NOAEL Studies Cosmetic Ingredient

Sodium Citrate NOAEL Studies

INCI: SODIUM CITRATE

CAS: 68-04-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 2500 mg/kg bw/day rat oral 56 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 4450 mg/kg bw/day rat oral 70 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ToxValDB_ECHA_IUCLID 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =16000 mg/kg bw/day Rat oral short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb95e4b0a7c65d226a17; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15303/7/6/2?documentUUID=c0f0be0b-54b5-40a7-9d7b-b986d4cdc02c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838787_15838788:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0096582fe7c54bd3b02590327e8d981f
ToxValDB_ECHA_IUCLID LOAEL =8000 mg/kg bw/day Mouse oral short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb95e4b0a7c65d226a1a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15303/7/6/2?documentUUID=c0f0be0b-54b5-40a7-9d7b-b986d4cdc02c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844834_15844835:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e0a6f2e706edaf1ad808533d836439a9
ToxValDB_ECHA_IUCLID NOAEL =8000 mg/kg bw/day Rat oral short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb95e4b0a7c65d226a17; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15303/7/6/2?documentUUID=c0f0be0b-54b5-40a7-9d7b-b986d4cdc02c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838787_15838788:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c65f8b41ecbb97d95fff00b3cec57147
ToxValDB_ECHA_IUCLID NOAEL =4000 mg/kg bw/day Mouse oral short-term; 10 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cb95e4b0a7c65d226a1a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/15303/7/6/2?documentUUID=c0f0be0b-54b5-40a7-9d7b-b986d4cdc02c; YEAR=1980; ORIGINAL_YEAR=1980; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15844834_15844835:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9a56bc33399edc0af7743c0ddb9b6db3
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier RS7A450LGA UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5O7.3Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RS7A450LGA"}
openFDA substances FDA UNII substance identifier RS7A450LGA UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5O7.3Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RS7A450LGA"}
openFDA substances FDA UNII substance identifier RS7A450LGA UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5O7.3Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RS7A450LGA"}
openFDA substances FDA UNII substance identifier RS7A450LGA UNII - - - chemical {"approval_status":null,"molecular_formula":"C6H5O7.3Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"RS7A450LGA"}