Is Quaternium-80 safe in cosmetics?
Quaternium-80 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Quaternium-80
Also known as: Siloxanes and Silicones, di-Me, 3-[3-[(3-coco amidopropyl)dimethylammonio]-2-hydroxypropoxy]propyl group-terminated, acetates (salts)
INCI: QUATERNIUM-80
Quaternium-80 (CAS 134737-05-6) is a cosmetic cosmetic ingredient functioning as Antistatic Agent, Hair Conditioning Agent, Skin Conditioning Agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 134737-05-6 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic Agent, Hair Conditioning Agent, Skin Conditioning Agent
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Listed in FDA GSRS. No specific restrictions. LD50 >5,000 mg/kg, Ames negative.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Quaternium-80.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "3.0", "typical_concentration_pct": "1.5", "product_type": "Hair Conditioner", "function_at_concentration": "Cationic conditioning agent", "source": "CIR Safety Assessment"}
emulsion_hlb
{"hlb_required_as_emulsifier": "yes", "emulsifier_type": "o_w", "critical_packing_parameter": "0.26-0.38", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "cetearyl_alcohol", "optimal_oil_phase_pct": "10-28", "optimal_water_phase_pct": "72-90", "electrolyte_tolerance": "moderate", "pH_emulsion_stability_range": "3.0-8.5", "viscosity_building_contribution": "moder…
hair_care
{"hair_function": "conditioning", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "kera…
hair_conditioning
{"cas_number": "134737-05-6", "ingredient_class": "cationic_conditioner", "chemical_type": "quaternary_ammonium", "charge_density_meq_g": "high", "substantivity_to_hair": "excellent", "deposition_from_shampoo": "no", "deposition_from_conditioner": "yes", "conditioning_mechanism": "electrostatic", "hair_penetration": "cuticle", "molecular_weight_effect_on_penetration": "ester_quat", "wet_combing_fo…
pediatric_safety
{"safe_for_newborn_0_6m": "caution", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "minimal", "immature_skin_barrier_risk": "low", "oral_ingestion_risk": "low", "eye_irritation_risk": "low", "diaper_are…
ph_stability
{"optimal_ph_min": "4.0", "optimal_ph_max": "9.0", "stable_ph_min": "3.5", "stable_ph_max": "10.0", "ph_dependent_function": "Cationic conditioning polymer", "formulation_note": "Hair care", "source": "Formulation literature"}
polymer
{"ingredient_class": "conditioning/film_former", "polymer_type": "silicone_based", "chemical_backbone": "other", "molecular_weight_Da_range": "6000-50000", "ionic_character": "cationic", "charge_density_meq_g": "0.4-0.9", "pH_viscosity_sensitivity": "moderate", "salt_tolerance": "moderate", "electrolyte_effect_on_viscosity": "moderate", "temperature_viscosity_sensitivity": "moderate", "film_transp…
silicone
{"cas_number": "68439-57-6", "silicone_class": "amodimethicone", "molecular_weight_Da": "7800.0", "viscosity_cSt": "3200", "volatility": "non_volatile", "evaporation_rate_relative_to_D5": "0.003", "refractive_index": "1.4053", "specific_gravity": "0.984", "flash_point_C": "118.0", "surface_tension_mN_m": "22.3", "spreading_coefficient": "3.65", "film_forming_ability": "excellent", "skin_feel": "ve…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Quaternium-80.
Known Synonyms
Siloxanes and Silicones, di-Me, 3-[3-[(3-coco amidopropyl)dimethylammonio]-2-hydroxypropoxy]propyl group-terminated, acetates (salts)
Chemical Function
Anti-static agent
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Quaternium-80 allowed in the EU?
Quaternium-80 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-80 do in cosmetics?
Quaternium-80 functions as: Antistatic Agent, Hair Conditioning Agent, Skin Conditioning Agent. It is classified as a cosmetic ingredient in our database. CAS number: 134737-05-6.
Compliance Tools
Check Quaternium-80 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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