NOAEL Studies Cosmetic Ingredient

Salicylaldehyde NOAEL Studies

INCI: SALICYLALDEHYDE

CAS: 90-02-8

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 300 mg/kg bw/day rat oral 18 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 13 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 13 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL 10 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=280f88f0-238b-4b1c-9cb9-2f3653ef19e6_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=280f88f0-238b-4b1c-9cb9-2f3653ef19e6/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=64b61873-d916-413e-ac19-d7053ca93c26
ECHA NOAEL 10 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=280f88f0-238b-4b1c-9cb9-2f3653ef19e6_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=280f88f0-238b-4b1c-9cb9-2f3653ef19e6/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=64b61873-d916-413e-ac19-d7053ca93c26
ECHA NOAEL 10 mg/kg bw/day rat oral: gavage - short-term repeated dose toxicity: oral dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=280f88f0-238b-4b1c-9cb9-2f3653ef19e6_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=280f88f0-238b-4b1c-9cb9-2f3653ef19e6/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=RepeatedDoseToxicityOral; literature=Name=Unnamed; ReferenceYear=1996; basis=histopathology: non-neoplastic; key_result=true; entry_uuid=64b61873-d916-413e-ac19-d7053ca93c26
ECHA NOEL 40 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=organ weights and organ / body weight ratios; key_result=true; entry_uuid=e5a06664-3ad1-4d77-934a-1ff1d131ee7c
ECHA NOEL 40 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=organ weights and organ / body weight ratios; key_result=true; entry_uuid=e5a06664-3ad1-4d77-934a-1ff1d131ee7c
ECHA NOEL 160 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=true; entry_uuid=e5b97965-1f34-4781-8e68-f29832a69e3e
ECHA NOEL 160 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=true; entry_uuid=e5b97965-1f34-4781-8e68-f29832a69e3e
ECHA NOEL 40 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=organ weights and organ / body weight ratios; key_result=true; entry_uuid=e5a06664-3ad1-4d77-934a-1ff1d131ee7c
ECHA NOEL 160 mg/kg bw/day rat oral: gavage - screening for reproductive / developmental toxicity dossier=37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6z; document=ed2c8644-78c9-4341-968b-55394cdd179d_37abd418-b3ae-48b1-b65e-a3e5850f7c34.i6d; document_key=ed2c8644-78c9-4341-968b-55394cdd179d/37abd418-b3ae-48b1-b65e-a3e5850f7c34; document_subtype=ToxicityReproduction; literature=Name=Unnamed; ReferenceYear=1996; basis=other:; key_result=true; entry_uuid=e5b97965-1f34-4781-8e68-f29832a69e3e
ECHA LEL ~500 mg/kg bw/day Rat oral - acute QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6605975fe4b063812d6fa6ed; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7577/7/3/2?documentUUID=37abd418-b3ae-48b1-b65e-a3e5850f7c34; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15810493:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a5b952e8e3e680d00bfb19cf392c7c23
ECHA NOAEL =10 mg/kg bw/day Rat oral subchronic; 49 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf50e4b0a7c65d1cd66a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7577/7/6/2?documentUUID=37abd418-b3ae-48b1-b65e-a3e5850f7c34; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic|organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15832386:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6cf4d62af38e1796b6da476a489ca9b4
ECHA NOEL =40 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba957; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7577/7/9/2?documentUUID=37abd418-b3ae-48b1-b65e-a3e5850f7c34; YEAR=1978; ORIGINAL_YEAR=1978; TOXICOLOGICAL_EFFECT=P0: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=ECHA IUCLID:15855807:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ca5a3bf649387429aafe1af2fa448b8f
ECHA NOEL =160 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab87e4b0a7c65d1ba957; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/7577/7/9/2?documentUUID=37abd418-b3ae-48b1-b65e-a3e5850f7c34; YEAR=1978; ORIGINAL_YEAR=1978; STUDY_GROUP=ECHA IUCLID:15856560:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d201d5bda17ebf24868a60864ce60617
EFSA 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA NOAEL =10 mg/kg bw/day Rat oral: gavage 49 days subchronic EFSA FEEDAP - 2012 - OutputID 607 - histopathology non neoplastic - hepatotoxicity - Scientific Opinion on the safety and efficacy of benzyl alcohols, aldehydes, acids, esters and acetals (chemical group 23) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2785
NTP ICE acute oral 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =520 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11266; row=2244; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylaldehyde; preferred_name=Salicylaldehyde; dtxsid=DTXSID1021792; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity OECD eChemPortal (undated); record_id=acute_oral_11265; row=2245; data_type=In Vivo; mixture=Chemical; chemical_name=Salicylaldehyde; preferred_name=Salicylaldehyde; dtxsid=DTXSID1021792; url=https://www.echemportal.org/echemportal/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792; source_file=acute_oral.xlsx
NTP ICE endocrine 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE endocrine AC50 58.3315401426754 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14166; RecordID=ERPathway2016_311; DatasetName=ERPathway2016; DTXSID=DTXSID1021792; Assay=ER Pathway Model, Antagonist; Endpoint=AC50; Response=58.3315401426754; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE endocrine ACC 50.401362189763 uM - - - ERPathway2016; ER Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14167; RecordID=ERPathway2016_311; DatasetName=ERPathway2016; DTXSID=DTXSID1021792; Assay=ER Pathway Model, Antagonist; Endpoint=ACC; Response=50.401362189763; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE endocrine Model Score 0 unitless - - - ARPathway2016; AR Pathway Model, Antagonist sheet=Integrated_approaches; excel_row=14162; RecordID=ARPathway2016_1693; DatasetName=ARPathway2016; DTXSID=DTXSID1021792; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE endocrine Model Score 0.0288 unitless - - - ERPathway2016; ER Pathway Model, Agonist sheet=Integrated_approaches; excel_row=14168; RecordID=ERPathway2016_311; DatasetName=ERPathway2016; DTXSID=DTXSID1021792; Assay=ER Pathway Model, Agonist; Endpoint=Model Score; Response=0.0288; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE skin sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE skin sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10974; Record_ID=skin_sensitization_invivo_2398; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021792; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80092-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE skin sensitization Induction dose per skin area 1350 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10973; Record_ID=skin_sensitization_invivo_2398; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021792; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80092-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
NTP ICE skin sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10977; Record_ID=skin_sensitization_invivo_2398; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1021792; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1976: report to RIFM|Anonymous 1979; Not available; 10.1016/S0015-6264(79)80092-9; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021792
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =0.164 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15634602:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_9abbf2ae5025a8f8ee2132beb28c3b12
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 17K64GZH20 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"17K64GZH20"}
openFDA substances FDA UNII substance identifier 17K64GZH20 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"17K64GZH20"}
openFDA substances FDA UNII substance identifier 17K64GZH20 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"17K64GZH20"}
openFDA substances FDA UNII substance identifier 17K64GZH20 UNII - - - chemical {"approval_status":null,"molecular_formula":"C7H6O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"17K64GZH20"}