Is sh-Polypeptide-9 safe in cosmetics?
sh-Polypeptide-9 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
sh-Polypeptide-9
Also known as: VEGF, Vascular endotheolial growth factor
INCI: SH-POLYPEPTIDE-9
sh-Polypeptide-9 (CAS 127464-60-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning; promotes perifollicular vascularization (hair cycle), cell. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 127464-60-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning; promotes perifollicular vascularization (hair cycle), cell migration, wound healing; key component of BIO-Placenta complexes
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA review; permitted in cosmetics. VEGF claims must stay cosmetic (not therapeutic)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for sh-Polypeptide-9.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "79896-34-9", "trade_name": "VEGF / Vascular Endothelial Growth Factor", "peptide_sequence_amino_acids": "Recombinant 165-amino acid protein", "peptide_length_residues": "165", "molecular_weight_daltons": "38200.0", "peptide_class": "signal", "mechanism_of_action": "Promotes angiogenesis and vascular permeability", "target_protein_or_receptor": "VEGFR1/VEGFR2", "biomimetic_of": "epi…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
No specific technical function
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for sh-Polypeptide-9.
Known Synonyms
VEGF
Vascular endotheolial growth factor
Chemical Function
Softener and conditioner
No specific technical function
Frequently Asked Questions
Is sh-Polypeptide-9 allowed in the EU?
sh-Polypeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does sh-Polypeptide-9 do in cosmetics?
sh-Polypeptide-9 functions as: Skin conditioning; promotes perifollicular vascularization (hair cycle), cell migration, wound healing; key component of BIO-Placenta complexes. It is classified as a cosmetic ingredient in our database. CAS number: 127464-60-2.
Compliance Tools
Check sh-Polypeptide-9 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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