Is Retinyl Linoleate safe in cosmetics?
Retinyl Linoleate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Retinyl Linoleate
Also known as: Retinol, 9,12-octadecadienoate, (Z,Z)-, UNII-61911N8D6W
INCI: RETINYL LINOLEATE
Retinyl Linoleate (CAS 631-89-0) is a cosmetic cosmetic ingredient functioning as Skin conditioning, anti-aging, brightening. EU Regulation 1223/2009 status: permitted, max 0.05% RE body lotions, 0.3% RE other products. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 631-89-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, anti-aging, brightening
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
[(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] (9Z,12Z)-octadeca-9,12-dienoate
InChIKey
XJKITIOIYQCXQR-SCUNHAKFSA-N
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.05% RE body lotions, 0.3% RE other products
US US Status
permitted
US Notes
No specific FDA restriction. CIR concluded retinyl palmitate and retinol safe in 1987. Retinyl linoleate considered for CIR re-assessment in 2012.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Retinyl Linoleate.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Retinyl Linoleate, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
665.1 Da
Log P
16.8
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Cosmetic Science
Additional Ingredient Properties
6 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "anti-wrinkle, barrier-repair", "mechanism_of_action": "Cofactor for enzymatic reactions, antioxidant activity", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "12", "sample_size": "30", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JAA…
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "95", "estimated_cost_per_kg_usd_high": "180", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "medium", "primary_source_region": "Global", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Retinyl Palmi…
dermal_absorption
{"molecular_weight_da": "665.1", "log_p_value": "16.8", "skin_penetration_level": "stratum-corneum", "penetration_depth": "stratum corneum", "absorption_pct": "0.5-2", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.2-1", "safety_margin_factor": "minimal", "sour…
pregnancy_detail
{"pregnancy_safe": "no", "breastfeeding_safe": "no", "trimester_restriction": "all", "risk_category": "not-rated", "reason": "Vitamin A derivative", "alternative_ingredient": "Bakuchiol", "source": "dermatology literature"}
uv_stability
{"uv_stable": "no", "uv_degradation_rate": "fast", "photosensitizer": "yes", "phototoxic": "yes", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "yes", "odor_change_uv": "yes", "efficacy_loss_uv_pct": "70", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv…
vitamin
{"cas_number": "633-53-4", "ingredient_class": "vitamin_A", "chemical_form": "ester", "derivative_type": "pro_vitamin", "molecular_weight_Da": "566.91", "water_solubility": "insoluble", "oil_solubility": "soluble", "log_P": "14.20", "stability_to_light": "moderate", "stability_to_heat": "good", "stability_to_oxidation": "moderate", "stability_to_pH_acid": "excellent", "stability_to_pH_alkaline": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Retinyl Linoleate.
Regulatory Flags
Restricted
Known Synonyms
Retinol, 9,12-octadecadienoate, (Z,Z)-
UNII-61911N8D6W
Chemical Function
Softener and conditioner
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.1%. This chemical is not to be used in topical products intended for the eye.
Frequently Asked Questions
Is Retinyl Linoleate allowed in the EU?
Retinyl Linoleate EU regulatory status: permitted. Maximum allowed concentration: 0.05% RE body lotions, 0.3% RE other products. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinyl Linoleate do in cosmetics?
Retinyl Linoleate functions as: Skin conditioning, anti-aging, brightening. It is classified as a cosmetic ingredient in our database. CAS number: 631-89-0.
Is Retinyl Linoleate used outside cosmetics?
Retinyl Linoleate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Retinyl Linoleate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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