Is Quercetin Dihydrate safe in cosmetics?
Quercetin Dihydrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Quercetin Dihydrate
Also known as: Flavone, 3,3',4',5,7-pentahydroxy-, dihydrate, UNII-53B03V78A6
INCI: QUERCETIN
Quercetin Dihydrate (CAS 6151-25-3) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, UV absorber, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 6151-25-3 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning, UV absorber, anti-inflammatory
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one;dihydrate
InChIKey
GMGIWEZSKCNYSW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; quercetin has extensive GRAS history as a food flavonoid. No FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Quercetin Dihydrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "117-39-5", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-inflammatory", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "117-39-5", "ingredient_class": "Nrf2_activator/AhR_antagonist/antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging/enzyme_induction", "pollution_types_targeted": "PM2_5/UV_A/ozone/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "yes", "ozone_protection": "yes", "lipid_peroxidatio…
antioxidant
{"cas_number": "117-39-5", "antioxidant_class": "flavonoid", "chemical_subclass": "flavonol", "molecular_weight_daltons": "302.23", "orac_value_umol_te_per_g": "14600", "dpph_radical_scavenging_ic50_ug_per_ml": "10-18", "abts_trolox_equivalent": "1.25", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "very high", "lipid_peroxidation_in…
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "35", "estimated_cost_per_kg_usd_high": "65", "natural_premium_markup_pct": "50", "organic_certified_premium_pct": "85", "supply_chain_volatility": "medium", "primary_source_region": "China/India", "synthetic_vs_natural_cost_ratio": "2.2", "bulk_discount_threshold_kg": "50", "seasonal_price_variation": "medium", "commodity_or_specialty": …
depigmentation
{"cas_number": "117-39-5", "ingredient_class": "tyrosinase_inhibitor", "primary_mechanism_of_action": "Flavonoid with copper chelation tyrosinase inhibition", "secondary_mechanisms": "Variable", "molecular_target": "tyrosinase", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": "15-30…
hair_care
{"hair_function": "scalp-care", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "yes", "heat_protectant": "yes", "color_safe": "neutral", "kerat…
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe topically; flavonoid antioxidant", "source": "dermatology literature"}
Expert Verdict
Expert safety assessment and concern-level summary for Quercetin Dihydrate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Quercetin Dihydrate by CAS number or substance name.
Studies
2
Lowest NOAEL
780 mg/kg bw/day
Highest NOAEL
3120 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Flavone, 3,3',4',5,7-pentahydroxy-, dihydrate
UNII-53B03V78A6
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1520590
Adverse Event Associations
51
Frequently Asked Questions
Is Quercetin Dihydrate allowed in the EU?
Quercetin Dihydrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quercetin Dihydrate do in cosmetics?
Quercetin Dihydrate functions as: Antioxidant, skin conditioning, UV absorber, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 6151-25-3.
Is Quercetin Dihydrate used outside cosmetics?
Quercetin Dihydrate also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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