Is Silymarin safe in cosmetics?
Silymarin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Silymarin
INCI: SILYMARIN
Silymarin is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, anti-inflammatory. EU Regulation 1223/2009 status: permitted.
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning, anti-inflammatory
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not restricted by FDA for cosmetic use; also has GRAS history in dietary supplements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silymarin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "65666-07-1", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restrictio…
anti_pollution
{"cas_number": "22888-70-6", "ingredient_class": "Nrf2_activator", "primary_mechanism": "enzyme_induction", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB…
antioxidant
{"cas_number": "65666-07-1", "antioxidant_class": "flavonoid", "chemical_subclass": "flavonolignan complex", "molecular_weight_daltons": "482.44", "orac_value_umol_te_per_g": "14500", "dpph_radical_scavenging_ic50_ug_per_ml": "14-24", "abts_trolox_equivalent": "1.05", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_perox…
synergy
{"inci_name_2": "Vitamin C + Ferulic Acid", "synergy_type": "antioxidant-synergy", "synergy_description": "Milk thistle flavonoid with vitamin antioxidants", "combined_benefit": "Enhanced hepatoprotection, skin antioxidant defense, anti-inflammatory", "efficacy_multiplier": "2.4x", "mechanism_of_action": "Silymarin provides flavonoid antioxidant action; vitamins enhance overall antioxidant capacit…
Expert Verdict
Expert safety assessment and concern-level summary for Silymarin.
Frequently Asked Questions
Is Silymarin allowed in the EU?
Silymarin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Silymarin do in cosmetics?
Silymarin functions as: Antioxidant, skin conditioning, anti-inflammatory. It is classified as a cosmetic ingredient in our database.
Compliance Tools
Check Silymarin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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