Is Quaternium-27 safe in cosmetics?
Quaternium-27 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Quaternium-27
Also known as: EINECS 268-531-2, 1-Methyl-1-(tallow alkyl amido)-2-nor(tallow alkyl)-2-imidazolinium, methylsulfate, 1-Methyl-1-tallowalkylamidoethyl-2-tallowalkylimidazoline methosulfate, 1-Methyl-1-(2-tallowamidoethyl)-2-tallowimidazolinium methylsulfate, 1-(2-Tallow amidoethyl)-1-methyl-2-nor(tallow alkyl)-2-imidazolinium methyl sulfate (+2 more)
INCI: QUATERNIUM-27
Quaternium-27 (CAS 68122-86-1) is a cosmetic cosmetic ingredient functioning as Antistatic, hair conditioning. NOAEL 2200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 68122-86-1 →
Auto-generated CPSR Part A draft with source citations
Function
Antistatic, hair conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted for cosmetic use; no specific restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Quaternium-27.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Quaternium-27 across SCCS product categories, with measured dermal absorption where available.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_care
{"hair_function": "conditioning", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "kera…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Biocide
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Quaternium-27.
Known Synonyms
EINECS 268-531-2
1-Methyl-1-(tallow alkyl amido)-2-nor(tallow alkyl)-2-imidazolinium, methylsulfate
1-Methyl-1-tallowalkylamidoethyl-2-tallowalkylimidazoline methosulfate
1-Methyl-1-(2-tallowamidoethyl)-2-tallowimidazolinium methylsulfate
1-(2-Tallow amidoethyl)-1-methyl-2-nor(tallow alkyl)-2-imidazolinium methyl sulfate
1-(2-Tallowamidoethyl)-1-methyl-2-tallowalkylimidazolinium methylsulfate
4,5-Dihydro-1-methyl-2-nortallow alkyl-1-(2-tallow amidoethyl) imidazolium compounds methyl sulfates
Chemical Function
Surfactant (surface active agent)
Biocide
Softener and conditioner
Anti-static agent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Quaternium-27 allowed in the EU?
Quaternium-27 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Quaternium-27 do in cosmetics?
Quaternium-27 functions as: Antistatic, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 68122-86-1.
Compliance Tools
Check Quaternium-27 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Same category
Hair conditioning; modified aminosili...
Acetamidoamodimethicone
Excellent
Same category
Hair conditioning agent (film-forming...
Glyceryl Dioleate/Linoleate/Linolenate
Excellent
Same category
Hair conditioning agent
Gondoic Acid
Excellent
Same category
Hair conditioning
Hydroxypropyldimethicone
Excellent
Same category
Skin/hair conditioning (silicone poly...
Hydroxypropyltrimonium Inulin
Excellent
Same category
Antistatic, hair conditioning
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
QUERCUS ALBA BARK
Good
Browse nearby
Skin Conditioning
QUERCUS INFECTORIA GALL EXTRACT
Good
Browse nearby
Anti-sebum, Astringent, Skin Conditio...
QUILLAJA SAPONARIA BARK EXTRACT
Good
Browse nearby
Anti-seborrheic, Cleansing, Foaming, ...
Is Quaternium-27 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Quaternium-27 in your formulation.