Is SH-Polypeptide-1 safe in cosmetics?
SH-Polypeptide-1 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
SH-Polypeptide-1
Also known as: bFGF, KGF, Basic astrolial growth factor, Basic FGF, Basic fibroblast growth factor, recombinant human, KCB-1 (+3 more)
INCI: SH-POLYPEPTIDE-1
SH-Polypeptide-1 (CAS 106096-93-9) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Film Forming, Anti-aging, Humectant, Barrier Support,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 106096-93-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Film Forming, Anti-aging, Humectant, Barrier Support, Collagen Network Mimicry
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR safety assessment published for SH-Polypeptide-1. Not a regulated drug ingredient. FDA permits topical cosmetic use with no specific restrictions. Caution: bFGF (the protein analog) has documented association with melanoma progression in the literature.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for SH-Polypeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "106096-93-3", "trade_name": "bFGF / Basic Fibroblast Growth Factor / FGF-2", "peptide_sequence_amino_acids": "Recombinant 146-amino acid protein", "peptide_length_residues": "146", "molecular_weight_daltons": "17200.0", "peptide_class": "signal", "mechanism_of_action": "Binds FGF receptor, promotes fibroblast proliferation and angiogenesis", "target_protein_or_receptor": "FGFR1/FGF…
Expert Verdict
Expert safety assessment and concern-level summary for SH-Polypeptide-1.
Regulatory Flags
data-gap
no-cir
no-sccs
melanoma-risk-flag
growth-factor
no-mos
no-absorption-data
recombinant-peptide
Known Synonyms
bFGF
KGF
Basic astrolial growth factor
Basic FGF
Basic fibroblast growth factor, recombinant human, KCB-1
Heparin-binding growth factor 2
Recombinant human basic fibroblast growth factor, KCB-1
UNII-S3529G9M9V
Regulatory Lists
Canada; pharmaceutical
Frequently Asked Questions
Is SH-Polypeptide-1 allowed in the EU?
SH-Polypeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-Polypeptide-1 do in cosmetics?
SH-Polypeptide-1 functions as: Skin Conditioning, Film Forming, Anti-aging, Humectant, Barrier Support, Collagen Network Mimicry. It is classified as a cosmetic ingredient in our database. CAS number: 106096-93-9.
Compliance Tools
Check SH-Polypeptide-1 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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