M., H. Raza, and A.M. Kidwai; DOI=10.1016/0278-6915(86)90261-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Potassium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595872_15599653_15599654_15600219_15607251_15610369_15610557:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6d30cad3857c32f9233d4da2d3a4a368 |
| ToxValDB_ECOTOX | LOEL | =5 | ppm | Rat | multiple | subchronic; 80 days | subchronic | LONG_REF=Biomed. Environ. Sci.11(1): 1-6 Zhao,X.L., and J.H. Wu Actions of Sodium Fluoride on Acetylcholinesterase Activities in Rats 1998; TITLE=Actions of Sodium Fluoride on Acetylcholinesterase Activities in Rats; AUTHOR=Zhao,X.L., and J.H. Wu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98472; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Enzyme(s): Acetylcholinesterase; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600015_15600016:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44f83bae74ee2d8d880c4b0814672f0a |
| ToxValDB_ECOTOX | LOEL | =96 | mM | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Food Chem. Toxicol.24(1): 33-36 Shayiq,R.M., H. Raza, and A.M. Kidwai Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ 1986; TITLE=Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ; AUTHOR=Shayiq,R.M., H. Raza, and A.M. Kidwai; DOI=10.1016/0278-6915(86)90261-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Biochemistry: Potassium content|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595872_15599653_15599654_15600219_15607251_15610369_15610557:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f98c888860bf6cc94e17464edc8ec33f |
| ToxValDB_ECOTOX | LOEL | =500 | mg/L | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=Environ. Toxicol. Pharmacol.9(4): 141-146 Ekambaram,P., and V. Paul Calcium Preventing Locomotor Behavioral and Dental Toxicities of Fluoride by Decreasing Serum Fluoride Level in Rats 2001; TITLE=Calcium Preventing Locomotor Behavioral and Dental Toxicities of Fluoride by Decreasing Serum Fluoride Level in Rats; AUTHOR=Ekambaram,P., and V. Paul; DOI=10.1016/s1382-6689(00)00063-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98335; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Behavior: Movements, number of|Biochemistry: Calcium content|Enzyme(s): Acetylcholinesterase|Feeding behavior: Food consumption|Growth: Weight|Histology: Lesions; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|food and/or water consumption|neurobehavior|neurotransmitter|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15600297:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e581a9d1e3859ed24971686b6e933d61 |
| ToxValDB_ECOTOX | LOEL | =10 | mg/kg bw/day | Rat | injection | chronic; 112 days | chronic | LONG_REF=Bone (New York)20(5): 439-449 Sogaard,C.H., L. Mosekilde, J.S. Thomsen, A. Richards, and J.E. McOsker A Comparison of the Effects of Two Anabolic Agents (Fluoride and PTH) on Ash Density and Bone Strength Assessed in an Osteopenic Rat Model 1997; TITLE=A Comparison of the Effects of Two Anabolic Agents (Fluoride and PTH) on Ash Density and Bone Strength Assessed in an Osteopenic Rat Model; AUTHOR=Sogaard,C.H., L. Mosekilde, J.S. Thomsen, A. Richards, and J.E. McOsker; DOI=10.1016/s8756-3282(97)00020-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=98845; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600790_15600791_15604402_15605707:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=40a53a24293e8f9ab42964cae1db415c |
| ToxValDB_ECOTOX | LOEL | =5.82 | mg/L | Mouse | oral | subchronic; 84 days | subchronic | LONG_REF=Fluoride34(4): 242-249 Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice 2001; TITLE=Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice; AUTHOR=Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98674; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Reproduction: Pregnant, Paris or Gravid; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596137_15600999_15603102_15603103:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=336c336ce1055834973897015bcc3ec9 |
| ToxValDB_ECOTOX | LOEL | =68 | mg/L | Rat | oral | subchronic; 50 days | subchronic | LONG_REF=Fluoride39(1): 17-21 Wan,S., J. Zhang, and J. Wang Effects of High Fluoride on Sperm Quality and Testicular Histology in Male Rats 2006; TITLE=Effects of High Fluoride on Sperm Quality and Testicular Histology in Male Rats; AUTHOR=Wan,S., J. Zhang, and J. Wang; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98572; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Cell(s): Viability|Morphology: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX:15601679:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=14673c5638754013b07d70236d04a923 |
| ToxValDB_ECOTOX | LOEL | =10 | mg/L | Mouse | oral | chronic; 182 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Accumulation: Uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601731_15605306:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea4f74f743e3a2240287cfe71ef8291b |
| ToxValDB_ECOTOX | LOEL | =18.43 | mg/L | Mouse | oral | short-term; 28 days | developmental | LONG_REF=Fluoride34(4): 242-249 Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice 2001; TITLE=Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice; AUTHOR=Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98674; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601839_15601840:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3d5486e7ace6728457e6dc0297482a52 |
| ToxValDB_ECOTOX | LOEL | =25 | mg/L | Mouse | oral | chronic; 168 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Accumulation: Uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602478:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ad1b9ba3b1e18aad2ef914d990052f12 |
| ToxValDB_ECOTOX | LOEL | =72 | mg/kg bw/day | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.69(1): 138-142 Maxwell,J.A., J.L. Caffrey, T. Yorio, and R.J. Sinclair Fluoride-Induced Changes in Renal Papillary Cyclic-AMP 1983; TITLE=Fluoride-Induced Changes in Renal Papillary Cyclic-AMP; AUTHOR=Maxwell,J.A., J.L. Caffrey, T. Yorio, and R.J. Sinclair; DOI=10.1016/0041-008x(83)90129-1; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=98242; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Biochemistry: Adenosine 3\',5\'-cyclic monophosphate|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|other; STUDY_GROUP=ECOTOX:15602672:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f36c596d158a8ea2ce1cbe8d8d25e138 |
| ToxValDB_ECOTOX | LOEL | =4.2 | mg/300 g | Rat | injection | short-term; 2 days | short-term | LONG_REF=Toxicol. Appl. Pharmacol.37(2): 349-361 Brodeur,J., P. Paquin, L. Authier, D. Geadah, M. Yamauchi, and M.G. Cote Influence of Phenobarbital Pretreatment on Methoxyflurane and Sodium Fluoride Nephropathy in Fischer 344 Rats 1976; TITLE=Influence of Phenobarbital Pretreatment on Methoxyflurane and Sodium Fluoride Nephropathy in Fischer 344 Rats; AUTHOR=Brodeur,J., P. Paquin, L. Authier, D. Geadah, M. Yamauchi, and M.G. Cote; DOI=10.1016/0041-008x(76)90098-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98403; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1976; ORIGINAL_YEAR=1976; TOXICOLOGICAL_EFFECT=Accumulation: Uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602908:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8efece368d85ef593d590b5e6c7966c5 |
| ToxValDB_ECOTOX | LOEL | =12.74 | mg/L | Mouse | oral | subchronic; 84 days | subchronic | LONG_REF=Fluoride34(4): 242-249 Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice 2001; TITLE=Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice; AUTHOR=Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98674; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596137_15600999_15603102_15603103:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2514927026db9a37a6a51bea622fcebd |
| ToxValDB_ECOTOX | LOEL | =8 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Bull. Environ. Contam. Toxicol.74(3): 566-572 Velazquez-Guadarrama,N., E. Madrigal-Bujaidar, D. Molina, and G. Chamorro Genotoxic Evaluation of Sodium Fluoride and Sodium Perborate in Mouse Bone Marrow Cells 2005; TITLE=Genotoxic Evaluation of Sodium Fluoride and Sodium Perborate in Mouse Bone Marrow Cells; AUTHOR=Velazquez-Guadarrama,N., E. Madrigal-Bujaidar, D. Molina, and G. Chamorro; DOI=10.1007/s00128-005-0621-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=97957; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: Genetics, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603329_15603330:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=94365439c61c5f8a12d19800bc9a25b4 |
| ToxValDB_ECOTOX | LOEL | =135 | ppm | Rat | oral | acute; 1 days | acute | LONG_REF=Arch. Toxicol.72(2): 104-109 Usuda,K., K. Kono, T. Dote, K. Nishiura, K. Miyata, H. Nishiura, M. Shimahara, and K. Sugimoto Urinary Biomarkers Monitoring for Experimental Fluoride Nephrotoxicity 1998; TITLE=Urinary Biomarkers Monitoring for Experimental Fluoride Nephrotoxicity; AUTHOR=Usuda,K., K. Kono, T. Dote, K. Nishiura, K. Miyata, H. Nishiura, M. Shimahara, and K. Sugimoto; DOI=10.1007/s002040050475; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=97995; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Accumulation: Elimination|Biochemistry: Creatinine|Enzyme(s): Glutathione S-transferase|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|gross pathology|other|urinalysis; STUDY_GROUP=ECOTOX:15605193:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=fd0ebdf6276a5b1e98be25d4d8a0c301 |
| ToxValDB_ECOTOX | LOEL | =2.99 | mg/L | Mouse | oral | chronic; 147 days | chronic | LONG_REF=J. Dent. Res.68(11): 1525-1528 Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies 1989; TITLE=Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies; AUTHOR=Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey; DOI=10.1177/00220345890680111101; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98306; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600619_15605339_15605340:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9e50fc20a0627131e283268340d0dcb2 |
| ToxValDB_ECOTOX | LOEL | =0.9 | mg/kg bw/day | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Toxicology24(3-4): 313-323 Strubelt,O., H. Iven, and M. Younes The Pathophysiological Profile of the Acute Cardiovascular Toxicity of Sodium Fluoride 1982; TITLE=The Pathophysiological Profile of the Acute Cardiovascular Toxicity of Sodium Fluoride; AUTHOR=Strubelt,O., H. Iven, and M. Younes; DOI=10.1016/0300-483x(82)90013-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98946; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15607367:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c9820bc502318a6057e6aae20c2f4953 |
| ToxValDB_ECOTOX | LOEL | =200 | mg/L | Mouse | oral | chronic; 182 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604230_15608930_15608931:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b3d974b91d3ea61c0d41e2083ea55877 |
| ToxValDB_ECOTOX | LOEL | =1296 | mg/kg bw/day | Rat | injection | acute; 0.0069 days | acute | LONG_REF=Toxicology24(3-4): 313-323 Strubelt,O., H. Iven, and M. Younes The Pathophysiological Profile of the Acute Cardiovascular Toxicity of Sodium Fluoride 1982; TITLE=The Pathophysiological Profile of the Acute Cardiovascular Toxicity of Sodium Fluoride; AUTHOR=Strubelt,O., H. Iven, and M. Younes; DOI=10.1016/0300-483x(82)90013-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98946; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Biochemistry: CO2 concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15610290:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=6dd24daf27d3dfe85e89c621c4f466a1 |
| ToxValDB_ECOTOX | LOEL | =50 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | LONG_REF=- | Biomed. Environ. Sci.19(6): 439-444 Yu,R.A., T. Xia, A.G. Wang, and X.M. Chen Effects of Selenium and Zinc on Renal Oxidative Stress and Apoptosis Induced by Fluoride in Rats 2006; TITLE=Effects of Selenium and Zinc on Renal Oxidative Stress and Apoptosis Induced by Fluoride in Rats; AUTHOR=Yu,R.A., T. Xia, A.G. Wang, and X.M. Chen; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=102017; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Biochemistry: Reduced glutathione, kidney | Enzyme(s): Reduced Glutathione peroxidase, serum | Cell Viability: Apoptosis | Cell Cycle: G2/M percentage | Biochemistry: gamma-glutamyl transpeptidase, urine | Biochemistry: Increased malondialdehyde, kidney; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other|urinalysis; STUDY_GROUP=ECOTOX:15612912:M/F:-adult; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=fc2a21ba4495ca3af3af7306d3d662bc |
| ToxValDB_ECOTOX | LOEL | =40 | mg/kg bw/day | Rat | oral | short-term; 16 days | reproduction developmental | LONG_REF=- | Food Chem. Toxicol.40(4): 551-554 Verma,R.J., and D.M.G. Sherlin Hypocalcaemia in Parental and F1 Generation Rats Treated with Sodium Fluoride 2002; TITLE=Hypocalcaemia in Parental and F1 Generation Rats Treated with Sodium Fluoride; AUTHOR=Verma,R.J., and D.M.G. Sherlin; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=98247; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Phosphorus, calcium, potassium, sodium serum levels; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15612917:F:P0-; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=9c28d1d7431c0a492ebaf25878012e03 |
| ToxValDB_ECOTOX | LOEL | =0.1638 | mg/kg bw/day | Rat | oral | chronic; 364 days | chronic | LONG_REF=- | Ph.D.Thesis, State University of New York at Binghamton, NY:177 p. Varner,J.A. The Neurotoxicological Evaluation of the Chronic Administration of Aluminum-Fluoride and Sodium Fluoride in Drinking Water 1995; TITLE=The Neurotoxicological Evaluation of the Chronic Administration of Aluminum-Fluoride and Sodium Fluoride in Drinking Water; AUTHOR=Varner,J.A.; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78799; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Movements, spontaneous alternations|Histology: Histological changes, general; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior|nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15613424:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=442a2b2a803aac07bcc2fbe88a39cdee |
| ToxValDB_ECOTOX | LOEL | =0.7 | mg/kg bw/day | Dog | oral | chronic; 182.64 days | chronic | LONG_REF=- | Calcif. Tissue Int.38(4): 217-221 Snow,G.R., and C. Anderson Short-Term Chronic Fluoride Administration and Trabecular Bone Remodeling in Beagles: A Pilot Study 1986; TITLE=Short-Term Chronic Fluoride Administration and Trabecular Bone Remodeling in Beagles: A Pilot Study; AUTHOR=Snow,G.R., and C. Anderson; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98384; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Morphology: mean depth and volume density of the resorptive lacunae; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECOTOX:15613474:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=6ae48231ed47693f5ef41f8f05216743 |
| ToxValDB_ECOTOX | LOEL | =2.21 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | LONG_REF=- | Fluoride36(2): 113-121 Suska,M., R. Nowak, and B. Machalinski Serum Fluoride and the Content of Adenine Nucleotides and 2,3-Bisphosphoglycerate in Erythrocytes of Rats Exposed to Sodium Fluoride 2003; TITLE=Serum Fluoride and the Content of Adenine Nucleotides and 2,3-Bisphosphoglycerate in Erythrocytes of Rats Exposed to Sodium Fluoride; AUTHOR=Suska,M., R. Nowak, and B. Machalinski; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98383; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Increased fluoride ions, Decrease ATP, ADP, TAN and increased AMP and 2.3-BPG in red blood cells; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613555:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=af0709ac72f45e3c4d5d6e04dcbc56ef |
| ToxValDB_ECOTOX | NOEL | =250 | mg/L | Rat | oral | chronic; 238 days | chronic | LONG_REF=Food Chem. Toxicol.35(9): 881-890 Sprando,R.L., T.F.X. Collins, T.N. Black, J. Rorie, M.J. Ames, and M. O\'Donnell Testing the Potential of Sodium Fluoride to Affect Spermatogenesis in the Rat 1997; TITLE=Testing the Potential of Sodium Fluoride to Affect Spermatogenesis in the Rat; AUTHOR=Sprando,R.L., T.F.X. Collins, T.N. Black, J. Rorie, M.J. Ames, and M. O\'Donnell; DOI=10.1016/s0278-6915(97)88938-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97994; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Cell(s): Number of cells|Growth: Weight|Hormone(s): Testosterone; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|nonneoplastic histopathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594791_15603552_15603553:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=45e8b3cbf168aec1870f1d1a7781e070 |
| ToxValDB_ECOTOX | NOEL | =48 | mg/kg bw/day | Mouse | injection | short-term; 5 days | reproduction developmental | LONG_REF=Environ. Res.37(2): 461-474 Daston,G.P., B.F. Rehnberg, B. Carver, and R.J. Kavlock Toxicity of Sodium Fluoride to the Postnatally Developing Rat Kidney 1985; TITLE=Toxicity of Sodium Fluoride to the Postnatally Developing Rat Kidney; AUTHOR=Daston,G.P., B.F. Rehnberg, B. Carver, and R.J. Kavlock; DOI=10.1016/0013-9351(85)90128-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98336; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Growth: Weight|Morphology: Weight|Physiology: Volume; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other|urinalysis; STUDY_GROUP=ECOTOX:15594940:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ebec5705e5eb4344a43284577b9fd7a1 |
| ToxValDB_ECOTOX | NOEL | =0.13 | mg/kg bw/day | Rat | injection | subchronic; 70 days | subchronic | LONG_REF=Neurotoxicol. Teratol.17(2): 169-177 Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan Neurotoxicity of Sodium Fluoride in Rats 1995; TITLE=Neurotoxicity of Sodium Fluoride in Rats; AUTHOR=Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan; DOI=10.1016/0892-0362(94)00070-t; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=97989; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Behavioral changes, general|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|neurobehavior; STUDY_GROUP=ECOTOX:15594959:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0509a3b76040b3cbb3db0039a7f87035 |
| ToxValDB_ECOTOX | NOEL | =20 | mg/kg bw/day | Rat | injection | short-term; 5 days | reproduction developmental | LONG_REF=Toxicol. Lett.21(2): 163-166 Soni,M.G., and S.S. Pawar Effect of Sodium Fluoride on Hepatic Microsomal Mixed-Function Oxidase System in Newborn and Adult Male Rats 1984; TITLE=Effect of Sodium Fluoride on Hepatic Microsomal Mixed-Function Oxidase System in Newborn and Adult Male Rats; AUTHOR=Soni,M.G., and S.S. Pawar; DOI=10.1016/0378-4274(84)90200-5; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98238; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595015_15607655_15607656:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9ccd882178736a9bf0928775064d5c55 |
| ToxValDB_ECOTOX | NOEL | =175 | mg/L | Mouse | oral | chronic; 721 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Injury: Tumor induction|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|mortality/survival; STUDY_GROUP=ECOTOX:15595116:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=91493d5bc28642189c9243179d1700ca |
| ToxValDB_ECOTOX | NOEL | =100 | mg/L | Rat | oral | chronic; 182 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595117_15595118_15603722:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=44bbe616d5413bf054783c7392548fb2 |
| ToxValDB_ECOTOX | NOEL | =4.5 | mg/L | Rat | oral | subchronic; 75 days | subchronic | LONG_REF=BioMetals18(3): 207-212 Pushpalatha,T., M. Srinivas, and P. Sreenivasula Reddy Exposure to High Fluoride Concentration in Drinking Water Will Affect Spermatogenesis and Steroidogenesis in Male Albino Rats 2005; TITLE=Exposure to High Fluoride Concentration in Drinking Water Will Affect Spermatogenesis and Steroidogenesis in Male Albino Rats; AUTHOR=Pushpalatha,T., M. Srinivas, and P. Sreenivasula Reddy; DOI=10.1007/s10534-005-0336-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98573; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595131_15595132_15595133:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7f901788f08bad1727691f37bf48b1d9 |
| ToxValDB_ECOTOX | NOEL | =75 | mg/L | Rat | oral | subchronic; 42 days | subchronic | LONG_REF=Neurotoxicol. Teratol.17(2): 169-177 Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan Neurotoxicity of Sodium Fluoride in Rats 1995; TITLE=Neurotoxicity of Sodium Fluoride in Rats; AUTHOR=Mullenix,P.J., P.K. Denbesten, A. Schunior, and W.J. Kernan; DOI=10.1016/0892-0362(94)00070-t; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97989; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Behavior: Behavioral changes, general|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|neurobehavior; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595801_15595802_15606131:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=28ae653a8442249c98a58ca88fdb6252 |
| ToxValDB_ECOTOX | NOEL | =48 | mM | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Food Chem. Toxicol.24(1): 33-36 Shayiq,R.M., H. Raza, and A.M. Kidwai Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ 1986; TITLE=Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ; AUTHOR=Shayiq,R.M., H. Raza, and A.M. Kidwai; DOI=10.1016/0278-6915(86)90261-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595872_15599653_15599654_15600219_15607251_15610369_15610557:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f7b1d11a27ec1f45345e2a495ba61fab |
| ToxValDB_ECOTOX | NOEL | =0.25 | mmol/kg | Rat | injection | acute; 0.8333 days | acute | LONG_REF=Toxicol. Appl. Pharmacol.59(3): 452-456 Shargel,L., and J. Masnyj Effect of Stannous Fluoride and Sodium Fluoride on Hepatic Mixed-Function Oxidase Activities in the Rat 1981; TITLE=Effect of Stannous Fluoride and Sodium Fluoride on Hepatic Mixed-Function Oxidase Activities in the Rat; AUTHOR=Shargel,L., and J. Masnyj; DOI=10.1016/0041-008x(81)90297-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98240; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1981; ORIGINAL_YEAR=1981; TOXICOLOGICAL_EFFECT=Enzyme(s): Aminopyrine n-demethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15596007:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=39e205e4129940711af76bde93d93fa5 |
| ToxValDB_ECOTOX | NOEL | =18.85 | mg/L | Mouse | oral | subchronic; 84 days | subchronic | LONG_REF=Fluoride34(4): 242-249 Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice 2001; TITLE=Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice; AUTHOR=Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98674; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596137_15600999_15603102_15603103:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=787cb1db59d96c254b742ee9fe96896f |
| ToxValDB_ECOTOX | NOEL | =100 | ppm | Rat | oral | chronic; 180 days | reproduction developmental | LONG_REF=Hum. Exp. Toxicol.24(2): 79-87 Cicek,E., G. Aydin, M. Akdogan, and H. Okutan Effects of Chronic Ingestion of Sodium Fluoride on Myocardium in a Second Generation of Rats 2005; TITLE=Effects of Chronic Ingestion of Sodium Fluoride on Myocardium in a Second Generation of Rats; AUTHOR=Cicek,E., G. Aydin, M. Akdogan, and H. Okutan; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=98175; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=mortality/survival; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596440_15600628_15600629_15610444:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dc249c4d693f447d1861788f1709efe7 |
| ToxValDB_ECOTOX | NOEL | =10 | mg/L | Rat | oral | chronic; 180 days | reproduction developmental | LONG_REF=J. Appl. Toxicol.23(6): 437-446 Aydin,G., E. Cicek, M. Akdogan, and O. Gokalp Histopathological and Biochemical Changes in Lung Tissues of Rats Following Administration of Fluoride Over Several Generations 2003; TITLE=Histopathological and Biochemical Changes in Lung Tissues of Rats Following Administration of Fluoride Over Several Generations; AUTHOR=Aydin,G., E. Cicek, M. Akdogan, and O. Gokalp; DOI=10.1002/jat.935; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98404; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Superoxide dismutase (SOD) enzyme activity|Growth: Weight|Injury: Inflammation; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596936_15596937_15600410_15600694:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=a50afb96fcdf15e8a4cb75ad158a964c |
| ToxValDB_ECOTOX | NOEL | =5 | mM | Mouse | oral | acute; 0.0556 days | acute | LONG_REF=Exp. Toxicol. Pathol.57(1): 59-64 Amira,S., S. Soufane, and K. Gharzouli Effect of Sodium Fluoride on Gastric Emptying and Intestinal Transit in Mice 2005; TITLE=Effect of Sodium Fluoride on Gastric Emptying and Intestinal Transit in Mice; AUTHOR=Amira,S., S. Soufane, and K. Gharzouli; DOI=10.1016/j.etp.2005.04.002; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98750; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Physiology: Physiology, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596951_15596952:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ccde74f6c83ebe1ecf9cebb39224e4d0 |
| ToxValDB_ECOTOX | NOEL | =6 | mg/L | Rat | oral | subchronic; 56 days | subchronic | LONG_REF=Bone (New York)22(1): 39-43 Ammann,P., R. Rizzoli, J. Caverzasio, and J.P. Bonjour Fluoride Potentiates the Osteogenic Effects of IGF-I in Aged Ovariectomized Rats 1998; TITLE=Fluoride Potentiates the Osteogenic Effects of IGF-I in Aged Ovariectomized Rats; AUTHOR=Ammann,P., R. Rizzoli, J. Caverzasio, and J.P. Bonjour; DOI=10.1016/s8756-3282(97)00206-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98751; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Biochemistry: General biochemical effect|Morphology: Calcium weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15598116:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8e1980bd06f3d3bf68313f670752fdf3 |
| ToxValDB_ECOTOX | NOEL | =10 | mg/kg bw/day | European Rabbit | injection | chronic; 100 days | chronic | LONG_REF=Fluoride27(3): 155-159 Shashi,A., J.P. Singh, and S.P. Thapar Effect of Long-Term Administration of Fluoride on Levels of Protein, Free Amino Acids and RNA in Rabbit Brain 1994; TITLE=Effect of Long-Term Administration of Fluoride on Levels of Protein, Free Amino Acids and RNA in Rabbit Brain; AUTHOR=Shashi,A., J.P. Singh, and S.P. Thapar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98959; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Genetics: RNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598143_15598144_15600242:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bcb0faa95162bbccd3082bff54886c44 |
| ToxValDB_ECOTOX | NOEL | =200 | mg/L | Rat | oral | short-term; 14 days | short-term | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599110_15599111:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=54186302ab948fa68295ba48f9c140bb |
| ToxValDB_ECOTOX | NOEL | =70.8 | mg/kg bw/day | Rat | oral | acute; 1 days | acute | LONG_REF=Arch. Toxicol.73(6): 346-351 Usuda,K., K. Kono, T. Dote, H. Nishiura, and T. Tagawa Usefulness of the Assessment of Urinary Enzyme Leakage in Monitoring Acute Fluoride Nephrotoxicity 1999; TITLE=Usefulness of the Assessment of Urinary Enzyme Leakage in Monitoring Acute Fluoride Nephrotoxicity; AUTHOR=Usuda,K., K. Kono, T. Dote, H. Nishiura, and T. Tagawa; DOI=10.1007/s002040050628; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98249; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Enzyme(s): Glutathione S-transferase|Physiology: Volume; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599124_15599125_15605993:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7c610348aa0ba9347f55d30cfc51f5e0 |
| ToxValDB_ECOTOX | NOEL | =300 | mg/L | Rat | oral | short-term; 10 days | reproduction developmental | LONG_REF=Fundam. Appl. Toxicol.30(2): 162-177 Heindel,J.J., H.K. Bates, C.J. Price, M.C. Marr, C.B. Myers, and B.A. Schwetz Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water 1996; TITLE=Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water; AUTHOR=Heindel,J.J., H.K. Bates, C.J. Price, M.C. Marr, C.B. Myers, and B.A. Schwetz; DOI=10.1006/faat.1996.0053; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98331; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599139_15603738_15603739:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4ec54108fcf0c7aa228bbc4e2e657901 |
| ToxValDB_ECOTOX | NOEL | =20 | mg/L | Rat | oral | subchronic; 63 days | subchronic | LONG_REF=Fluoride25(3): 129-134 Czarnowski,W., J. Krechniak, and K. Wrzesniowska The Influence of Sodium Hydrogen Carbonate on the Elimination of Fluoride in Rats 1992; TITLE=The Influence of Sodium Hydrogen Carbonate on the Elimination of Fluoride in Rats; AUTHOR=Czarnowski,W., J. Krechniak, and K. Wrzesniowska; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98346; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599650_15610629:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0b1f103bf7df21da13d33581604e5073 |
| ToxValDB_ECOTOX | NOEL | =50 | ppm | Rat | multiple | subchronic; 80 days | subchronic | LONG_REF=Biomed. Environ. Sci.11(1): 1-6 Zhao,X.L., and J.H. Wu Actions of Sodium Fluoride on Acetylcholinesterase Activities in Rats 1998; TITLE=Actions of Sodium Fluoride on Acetylcholinesterase Activities in Rats; AUTHOR=Zhao,X.L., and J.H. Wu; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98472; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Behavior: Activity, general|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|organ weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600015_15600016:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0d513ead7154c9640cc7cb7229a5744f |
| ToxValDB_ECOTOX | NOEL | =150 | mg/L | European Rabbit | oral | subchronic; 49 days | subchronic | LONG_REF=Nature246:165-166 Joseph,J., and M. Tydd Effect of Sodium Fluoride on Regeneration in the Rabbit Ear 1973; TITLE=Effect of Sodium Fluoride on Regeneration in the Rabbit Ear; AUTHOR=Joseph,J., and M. Tydd; DOI=10.1038/246165a0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=50740; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1973; ORIGINAL_YEAR=1973; TOXICOLOGICAL_EFFECT=Growth: Limb/ body part regeneration; STUDY_GROUP=ECOTOX:15600086:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=7f3af69fc6c2fad788d91d3766690b37 |
| ToxValDB_ECOTOX | NOEL | =22.82 | mg/L | Mouse | oral | chronic; 147 days | chronic | LONG_REF=J. Dent. Res.68(11): 1525-1528 Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies 1989; TITLE=Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies; AUTHOR=Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey; DOI=10.1177/00220345890680111101; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98306; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Cell(s): Polychromatic cells, micronucleated|Feeding behavior: Water consumption|Growth: Weight|Morphology: Weight|Reproduction: Abnormal; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|nonneoplastic histopathology|other|reproduction; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600619_15605339_15605340:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=9e1d8c9b1169bbe03ab7a26dc06883cd |
| ToxValDB_ECOTOX | NOEL | =1 | mg/kg bw/day | Rat | injection | chronic; 112 days | chronic | LONG_REF=Bone (New York)20(5): 439-449 Sogaard,C.H., L. Mosekilde, J.S. Thomsen, A. Richards, and J.E. McOsker A Comparison of the Effects of Two Anabolic Agents (Fluoride and PTH) on Ash Density and Bone Strength Assessed in an Osteopenic Rat Model 1997; TITLE=A Comparison of the Effects of Two Anabolic Agents (Fluoride and PTH) on Ash Density and Bone Strength Assessed in an Osteopenic Rat Model; AUTHOR=Sogaard,C.H., L. Mosekilde, J.S. Thomsen, A. Richards, and J.E. McOsker; DOI=10.1016/s8756-3282(97)00020-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=98845; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1997; ORIGINAL_YEAR=1997; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600790_15600791_15604402_15605707:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=cb9341f7462bd880253e05edf12eaaa3 |
| ToxValDB_ECOTOX | NOEL | =50 | mg/L | Rat | oral | short-term; 14 days | short-term | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600850_15600851:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=66451d92b6c2fa5ff42109286a3efa0b |
| ToxValDB_ECOTOX | NOEL | =400 | mg/L | European Rabbit | oral | short-term; 15 days | reproduction developmental | LONG_REF=Fundam. Appl. Toxicol.30(2): 162-177 Heindel,J.J., H.K. Bates, C.J. Price, M.C. Marr, C.B. Myers, and B.A. Schwetz Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water 1996; TITLE=Developmental Toxicity Evaluation of Sodium Fluoride Administered to Rats and Rabbits in Drinking Water; AUTHOR=Heindel,J.J., H.K. Bates, C.J. Price, M.C. Marr, C.B. Myers, and B.A. Schwetz; DOI=10.1006/faat.1996.0053; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98331; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Growth: Weight gain|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601146_15607505_15607506:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3bca50e5748c12bf9f9043b88b0afa23 |
| ToxValDB_ECOTOX | NOEL | =10 | ppm | Rat | multiple | subchronic; 56 days | subchronic | LONG_REF=Aust.Dent.J.37(1): 55-62 Harbrow,D.J., M.G. Robinson, and P.A. Monsour The Effect of Chronic Fluoride Administration on Rat Condylar Cartilage 1992; TITLE=The Effect of Chronic Fluoride Administration on Rat Condylar Cartilage; AUTHOR=Harbrow,D.J., M.G. Robinson, and P.A. Monsour; DOI=10.1111/j.1834-7819.1992.tb00834.x; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97969; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Cell(s): Area|Morphology: Thickness; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601389_15601390_15603952:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=14e95e5ae810ae455072e80cecdc3670 |
| ToxValDB_ECOTOX | NOEL | =9.52 | mg/L | Mouse | oral | short-term; 28 days | developmental | LONG_REF=Fluoride34(4): 242-249 Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice 2001; TITLE=Effects of Sodium Fluoride in Drinking Water on Fertility in Female Mice; AUTHOR=Darmani,H., A.S. Al-Hiyasat, and A.M. Elbetieha; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98674; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Development: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601839_15601840:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=21c50736614271d83c38f4e8651c3bc4 |
| ToxValDB_ECOTOX | NOEL | =0.4 | mg/mL | Rat | environmental | acute; 0.2292 days | acute | LONG_REF=Arch. Environ. Health29:230-235 Jagiello,G., and J.S. Lin Sodium Fluoride as Potential Mutagen in Mammalian Eggs 1974; TITLE=Sodium Fluoride as Potential Mutagen in Mammalian Eggs; AUTHOR=Jagiello,G., and J.S. Lin; DOI=10.1080/00039896.1974.10666574; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=50570; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1974; ORIGINAL_YEAR=1974; TOXICOLOGICAL_EFFECT=Genetics: Meiotic abnormalities, 1st metaphase; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15602189:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=decaa3855650ca1d1f39fcfe2121c45a |
| ToxValDB_ECOTOX | NOEL | =0.12 | mmol/kg | Rat | injection | short-term; 15 days | short-term | LONG_REF=Am. J. Physiol.232(4): F335 - F340 Wallin,J.D., and R.A. Kaplan Effect of Sodium Fluoride on Concentrating and Diluting Ability in the Rat 1977; TITLE=Effect of Sodium Fluoride on Concentrating and Diluting Ability in the Rat; AUTHOR=Wallin,J.D., and R.A. Kaplan; DOI=10.1152/ajprenal.1977.232.4.F335; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=55351; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Biochemistry: Creatinine; TOXICOLOGICAL_EFFECT_CATEGORY=urinalysis; STUDY_GROUP=ECOTOX:15602776:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b162c7c1c7bcf1df9c47fa847df97a1d |
| ToxValDB_ECOTOX | NOEL | =4 | mg/kg bw/day | Mouse | injection | acute; 1 days | acute | LONG_REF=Bull. Environ. Contam. Toxicol.74(3): 566-572 Velazquez-Guadarrama,N., E. Madrigal-Bujaidar, D. Molina, and G. Chamorro Genotoxic Evaluation of Sodium Fluoride and Sodium Perborate in Mouse Bone Marrow Cells 2005; TITLE=Genotoxic Evaluation of Sodium Fluoride and Sodium Perborate in Mouse Bone Marrow Cells; AUTHOR=Velazquez-Guadarrama,N., E. Madrigal-Bujaidar, D. Molina, and G. Chamorro; DOI=10.1007/s00128-005-0621-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=97957; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Genetics: Genetics, general; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15603329_15603330:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d831a8c7e9c5abfbfab54510d7cf6832 |
| ToxValDB_ECOTOX | NOEL | =2.5 | mg/kg bw/day | Rat | injection | short-term; 5 days | reproduction developmental | LONG_REF=Toxicol. Lett.21(2): 163-166 Soni,M.G., and S.S. Pawar Effect of Sodium Fluoride on Hepatic Microsomal Mixed-Function Oxidase System in Newborn and Adult Male Rats 1984; TITLE=Effect of Sodium Fluoride on Hepatic Microsomal Mixed-Function Oxidase System in Newborn and Adult Male Rats; AUTHOR=Soni,M.G., and S.S. Pawar; DOI=10.1016/0378-4274(84)90200-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=98238; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=Enzyme(s): Cytochrome B-5; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596636_15604621_15604622:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b0bb59d330fc910e1c24852ea2af7acd |
| ToxValDB_ECOTOX | NOEL | =800 | mg/L | Mouse | oral | short-term; 14 days | short-term | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15605112:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4eaed21423e8399e00fcf5157b82c44c |
| ToxValDB_ECOTOX | NOEL | =600 | mg/L | Mouse | oral | chronic; 182 days | chronic | LONG_REF=Natl. Toxicol. Program Tech. Rep. Ser.393:448 p. National Toxicology Program (NTP) Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) 1990; TITLE=Toxicology and Carcinogenesis Studies of Sodium Fluoride (CAS No. 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies); AUTHOR=National Toxicology Program (NTP); QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=97855; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15601731_15605306:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4fa3cb9e4ace507d29e78d6078fc5e16 |
| ToxValDB_ECOTOX | NOEL | =0.31 | mg/L | Mouse | oral | chronic; 147 days | chronic | LONG_REF=J. Dent. Res.68(11): 1525-1528 Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies 1989; TITLE=Genotoxic Evaluation of Chronic Fluoride Exposure: Micronucleus and Sperm Morphology Studies; AUTHOR=Dunipace,A.J., W. Zhang, T.W. Noblitt, Y. Li, and G.K. Stookey; DOI=10.1177/00220345890680111101; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98306; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600619_15605339_15605340:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2e50d961d8a8eda76c9b07f51918ddf7 |
| ToxValDB_ECOTOX | NOEL | =12 | mM | Rat | injection | acute; 0.0208 days | acute | LONG_REF=Food Chem. Toxicol.24(1): 33-36 Shayiq,R.M., H. Raza, and A.M. Kidwai Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ 1986; TITLE=Effects of Fluoride on Membrane Permeability and Brush Border Enzymes of Rat Intestine In Situ; AUTHOR=Shayiq,R.M., H. Raza, and A.M. Kidwai; DOI=10.1016/0278-6915(86)90261-9; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=98181; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1986; ORIGINAL_YEAR=1986; TOXICOLOGICAL_EFFECT=Enzyme(s): gamma-glutamyl transpeptidase|Physiology: Fluid volume; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|gross pathology; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595872_15599653_15599654_15600219_15607251_15610369_15610557:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=18bf9143775986813dc106786c64771b |
| ToxValDB_ECOTOX | NOEL | =250 | ppm | Rat | injection | short-term; 21 days | short-term | LONG_REF=Food Chem. Toxicol.34(4): 377-384 Sprando,R.L., T.N. Black, M.J. Ames, J.I. Rorie, and T.F.X. Collins Effect of Intratesticular Injection of Sodium Fluoride on Spermatogenesis 1996; TITLE=Effect of Intratesticular Injection of Sodium Fluoride on Spermatogenesis; AUTHOR=Sprando,R.L., T.N. Black, M.J. Ames, J.I. Rorie, and T.F.X. Collins; DOI=10.1016/0278-6915(96)84542-x; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=98253; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15608213:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=158d29049763ed780b3f5e66216714cf |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL local | =2.5 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634804:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_524884d9d0b877825839228fda257d82 |
ToxValDB_HAWC_Project 64 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_HAWC_Project | LOEL | =9.05 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=Banji D et al. Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride. Food Chem 2013; 140 (1-2):321-31.; TITLE=Investigation on the role of Spirulina platensis in ameliorating behavioural changes, thyroid dysfunction and oxidative stress in offspring of pregnant rats exposed to fluoride.; AUTHOR=Banji D, Banji OJ, Pratusha NG, Annamalai AR; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7272/ |::| https://hawcproject.org/ani/endpoint/7273/ |::| https://hawcproject.org/ani/endpoint/7274/ |::| https://hawcproject.org/ani/endpoint/7275/ |::| https://hawcproject.org/ani/endpoint/7278/ |::| https://hawcproject.org/ani/endpoint/7280/ |::| https://hawcproject.org/ani/endpoint/7283/ |::| https://hawcproject.org/ani/endpoint/7326/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=F1: elevated plus maze (open arm entries)|F1: elevated plus maze (time in open arms)|F1: mid-air righting (number of animals successful, PND 17)|F1: mid-air righting (number of animals successful, PND 18)|F1: mid-air righting (number of animals successful, PND 19)|F1: open field (rearing events)|F1: open field (time spent freezing)|F1: rotarod (latency to fall, 40 rpm); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636231:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_fdd068270cbb9c909f0750d681918c56 |
| ToxValDB_HAWC_Project | LOEL | =7.52 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Jiang S et al. Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats. PLoS ONE 2014; 9 (4):e96041.; TITLE=Fluoride and arsenic exposure impairs learning and memory and decreases mGluR5 expression in the hippocampus and cortex in rats.; AUTHOR=Jiang S, Su J, Yao S, Zhang Y, Cao F, Wang F, Wang H, Li J, Xi S; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7327/ |::| https://hawcproject.org/ani/endpoint/7330/ |::| https://hawcproject.org/ani/endpoint/7331/ |::| https://hawcproject.org/ani/endpoint/7332/ |::| https://hawcproject.org/ani/endpoint/7333/ |::| https://hawcproject.org/ani/endpoint/7334/ |::| https://hawcproject.org/ani/endpoint/7335/ |::| https://hawcproject.org/ani/endpoint/7336/ |::| https://hawcproject.org/ani/endpoint/7337/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, day 1)|Morris water maze (escape time, acquisition, day 11)|Morris water maze (escape time, acquisition, day 4)|Morris water maze (platform crossing, probe test, day 11)|Morris water maze (platform crossing, probe test, day 4)|Morris water maze (time in target quadrant, probe test, day 11)|Morris water maze (time in target quadrant, probe test, day 4)|Morris water maze (time to find platform, probe test, day 11)|Morris water maze (time to find platform, probe test, day 4); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636235:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5d71c1f0f744681ff8f0ae36cea045b8 |
| ToxValDB_HAWC_Project | LOEL | =6.67 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Zhang C et al. The analog of Ginkgo biloba extract 761 is a protective factor of cognitive impairment induced by chronic fluorosis. Biol Trace Elem Res 2013; 153 (1-3):229-36.; TITLE=The analog of Ginkgo biloba extract 761 is a protective factor of cognitive impairment induced by chronic fluorosis.; AUTHOR=Zhang C, Ren C, Chen H, Geng R, Fan H, Zhao H, Guo K, Geng D; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7338/ |::| https://hawcproject.org/ani/endpoint/7642/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=Y-maze (number of training runs to meet 90% learning standard, day 23)|Y-maze (number of training runs to meet 90% learning standard, day 9); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636236:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_12216d08312f4d93b587bc57ef346050 |
| ToxValDB_HAWC_Project | LOEL | =8.52 | mg/L urine | Rat | oral | - | developmental | LONG_REF=Gui CZ et al. Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis. Neurotoxicol Teratol 2010; 32 (5):536-41.; TITLE=Changes of learning and memory ability and brain nicotinic receptors of rat offspring with coal burning fluorosis.; AUTHOR=Gui CZ, Ran LY, Li JP, Guan ZZ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7862/ |::| https://hawcproject.org/ani/endpoint/7863/ |::| https://hawcproject.org/ani/endpoint/7864/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=F1: Morris water maze (escape time, acquisition, day 6)|F1: Morris water maze (platform crossing, probe test, day 7)|F1: Morris water maze (time in platform area, probe test, day 7); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636245:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3c2f4ceffdb91a6d7373c5c608dfafd7 |
| ToxValDB_HAWC_Project | LOEL | =14.7 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | LONG_REF=Bhatnagar M et al. Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice. Indian J. Exp. Biol. 2002; 40 (5):546-54.; TITLE=Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice.; AUTHOR=Bhatnagar M, Rao P, Sushma J, Bhatnagar R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7946/ |::| https://hawcproject.org/ani/endpoint/7947/ |::| https://hawcproject.org/ani/endpoint/7948/ |::| https://hawcproject.org/ani/endpoint/7949/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=maze test (latency)|motor coordination (akinesia, latency time)|motor coordination (catalepsy, latency time)|swim test (total swim time); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636251:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c26f6931c77f596e6768f29867154805 |
| ToxValDB_HAWC_Project | LOEL | =0.113 | mg | Mouse | oral | - | reproduction developmental | LONG_REF=V Baran-Poesina, S Negres, D Dobrescu, N Dimcevici-Poesina, A Dimcevici-Poesina, A Feghiu, T Soare and M Militaru. 2013. Experimental pharmacological researches regarding the influence of sodium fluoride in allopathic and homeopathic doses on central nervous system's performances. A correlation between behavioral response in classic maze test and morphological aspects of cerebral cortex. Farmacia 61(4): 781-799._x000D_ _x000D_; TITLE=EXPERIMENTAL PHARMACOLOGICAL RESEARCHES REGARDING THE INFLUENCE OF SODIUM FLUORIDE IN ALLOPATHIC AND HOMEOPATHIC DOSES ON CENTRAL NERVOUS SYSTEM'S PERFORMANCES. A CORRELATION BETWEEN BEHAVIORAL RESPONSE IN CLASSIC MAZE TEST AND MORPHOLOGICAL ASPECTS OF CEREBRAL CORTEX; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7956/ |::| https://hawcproject.org/ani/endpoint/7958/; TOXICOLOGICAL_EFFECT=P0: maze test (completion time, assessment 1)|P0: maze test (completion time, assessment 3); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636254:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e15a86f9f9d02e5d233f93508a978f2d |
| ToxValDB_HAWC_Project | LOEL | =3.12 | mg/kg bw/day | Rat | oral | subchronic (developmental) | developmental | LONG_REF=H S El-Lethey, M M Kamel and I B Shaheed. 2011. Perinatal Exposure to Sodium Fluoride with Emphasis on Territorial Aggression, Sexual Behaviour and Fertility in Male Rats. Life Science Journal-Acta Zhengzhou University Overseas Edition 8(2): 686-694; TITLE=Perinatal Exposure to Sodium Fluoride with Emphasis on Territorial Aggression, Sexual Behaviour and Fertility in Male Rats; AUTHOR=H S El-Lethey, M M Kamel and I B Shaheed; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7987/ |::| https://hawcproject.org/ani/endpoint/7988/ |::| https://hawcproject.org/ani/endpoint/7989/ |::| https://hawcproject.org/ani/endpoint/7990/ |::| https://hawcproject.org/ani/endpoint/7991/ |::| https://hawcproject.org/ani/endpoint/7992/ |::| https://hawcproject.org/ani/endpoint/7993/ |::| https://hawcproject.org/ani/endpoint/7994/ |::| https://hawcproject.org/ani/endpoint/7995/ |::| https://hawcproject.org/ani/endpoint/7996/ |::| https://hawcproject.org/ani/endpoint/7997/ |::| https://hawcproject.org/ani/endpoint/7998/; TOXICOLOGICAL_EFFECT=F1: sexual behavior (% of males ejaculating)|F1: sexual behavior (ejaculation frequency)|F1: sexual behavior (ejaculation latency)|F1: sexual behavior (intromission latency)|F1: sexual behavior (mount latency time)|F1: sexual behavior (post-ejaculatory interval)|F1: sexual behavior (total intromission frequency)|F1: sexual behavior (total mount frequency)|F1: territorial aggression (boxing bouts with stud male)|F1: territorial aggression (fights with stud male)|F1: territorial aggression (lateralization by stud male events)|F1: territorial aggression (ventral presenting posture events of stud male); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior|reproduction; STUDY_GROUP=HAWC Project:15636257:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4d31aaeecf1e391ab598df04464e568b |
| ToxValDB_HAWC_Project | LOEL | =5.84 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=C X Wu, X L Gu, Y M Ge, J H Zhang and J D Wang. 2006. Effects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats. Fluoride 39(4): 274-279; TITLE=ffects of high fluoride and arsenic on brain biochemical indexes and learning-memory in rats; AUTHOR=C X Wu, X L Gu, Y M Ge, J H Zhang and J D Wang; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8042/ |::| https://hawcproject.org/ani/endpoint/8043/ |::| https://hawcproject.org/ani/endpoint/8044/; TOXICOLOGICAL_EFFECT=passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 30)|passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 60)|passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 90); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636261:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4d69eaf28010dcb5f7798f5f575337e5 |
| ToxValDB_HAWC_Project | LOEL | =110.71 | mg/kg bw/day | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=P Ekambaram and V Paul. 2003. Effect of vitamin D on chronic behavioral and dental toxicities of sodium fluoride in rats. Fluoride 36(3): 189-197_x000D_; TITLE=ffect of vitamin D on chronic behavioral and dental toxicities of sodium fluoride in rats; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8163/ |::| https://hawcproject.org/ani/endpoint/8164/; TOXICOLOGICAL_EFFECT=activity cage (exploratory motor activity events)|rotarod (latency to fall, 14 rpm); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636278:F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5aab93c6f71348566534f899b3665e24 |
| ToxValDB_HAWC_Project | LOEL | =1.94 | mg/L serum | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=Ekambaram P and Paul V. Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats. Environ. Toxicol. Pharmacol. 2001; 9 (4):141-146.; TITLE=Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats.; AUTHOR=Ekambaram P, Paul V; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8165/ |::| https://hawcproject.org/ani/endpoint/8166/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=activity cage (motor activity events)|rotarod (latency to fall, 14 rpm); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636279:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2d327477a19c2bd630951ee7dcd449f1 |
| ToxValDB_HAWC_Project | LOEL | =10.6 | mg% thigh bone | Rat | oral | short-term; 30 days | short-term | LONG_REF=Rumiantsev GI et al. [Experimental study of the biological effect of salts of hydrofluosilicic acid]. Gig Sanit 1988; (11):80-2.; TITLE=[Experimental study of the biological effect of salts of hydrofluosilicic acid].; AUTHOR=Rumiantsev GI, Novikov SM, Mel'nikova NN, Levchenko NI, Kozeeva EE; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8218/ |::| https://hawcproject.org/ani/endpoint/8219/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=motor activity (spontaneous)|orienting reflex; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636284:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_2e62da498d2751d319d4bfa7f70ca40c |
| ToxValDB_HAWC_Project | LOEL | =1.63 | mg/kg bw/day | Rat | oral | subchronic (developmental); 81 days | developmental | LONG_REF=Jiang C et al. Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain. Neuromolecular Med. 2014; 16 (1):94-105.; TITLE=Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain.; AUTHOR=Jiang C, Zhang S, Liu H, Guan Z, Zeng Q, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Zhang X, Cui Y, Yu L, Wang A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8223/ |::| https://hawcproject.org/ani/endpoint/8224/ |::| https://hawcproject.org/ani/endpoint/8226/ |::| https://hawcproject.org/ani/endpoint/8227/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=F1: Morris water maze (distance traveled to reach platform, acquisition, day 4)|F1: Morris water maze (latency to reach platform, acquisition, day 4)|F1: Morris water maze (percent of time in target quadrant, probe test, day 5)|F1: Morris water maze (percent swim distance in target quadrant, probe test, day 5); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635867_15636286:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_50947ecfaa3ab3e7d29fabede6d8983b |
| ToxValDB_HAWC_Project | LOEL | =4.52 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=K Gopal, R Saxena, G S D Gupta, M D Rana and D Agrawal. 2006. Fluoride induced alterations in neurobehavioural and cardiovascular responses in rats. Journal of Advanced Zoology 27(1): 1-7_x000D_; TITLE=Fluoride induced alterations in neurobehavioural and cardiovascular responses in rats; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8241/; TOXICOLOGICAL_EFFECT=open field (squares crossed); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635869_15636289:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_06101397767dd6287e0f04b9e63754bf |
| ToxValDB_HAWC_Project | LOEL | =0.58 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=Zhang Z, Shen X, and Xu X. Effects of selenium on the damage of learning-memory ability of mice induced by fluoride. Wei Sheng Yan Jiu 2001; 30 (3):144-6.; TITLE=[Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].; AUTHOR=Zhang Z, Shen X, Xu X; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8262/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Y-maze (number of training runs to meet 90% learning standard); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635876_15635877_15636293:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a601a68cbafb909f48e8c45a1cefce3c |
| ToxValDB_HAWC_Project | LOEL | =4.35 | mg/kg bw/day | Rat | oral | short-term (developmental); 21 days | developmental | LONG_REF=Liu WX. [Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat]. Zhonghua Bing Li Xue Za Zhi 1989; 18 (4):290-2.; TITLE=[Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat].; AUTHOR=Liu WX; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8265/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=F1: active avoidance (shuttle box, conditioned avoidance response, day 2); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635878_15636294_15636295:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9c3afda47a9cfd12331cb8b595f24c55 |
| ToxValDB_HAWC_Project | LOEL | =6.91 | mg/kg bw/day | Rat | oral | chronic (developmental); 111 days | developmental | LONG_REF=Hong J.H, Ge, Y.M., Ning. H.M., and Wang J.D., "Effects of High Fluoride and Low Iodine on Learning-Memory and TchE of Brain in Offspring Rats." China Preventive Medicine 6 (2005): 000.; TITLE=Effects of High Fluoride and Low Iodine on Learning-Memory and TchE of Brain in Offspring Rats; AUTHOR=Hong J.H, Ge, Y.M., Ning. H.M., and Wang J.D; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8333/ |::| https://hawcproject.org/ani/endpoint/8334/ |::| https://hawcproject.org/ani/endpoint/8335/ |::| https://hawcproject.org/ani/endpoint/8336/ |::| https://hawcproject.org/ani/endpoint/8337/ |::| https://hawcproject.org/ani/endpoint/8338/ |::| https://hawcproject.org/ani/endpoint/8339/ |::| https://hawcproject.org/ani/endpoint/8340/ |::| https://hawcproject.org/ani/endpoint/8341/; TOXICOLOGICAL_EFFECT=F1: passive avoidance (step-down test, number of shocks, session 1, day 30)|F1: passive avoidance (step-down test, number of shocks, session 1, day 60)|F1: passive avoidance (step-down test, number of shocks, session 1, day 90)|F1: passive avoidance (step-down test, number of shocks, session 2, day 30)|F1: passive avoidance (step-down test, number of shocks, session 2, day 60)|F1: passive avoidance (step-down test, number of shocks, session 2, day 90)|F1: passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 30)|F1: passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 60)|F1: passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 90); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636304:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9af60bd273d1fc420df83682ac78d000 |
| ToxValDB_HAWC_Project | LOEL | =1.36 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Zhu, Yu-long, et al. "Effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats." Journal of Xinjiang Medical University 3 (2012): 014.; TITLE=Effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats; AUTHOR=Zhu, Yu-long, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8342/ |::| https://hawcproject.org/ani/endpoint/8346/; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, day 1)|Morris water maze (escape time, acquisition, day 5); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635886_15636305:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf36671c17e669d60e4e97e0cfc2923c |
| ToxValDB_HAWC_Project | LOEL | =0.36 | mg/kg bw/day | Rat | oral | short-term (developmental) | developmental | LONG_REF=Zhang J, et al. (2009). The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats. Chinese Journal of Public Health 25(11):1347-48.; TITLE=The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats; AUTHOR=Zhang J, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8349/; TOXICOLOGICAL_EFFECT=F1: open field test (grid entry, 3 minutes); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635887_15635888_15636306_15636307:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fff03adb6a9a53315710420859b7ce44 |
| ToxValDB_HAWC_Project | LOEL | =9.8 | mg/kg bw/day | Rat | oral | chronic; 5 months | chronic | LONG_REF=Xiuying, Shen, Zhang Zigui, and Xu Xiaolu. "Effect of iodine and selenium on learning memory impairment induced by fluorosis and blood biochemical criterion of rats." Occupation and Health 1 (2004): 003.; TITLE=Effect of iodine and selenium on learning memory impairment induced by fluorosis and blood biochemical criterion of rats; AUTHOR=Xiuying, Shen, Zhang Zigui, and Xu Xiaolu; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8364/ |::| https://hawcproject.org/ani/endpoint/8365/; TOXICOLOGICAL_EFFECT=Y-maze (number of correct responses over 10 trainings after 24 hours)|Y-maze (number of training runs to meet learning standard 90%); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636311:-:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a290e5285ef87cc4559fa6c1ee3724c7 |
| ToxValDB_HAWC_Project | LOEL | =0.27 | mg/kg bw/day | Rat | oral | subchronic (developmental); 42 days | developmental | LONG_REF=Bartos M, Gumilar F, Bras C, Gallegos CE, Giannuzzi L, Cancela LM, Minetti A. Neurobehavioral effects of exposure to fluoride in the earliest stages of rat development. Physiology and Behavior. 2015. 147: 205-212.; TITLE=Neurobehavioral effects of exposure to fluoride in the earliest stages of rat development; AUTHOR=Bartos M, Gumilar F, Bras C, Gallegos CE, Giannuzzi L, Cancela LM, Minetti A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17589/ |::| https://hawcproject.org/ani/endpoint/17597/ |::| https://hawcproject.org/ani/endpoint/17599/ |::| https://hawcproject.org/ani/endpoint/17609/; TOXICOLOGICAL_EFFECT=F1: elevated plus maze (open arm entries)|F1: elevated plus maze (time in open arms)|F1: open field (grooming events)|F1: open field (squares crossed, 15 min); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635893_15635894_15635896_15636313_15636315_15636317:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5d263d6e602715064dcdbe6d725a77f7 |
| ToxValDB_HAWC_Project | LOEL | =1.8 | mg/kg bw/day | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=Jain A, Mehta VK, Chittora R, Mahdi AA, Bhatnagar, M. Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence. Asian Journal of Pharmaceutical and Clinical Research. 2015. 8 (4): 164-167.; TITLE=Melatonin ameliorates fluoride induced neurotoxicity in young rats: an in vivo evidence; AUTHOR=Jain A, Mehta VK, Chittora R, Mahdi AA, Bhatnagar, M; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17627/; TOXICOLOGICAL_EFFECT=passive avoidance (retention, latency); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636322:-:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9bdc7b13136eb30a50341802cf726c10 |
| ToxValDB_HAWC_Project | LOEL | =2.16 | mg/L urine | Rat | oral | chronic; 10 months | chronic | LONG_REF=Dong Y, Wang Y, Wei N, Guan Z. 2015. Expression of muscarinic acetylcholine receptors in the brain of rats with chronic fluorosis. Journal of Endemiology 2015, Vol. 34 Issue (2): 84-88.; TITLE=Expression of muscarinic acetylcholine receptors in the brain of rats with chronic fluorosis; AUTHOR=Dong Y, Wang Y, Wei N, Guan Z; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17628/ |::| https://hawcproject.org/ani/endpoint/17629/; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, average over days 1-6)|Morris water maze (platform crossing, probe test, day 7); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636323:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3d9a966c97eaf676d428093ae0bb1f7a |
| ToxValDB_HAWC_Project | LOEL | =3.27 | mg/kg bw/day | Rat | oral | chronic (developmental) | developmental | LONG_REF=Dong Y, Wang Y, Wei N, Guan Z. 2015. Expression levels of brain muscarinic acetylcholine receptor in offspring rats of drinking-water borne fluorosis. Chinese Journal of Endemiology 34(5):326-330.; TITLE=Expression levels of brain muscarinic acetylcholine receptor in offspring rats of drinking -water borne fluorosis; AUTHOR=Dong Y, Wang Y, Wei N, Guan Z; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17630/ |::| https://hawcproject.org/ani/endpoint/17631/ |::| https://hawcproject.org/ani/endpoint/17632/; TOXICOLOGICAL_EFFECT=F1: Morris water maze (escape time, acquisition, average over days 1-6)|F1: Morris water maze (platform crossing, probe test, day 7)|F1: Morris water maze (time in platform location, probe test, day 7); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15636324:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_d959d37ebc68395cfac9da1f50233853 |
| ToxValDB_HAWC_Project | NOEL | =1.16 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Liu F et al. Fluoride exposure during development affects both cognition and emotion in mice. Physiol. Behav. 2014; 124 ():1-7.; TITLE=Fluoride exposure during development affects both cognition and emotion in mice.; AUTHOR=Liu F, Ma J, Zhang H, Liu P, Liu YP, Xing B, Dang YH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7276/ |::| https://hawcproject.org/ani/endpoint/7277/ |::| https://hawcproject.org/ani/endpoint/7279/ |::| https://hawcproject.org/ani/endpoint/7281/ |::| https://hawcproject.org/ani/endpoint/7282/ |::| https://hawcproject.org/ani/endpoint/7285/ |::| https://hawcproject.org/ani/endpoint/7286/ |::| https://hawcproject.org/ani/endpoint/7287/ |::| https://hawcproject.org/ani/endpoint/7289/ |::| https://hawcproject.org/ani/endpoint/7292/ |::| https://hawcproject.org/ani/endpoint/7293/ |::| https://hawcproject.org/ani/endpoint/7294/ |::| https://hawcproject.org/ani/endpoint/7387/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=activity cage (locomotion events, 10 min)|activity cage (rearing events, 10 min)|activity cage (rearing events, 60 min)|elevated plus maze (closed arm entries)|elevated plus maze (open arm entries)|elevated plus maze (total arm entries)|Morris water maze (escape time, acquisition, day 1)|Morris water maze (platform crossing, acquisition, day 1)|Morris water maze (swim speed, acquisition, day 1)|Morris water maze (time in target quadrant, acquisition, day 1)|novel object test (exploratory preference, training phase)|novel object test (total exploration time, retention phase)|novel object test (total exploration time, training phase); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635820_15635821_15635822_15636232_15636233:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ccb4e3b07b7ee05ee7f7cc271164830a |
| ToxValDB_HAWC_Project | NOEL | =0.23 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Liu F et al. Fluoride exposure during development affects both cognition and emotion in mice. Physiol. Behav. 2014; 124 ():1-7.; TITLE=Fluoride exposure during development affects both cognition and emotion in mice.; AUTHOR=Liu F, Ma J, Zhang H, Liu P, Liu YP, Xing B, Dang YH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7284/ |::| https://hawcproject.org/ani/endpoint/7288/ |::| https://hawcproject.org/ani/endpoint/7290/ |::| https://hawcproject.org/ani/endpoint/7295/ |::| https://hawcproject.org/ani/endpoint/7296/ |::| https://hawcproject.org/ani/endpoint/7382/ |::| https://hawcproject.org/ani/endpoint/7671/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=activity cage (locomotion events, 60 min)|Morris water maze (escape time, acquisition, day 5)|Morris water maze (platform crossing, probe test, day 7)|Morris water maze (time in target quadrant, probe test, day 7)|novel object test (exploratory preference, retention phase)|tail suspension test (immobility time, last 4 min)|tail suspension test (immobility time, total 6 min); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635820_15635821_15635822_15636232_15636233:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b145f3d6128b0bfe748fe317b522c598 |
| ToxValDB_HAWC_Project | NOEL | =0.58 | mg/kg bw/day | Mouse | oral | short-term; 28 days | short-term | LONG_REF=Liu F et al. Fluoride exposure during development affects both cognition and emotion in mice. Physiol. Behav. 2014; 124 ():1-7.; TITLE=Fluoride exposure during development affects both cognition and emotion in mice.; AUTHOR=Liu F, Ma J, Zhang H, Liu P, Liu YP, Xing B, Dang YH; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7291/ |::| https://hawcproject.org/ani/endpoint/7297/ |::| https://hawcproject.org/ani/endpoint/7298/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=elevated plus maze (time in open arms)|forced swim (immobility time, last 4 min)|forced swim (immobility time, total 6 min); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635820_15635821_15635822_15636232_15636233:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37e78fbe742a94aca07e215c2a547ffc |
| ToxValDB_HAWC_Project | NOEL | =14.75 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Raghu J et al. The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure. Interdiscip Toxicol 2013; 6 (4):217-21.; TITLE=The ameliorative effect of ascorbic acid and Ginkgo biloba on learning and memory deficits associated with fluoride exposure.; AUTHOR=Raghu J, Raghuveer VC, Rao MC, Somayaji NS, Babu PB; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7322/ |::| https://hawcproject.org/ani/endpoint/7323/; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=passive avoidance (exploration, number of crossings)|passive avoidance (exploration, time in small compartment); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635823_15636234:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6c0ae12cc9918d745e534396b05b5bcc |
| ToxValDB_HAWC_Project | NOEL | =12.27 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | LONG_REF=Balaji B, Kumar EP, and Kumar A. Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice. Toxicol Ind Health 2015; 31 (1):18-30.; TITLE=Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice.; AUTHOR=Balaji B, Kumar EP, Kumar A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7370/; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=rotarod (latency to fall, 25 rpm); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635828_15635829_15636241_15636242:F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b814f9e9321bac508d9adb3afccd05de |
| ToxValDB_HAWC_Project | NOEL | =24.53 | mg/kg bw/day | Mouse | oral | short-term; 30 days | short-term | LONG_REF=Balaji B, Kumar EP, and Kumar A. Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice. Toxicol Ind Health 2015; 31 (1):18-30.; TITLE=Evaluation of standardized Bacopa monniera extract in sodium fluoride-induced behavioural, biochemical, and histopathological alterations in mice.; AUTHOR=Balaji B, Kumar EP, Kumar A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7375/ |::| https://hawcproject.org/ani/endpoint/7376/ |::| https://hawcproject.org/ani/endpoint/7377/ |::| https://hawcproject.org/ani/endpoint/7378/ |::| https://hawcproject.org/ani/endpoint/7607/; YEAR=2015; ORIGINAL_YEAR=2015; TOXICOLOGICAL_EFFECT=elevated plus maze (time to move from open to closed arm, trial 1)|open field (fecal matter)|open field (grooming time)|open field (rearing events)|open field (time in center); TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635828_15635829_15636241_15636242:F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7bbaa06d6b02913c123ea19c9756fb9f |
| ToxValDB_HAWC_Project | NOEL | =3.28 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | LONG_REF=Liu YJ et al. Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory. Toxicol. Lett. 2010; 192 (3):324-9.; TITLE=Alterations of nAChRs and ERK1/2 in the brains of rats with chronic fluorosis and their connections with the decreased capacity of learning and memory.; AUTHOR=Liu YJ, Gao Q, Wu CX, Guan ZZ; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7824/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, day 1); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635830_15636243:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was manually checked; QC_STATUS=pass; SOURCE_HASH=ToxValhc_aca007835d5829472ad92a610978fe2f |
| ToxValDB_HAWC_Project | NOEL | =6.67 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Pereira M et al. Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels. Neurotox Res 2011; 19 (1):55-62.; TITLE=Memory impairment induced by sodium fluoride is associated with changes in brain monoamine levels.; AUTHOR=Pereira M, Dombrowski PA, Losso EM, Chioca LR, Da Cunha C, Andreatini R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7831/ |::| https://hawcproject.org/ani/endpoint/7832/ |::| https://hawcproject.org/ani/endpoint/7833/ |::| https://hawcproject.org/ani/endpoint/7834/ |::| https://hawcproject.org/ani/endpoint/7835/ |::| https://hawcproject.org/ani/endpoint/7836/ |::| https://hawcproject.org/ani/endpoint/7838/ |::| https://hawcproject.org/ani/endpoint/7839/ |::| https://hawcproject.org/ani/endpoint/7840/ |::| https://hawcproject.org/ani/endpoint/7841/ |::| https://hawcproject.org/ani/endpoint/7842/ |::| https://hawcproject.org/ani/endpoint/7843/; YEAR=2011; ORIGINAL_YEAR=2011; TOXICOLOGICAL_EFFECT=open field (squares crossed, day 1 - minute 1)|open field (squares crossed, day 1 - minute 2)|open field (squares crossed, day 1)|open field (squares crossed, day 2 - minute 1)|open field (squares crossed, day 2 - minute 2)|open field (squares crossed, day 2); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15635831:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1e53e7e3a1673611acf74d83b3160918 |
| ToxValDB_HAWC_Project | NOEL | =2.78 | mg/L serum | Rat | oral | - | developmental | LONG_REF=Niu R et al. Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead. Environ. Toxicol. Pharmacol. 2009; 28 (2):254-8.; TITLE=Decreased learning ability and low hippocampus glutamate in offspring rats exposed to fluoride and lead.; AUTHOR=Niu R, Sun Z, Cheng Z, Li Z, Wang J; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7845/ |::| https://hawcproject.org/ani/endpoint/7849/ |::| https://hawcproject.org/ani/endpoint/7852/ |::| https://hawcproject.org/ani/endpoint/7856/; YEAR=2009; ORIGINAL_YEAR=2009; TOXICOLOGICAL_EFFECT=F1: Y-maze (error number, 12 weeks)|F1: Y-maze (error number, 6 weeks)|F1: Y-maze (time to meet learning standard 90%, 6 weeks)|F1: Y-maze (total reaction time, 12 weeks); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635832_15636244:-:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3b000f0782836bc0f826c07a1c29fd7f |
| ToxValDB_HAWC_Project | NOEL | =2.3 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | LONG_REF=Sarkozi K et al. Behavioral and general effects of subacute oral arsenic exposure in rats with and without fluoride. Int J Environ Health Res 2014; ():1-14.; TITLE=Behavioral and general effects of subacute oral arsenic exposure in rats with and without fluoride.; AUTHOR=Sarkozi K, Horvath E, Vezer T, Papp A, Paulik E; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7884/ |::| https://hawcproject.org/ani/endpoint/7885/ |::| https://hawcproject.org/ani/endpoint/7887/ |::| https://hawcproject.org/ani/endpoint/7888/ |::| https://hawcproject.org/ani/endpoint/7890/ |::| https://hawcproject.org/ani/endpoint/7891/ |::| https://hawcproject.org/ani/endpoint/7894/ |::| https://hawcproject.org/ani/endpoint/7895/ |::| https://hawcproject.org/ani/endpoint/7896/ |::| https://hawcproject.org/ani/endpoint/7898/ |::| https://hawcproject.org/ani/endpoint/7899/ |::| https://hawcproject.org/ani/endpoint/7901/ |::| https://hawcproject.org/ani/endpoint/7902/ |::| https://hawcproject.org/ani/endpoint/7904/ |::| https://hawcproject.org/ani/endpoint/7905/ |::| https://hawcproject.org/ani/endpoint/7907/ |::| https://hawcproject.org/ani/endpoint/7908/ |::| https://hawcproject.org/ani/endpoint/7910/ |::| https://hawcproject.org/ani/endpoint/7911/ |::| https://hawcproject.org/ani/endpoint/7913/ |::| https://hawcproject.org/ani/endpoint/7914/ |::| https://hawcproject.org/ani/endpoint/7916/ |::| https://hawcproject.org/ani/endpoint/7917/ |::| https://hawcproject.org/ani/endpoint/7919/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=open field (ambulation distance, 12 wks)|open field (ambulation distance, 3 wks)|open field (ambulation events, 12 wks)|open field (ambulation events, 3 wks)|open field (ambulation time, 12 wks)|open field (ambulation time, 3 wks)|open field (central zone time, 12 wks)|open field (central zone time, 3 wks)|open field (corner zone time, 12 wks)|open field (corner zone time, 3 wks)|open field (immobility events, 12 wks)|open field (immobility events, 3 wks)|open field (immobility time, 12 wks)|open field (immobility time, 3 wks)|open field (local activity events, 12 wks)|open field (local activity events, 3 wks)|open field (local activity time, 12 wks)|open field (local activity time, 3 wks)|open field (rearing events, 12 wks)|open field (rearing events, 3 wks)|open field (rearing time, 12 wks)|open field (rearing time, 3 wks)|open field (side zone time, 12 wks)|open field (side zone time, 3 wks); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15635835:-:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_a6b94960e7c5de0df247de0b4001e87e |
| ToxValDB_HAWC_Project | NOEL | =1.13 | mg/kg bw/day | Rat | oral | short-term (developmental) | developmental | LONG_REF=Flace P et al. Effects of developmental fluoride exposure on rat ultrasonic vocalization, acoustic startle reflex and pre-pulse inhibition. Eur Rev Med Pharmacol Sci 2010; 14 (6):507-12.; TITLE=Effects of developmental fluoride exposure on rat ultrasonic vocalization, acoustic startle reflex and pre-pulse inhibition.; AUTHOR=Flace P, Benagiano V, Vermesan D, Sabatini R, Inchingolo AM, Inchingolo A, Auteri P, Ambrosi G, Tarullo A, Cagiano R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7938/ |::| https://hawcproject.org/ani/endpoint/7940/ |::| https://hawcproject.org/ani/endpoint/7941/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=F1: auditory startle reflex (peak latency)|F1: auditory startle reflex (pre-pulse inhibition peak latency)|F1: vocalization (number ultrasonic over 30 sec.); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635836_15636249_15636250:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d66ab7bdd5aab52d3992e761563300b8 |
| ToxValDB_HAWC_Project | NOEL | =2.26 | mg/kg bw/day | Rat | oral | short-term (developmental) | developmental | LONG_REF=Flace P et al. Effects of developmental fluoride exposure on rat ultrasonic vocalization, acoustic startle reflex and pre-pulse inhibition. Eur Rev Med Pharmacol Sci 2010; 14 (6):507-12.; TITLE=Effects of developmental fluoride exposure on rat ultrasonic vocalization, acoustic startle reflex and pre-pulse inhibition.; AUTHOR=Flace P, Benagiano V, Vermesan D, Sabatini R, Inchingolo AM, Inchingolo A, Auteri P, Ambrosi G, Tarullo A, Cagiano R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7942/ |::| https://hawcproject.org/ani/endpoint/7943/ |::| https://hawcproject.org/ani/endpoint/7944/ |::| https://hawcproject.org/ani/endpoint/7945/; YEAR=2010; ORIGINAL_YEAR=2010; TOXICOLOGICAL_EFFECT=F1: auditory startle reflex (amplitude)|F1: auditory startle reflex (peak latency)|F1: auditory startle reflex (pre-pulse inhibition peak latency)|F1: vocalization (number ultrasonic over 30 sec.); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15635837:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9aaf306b469f956a0c6bbd19459fe6ff |
| ToxValDB_HAWC_Project | NOEL | =18.4 | mg/kg bw/day | Mouse | oral | subchronic (developmental) | developmental | LONG_REF=Niu R et al. Proteomic analysis of hippocampus in offspring male mice exposed to fluoride and lead. Biol Trace Elem Res 2014; 162 (1-3):227-33.; TITLE=Proteomic analysis of hippocampus in offspring male mice exposed to fluoride and lead.; AUTHOR=Niu R, Liu S, Wang J, Zhang J, Sun Z, Wang J; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/7980/ |::| https://hawcproject.org/ani/endpoint/7981/ |::| https://hawcproject.org/ani/endpoint/7982/ |::| https://hawcproject.org/ani/endpoint/7983/ |::| https://hawcproject.org/ani/endpoint/7984/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=F1: activity chamber (ambulation events)|F1: activity chamber (rearing events)|F1: novel object test (adaptation phase memory index)|F1: novel object test (long-term memory index)|F1: novel object test (short-term memory index); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project:15635838:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_09b582a5794a5c5ea7f6fa1292b4ba59 |
| ToxValDB_HAWC_Project | NOEL | =10.37 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=R Y Niu, Z L Sun, J M Wang, Z T Cheng and J D Wang. 2008. Effects of fluoride and lead on locomotor behavior and expression of Nissl body in brain of adult rats. Fluoride 41(4): 276-282_x000D_; TITLE=EFFECTS OF FLUORIDE AND LEAD ON LOCOMOTOR BEHAVIOR AND EXPRESSION OF NISSL BODY IN BRAIN OF ADULT RATS; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8019/ |::| https://hawcproject.org/ani/endpoint/8021/ |::| https://hawcproject.org/ani/endpoint/8023/ |::| https://hawcproject.org/ani/endpoint/8025/ |::| https://hawcproject.org/ani/endpoint/8026/ |::| https://hawcproject.org/ani/endpoint/8032/ |::| https://hawcproject.org/ani/endpoint/8033/ |::| https://hawcproject.org/ani/endpoint/8036/; TOXICOLOGICAL_EFFECT=activity cage (ambulatory events)|activity cage (head turning events)|activity cage (head turning time)|activity cage (rearing events)|activity cage (standing events)|Y-maze (error number, day 5)|Y-maze (total reaction time, day 1)|Y-maze (total reaction time, day 4); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635840_15636260:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_100d14bea7697241ddcc2fe569a93f04 |
| ToxValDB_HAWC_Project | NOEL | =4.87 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Chioca LR et al. Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats. Eur. J. Pharmacol. 2008; 579 (1-3):196-201.; TITLE=Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats.; AUTHOR=Chioca LR, Raupp IM, Da Cunha C, Losso EM, Andreatini R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8048/ |::| https://hawcproject.org/ani/endpoint/8050/ |::| https://hawcproject.org/ani/endpoint/8055/ |::| https://hawcproject.org/ani/endpoint/8057/ |::| https://hawcproject.org/ani/endpoint/8058/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=active avoidance (shuttle box, number of escapes of conditioned shock stimulus)|active avoidance (shuttle box, number of failures to avoid/escape the conditioned shock stimulus)|active avoidance (shuttle box, response latency to conditioned stimulus, blocks 1-5)|active avoidance (shuttle box, response latency to conditioned stimulus, blocks 26-30)|open field (squares crossed, training session); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635841_15635842_15636262_15636263:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2f8babc109388d4cf40dcb34c34a8de7 |
| ToxValDB_HAWC_Project | NOEL | =2.33 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Chioca LR et al. Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats. Eur. J. Pharmacol. 2008; 579 (1-3):196-201.; TITLE=Subchronic fluoride intake induces impairment in habituation and active avoidance tasks in rats.; AUTHOR=Chioca LR, Raupp IM, Da Cunha C, Losso EM, Andreatini R; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8056/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=active avoidance (shuttle box, number of avoidances of conditioned shock stimulus); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635841_15635842_15636262_15636263:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7e10092443b0660087f67e1888504edd |
| ToxValDB_HAWC_Project | NOEL | =0.59 | mg/kg bw/day | Mouse | oral | subchronic; 10 weeks | subchronic | LONG_REF=Zhang Z et al. [Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice]. Wei Sheng Yan Jiu 1999; 28 (4):210-2.; TITLE=[Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice].; AUTHOR=Zhang Z, Xu X, Shen X, Xu X; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8068/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Y-maze (number of training runs to meet 90% learning standard); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635844_15635845_15636265:-:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5fcda1cb0c7cdb841d152aba87c8d8a6 |
| ToxValDB_HAWC_Project | NOEL | =1.19 | mg/kg bw/day | Mouse | oral | subchronic; 10 weeks | subchronic | LONG_REF=Zhang Z et al. [Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice]. Wei Sheng Yan Jiu 1999; 28 (4):210-2.; TITLE=[Effect of fluoride exposure on synaptic structure of brain areas related to learning-memory in mice].; AUTHOR=Zhang Z, Xu X, Shen X, Xu X; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8069/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Y-maze (% of correct responses 24 hrs after mastering learning standard); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635844_15635845_15636265:-:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5466248b323489aa79ec028f2fd77350 |
| ToxValDB_HAWC_Project | NOEL | =6.914 | mg/kg bw/day | Rat | oral | subchronic (developmental); 51 days | developmental | LONG_REF=J Wang, Y Ge, H Ning and S Wang. 2004. Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats. Fluoride 37(3): 201-208; TITLE=Effects of high fluoride and low iodine on biochemical indexes of the brain and learning-memory of offspring rats; AUTHOR=J Wang, Y Ge, H Ning and S Wang; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8139/ |::| https://hawcproject.org/ani/endpoint/8140/ |::| https://hawcproject.org/ani/endpoint/8141/ |::| https://hawcproject.org/ani/endpoint/8143/ |::| https://hawcproject.org/ani/endpoint/8144/ |::| https://hawcproject.org/ani/endpoint/8146/ |::| https://hawcproject.org/ani/endpoint/8147/; TOXICOLOGICAL_EFFECT=F1: passive avoidance (step-down test, number of shocks, session 1, day 30)|F1: passive avoidance (step-down test, number of shocks, session 1, day 60)|F1: passive avoidance (step-down test, number of shocks, session 1, day 90)|F1: passive avoidance (step-down test, number of shocks, session 2, day 60)|F1: passive avoidance (step-down test, number of shocks, session 2, day 90)|F1: passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 60)|F1: passive avoidance (step-down test, time to move from rubber mat to electrified bar, session 2, day 90); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635857_15636274:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f2c093a8b92fd2accf21428aa1775bd |
| ToxValDB_HAWC_Project | NOEL | =40.03 | mg/kg bw/day | Rat | oral | short-term; 30 days | short-term | LONG_REF=Basha PM and Sujitha NS. Combined impact of exercise and temperature in learning and memory performance of fluoride toxicated rats. Biol Trace Elem Res 2012; 150 (1-3):306-13.; TITLE=Combined impact of exercise and temperature in learning and memory performance of fluoride toxicated rats.; AUTHOR=Basha PM, Sujitha NS; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8151/; YEAR=2012; ORIGINAL_YEAR=2012; TOXICOLOGICAL_EFFECT=T-maze (number of errors, retention phase); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635858_15636275:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_527ba183129faeaebba1ba5527a61e20 |
| ToxValDB_HAWC_Project | NOEL | =18.81 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | LONG_REF=H N Bataineh and M K Nusier. 2006. Impact of 12-week ingestion of sodium fluoride on aggression, sexual behavior, and fertility in adult male rats. Fluoride 39(4): 293-301; TITLE=Impact of 12-week ingestion of sodium fluoride on aggression, sexual behavior, and fertility in adult male rats; AUTHOR=H N Bataineh and M K Nusier; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8154/ |::| https://hawcproject.org/ani/endpoint/8158/; TOXICOLOGICAL_EFFECT=sexual behavior (ejaculation latency)|territorial aggression (fights with stud male); TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|reproduction; STUDY_GROUP=HAWC Project_dup_-_15635859_15635860_15636276_15636277:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c599a361fa0d683d1518e8fc1a4836a1 |
| ToxValDB_HAWC_Project | NOEL | =6.27 | mg/kg bw/day | Rat | oral | subchronic; 12 weeks | subchronic | LONG_REF=H N Bataineh and M K Nusier. 2006. Impact of 12-week ingestion of sodium fluoride on aggression, sexual behavior, and fertility in adult male rats. Fluoride 39(4): 293-301; TITLE=Impact of 12-week ingestion of sodium fluoride on aggression, sexual behavior, and fertility in adult male rats; AUTHOR=H N Bataineh and M K Nusier; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8155/; TOXICOLOGICAL_EFFECT=territorial aggression (ventral presenting posture events of stud male); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635859_15635860_15636276_15636277:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_c08a9f8110f5875a66b51b815a4a0f88 |
| ToxValDB_HAWC_Project | NOEL | =18.1 | mg/kg bw/day | Rat | oral | subchronic; 60 days | subchronic | LONG_REF=Paul V, Ekambaram P, and Jayakumar AR. Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats. Environ. Toxicol. Pharmacol. 1998; 6 (3):187-91.; TITLE=Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats.; AUTHOR=Paul V, Ekambaram P, Jayakumar AR; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8168/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=rotarod (latency to fall, 14 rpm); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635861_15636280:F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c032a70d88eecf1107ddefbbe42f6ce6 |
| ToxValDB_HAWC_Project | NOEL | =6.53 | mg/kg bw/day | Rat | oral | subchronic (developmental); 81 days | developmental | LONG_REF=Jiang C et al. Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain. Neuromolecular Med. 2014; 16 (1):94-105.; TITLE=Low glucose utilization and neurodegenerative changes caused by sodium fluoride exposure in rat's developmental brain.; AUTHOR=Jiang C, Zhang S, Liu H, Guan Z, Zeng Q, Zhang C, Lei R, Xia T, Wang Z, Yang L, Chen Y, Wu X, Zhang X, Cui Y, Yu L, Wang A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8225/; YEAR=2014; ORIGINAL_YEAR=2014; TOXICOLOGICAL_EFFECT=F1: Morris water maze (swim speed to reach platform, acquisition, day 4); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635867_15636286:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bdf71ac089ce6ed230f49fe8dbbeaefb |
| ToxValDB_HAWC_Project | NOEL | =9.05 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=K Gopal, R Saxena, G S D Gupta, M D Rana and D Agrawal. 2006. Fluoride induced alterations in neurobehavioural and cardiovascular responses in rats. Journal of Advanced Zoology 27(1): 1-7_x000D_; TITLE=Fluoride induced alterations in neurobehavioural and cardiovascular responses in rats; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8236/ |::| https://hawcproject.org/ani/endpoint/8237/ |::| https://hawcproject.org/ani/endpoint/8238/ |::| https://hawcproject.org/ani/endpoint/8239/ |::| https://hawcproject.org/ani/endpoint/8240/ |::| https://hawcproject.org/ani/endpoint/8242/; TOXICOLOGICAL_EFFECT=open field (ambulation distance)|open field (ambulation time)|open field (immobility time)|open field, stereotypic events|open field, stereotypic time|rotarod (latency to fall, accelerating speed); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635869_15636289:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1b567491f5cb6de2c2e10d36769d0c5d |
| ToxValDB_HAWC_Project | NOEL | =0.33 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Q Gao, Y J Liu, C X Wu, Y G Long and Z Z Guan. 2008. Effects of fluoride on learning and memory and cholinesterase activity in rat brains. Chinese Journal of Endemiology 27(2): 128-130_x000D_; TITLE=Effects of fluoride on learning and memory and cholinesterase activity in rat brains; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8249/; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, day 6); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635871_15635872_15636290:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8eec8d1163ae7c306dc9275bcb765eff |
| ToxValDB_HAWC_Project | NOEL | =3.27 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Q Gao, Y J Liu, C X Wu, Y G Long and Z Z Guan. 2008. Effects of fluoride on learning and memory and cholinesterase activity in rat brains. Chinese Journal of Endemiology 27(2): 128-130_x000D_; TITLE=Effects of fluoride on learning and memory and cholinesterase activity in rat brains; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8250/ |::| https://hawcproject.org/ani/endpoint/8251/; TOXICOLOGICAL_EFFECT=Morris water maze (platform crossing, probe test, day 7)|Morris water maze (time in target quadrant, probe test, day 7); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635871_15635872_15636290:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f8758b9b2fd9f765730c64bea0537ff5 |
| ToxValDB_HAWC_Project | NOEL | =0.12 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=Zhang Z, Shen X, and Xu X. Effects of selenium on the damage of learning-memory ability of mice induced by fluoride. Wei Sheng Yan Jiu 2001; 30 (3):144-6.; TITLE=[Effects of selenium on the damage of learning-memory ability of mice induced by fluoride].; AUTHOR=Zhang Z, Shen X, Xu X; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8262/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Y-maze (number of training runs to meet 90% learning standard); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635876_15635877_15636293:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_f0fe0cd6bd0b80b84c5d9d20a15c0f4a |
| ToxValDB_HAWC_Project | NOEL | =2.18 | mg/kg bw/day | Rat | oral | short-term (developmental); 21 days | developmental | LONG_REF=Liu WX. [Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat]. Zhonghua Bing Li Xue Za Zhi 1989; 18 (4):290-2.; TITLE=[Experimental study of behavior and cerebral morphology of rat pups generated by fluorotic female rat].; AUTHOR=Liu WX; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8265/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=F1: active avoidance (shuttle box, conditioned avoidance response, day 2); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635878_15636294_15636295:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8872aba167008442de565719275e4e05 |
| ToxValDB_HAWC_Project | NOEL | =3.44 | mg/kg bw/day | Rat | oral | subchronic (developmental); 51 days | developmental | LONG_REF=N Wei, Y Dong, Y Wang and Z Guan. 2014. Effects of chronic fluorosis on neurobehavioral development in offspring of rats and antagonistic effect of Vitamin E. Chinese Journal of Endemiology 33(2): 125-128_x000D_; TITLE=Effects of chronic fluorosis on neurobehavioral development in offspring of rats and antagonistic effect of Vitamin E.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8273/ |::| https://hawcproject.org/ani/endpoint/8274/; TOXICOLOGICAL_EFFECT=F1: auditory startle (response to metal object sound)|F1: cliff avoidance; TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635879_15636296:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d7b101d53da96f1e2a50d3c4c85f5cc8 |
| ToxValDB_HAWC_Project | NOEL | =3.34 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | LONG_REF=Chen H and Geng D. 2011. [The change of cognition induced by chronic fluoride in rats]. Acta Academiae Medicinae 31(5) 319-322.; TITLE=The establishment and assessment of animal model of chronic fluorsis-induced cognitive dysfunction in rats.; AUTHOR=Chen H and Geng D; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8308/ |::| https://hawcproject.org/ani/endpoint/8318/ |::| https://hawcproject.org/ani/endpoint/8322/ |::| https://hawcproject.org/ani/endpoint/8324/; TOXICOLOGICAL_EFFECT=open field (standing attempts, day 1)|open field (standing attempts, day 9)|open field (time in central grid, day 1)|Y-maze (correct responses, day 1); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635883_15635884_15635885_15636301_15636302_15636303:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_efbe3efa208acf3f7422ca0f7b2e077c |
| ToxValDB_HAWC_Project | NOEL | =10.01 | mg/kg bw/day | Rat | oral | chronic; 6 months | chronic | LONG_REF=Chen H and Geng D. 2011. [The change of cognition induced by chronic fluoride in rats]. Acta Academiae Medicinae 31(5) 319-322.; TITLE=The establishment and assessment of animal model of chronic fluorsis-induced cognitive dysfunction in rats.; AUTHOR=Chen H and Geng D; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8312/ |::| https://hawcproject.org/ani/endpoint/8317/; TOXICOLOGICAL_EFFECT=open field (entries to neighboring grids, day 9)|open field (time in central grid, day 9); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635883_15635884_15635885_15636301_15636302_15636303:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2233fd80ff2f1b259c9aab7dfb0d2d90 |
| ToxValDB_HAWC_Project | NOEL | =0.68 | mg/kg bw/day | Rat | oral | subchronic; 3 months | subchronic | LONG_REF=Zhu, Yu-long, et al. "Effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats." Journal of Xinjiang Medical University 3 (2012): 014.; TITLE=Effects of fluoride exposure on performance in water labyrinth and monoamine neurotransmitters of rats; AUTHOR=Zhu, Yu-long, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8342/ |::| https://hawcproject.org/ani/endpoint/8346/; TOXICOLOGICAL_EFFECT=Morris water maze (escape time, acquisition, day 1)|Morris water maze (escape time, acquisition, day 5); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635886_15636305:M/F:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8fdce3d991cdf3522353d68692e743ec |
| ToxValDB_HAWC_Project | NOEL | =0.71 | mg/kg bw/day | Rat | oral | short-term (developmental) | developmental | LONG_REF=Zhang J, et al. (2009). The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats. Chinese Journal of Public Health 25(11):1347-48.; TITLE=The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats; AUTHOR=Zhang J, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8348/ |::| https://hawcproject.org/ani/endpoint/8351/ |::| https://hawcproject.org/ani/endpoint/8354/ |::| https://hawcproject.org/ani/endpoint/8355/; TOXICOLOGICAL_EFFECT=F1: Morris water maze (escape time, average across all 4 training days)|F1: Morris water maze (escape time, training day 1)|F1: Morris water maze (escape time, training day 4)|F1: open field test (grid entry, 1 minute); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635887_15635888_15636306_15636307:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b119a2f425179e30e7379122b50ed861 |
| ToxValDB_HAWC_Project | NOEL | =0.18 | mg/kg bw/day | Rat | oral | short-term (developmental) | developmental | LONG_REF=Zhang J, et al. (2009). The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats. Chinese Journal of Public Health 25(11):1347-48.; TITLE=The effect of fluorine exposure of pregnant rats on the learning and memory capabilities of baby rats; AUTHOR=Zhang J, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8349/; TOXICOLOGICAL_EFFECT=F1: open field test (grid entry, 3 minutes); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635887_15635888_15636306_15636307:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_5cc06267c42241d42fc95c02913c6e50 |
| ToxValDB_HAWC_Project | NOEL | =1.39 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=Xu X, et al. (2001). Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content. China Public Health 17(1):8-10.; TITLE=Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content; AUTHOR=Xu X, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8358/ |::| https://hawcproject.org/ani/endpoint/8360/ |::| https://hawcproject.org/ani/endpoint/8361/ |::| https://hawcproject.org/ani/endpoint/8363/; TOXICOLOGICAL_EFFECT=open field (grid entry, 1 minute)|open field (rearing events)|open field (standing against wall events)|Y-maze (percent correct responses after 24 hours); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635889_15635890_15635891_15636309_15636310:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d14cfbb8ec38c8765823138656a1c7e1 |
| ToxValDB_HAWC_Project | NOEL | =0.7 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=Xu X, et al. (2001). Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content. China Public Health 17(1):8-10.; TITLE=Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content; AUTHOR=Xu X, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8359/; TOXICOLOGICAL_EFFECT=open field (grid entry, 3 minutes); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635889_15635890_15635891_15636309_15636310:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_b24aaa4f0c5d6c3e52ead61e4968fbc3 |
| ToxValDB_HAWC_Project | NOEL | =0.35 | mg/kg bw/day | Mouse | oral | subchronic; 8 weeks | subchronic | LONG_REF=Xu X, et al. (2001). Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content. China Public Health 17(1):8-10.; TITLE=Effect of fluorosis on mice learning and memory behaviors and brain SOD activity and MDA content; AUTHOR=Xu X, et al; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/8362/; TOXICOLOGICAL_EFFECT=Y-maze (number of training runs to meet 90% learning standard); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635889_15635890_15635891_15636309_15636310:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9629ff9ff108268aac834928f09b7630 |
| ToxValDB_HAWC_Project | NOEL | =0.54 | mg/kg bw/day | Rat | oral | subchronic (developmental); 42 days | developmental | LONG_REF=Bartos M, Gumilar F, Bras C, Gallegos CE, Giannuzzi L, Cancela LM, Minetti A. Neurobehavioral effects of exposure to fluoride in the earliest stages of rat development. Physiology and Behavior. 2015. 147: 205-212.; TITLE=Neurobehavioral effects of exposure to fluoride in the earliest stages of rat development; AUTHOR=Bartos M, Gumilar F, Bras C, Gallegos CE, Giannuzzi L, Cancela LM, Minetti A; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17575/ |::| https://hawcproject.org/ani/endpoint/17577/ |::| https://hawcproject.org/ani/endpoint/17579/ |::| https://hawcproject.org/ani/endpoint/17603/; TOXICOLOGICAL_EFFECT=F1: cliff avoidance|F1: ear opening|F1: negative geotaxis|F1: surface righting; TOXICOLOGICAL_EFFECT_CATEGORY=development|neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635892_15635895_15635897_15636314_15636316_15636318:M:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d21901f852452d95aa41c00dfd2501e0 |
| ToxValDB_HAWC_Project | NOEL | =11.58 | mg/kg bw/day | Mouse | oral | subchronic; 64 days | subchronic | LONG_REF=Ma J, Liu F, Liu P, Dong Y-Y, Chu Z, Hou T-Z. Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice. Int. J. Devl Neuroscience. 47 (2015) 165-171.; TITLE=Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice; AUTHOR=Ma J, Liu F, Liu P, Dong Y-Y, Chu Z, Hou T-Z; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17613/ |::| https://hawcproject.org/ani/endpoint/17614/ |::| https://hawcproject.org/ani/endpoint/17617/ |::| https://hawcproject.org/ani/endpoint/17619/ |::| https://hawcproject.org/ani/endpoint/17623/ |::| https://hawcproject.org/ani/endpoint/17625/; TOXICOLOGICAL_EFFECT=formalin test (licking time, late phase, 60 min)|formalin test (licking time/10 min, 60 min)|open field (total distance moved, 1 hr)|open field (total distance moved, 10 min)|pain response (latency time to respond to hot plate, 46C)|pain response (latency time to respond to hot plate, 54C); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635898_15635899_15636319_15636320:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3da45df875a1c83bdabf37b55bdd02c0 |
| ToxValDB_HAWC_Project | NOEL | =5.79 | mg/kg bw/day | Mouse | oral | subchronic; 64 days | subchronic | LONG_REF=Ma J, Liu F, Liu P, Dong Y-Y, Chu Z, Hou T-Z. Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice. Int. J. Devl Neuroscience. 47 (2015) 165-171.; TITLE=Impact of early developmental fluoride exposure on the peripheral pain sensitivity in mice; AUTHOR=Ma J, Liu F, Liu P, Dong Y-Y, Chu Z, Hou T-Z; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/652d4faae4b045b9ff7a30d3; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://hawcproject.org/assessment/126/; SUBSOURCE_URL=https://hawcproject.org/ani/endpoint/17615/ |::| https://hawcproject.org/ani/endpoint/17618/ |::| https://hawcproject.org/ani/endpoint/17620/ |::| https://hawcproject.org/ani/endpoint/17621/ |::| https://hawcproject.org/ani/endpoint/17622/ |::| https://hawcproject.org/ani/endpoint/17624/; TOXICOLOGICAL_EFFECT=formalin test (flinches, early phase, 10 min)|formalin test (flinches, late phase, 60 min)|formalin test (flinches/10 min, 60 min)|formalin test (licking time, early phase, 10 min)|pain response (latency time to respond to hot plate, 50C)|Von Frey hairs test (withdrawal threshold); TOXICOLOGICAL_EFFECT_CATEGORY=neurobehavior; STUDY_GROUP=HAWC Project_dup_-_15635898_15635899_15636319_15636320:M:-adult; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7cde0ac3b619c0aaba77719f6b5a7d82 |
ToxValDB_RSL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_RSL | RfC | =0.014 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759b87ce4b0a7c65d37b4e4; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.epa.gov/risk/regional-screening-levels-rsls-generic-tables; STUDY_GROUP=RSL:15658958:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ea93d613905d53ecfffbaf6684ebb959 |
ToxValDB_ToxRefDB 12 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ToxRefDB | LEL | =2.8 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice. NTP TR 393. US Dept. of Health and Human Services, NIH.; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=1937; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-flouride-fluoride|systemic: in life observation-clinical signs-tooth-discolored|systemic: in life observation-clinical signs-tooth-mottling|systemic: pathology microscopic-liver-hepatoblastoma|systemic: clinical chemistry-alkaline phosphatase (alp/alk)-alkaline phosphatase (alp/alk)|systemic: in life observation-clinical signs-tooth-attrition|systemic: pathology gross-full gross necropsy-histiocytic sarcoma|systemic: pathology gross-full gross necropsy-lymphoma malignant; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15690931_15690932:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2ee5bba583e56ba39a4fed256442d865 |
| ToxValDB_ToxRefDB | LEL | =2.4 | mg/kg bw/day | Mouse | oral | chronic; 103 weeks | chronic | LONG_REF=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice. NTP TR 393. US Dept. of Health and Human Services, NIH.; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=1937; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: clinical chemistry-flouride-fluoride|systemic: in life observation-clinical signs-tooth-mottling|systemic: in life observation-clinical signs-tooth-attrition|systemic: pathology microscopic-liver-hepatoblastoma|systemic: in life observation-clinical signs-tooth-discolored|systemic: in life observation-clinical signs-tooth-dysplasia; TOXICOLOGICAL_EFFECT_CATEGORY=cancer|clinical chemistry|clinical signs; STUDY_GROUP=ToxRefDB_dup_-_15690933_15690934:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_97cdffd6dd99571a2fa47afee11e3029 |
| ToxValDB_ToxRefDB | LEL | =1.3 | mg/kg bw/day | Rat | oral | chronic; 103 weeks | chronic | LONG_REF=NTP (1990). TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Rats. NTP TR 393.; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES). Two-Year Drinking Water Study in Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=1938; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-tooth-mottling|systemic: clinical chemistry-flouride-fluoride|systemic: in life observation-clinical signs-tooth-dysplasia|systemic: in life observation-clinical signs-tooth-degeneration|systemic: in life observation-clinical signs-tooth-discolored|systemic: pathology microscopic-bone-osteosclerosis|systemic: in life observation-clinical signs-tooth-deformity; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|clinical signs|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15690935_15690936:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d6ec7bedc4af6aa3155e9616b9c783e8 |
| ToxValDB_ToxRefDB | LEL | =120 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5975; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710362_15710363:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a586df111de9eb45f73d19bbd0ab65ea |
| ToxValDB_ToxRefDB | LEL | =15 | mg/kg bw/day | Mouse | oral | chronic; 6 months | subchronic | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5977; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-dental fluorosis|systemic: pathology microscopic-bone-proliferation|systemic: in life observation-body weight-body weight gain|systemic: in life observation-clinical signs-[other]|systemic: in life observation-mortality-mortality|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-syncytial alteration|systemic: pathology microscopic-heart-degeneration|systemic: pathology microscopic-liver-[other]|systemic: pathology microscopic-heart-mineralization|systemic: in life observation-clinical signs-tooth-degeneration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710375_15710376_15710377_15710378:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6464c42126e787889035da18f3e9d62d |
| ToxValDB_ToxRefDB | LOAEL | =7.5 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5975; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710364_15710365_15710366:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a1bdf501ecb9aaa5179288b15beed126 |
| ToxValDB_ToxRefDB | LOAEL | =15 | mg/kg bw/day | Rat | oral | chronic; 6 months | subchronic | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5976; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: pathology gross-stomach-hemorrhage|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-depletion cellular|systemic: pathology microscopic-stomach-mitotic alteration|systemic: pathology microscopic-stomach-apoptosis|systemic: pathology microscopic-stomach-nuclear alteration|systemic: pathology microscopic-stomach-hyperplasia; TOXICOLOGICAL_EFFECT_CATEGORY=gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710367_15710368_15710369_15710370:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_96785222382aa03eb6f9e27d23696b7a |
| ToxValDB_ToxRefDB | LOAEL | =30 | mg/kg bw/day | Mouse | oral | chronic; 6 months | subchronic | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5977; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ToxRefDB_dup_-_15710375_15710376_15710377_15710378:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7764d6b6f07a88cadd83c1a759bf097a |
| ToxValDB_ToxRefDB | NEL | =60 | mg/kg bw/day | Mouse | oral | short-term; 14 days | short-term | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5975; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption; STUDY_GROUP=ToxRefDB_dup_-_15710362_15710363:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56e71b2ab45e3e272c0f15e0f338122e |
| ToxValDB_ToxRefDB | NEL | =1.5 | mg/kg bw/day | Rat | oral | chronic; 6 months | subchronic | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subchronic_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5976; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-body weight-body weight|systemic: in life observation-food consumption-food consumption|systemic: clinical chemistry-flouride-fluoride|systemic: pathology gross-stomach-ulcer|systemic: pathology microscopic-stomach-depletion cellular|systemic: in life observation-clinical signs-fur (altered appearance)|systemic: in life observation-clinical signs-dental fluorosis|systemic: pathology gross-stomach-hemorrhage|systemic: in life observation-clinical signs-[other]|systemic: pathology microscopic-stomach-hyperplasia|systemic: in life observation-water consumption-water consumption|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-stomach-nuclear alteration|systemic: pathology microscopic-stomach-apoptosis|systemic: pathology microscopic-stomach-mitotic alteration; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|clinical signs|food and/or water consumption|gross pathology|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710367_15710368_15710369_15710370:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_afdf1290e87e0895b7f83bd3a67aacb1 |
| ToxValDB_ToxRefDB | NEL | =7.5 | mg/kg bw/day | Mouse | oral | chronic; 6 months | subchronic | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3F1 MICE (DRINKING WATER STUDIES)_Subchronic_Mice; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5977; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-[other]|systemic: pathology microscopic-liver-syncytial alteration|systemic: in life observation-mortality-mortality|systemic: in life observation-clinical signs-dental fluorosis|systemic: pathology microscopic-kidney-nephropathy|systemic: pathology microscopic-liver-[other]|systemic: pathology microscopic-heart-mineralization|systemic: pathology microscopic-bone-proliferation|systemic: in life observation-clinical signs-tooth-degeneration|systemic: in life observation-body weight-body weight gain|systemic: pathology microscopic-heart-degeneration|systemic: in life observation-body weight-body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|mortality/survival|nonneoplastic histopathology; STUDY_GROUP=ToxRefDB_dup_-_15710375_15710376_15710377_15710378:F:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b0bf68032d2851b46408ab3d170b6872 |
| ToxValDB_ToxRefDB | NOAEL | =2.5 | mg/kg bw/day | Rat | oral | short-term; 14 days | short-term | LONG_REF=NTP_1990_TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; TITLE=TOXICOLOGY AND CARCINOGENESIS STUDIES OF SODIUM FLUORIDE (CAS NO. 7681-49-4) IN F344/N RATS AND B6C3Fl MICE (DRINKING WATER STUDIES)_Subacute_Rats; AUTHOR=NTP; EXTERNAL_SOURCE_ID=5972; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1990; ORIGINAL_YEAR=1990; TOXICOLOGICAL_EFFECT=systemic: in life observation-clinical signs-hunched posture|systemic: in life observation-water consumption-water consumption|systemic: in life observation-clinical signs-dehydration|systemic: in life observation-mortality-mortality|systemic: in life observation-body weight-body weight|systemic: in life observation-clinical signs-lethargy; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|food and/or water consumption|mortality/survival; STUDY_GROUP=ToxRefDB_dup_-_15710358_15710359_15710360_15710361:M:F0adult; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_cf923f768ae6d8790b4751d8e1acbacc |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 8ZYQ1474W7 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"F.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8ZYQ1474W7"} |
| openFDA substances | FDA UNII substance identifier | 8ZYQ1474W7 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"F.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8ZYQ1474W7"} |
| openFDA substances | FDA UNII substance identifier | 8ZYQ1474W7 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"F.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8ZYQ1474W7"} |
| openFDA substances | FDA UNII substance identifier | 8ZYQ1474W7 | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"F.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8ZYQ1474W7"} |