Is Protamine Sulfate safe in cosmetics?
Protamine Sulfate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Protamine Sulfate
INCI: PROTAMINE SULFATE
Protamine Sulfate (CAS 9009-65-8 (from salmon sperm) / 53597-25-4 (synthetic)) is a cosmetic cosmetic ingredient functioning as Skin conditioning, hair conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
9009-65-8 (from salmon sperm) / 53597-25-4 (synthetic)
View industrial chemical safety profile →
Function
Skin conditioning, hair conditioning
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA-approved as a pharmaceutical (heparin reversal agent). Permitted in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Protamine Sulfate.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Protamine Sulfate.
Regulatory Flags
potential-allergen
Frequently Asked Questions
Is Protamine Sulfate allowed in the EU?
Protamine Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Protamine Sulfate do in cosmetics?
Protamine Sulfate functions as: Skin conditioning, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9009-65-8 (from salmon sperm) / 53597-25-4 (synthetic).
Compliance Tools
Check Protamine Sulfate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Is Protamine Sulfate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Protamine Sulfate in your formulation.