Is Schisandrin safe in cosmetics?
Schisandrin has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Schisandrin
INCI: SCHISANDRIN (ALSO KNOWN AS SCHISANDROL A)
Schisandrin (CAS 7432-28-2) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning (lignan compound from *Schisandra chinensis*). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 7432-28-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning (lignan compound from *Schisandra chinensis*)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(9S,10S)-3,4,5,14,15,16-hexamethoxy-9,10-dimethyltricyclo[10.4.0.02,7]hexadeca-1(16),2,4,6,12,14-hexaen-9-ol
InChIKey
YEFOAORQXAOVJQ-RZFZLAGVSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Not specifically regulated; falls under general cosmetic ingredient provisions (no FDA pre-market approval required)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Schisandrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Bleaching agent
Expert Verdict
Expert safety assessment and concern-level summary for Schisandrin.
Chemical Function
Bleaching agent
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SCHIZANDRIN
ChEMBL ID
CHEMBL253688
Frequently Asked Questions
Is Schisandrin allowed in the EU?
Schisandrin EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Schisandrin do in cosmetics?
Schisandrin functions as: Antioxidant, skin conditioning (lignan compound from *Schisandra chinensis*). It is classified as a cosmetic ingredient in our database. CAS number: 7432-28-2.
Is Schisandrin used outside cosmetics?
Schisandrin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Schisandrin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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SCHIZOSACCHAROMYCES/(SOLANUM LYCOPERSICUM/CUCUMIS SATIVUS/ANANAS COMOSUS/CITRUS LIMON/PYRUS MALUS/CUCURBITA MAXIMA/CARICA PAPAYA/CITRULLUS LANATUS/CUCUMIS MELO/PRUNUS ARMENIACA/AMYGDALUS PERSICA/FICUS CARICA/AKEBIA QUINATA/CHAENOMELES SINENSIS/FRAGARIA ANNANASSA/VITIS VINIFERA/ACTINIDIA DELICIOSA/PRUNUS MUME/ERIOBOTYRA JAPONICA/PRUNUS SALICINA/BENINCASA HISPIDA) FRUIT/(RAPHANUS SATIVUS/BRASSICA OLERACEA CAPITATA/DAUCUS CAROTA/ALOE ARBORESCENS/SASA VEITCHII/DIOSPYROS KAKI/PERILLA FRUTESCENS) LEAF/(RAPHANUS SATIVUS/DAUCUS CAROTA/SOLANUM TUBEROSUM/IPOMOEA BATATAS/COLOCASIA ESCULENTA/NELUMBO NUCIFERA/ARCTIUM LAPPA/DIOSCOREA JAPONICA/ZINGIBER OFFICINALE) ROOT/(GLYCINE MAX/VIGNA ANGULARIS/COIX LACRYMA-JOBI MA-YUEN/SETARIA ITALICA/PANICUM MILIACEUM) SEED/FARFUGIUM JAPONICUM STEM/EQUISETUM ARVENSE/OENANTHE JAVANICA/CRYPTOTAENIA JAPONICA/ORYZA SATIVA/LENTINUS EDODES FRUITING BODY/UNDARIA PINNATIFIDA FERMENT FILTRATE
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