NOAEL Studies Cosmetic Ingredient

Sodium Erythorbate NOAEL Studies

INCI: SODIUM ERYTHORBATE

CAS: 6381-77-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1030 mg/kg bw/day mouse oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 900 mg/kg bw/day rat oral NA Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 364 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 2968 mg/kg bw/day rat oral 224 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 12500 mg/kg bw/day mouse oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3300 mg/kg bw/day mouse oral 672 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 3435 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =650 mg/kg bw/day Rat oral: drinking water 730 days chronic/long term toxicity EFSA ANS - 2016 - OutputID 2740 - body weight - systemic - Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives - doi:10.2903/j.efsa.2016.4360
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =6 mg/kg bw/day Consumers - - ADI EFSA ANS - 2016 - OutputID 2740 - Consumers - Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives - doi:10.2903/j.efsa.2016.4360
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx ADI =6 mg/kg bw/day Consumers - - ADI EFSA ANS - 2016 - OutputID 2740 - Consumers - Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives - doi:10.2903/j.efsa.2016.4360
NTP_ICE_endocrine 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14540; RecordID=ARPathway2016_1434; DatasetName=ARPathway2016; DTXSID=DTXSID5020570; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020570; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5020570
ToxValDB_ECHA_IUCLID 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID NOAEL =900 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac4ae4b0a7c65d1be557; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11622/7/9/3?documentUUID=33864433-5cac-45b6-bbd9-e6a2c933cb73; YEAR=1984; ORIGINAL_YEAR=1984; TOXICOLOGICAL_EFFECT=fetus: reduction in number of live offspring|fetus: changes in litter size and weights|fetus: skeletal malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development|reproduction; STUDY_GROUP=ECHA IUCLID:15821059:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca2f5a850e079684ded0af782f6b55e9
ToxValDB_ECOTOX 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =6.87 % diet Rat oral subchronic; 70 days subchronic LONG_REF=Carcinogenesis16(2): 343-348 Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold Urinary and Urothelial Effects of Sodium Salts in Male Rats 1995; TITLE=Urinary and Urothelial Effects of Sodium Salts in Male Rats; AUTHOR=Cohen,S.M., M. Cano, E.M. Garland, M. St.John, and L.L. Arnold; DOI=10.1093/carcin/16.2.343; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=111191; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: pH|Histology: Hyperplasia|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597285_15597286:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=32aba7a7148a096be4e21d44737d2a6a
ToxValDB_EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA NOAEL =650 mg/kg bw/day Rat oral chronic; 2 years chronic LONG_REF=EFSA ANS (2016). Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives. doi:10.2903/j.efsa.2016.4360.; TITLE=Scientific Opinion on the re-evaluation of erythorbic acid (E 315) and sodium erythorbate (E 316) as food additives; AUTHOR=EFSA ANS; DOI=doi:10.2903/j.efsa.2016.4360; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=EFSA:15624199:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ec7d74b17007dc12c58328d87cda27f
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =10.57 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631142:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a75c6276d47d5fb6982cea1563b9835
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier BZ468R6XRD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZ468R6XRD"}
openFDA substances FDA UNII substance identifier BZ468R6XRD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZ468R6XRD"}
openFDA substances FDA UNII substance identifier BZ468R6XRD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZ468R6XRD"}
openFDA substances FDA UNII substance identifier BZ468R6XRD UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H7O6.Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"BZ468R6XRD"}