NOAEL Studies
Cosmetic Ingredient
Saccharin NOAEL Studies
INCI: SACCHARIN
CAS: 81-07-2
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
California Proposition 65 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 1989-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1989-10-01","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 1989-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1989-10-01","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 1989-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1989-10-01","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
| California Proposition 65 | California Proposition 65 listing | LCcancer | listing type | - | - | 1989-10-01 | California Proposition 65 listing | {"cancer_reproductive":"cancer","listed_date":"1989-10-01","listing_mechanism":"LC","madl":null,"nsrl":null,"source_table":"prop65_listings"} |
EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =3.8 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2014 - OutputID 2545 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance ethametsulfuron (evaluated variant ethametsulfuron-methyl) - doi:10.2903/j.efsa.2014.3787 |
| EFSA_OpenFoodTox_EFSA_ReferenceValues.xlsx | ADI | =3.8 | mg/kg bw/day | Consumers | - | - | ADI | EFSA - 2014 - OutputID 2545 - Consumers - Conclusion on the peer review of the pesticide risk assessment of the active substance ethametsulfuron (evaluated variant ethametsulfuron-methyl) - doi:10.2903/j.efsa.2014.3787 |
IARC Monographs 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| IARC Monographs | IARC carcinogenicity classification | 3 | IARC group | - | - | 1998 | IARC Monographs | {"additional_info":"NB Overall evaluation downgraded to Group 3 with supporting evidence from other relevant data; volume_publication_year=1999","evaluation_year":1998,"source_table":"iarc_classifications","volume":"Sup 7, 73"} |
INCHEM_WHO_jecfa_jecmono_v17je25 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| INCHEM_WHO_jecfa_jecmono_v17je25 | ADI | =5 | mg/kg bw/day | - | oral | - | Health guidance value | document_id=jecfa_jecmono_v17je25; title=545. Saccharin (WHO Food Additives Series 17); path=mirror/documents/jecfa/jecmono/v17je25.htm; row_hash=3877053771c5d315; raw_unit=mg/kg; context=In 1978, the Committee changed the ADI from 5 mg/kg to a temporary ADI of 2.5 mg/kg and withdrew the conditional ADI of 15 mg/kg for dietetic purposes only. |
| INCHEM_WHO_jecfa_jecmono_v17je25 | ADI | =2.5 | mg/kg bw/day | - | - | - | Health guidance value | document_id=jecfa_jecmono_v17je25; title=545. Saccharin (WHO Food Additives Series 17); path=mirror/documents/jecfa/jecmono/v17je25.htm; row_hash=b7ec1fb263a01ae9; raw_unit=mg/kg; context=At the 1980 meeting the temporary ADI of 2.5 mg/kg was extended pending the completion of current investigations. |
NTP_ICE_acute_oral 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =14200 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_10612; row=8572; data_type=In Vivo; mixture=Chemical; chemical_name=Saccharin; preferred_name=Saccharin; dtxsid=DTXSID5021251; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021251; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | <9710 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10611; row=8573; data_type=In Vivo; mixture=Chemical; chemical_name=Saccharin; preferred_name=Saccharin; dtxsid=DTXSID5021251; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021251; source_file=acute_oral.xlsx |
| NTP_ICE_acute_oral | LD50 | >8440 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | record_id=acute_oral_10610; row=8574; data_type=In Vivo; mixture=Chemical; chemical_name=Saccharin; preferred_name=Saccharin; dtxsid=DTXSID5021251; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID5021251; source_file=acute_oral.xlsx |
NTP_ICE_adme_parameters 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_adme_parameters | Clint | 1.917 | uL/min/10^6 cells | Human | - | - | Measured; httk, Human Hepatic Intrinsic Clearance | sheet=Data; excel_row=1965; Record_ID=adme_parameters_1202; Data_Type=Measured; DTXSID=DTXSID5021251; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=1.917; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_adme_parameters | Fu | 0.2258 | fraction | Human | - | - | Measured; httk, Human Plasma Fraction Unbound | sheet=Data; excel_row=1964; Record_ID=adme_parameters_1202; Data_Type=Measured; DTXSID=DTXSID5021251; Assay=httk, Human Plasma Fraction Unbound; Endpoint=Fu; Response=0.2258; Response_Unit=Unitless Fraction; Species=Human; Reference=httk2.3.1, Paini 2020; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
NTP_ICE_cancer 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_cancer | IARC group | 3 | unitless | - | - | - | WOE; IARC Carcinogenicity | sheet=Data; excel_row=5685; Record_ID=cancer_4317; Data_Type=WOE; Formulation_Name=Saccharin; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=IARC Carcinogenicity; Endpoint=IARC group; Response=3; Response_Unit=Unitless; URL=http://publications.iarc.fr/139; http://publications.iarc.fr/91; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
NTP_ICE_endocrine 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=14146; RecordID=ARPathway2016_1609; DatasetName=ARPathway2016; DTXSID=DTXSID5021251; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
NTP_ICE_skin_sensitization 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | CD86, EC150 | >1282.26 | ug/mL | - | Dermal | - | In Vitro; Urbisch_SkinSensitization2020; U-SENS | sheet=Data_invitro; excel_row=8182; Record_ID=skin_sensitization_invitro_2205; Data_Type=In Vitro; Internal_Data_Source=Urbisch_SkinSensitization2020; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=U-SENS; Endpoint=CD86, EC150; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=7000; Reported_Response_Unit=uM; Conversion_Factor_Value=183.18; Conversion_Factor_Source=EPA Dashboard; Converted_Response_Modifier=>; Converted_Response=1282.26; Converted_Response_Unit=ug/mL; Response=1282.26; Response_Unit=ug/mL; Reference=Urbisch et al. 2015; 25541156; 10.1016/j.yrtph.2014.12.008; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | CV75 | <1000 | ug/mL | - | Dermal | - | In Vitro; hCLAT2015; h-CLAT | sheet=Data_invitro; excel_row=3199; Record_ID=skin_sensitization_invitro_742; Data_Type=In Vitro; Internal_Data_Source=hCLAT2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=h-CLAT; Endpoint=CV75; Response_Modifier=<; Reported_Response_Modifier=<; Reported_Response=1000; Reported_Response_Unit=ug/mL; Response=1000; Response_Unit=ug/mL; Reference=Ashikaga et al. 2010; 20822320; 10.1177/026119291003800403|Nukada et al. 2012; 22796097; 10.1016/j.tiv.2012.07.001|Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Cys | 2.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1067; Record_ID=skin_sensitization_invitro_291; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=2.4; Reported_Response_Unit=%; Response=2.4; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Cys | 48.7 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1075; Record_ID=skin_sensitization_invitro_292; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Cys; Reported_Response=48.7; Reported_Response_Unit=%; Response=48.7; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Lys | 0 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1066; Record_ID=skin_sensitization_invitro_291; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=0; Reported_Response_Unit=%; Response=0; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Lys | -2.4 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1073; Record_ID=skin_sensitization_invitro_292; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Lys; Reported_Response=-2.4; Reported_Response_Unit=%; Response=-2.4; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 1.2 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1069; Record_ID=skin_sensitization_invitro_291; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=1.2; Reported_Response_Unit=%; Response=1.2; Response_Unit=%; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Depletion Lys + Cys | 24 | % | - | Dermal | - | In Vitro; DPRA2015; DPRA | sheet=Data_invitro; excel_row=1077; Record_ID=skin_sensitization_invitro_292; Data_Type=In Vitro; Internal_Data_Source=DPRA2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=DPRA; Endpoint=Depletion Lys + Cys; Reported_Response=24; Reported_Response_Unit=%; Response=24; Response_Unit=%; Reference=Nukada et al. 2013; 23149339; 10.1016/j.tiv.2012.11.006|Nukada personal communication (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | EC1.5 | >2000 | uM | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6682; Record_ID=skin_sensitization_invitro_1582; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=KeratinoSens; Endpoint=EC1.5; Response_Modifier=>; Reported_Response_Modifier=>; Reported_Response=2000; Reported_Response_Unit=uM; Response=2000; Response_Unit=uM; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
| NTP_ICE_skin_sensitization | Imax | 1.1 | ratio | - | Dermal | - | In Vitro; KeratinoSens2015; KeratinoSens | sheet=Data_invitro; excel_row=6684; Record_ID=skin_sensitization_invitro_1582; Data_Type=In Vitro; Internal_Data_Source=KeratinoSens2015; Mixture=Chemical; DTXSID=DTXSID5021251; Assay=KeratinoSens; Endpoint=Imax; Reported_Response=1.1000000000000001; Reported_Response_Unit=Unitless; Response=1.1; Response_Unit=Ratio; Reference=Natsch et al. 2013; 23576290; 10.1002/jat.2868; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5021251; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID5021251 |
ToxValDB_ECHA_IUCLID 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | LOEL | =1000 | mg/kg bw/day | Mouse | oral | chronic; 1 years | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf15e4b0a7c65d1cc6c6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/6/2?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15847704:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_4920af70acaaf03841ce31af8afb8f48 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2000 | mg/kg bw/day | Mouse | injection | - | developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d232021; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/9/3?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15821019:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d916ae144f63869c5abae03cb5af6ab4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =353 | mg/kg bw/day | Hamster | oral | chronic; 60 weeks | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbf1e4b0a7c65d2282a6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/6/2?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15831287:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b2fd57ef0930387ae5185ef32225c6cb |
| ToxValDB_ECHA_IUCLID | NOAEL | =286 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba25a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/9/2?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856515_15863026:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_eee6f8c738b4743830c173598eca5c94 |
| ToxValDB_ECHA_IUCLID | NOAEL | =714 | mg/kg bw/day | Mouse | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba25a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/9/2?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15856515_15863026:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_936db38a7e36ba18d4422625126c6260 |
| ToxValDB_ECHA_IUCLID | NOAEL | =2500 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eab68e4b0a7c65d1ba264; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/11056/7/9/2?documentUUID=7dae701a-e4f9-49e1-849d-e9ccf6dec4dc; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15863027:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_42832b8b7c0e6fa49c824ef4b54474ac |
ToxValDB_ECOTOX 9 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECOTOX | LOEL | =0.0001 | mg/org | Rat | injection | acute; 1 days | developmental | LONG_REF=Toxicol. In Vitro8(2): 153-166 Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique 1994; TITLE=Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique; AUTHOR=Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten; DOI=10.1016/0887-2333(94)90178-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Development: Organ/tissue formation|Growth: Length|Histology: Histological changes, general|Morphology: Quantity|Physiology: Heart rate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs|development|nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX:15594984:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=793214c99d7d21123411cf2f8d7be14c |
| ToxValDB_ECOTOX | LOEL | =200 | mmol/kg | Rat | oral | subchronic; 70 days | subchronic | LONG_REF=Food Chem. Toxicol.26(8): 665-669 Anderson,R.L., F.R. Lefever, and J.K. Maurer The Effect of Various Saccharin Forms on Gastro-Intestinal Tract, Urine and Bladder of Male Rats 1988; TITLE=The Effect of Various Saccharin Forms on Gastro-Intestinal Tract, Urine and Bladder of Male Rats; AUTHOR=Anderson,R.L., F.R. Lefever, and J.K. Maurer; DOI=10.1016/0278-6915(88)90065-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82947; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Morphology: Organ weight in relationship to body weight|Physiology: Excretion rate|Physiology: Food conversion efficiency|Physiology: Phosphorus excretion|Physiology: Sodium Excretion; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|organ weight|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15598005_15600153:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=740efad011cef0a704679818132c74fc |
| ToxValDB_ECOTOX | LOEL | =1000 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604572_15604573:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=887f278a29a74ffe176d70884c84c37f |
| ToxValDB_ECOTOX | LOEL | =50 | mg/L | Rat | environmental | acute; 1 days | acute | LONG_REF=Toxicol. In Vitro8(2): 153-166 Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique 1994; TITLE=Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique; AUTHOR=Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten; DOI=10.1016/0887-2333(94)90178-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605889_15605890_15610349:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e19cc09190fc0c2bfe47869af13b9077 |
| ToxValDB_ECOTOX | NOEL | =800 | mg/L | Rat | environmental | short-term; 2 days | short-term | LONG_REF=Experientia44(10): 833-840 Cicurel,L., and B.P. Schmid Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds 1988; TITLE=Postimplantation Embryo Culture for the Assessment of the Teratogenic Potential and Potency of Compounds; AUTHOR=Cicurel,L., and B.P. Schmid; DOI=10.1007/BF01941180; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=94518; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Growth: Length|Morphology: General morphological changes; STUDY_GROUP=ECOTOX:15600413:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d70dd99eeb4f6f244e70623f27acf86f |
| ToxValDB_ECOTOX | NOEL | =1 | mM | Rat | environmental | short-term; 2 days | developmental | LONG_REF=Food Chem. Toxicol.21(5): 537-541 Kitchin,K.T., and M.T. Ebron Studies of Saccharin and Cyclohexylamine in a Coupled Microsomal Activating/Embryo Culture System 1983; TITLE=Studies of Saccharin and Cyclohexylamine in a Coupled Microsomal Activating/Embryo Culture System; AUTHOR=Kitchin,K.T., and M.T. Ebron; DOI=10.1016/0278-6915(83)90137-0; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=90513; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Development: Abnormal|Growth: Length|Morphology: Quantity|Mortality: Survival; TOXICOLOGICAL_EFFECT_CATEGORY=development|mortality/survival|other; STUDY_GROUP=ECOTOX:15600490:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=59952e9a85b4407dc126debe0852fb80 |
| ToxValDB_ECOTOX | NOEL | =0.0001 | mg/org | Rat | injection | acute; 1 days | acute | LONG_REF=Toxicol. In Vitro8(2): 153-166 Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique 1994; TITLE=Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique; AUTHOR=Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten; DOI=10.1016/0887-2333(94)90178-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX:15603892:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=669c5ee41f137ca02effad86a39b4d1a |
| ToxValDB_ECOTOX | NOEL | =100 | mg/kg bw/day | Mouse | oral | acute; 1 days | acute | LONG_REF=Mutat. Res.519(1/2): 103-119 Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives 2002; TITLE=The Comet Assay with 8 Mouse Organs: Results with 39 Currently Used Food Additives; AUTHOR=Sasaki,Y.F., S. Kawaguchi, A. Kamaya, M. Ohshita, K. Kabasawa, K. Iwama, K. Taniguchi, and S. Tsuda; DOI=10.1016/s1383-5718(02)00128-6; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=75840; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Genetics: Damage; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15604572_15604573:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=daabc0b61691a30f04c379f09dc21618 |
| ToxValDB_ECOTOX | NOEL | =5 | mg/L | Rat | environmental | acute; 1 days | acute | LONG_REF=Toxicol. In Vitro8(2): 153-166 Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique 1994; TITLE=Further Evaluation of a Teratogenicity Screen Using an Intravitelline Injection Technique; AUTHOR=Cumberland,P.F.T., M. Richold, J.F. Parsons, and M.K. Pratten; DOI=10.1016/0887-2333(94)90178-3; QUALITY=Control type: Multiple control types; EXTERNAL_SOURCE_ID=91195; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=Biochemistry: Protein content|Genetics: DNA concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15605889_15605890_15610349:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f82129474bdf6403ca5f6957876a5420 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =131.3 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15630019:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_31b14936ba6be8db42bbb7f175f99dcc |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | FST467XS7D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FST467XS7D"} |
| openFDA substances | FDA UNII substance identifier | FST467XS7D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FST467XS7D"} |
| openFDA substances | FDA UNII substance identifier | FST467XS7D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FST467XS7D"} |
| openFDA substances | FDA UNII substance identifier | FST467XS7D | UNII | - | - | - | chemical | {"approval_status":null,"molecular_formula":"C7H5NO3S","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"FST467XS7D"} |